{"id":"https://openalex.org/W4391996217","doi":"https://doi.org/10.1002/alz.13718","title":"Whole genome\u2010wide sequence analysis of long\u2010lived families (Long\u2010Life Family Study) identifies MTUS2 gene associated with late\u2010onset Alzheimer's disease","display_name":"Whole genome\u2010wide sequence analysis of long\u2010lived families (Long\u2010Life Family Study) identifies MTUS2 gene associated with late\u2010onset Alzheimer's disease","publication_year":2024,"publication_date":"2024-02-21","ids":{"openalex":"https://openalex.org/W4391996217","doi":"https://doi.org/10.1002/alz.13718","pmid":"https://pubmed.ncbi.nlm.nih.gov/38380866","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11032545"},"language":"en","primary_location":{"id":"doi:10.1002/alz.13718","doi":"https://doi.org/10.1002/alz.13718","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.13718","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.13718","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.13718","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018394396","display_name":"Laura Xicota","orcid":"https://orcid.org/0000-0003-2832-9214","observed_orcids":["https://orcid.org/0000-0003-2832-9214"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Xicota","raw_affiliation_strings":["Department of Neurology, Columbia University Irving Medical Center, New York City, New York, USA","The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078461205","display_name":"Stephanie Cosentino","orcid":"https://orcid.org/0000-0001-5684-143X","observed_orcids":["https://orcid.org/0000-0001-5684-143X"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Cosentino","raw_affiliation_strings":["Department of Neurology, Columbia University Irving Medical Center, New York City, New York, USA","The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091023924","display_name":"Badri Narayan Vardarajan","orcid":"https://orcid.org/0000-0002-5560-4085","observed_orcids":["https://orcid.org/0000-0002-5560-4085"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Badri Vardarajan","raw_affiliation_strings":["Department of Neurology, Columbia University Irving Medical Center, New York City, New York, USA","Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York City, New York, USA","The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077632970","display_name":"Richard P Mayeux","orcid":"https://orcid.org/0000-0001-6519-9696","observed_orcids":["https://orcid.org/0000-0001-6519-9696"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Mayeux","raw_affiliation_strings":["Department of Neurology, Columbia University Irving Medical Center, New York City, New York, USA","Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York City, New York, USA","The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031579243","display_name":"Thomas T. Perls","orcid":"https://orcid.org/0000-0002-2492-4334","observed_orcids":["https://orcid.org/0000-0002-2492-4334","https://orcid.org/0000-0003-1545-1720"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas T. Perls","raw_affiliation_strings":["Section of Geriatrics, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Geriatrics, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102850471","display_name":"Stacy L. Andersen","orcid":"https://orcid.org/0000-0002-2442-6386","observed_orcids":["https://orcid.org/0000-0002-2442-6386"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacy L. Andersen","raw_affiliation_strings":["Section of Geriatrics, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Geriatrics, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056009082","display_name":"Joseph M. Zmuda","orcid":"https://orcid.org/0000-0001-7237-3162","observed_orcids":["https://orcid.org/0000-0001-7237-3162"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M. Zmuda","raw_affiliation_strings":["Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063652834","display_name":"Bharat Thyagarajan","orcid":"https://orcid.org/0000-0001-6968-6985","observed_orcids":["https://orcid.org/0000-0001-6968-6985"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bharat Thyagarajan","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111899212","display_name":"Anatoli I. Yashin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anatoli Yashin","raw_affiliation_strings":["Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031200792","display_name":"Mary K. Wojczynski","orcid":"https://orcid.org/0000-0002-2420-162X","observed_orcids":["https://orcid.org/0000-0002-2420-162X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary K. Wojczynski","raw_affiliation_strings":["Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013601476","display_name":"Sharon J. Krinsky\u2010McHale","orcid":"https://orcid.org/0000-0002-7205-7319","observed_orcids":["https://orcid.org/0000-0002-7205-7319"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon Krinsky\u2010McHale","raw_affiliation_strings":["Department of Psychology, New York Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA","Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York City, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, New York Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA","institution_ids":[]},{"raw_affiliation_string":"Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008552659","display_name":"Benjamin L. Handen","orcid":"https://orcid.org/0000-0001-9550-1665","observed_orcids":["https://orcid.org/0000-0001-9550-1665"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin L. Handen","raw_affiliation_strings":["Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102791472","display_name":"Bradley