{"id":"https://openalex.org/W4391990607","doi":"https://doi.org/10.1055/s-0044-1779933","title":"AQP-4 Expression and Peritumoral Edema in Secretory Meningiomas: Insights from Immunohistochemical Analysis","display_name":"AQP-4 Expression and Peritumoral Edema in Secretory Meningiomas: Insights from Immunohistochemical Analysis","publication_year":2024,"publication_date":"2024-02-01","ids":{"openalex":"https://openalex.org/W4391990607","doi":"https://doi.org/10.1055/s-0044-1779933"},"language":"en","primary_location":{"id":"doi:10.1055/s-0044-1779933","doi":"https://doi.org/10.1055/s-0044-1779933","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0044-1779933","pdf_url":null,"source":{"id":"https://openalex.org/S4210197100","display_name":"Journal of Neurological Surgery Part B Skull Base","issn_l":"2193-6331","issn":["2193-6331","2193-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurological Surgery Part B: Skull Base","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067392697","display_name":"Derrick Obiri\u2010Yeboah","orcid":"https://orcid.org/0009-0000-4798-1334","observed_orcids":["https://orcid.org/0009-0000-4798-1334"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derrick Obiri-Yeboah","raw_affiliation_strings":["Cleveland Clinic, Cleveland, Ohio, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, Ohio, United States","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002892099","display_name":"Ajay H. Zalavadia","orcid":"https://orcid.org/0000-0002-4468-3865","observed_orcids":["https://orcid.org/0000-0002-4468-3865"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ajay Zalavadia","raw_affiliation_strings":["Cleveland Clinic, Cleveland, Ohio, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, Ohio, United States","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044074981","display_name":"Judy A. Drazba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judy Drazba","raw_affiliation_strings":["Cleveland Clinic, Cleveland, Ohio, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, Ohio, United States","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004589257","display_name":"Justin Durla Lathia","orcid":"https://orcid.org/0000-0003-3168-7290","observed_orcids":["https://orcid.org/0000-0003-3168-7290"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Lathia","raw_affiliation_strings":["Cleveland Clinic, Cleveland, Ohio, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, Ohio, United States","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035265304","display_name":"Pablo F. Recinos","orcid":"https://orcid.org/0000-0002-9748-2784","observed_orcids":["https://orcid.org/0000-0002-9748-2784"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pablo Recinos","raw_affiliation_strings":["Cleveland Clinic, Cleveland, Ohio, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, Ohio, United States","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029199462","display_name":"Varun R. Kshettry","orcid":"https://orcid.org/0000-0003-3217-8279","observed_orcids":["https://orcid.org/0000-0003-3217-8279"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Varun Kshettry","raw_affiliation_strings":["Cleveland Clinic, Cleveland, Ohio, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, Ohio, United States","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1316902750"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02751171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"85","issue":"S 01","first_page":"S1","last_page":"S398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.02449999935925007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aquaporin-4","display_name":"aquaporin-4","score":0.9380000233650208},{"id":"https://openalex.org/keywords/peritumoral-edema","display_name":"peritumoral edema","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.8090000152587891},{"id":"https://openalex.org/keywords/secretory-phenotype","display_name":"secretory phenotype","score":0.49300000071525574},{"id":"https://openalex.org/keywords/somatostatin-receptor-2","display_name":"somatostatin receptor 2","score":0.7149999737739563},{"id":"https://openalex.org/keywords/cea","display_name":"CEA","score":0.7160000205039978},{"id":"https://openalex.org/keywords/immunohistochemical-staining","display_name":"immunohistochemical staining","score":0.5099999904632568},{"id":"https://openalex.org/keywords/h-score","display_name":"H-score","score":0.5989999771118164},{"id":"https://openalex.org/keywords/water-transport","display_name":"water transport","score":0.45100000500679016},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.33500000834465027},{"id":"https://openalex.org/keywords/qupath","display_name":"QuPath","score":0.47999998927116394},{"id":"https://openalex.org/keywords/slic-superpixels","display_name":"SLIC