{"id":"https://openalex.org/W4391993739","doi":"https://doi.org/10.1055/s-0044-1779860","title":"Evaluation of the Immune Microenvironment with Tumor Recurrence in Sinonasal Undifferentiated Carcinoma","display_name":"Evaluation of the Immune Microenvironment with Tumor Recurrence in Sinonasal Undifferentiated Carcinoma","publication_year":2024,"publication_date":"2024-02-01","ids":{"openalex":"https://openalex.org/W4391993739","doi":"https://doi.org/10.1055/s-0044-1779860"},"language":"en","primary_location":{"id":"doi:10.1055/s-0044-1779860","doi":"https://doi.org/10.1055/s-0044-1779860","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0044-1779860","pdf_url":null,"source":{"id":"https://openalex.org/S4210197100","display_name":"Journal of Neurological Surgery Part B Skull Base","issn_l":"2193-6331","issn":["2193-6331","2193-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurological Surgery Part B: Skull Base","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101439730","display_name":"Yoko Takahashi","orcid":"https://orcid.org/0000-0003-2390-1998","observed_orcids":["https://orcid.org/0000-0003-2390-1998"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoko Takahashi","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069469851","display_name":"Javier A. Gomez","orcid":"https://orcid.org/0000-0002-6579-744X","observed_orcids":["https://orcid.org/0000-0002-6579-744X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javier Gomez","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068586000","display_name":"Jared Burks","orcid":"https://orcid.org/0000-0002-6173-9074","observed_orcids":["https://orcid.org/0000-0002-6173-9074"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared Burks","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020811172","display_name":"Moran Amit","orcid":"https://orcid.org/0000-0002-9720-7766","observed_orcids":["https://orcid.org/0000-0002-9720-7766"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moran Amit","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033894551","display_name":"Diana Bell","orcid":"https://orcid.org/0000-0002-3531-8241","observed_orcids":["https://orcid.org/0000-0002-3531-8241"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana Bell","raw_affiliation_strings":["City of Hope, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope, United States","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073502048","display_name":"Tongxin Xie","orcid":"https://orcid.org/0009-0005-1620-8927","observed_orcids":["https://orcid.org/0009-0005-1620-8927"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tong-Xin Xie","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056232742","display_name":"Austin T.K. Hoke","orcid":"https://orcid.org/0000-0002-7262-7510","observed_orcids":["https://orcid.org/0000-0002-7262-7510"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Austin Hoke","raw_affiliation_strings":["Vanderbilt University, Nashville, Tennessee, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University, Nashville, Tennessee, United States","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047365774","display_name":"Nyall R. London","orcid":"https://orcid.org/0000-0002-2902-4407","observed_orcids":["https://orcid.org/0000-0002-2902-4407"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nyall London","raw_affiliation_strings":["National Institutes of Health, Bethesda, Maryland, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda, Maryland, United States","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077244830","display_name":"Ehab Y. Hanna","orcid":"https://orcid.org/0000-0003-3241-2440","observed_orcids":["https://orcid.org/0000-0003-3241-2440"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ehab Y Hanna","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03161915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"85","issue":"S 01","first_page":"S1","last_page":"S398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sinonasal-undifferentiated-carcinoma","display_name":"sinonasal undifferentiated carcinoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.9049999713897705},{"id":"https://openalex.org/keywords/immune-microenvironment","display_name":"immune microenvironment","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cell-cell-interactions","display_name":"cell-cell interactions","score":0.7900000214576721},{"id":"https://openalex.org/keywords/pancytokeratin","display_name":"pancytokeratin","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cd56","display_name":"CD56","score":0.7300000190734863},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7149999737739563},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8519999980926514},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.6140000224113464},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.5770000219345093},{"id":"https://openalex.org/keywords/cd68-macrophages","display_name":"CD68+ macrophages","score":0.7490000128746033},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5915479063987732},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5207926630973816},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46581342816352844},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3988294005393982},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3561726212501526},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3382878303527832},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33736705780029297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3288993835449219},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1935424506664276}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0044-1779860","doi":"https://doi.org/10.1055/s-0044-1779860","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0044-1779860","pdf_url":null,"source":{"id":"https://openalex.org/S4210197100","display_name":"Journal