T. Christian","orcid":"https://orcid.org/0000-0002-9653-559X","observed_orcids":["https://orcid.org/0000-0002-9653-559X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley T. Christian","raw_affiliation_strings":["Department of Medical Physics, University of Wisconsin-Madison School of Medicine, and Public Health, Madison, Wisconsin, USA","Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, University of Wisconsin-Madison School of Medicine, and Public Health, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070892687","display_name":"Elizabeth Head","orcid":"https://orcid.org/0000-0003-1115-6396","observed_orcids":["https://orcid.org/0000-0003-1115-6396"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Head","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of California, Irvine, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081303009","display_name":"Mark E. Mapstone","orcid":"https://orcid.org/0000-0003-0280-8057","observed_orcids":["https://orcid.org/0000-0003-0280-8057"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark E. Mapstone","raw_affiliation_strings":["Department of Neurology, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041371000","display_name":"Nicole Schupf","orcid":"https://orcid.org/0000-0001-7560-7657","observed_orcids":["https://orcid.org/0000-0001-7560-7657"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Schupf","raw_affiliation_strings":["The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016050187","display_name":"Joseph Hyungwoo Lee","orcid":"https://orcid.org/0000-0002-2000-4821","observed_orcids":["https://orcid.org/0000-0002-2000-4821"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph H. Lee","raw_affiliation_strings":["Department of Neurology, Columbia University Irving Medical Center, New York City, New York, USA","Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York City, New York, USA","The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055755754","display_name":"Sandra Barral","orcid":"https://orcid.org/0000-0001-5623-4939","observed_orcids":["https://orcid.org/0000-0001-5623-4939"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sandra Barral","raw_affiliation_strings":["Department of Neurology, Columbia University Irving Medical Center, New York City, New York, USA","Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York City, New York, USA","The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":null,"display_name":"the Long\u2010Life Family Study (LLFS)","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"the Long\u2010Life Family Study (LLFS)","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5055755754"],"corresponding_institution_ids":["https://openalex.org/I2799503643"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":{"value":4000,"currency":"USD","value_usd":4000},"fwci":4.2168,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.94642094,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"20","issue":"4","first_page":"2670","last_page":"2679"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.039000000804662704,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/late-onset-alzheimer-s-disease","display_name":"late-onset Alzheimer's disease","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5178611278533936},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.46875834465026855},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46351540088653564},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4614822268486023},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.4551955461502075},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3949340879917145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38168805837631226},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.34667932987213135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2208687961101532},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/alz.13718","doi":"https://doi.org/10.1002/alz.13718","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.13718","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.13718","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11032545","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11032545","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11032545/pdf/ALZ-20-2670.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimers Dement","raw_type":"Text"},{"id":"pmid:38380866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38380866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & dementia : the journal of the Alzheimer's Association","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8h4405s2","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8h4405s2","pdf_url":"https://escholarship.org/content/qt8h4405s2/qt8h4405s2.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alzheimer's & Dementia, vol 20, iss 4","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/alz.13718","doi":"https://doi.org/10.1002/alz.13718","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.13718","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.13718","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1020191986","display_name":null,"funder_award_id":"R01 AG037212","funder_id":"https://openalex.org/F4320309111","funder_display_name":"Columbia University"},{"id":"https://openalex.org/G1129744104","display_name":"Epidemiologic Study of Neural Reserve and Neurobiology of Aging","funder_award_id":"R01AG017917","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1173778324","display_name":null,"funder_award_id":"AG 016976","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1364228619","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P30AG066512","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1369195717","display_name":null,"funder_award_id":"AG062421","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1521519865","display_name":"Genetic Epidemiology of Alzheimer's Disease in African Americans","funder_award_id":"R01AG028786","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1635908778","display_name":"Epidemiological Integration of Genetic Variants and Metabolomics Profiles in Washington Heights Columbia Aging Project","funder_award_id":"RF1AG066107","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2044076563","display_name":null,"funder_award_id":"R01 AG028786","funder_id":"https://openalex.org/F4320309111","funder_display_name":"Columbia University"},{"id":"https://openalex.org/G2142974134","display_name":null,"funder_award_id":"AG066519","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2144249069","display_name":"Epidemiology of Biomarkers of Risk and Progression in LOAD","funder_award_id":"R01AG037212","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2271988818","display_name":"Long Life Family Study: Boston Field Center","funder_award_id":"U01AG023755","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2356271335","display_name":null,"funder_award_id":"AG063893","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2640555407","display_name":null,"funder_award_id":"AG-005133","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2682194152","display_name":"Waisman Intellectual and Developmental Disabilities Research Center","funder_award_id":"U54HD090256","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3004476995","display_name":"Racial Differences in Late-Life Cognitive decline and risk of Alzheimer's Disease","funder_award_id":"RF1AG022018","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3080460668","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P50AG005133","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3196599506","display_name":"1Florida Alzheimer's Disease Research Center","funder_award_id":"P30AG066506","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G330169411","display_name":"National Alzheimer's Coordinating Center","funder_award_id":"U01AG016976","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3487525919","display_name":null,"funder_award_id":"R37-AG015473","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3551608766","display_name":"Clinical Impact of Unstable AED Levels in Elderly Nursing Home Epilepsy Patients","funder_award_id":"R01AG026390","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3804978007","display_name":"Institute for Clinical and Translational Science","funder_award_id":"UL1TR001414","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3818147302","display_name":null,"funder_award_id":"AG062715","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3969399748","display_name":"Neurodegeneration in Aging Down Syndrome (NiAD): A Longitudinal Study of Cognition and Biomarkers of Alzheimer's Disease","funder_award_id":"U01AG051406","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4189128803","display_name":"Long Life Family Study: Duke Univ./Univ. of Southern Denmark Field Center","funder_award_id":"U01AG023712","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4238128637","display_name":"Nevada Exploratory Alzheimer's Disease Research Center (NVEADRC)","funder_award_id":"P20AG068053","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4875156105","display_name":"Risk Factors, Pathology, and Clinical Expressions of AD","funder_award_id":"R01AG015819","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4894953841","display_name":"UAB Alzheimer's Disease Research Center","funder_award_id":"P20AG068024","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4999128769","display_name":"Biomarkers of Alzheimer's Disease in Adults with Down Syndrome","funder_award_id":"U01AG051412","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5029820101","display_name":"Rush Alzheimer's Disease Core Center","funder_award_id":"P30AG010161","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5273013668","display_name":"Alzheimer's Disease Genetics Consortium","funder_award_id":"U01AG032984","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5365902117","display_name":null,"funder_award_id":"R37 AG015473","funder_id":"https://openalex.org/F4320309111","funder_display_name":"Columbia University"},{"id":"https://openalex.org/G5390520707","display_name":null,"funder_award_id":"U01\u2010AG016976","funder_id":"https://openalex.org/F4320320015","funder_display_name":"National Association for Colitis and Crohn's Disease"},{"id":"https://openalex.org/G5437871763","display_name":null,"funder_award_id":"AG028786","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5452852055","display_name":"WASHINGTON UNIVERSITY INTELLECTUAL AND DEVELOPMENTAL DISABILITIES RESEARCH CENTER","funder_award_id":"U54HD087011","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6076188920","display_name":"Epidemiology of Familial Late-Onset Alzheimer's Disease","funder_award_id":"R01AG041797","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6169896762","display_name":"Alzheimer's Disease Research Center - Overall","funder_award_id":"P50AG008702","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6213992974","display_name":null,"funder_award_id":"AG037212","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6539706714","display_name":"Long Life Family Study: University of Pittsburgh Field Center","funder_award_id":"U01AG023744","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6560034963","display_name":"Long Life Family Study:  Data Management and Coordinating