of Neurological Surgery Part B Skull Base","issn_l":"2193-6331","issn":["2193-6331","2193-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurological Surgery Part B: Skull Base","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4327931975","https://openalex.org/W4391993761","https://openalex.org/W2788691592","https://openalex.org/W4403087652","https://openalex.org/W2890765976","https://openalex.org/W3138361155","https://openalex.org/W4394706070","https://openalex.org/W3156309064","https://openalex.org/W1974793434","https://openalex.org/W7170193564"],"abstract_inverted_index":{"Background:":[0],"Sinonasal":[1],"undifferentiated":[2],"carcinoma":[3],"(SNUC)":[4],"is":[5,59,357],"a":[6,62,234,291,307,318,351,361],"rare,":[7],"highly":[8],"aggressive":[9,21],"cancer":[10],"that":[11,350],"arises":[12],"in":[13,88,101,128,321,379],"the":[14,24,29,106,132,137,146,250,277,365,372],"nasal":[15],"cavity":[16],"and":[17,28,112,145,175,183,204,249],"paranasal":[18],"sinuses.":[19],"Despite":[20],"multimodal":[22],"therapy,":[23],"prognosis":[25],"remains":[26],"poor":[27],"most":[30],"common":[31],"cause":[32],"of":[33,46,51,53,108,124,139,195,238,262,298,354,367,374],"treatment":[34,44,375],"failure":[35],"are":[36],"local-regional":[37],"recurrence":[38,55,87,100,243,270],"or":[39],"distant":[40,272],"metastasis.":[41,273],"To":[42],"improve":[43],"outcomes":[45],"patients":[47,58,103,120,133,264,380],"with":[48,78,85,121,192,293,306,360,381],"SNUC,":[49],"identification":[50],"predictors":[52],"tumor":[54,73,86,208],"for":[56,160,230],"SNUC":[57,89,102,125,322],"crucial.":[60],"In":[61,274],"previous":[63],"study,":[64],"we":[65],"reported":[66],"some":[67],"cell-cell":[68],"interactions,":[69,282],"particularly":[70],"low-expressing":[71],"CK":[72,196,212,217,278,283,326,355,368],"cell":[74,81,173,232],"(CK":[75],"low":[76,193,201,213,215,279,327,356,369],")":[77,219],"CD56":[79],"+":[80,216,218,281,284,286,329],"interactions":[82,98,223,287,330],"were":[83,126,134,186,197,224,254,331],"correlated":[84],"patients.":[90,323],"This":[91],"study":[92,348],"seeks":[93],"to":[94,104,276,302],"dig":[95],"deeper":[96],"these":[97],"within":[99,207,233],"advance":[105],"management":[107],"this":[109,129],"disease.":[110],"Materials":[111],"Methods:":[113],"Tumor":[114,190],"samples":[115],"from":[116],"14":[117,263],"previously":[118],"untreated":[119],"confirmed":[122],"diagnosis":[123],"used":[127],"study.":[130],"All":[131,394],"treated":[135],"at":[136,371],"University":[138],"Texas":[140],"MD":[141],"Anderson":[142],"Cancer":[143],"Center,":[144],"median":[147],"follow-up":[148],"period":[149],"was":[150,177,209,244,300,339],"32.2":[151],"months":[152],"(range:":[153],"8.1-176.2":[154],"months).":[155],"Opal":[156],"7-color":[157],"multiplex":[158],"immunofluorescence":[159],"pan-cytokeratin":[161],"(CK,":[162],"clone":[163],"80":[164],"monoclonal":[165],"antibody)":[166],"CD3,":[167],"CD8,":[168],"PD-L1,":[169],"CD68,":[170],"CD56/NCAM":[171],"(NK":[172],"marker)":[174],"DAPI":[176],"performed.":[178],"Tissue":[179],"identification,":[180],"marker":[181,240,320],"detection,":[182],"data":[184],"extraction":[185],"done":[187],"using":[188,256],"Visiopharm.":[189],"cells":[191,203,229,370],"expression":[194],"defined":[198],"as":[199,211,317],"\u2018CK":[200],"\u2019":[202],"their":[205],"proportion":[206,297,353],"calculated":[210,255],"/(CK":[214],"\u00d7":[220],"100.":[221],"Cell-cell":[222],"determined":[225],"by":[226,246],"identifying":[227],"neighboring":[228],"each":[231,239],"50-\u00b5m":[235],"radius.":[236],"Expression":[237],"versus":[241],"disease":[242],"assessed":[245],"Wilcoxon":[247],"test,":[248],"survival":[251],"rate":[252],"differences":[253],"Log-Rank":[257],"test.":[258],"Results:":[259],"Seven":[260],"out":[261],"(50%)":[265],"experienced":[266],"recurrence,":[267],"including":[268],"regional":[269],"and/or":[271],"contract":[275],"\u2013CD56":[280,285,328],"did":[288],"not":[289,340],"show":[290],"correlation":[292],"recurrence.":[294],"A":[295],"higher":[296,325],"CKlow":[299],"found":[301],"be":[303,377],"significantly":[304,358],"associated":[305,359],"no-recurrent":[308],"status":[309],"(":[310,342],"p":[311,343],"=":[312,344],"0.0124),":[313],"suggesting":[314],"its":[315],"potential":[316],"predictive":[319],"While":[324],"trended":[332],"towards":[333],"longer":[334],"disease-free":[335],"survival,":[336],"statistical":[337],"significance":[338],"reached":[341],"0.0529).":[345],"Conclusions:":[346],"Our":[347],"showed":[349],"high":[352],"nonrecurrent":[362],"status.":[363],"Investigating":[364],"population":[366],"beginning":[373],"might":[376],"important":[378],"SNUC.":[382],"Publication":[383],"History":[384],"Article":[385],"published":[386],"online:":[387],"05":[388],"February":[389],"2024":[390],"\u00a9":[391],"2024.":[392],"Thieme.":[393],"rights":[395],"reserved.":[396],"Georg":[397],"Thieme":[398],"Verlag":[399],"KG":[400],"R\u00fcdigerstra\u00dfe":[401],"14,":[402],"70469":[403],"Stuttgart,":[404],"Germany":[405]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2024-02-22T00:00:00"}