Center","funder_award_id":"U01AG023746","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6648385527","display_name":null,"funder_award_id":"AG032984","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6880427221","display_name":"New Mexico Alzheimer's Disease Research Center","funder_award_id":"P20AG068077","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6914157503","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P50AG005681","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6922373506","display_name":null,"funder_award_id":"U24\u2010AG041689","funder_id":"https://openalex.org/F4320309370","funder_display_name":"University of Pennsylvania"},{"id":"https://openalex.org/G7004153410","display_name":null,"funder_award_id":"AG072474","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7172061274","display_name":null,"funder_award_id":"R01AG041797","funder_id":"https://openalex.org/F4320309370","funder_display_name":"University of Pennsylvania"},{"id":"https://openalex.org/G7234639423","display_name":null,"funder_award_id":"U24 AG026395","funder_id":"https://openalex.org/F4320309370","funder_display_name":"University of Pennsylvania"},{"id":"https://openalex.org/G7495503563","display_name":"Genetic Consortium for Late Onset Alzheimer's Disease","funder_award_id":"U24AG026395","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G75188610","display_name":null,"funder_award_id":"AG068054","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7529039297","display_name":null,"funder_award_id":"U24 AG026390","funder_id":"https://openalex.org/F4320309370","funder_display_name":"University of Pennsylvania"},{"id":"https://openalex.org/G7633843673","display_name":"Vanderbilt Alzheimer's Disease Research Center","funder_award_id":"P20AG068082","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8398637310","display_name":"Genome Wide associate analysis of Alzheimer's Disease","funder_award_id":"RC2AG036528","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8622449400","display_name":null,"funder_award_id":"U54 AG052427","funder_id":"https://openalex.org/F4320309370","funder_display_name":"University of Pennsylvania"},{"id":"https://openalex.org/G873702183","display_name":null,"funder_award_id":"AG005681","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8919065834","display_name":"Genetic Epidemiology of Alzheimer's Disease in Hispanics","funder_award_id":"5r37ag015473-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000000175","display_name":null,"funder_award_id":"AG062421","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000030076","display_name":null,"funder_award_id":"AG016976","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000061259","display_name":null,"funder_award_id":"HD105353","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000070217","display_name":null,"funder_award_id":"AG005133","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000126115","display_name":null,"funder_award_id":"AG005681","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000134521","display_name":null,"funder_award_id":"AG066519","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000182367","display_name":null,"funder_award_id":"R37 AG015473","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000198685","display_name":null,"funder_award_id":"HD090256","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000239813","display_name":null,"funder_award_id":"HD087011","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000354213","display_name":null,"funder_award_id":"AG008702","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000857426","display_name":"Clinical and Translational Science Award","funder_award_id":"UL1TR001873","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000857685","display_name":"University of Pittsburgh Clinical and Translational Science Institute","funder_award_id":"UL1TR001857","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000860342","display_name":"Genome Center for Alzheimer's Disease (GCAD)","funder_award_id":"U54AG052427","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000860406","display_name":"National Institute on Aging Alzheimer's Disease Family-Based Study (NIA-AD FBS)","funder_award_id":"U24AG056270","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000861884","display_name":"University of Wisconsin Institute for Clinical and Translational Research","funder_award_id":"UL1TR002373","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000861986","display_name":"Boston University Alzheimer's Disease Research Center","funder_award_id":"P30AG072978","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000862803","display_name":"Yale Alzheimer Disease Research Center","funder_award_id":"P30AG066508","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000863725","display_name":"The Long Life Family Study","funder_award_id":"U19AG063893","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000865327","display_name":"UCSD Shiley-Marcos Alzheimer's Disease Research Center P30","funder_award_id":"P30AG062429","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000868649","display_name":"Frontotemporal Dementia: Genes, Images, and Emotions","funder_award_id":"P01AG019724","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000872824","display_name":"Joint Estimate Diffusion Imaging (JEDI) for improved Tissue Characterization and Neural Connectivity in Aging and Alzheimer's Disease","funder_award_id":"R01AG079280","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000876459","display_name":"Michigan Alzheimer's Disease Research Center","funder_award_id":"P30AG072931","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000877962","display_name":"University of Kansas Alzheimer's Disease Research Center (KU ADRC)","funder_award_id":"P30AG072973","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000878717","display_name":"Alzheimer Disease Research Center","funder_award_id":"P30AG066468","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000878846","display_name":"Waisman Center Intellectual and Developmental Disabilities Research Center","funder_award_id":"P50HD105353","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000879286","display_name":"THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE","funder_award_id":"U24AG041689","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000880650","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P30AG066462","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000881376","display_name":"Oregon Alzheimer's Disease Research Center","funder_award_id":"P30AG066518","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000882465","display_name":"Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)","funder_award_id":"U19AG068054","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000883349","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P30AG066444","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000885563","display_name":"UC Davis Alzheimer's Disease Research Center","funder_award_id":"P30AG072972","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000888980","display_name":"Johns Hopkins Alzheimer's Disease Research Center","funder_award_id":"P30AG066507","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000890195","display_name":"Indiana Alzheimer's Disease Research Center","funder_award_id":"P30AG072976","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000890560","display_name":"Cleveland Alzheimers Disease Research Center","funder_award_id":"P30AG072959","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000892184","display_name":"New Approaches to Dementia Heterogeneity","funder_award_id":"P30AG062422","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000893777","display_name":"Washington University Institute of Clinical and Translational Sciences","funder_award_id":"UL1TR002345","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000894250","display_name":"Stanford Alzheimer's Disease Research Center","funder_award_id":"P30AG066515","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000899102","display_name":"Mount Sinai Alzheimer's Disease Research Center","funder_award_id":"P30AG066514","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000899208","display_name":"Mayo Alzheimer's Disease Research Center","funder_award_id":"P30AG062677","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000900711","display_name":"University of Washington Alzheimer's Disease Research Center","funder_award_id":"P30AG066509","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000904644","display_name":"Epidemiological and Genetic Investigations of Blood-Based Biomarkers for Alzheimer's Disease in the Multiethnic, Washington Heights, Inwood, Columbia Aging Project (WHICAP)","funder_award_id":"R01AG072474","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000906862","display_name":"Duke/UNC Alzheimer's Disease Research Center","funder_award_id":"P30AG072958","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000907065","display_name":"Wisconsin Alzheimer's Disease Research Center","funder_award_id":"P30AG062715","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000908727","display_name":"Alzheimer's Disease Research Centers","funder_award_id":"P30AG066530","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000911053","display_name":"National Alzheimer's Coordinating Center","funder_award_id":"U24AG072122","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000911681","display_name":"University of Kentucky Alzheimer's Disease Research Center","funder_award_id":"P30AG072946","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000912128","display_name":"NORTHWESTERN Alzheimer's Disease Research Center","funder_award_id":"P30AG072977","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000912895","display_name":"Penn Alzheimer's Disease Research Center (ADRC)","funder_award_id":"P30AG072979","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000916178","display_name":"National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)","funder_award_id":"U24AG021886","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000916320","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P30AG072947","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000916845","display_name":"Massachusetts Alzheimer's Disease Research Center (MADRC)","funder_award_id":"P30AG062421","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000918208","display_name":"South Texas Alzheimer's Disease Center","funder_award_id":"P30AG066546","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000918277","display_name":"Goizueta Alzheimer's Disease Research Center","funder_award_id":"P30AG066511","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000918714","display_name":"The Alzheimer's Disease Research Center at the University of California, Irvine","funder_award_id":"P30AG066519","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000921028","display_name":"Rush Alzheimer's Disease Research Center","funder_award_id":"P30AG072975","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G927875252","display_name":"Long Life Family Study: Columbia University","funder_award_id":"U01AG023749","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G962293679","display_name":null,"funder_award_id":"P50AG008702","funder_id":"https://openalex.org/F4320309111","funder_display_name":"Columbia University"}],"funders":[{"id":"https://openalex.org/F4320309111","display_name":"Columbia University","ror":"https://ror.org/00hj8s172"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320320015","display_name":"National Association for Colitis and Crohn's Disease","ror":"https://ror.org/058c0xb46"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391996217.pdf","grobid_xml":"https://content.openalex.org/works/W4391996217.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W109598302","https://openalex.org/W1772450053","https://openalex.org/W1964268352","https://openalex.org/W1966613471","https://openalex.org/W1966831629","https://openalex.org/W1974015070","https://openalex.org/W1980168725","https://openalex.org/W1981802311","https://openalex.org/W1990555893","https://openalex.org/W1991952617","https://openalex.org/W1995050894","https://openalex.org/W2018173236","https://openalex.org/W2047514208","https://openalex.org/W2052389355","https://openalex.org/W2053116497","https://openalex.org/W2070976880","https://openalex.org/W2080819526","https://openalex.org/W2082429191","https://openalex.org/W2087574229","https://openalex.org/W2088486634","https://openalex.org/W2089220159","https://openalex.org/W2096410114","https://openalex.org/W2099145543","https://openalex.org/W2099800366","https://openalex.org/W2104132043","https://openalex.org/W2115017507","https://openalex.org/W2115386352","https://openalex.org/W2115779804","https://openalex.org/W2121820194","https://openalex.org/W2134995848","https://openalex.org/W2135374418","https://openalex.org/W2149791927","https://openalex.org/W2152119060","https://openalex.org/W2152532350","https://openalex.org/W2158929935","https://openalex.org/W2159228230","https://openalex.org/W2161633633","https://openalex.org/W2163013660","https://openalex.org/W2166336042","https://openalex.org/W2169147852","https://openalex.org/W2510053021","https://openalex.org/W2510973425","https://openalex.org/W2611054251","https://openalex.org/W2616015692","https://openalex.org/W2787933178","https://openalex.org/W2908002252","https://openalex.org/W2916749909","https://openalex.org/W2948815538","https://openalex.org/W2950886245","https://openalex.org/W2952169426","https://openalex.org/W2970474312","https://openalex.org/W2995323110","https://openalex.org/W3022868799","https://openalex.org/W3032790512","https://openalex.org/W3040075596","https://openalex.org/W3047582987","https://openalex.org/W3095839101","https://openalex.org/W3115346491","https://openalex.org/W3123813045","https://openalex.org/W3138513807","https://openalex.org/W3142337822","https://openalex.org/W3172294552","https://openalex.org/W3188306461","https://openalex.org/W3193810047","https://openalex.org/W3197290161","https://openalex.org/W3207412165","https://openalex.org/W3210119926","https://openalex.org/W4205251813","https://openalex.org/W4206038508","https://openalex.org/W4210821588","https://openalex.org/W4220756526","https://openalex.org/W4223591189","https://openalex.org/W4233829850","https://openalex.org/W4281383144","https://openalex.org/W4281388023","https://openalex.org/W4300196896"],"related_works":["https://openalex.org/W1584036575","https://openalex.org/W4390201336","https://openalex.org/W2943548291","https://openalex.org/W1975470883","https://openalex.org/W2096824498","https://openalex.org/W71269467","https://openalex.org/W2016137754","https://openalex.org/W2534621281","https://openalex.org/W1966831629","https://openalex.org/W747477774"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Late-onset":[1],"Alzheimer's":[2,147],"disease":[3],"(LOAD)":[4,149],"has":[5],"a":[6,22,32,53,62,114,130,198],"strong":[7],"genetic":[8],"component.":[9],"Participants":[10],"in":[11,45,61,92,119],"Long-Life":[12,138],"Family":[13,139],"Study":[14,140],"(LLFS)":[15,141],"exhibit":[16],"delayed":[17],"onset":[18,146],"of":[19,37,56,64,74,85,104,124,173,178,187],"dementia,":[20],"offering":[21],"unique":[23],"opportunity":[24],"to":[25,108,133,168],"investigate":[26,134],"LOAD":[27,57,75,89,135,174,181,200],"genetics.":[28],"METHODS:":[29],"We":[30],"conducted":[31],"whole":[33,152],"genome":[34,153],"sequence":[35,154],"analysis":[36,60,155],"3475":[38],"LLFS":[39,66,151,165],"members.":[40],"Genetic":[41],"associations":[42],"were":[43],"examined":[44],"six":[46],"independent":[47,95],"studies":[48,96],"(N":[49,68],"=":[50,69],"14,260)":[51],"with":[52,77,88,161,170,180],"wide":[54,171],"range":[55,172],"risk.":[58,175],"Association":[59,84],"sub-sample":[63],"the":[65,72,93,120,125],"cohort":[67],"1739)":[70],"evaluated":[71],"association":[73,177],"variants":[76,87,159,166],"beta":[78,188],"amyloid":[79],"(A\u03b2)":[80],"levels.":[81],"RESULTS:":[82],").":[83],"MTUS2":[86,112,157,179,195],"was":[90,98,182],"observed":[91,164],"five":[94],"and":[97,122],"significantly":[99],"stronger":[100,183],"within":[101,184],"high":[102,185],"levels":[103,186],"A\u03b242/40":[105],"ratio":[106],"compared":[107],"lower":[109],"amyloid.":[110,189],"DISCUSSION:":[111],"encodes":[113],"microtubule":[115],"associated":[116,160],"protein":[117],"implicated":[118],"development":[121],"function":[123],"nervous":[126],"system,":[127],"making":[128],"it":[129],"plausible":[131],"candidate":[132,201],"biology.":[136],"HIGHLIGHTS:":[137],"families":[142],"may":[143],"harbor":[144],"late":[145],"dementia":[148],"variants.":[150],"identified":[156],"gene":[158,196],"LOAD.":[162],"The":[163,176],"generalized":[167],"cohorts":[169],"Our":[190],"results":[191],"provide":[192],"evidence":[193],"for":[194],"as":[197],"novel":[199],"locus.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2024-02-22T00:00:00"}