superpixels","score":0.7260000109672546},{"id":"https://openalex.org/keywords/color-deconvolution","display_name":"color deconvolution","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7595068216323853},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.558537483215332},{"id":"https://openalex.org/C3019162651","wikidata":"https://www.wikidata.org/wiki/Q979168","display_name":"Brain edema","level":2,"score":0.4970853626728058},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.416271448135376},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35432112216949463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29456979036331177},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.05584880709648132}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0044-1779933","doi":"https://doi.org/10.1055/s-0044-1779933","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0044-1779933","pdf_url":null,"source":{"id":"https://openalex.org/S4210197100","display_name":"Journal of Neurological Surgery Part B Skull Base","issn_l":"2193-6331","issn":["2193-6331","2193-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurological Surgery Part B: Skull Base","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1977058010","https://openalex.org/W2514833018","https://openalex.org/W2385103172","https://openalex.org/W1999667364","https://openalex.org/W3128450735","https://openalex.org/W2131130347","https://openalex.org/W2065875660","https://openalex.org/W2392727450","https://openalex.org/W1683265164","https://openalex.org/W6945708325"],"abstract_inverted_index":{"Introduction:":[0],"Peritumoral":[1],"edema":[2,56,87,122,131,137,144,327,332,412,421,425,450],"is":[3],"a":[4,49],"common":[5],"occurrence":[6],"in":[7,35,51,60,76,241,345,367,400,477],"secretory":[8,77,95,299,349,368,379,401,440],"meningiomas,":[9],"often":[10],"leading":[11],"to":[12,47,70,221,234,287,372,387,407,443,468],"significant":[13,318,343,394],"neurologic":[14],"symptoms.":[15],"Aquaporins":[16],"(AQPs),":[17],"integral":[18],"membrane":[19],"protein":[20],"water":[21,25],"channels":[22],"crucial":[23],"for":[24,115,230],"transport":[26],"and":[27,42,79,85,98,118,142,167,173,202,206,214,268,277,279,301,312,329,352],"fluid":[28],"balance":[29],"maintenance,":[30],"have":[31],"exhibited":[32,382,454],"heightened":[33,448],"presence":[34],"edematous":[36,478],"human":[37,94],"brain":[38],"tumors":[39,446,460],"like":[40],"astrocytomas":[41],"metastases.":[43],"They":[44],"are":[45],"believed":[46],"play":[48],"role":[50],"the":[52,72,185,195,236,242,250,283,325,330,415,469],"formation":[53],"of":[54,74,179,249,472],"cerebral":[55],"by":[57],"being":[58],"located":[59],"astrocytic":[61],"foot":[62],"processes":[63],"near":[64],"endothelial":[65],"cells.":[66],"This":[67],"study":[68],"aimed":[69],"investigate":[71],"expression":[73,84,239,320,347,363,405,434,458],"AQP4":[75,83,172],"meningiomas":[78,356,441],"establish":[80],"correlations":[81],"between":[82,298,324,348,420],"peritumoral":[86,121,449,463],"observed":[88,419],"through":[89],"imaging.":[90],"Methods:":[91],"Nine":[92],"fresh-frozen":[93],"meningioma":[96,104,300,311,350,369,380,402],"specimens":[97],"nine":[99],"control":[100,302,313,353,373],"nonsecretory":[101,314],"grade":[102,315,354],"1":[103,316,355,423,481],"samples":[105,308,351,370,381],"were":[106,152,188,192,208,253,271,296,322],"utilized.":[107],"Immunohistochemical":[108],"staining":[109,197,385],"was":[110,125,228,258,341,364,391,435],"performed":[111],"using":[112,157,198,262],"validated":[113],"antibodies":[114],"AQP4,":[116],"CEA,":[117],"SSTR2.":[119],"The":[120,255],"index":[123],"(EI)":[124],"categorized":[126],"into":[127,210,260,273],"three":[128],"groups:":[129],"(1)":[130],"size":[132],"<":[133],"tumor":[134,140,147],"volume,":[135,141],"(2)":[136],"volume":[138,145],"=":[139,336,359,376,397,430],"(3)":[143],">":[146],"volume.":[148],"Whole":[149],"tissue":[150,186,243,256],"sections":[151,252],"scanned":[153],"at":[154],"20x":[155],"magnification":[156],"an":[158],"Aperio":[159],"AT2":[160],"slide":[161],"scanner":[162],"(Leica":[163],"Biosystems":[164],"Imaging,":[165],"Inc.)":[166],"analyzed":[168,309],"with":[169,410,414,439,447,461],"QuPath.":[170],"For":[171,245],"SSTR2":[174,346],"stained":[175],"sections,":[176],"six":[177,232],"regions":[178],"interest":[180],"representing":[181],"different":[182],"areas":[183],"on":[184,217,282,474],"section":[187],"selected.":[189],"Individual":[190],"cells":[191],"identified":[193],"from":[194],"hematoxylin":[196],"QuaPath\u2019s":[199],"color":[200],"deconvolution":[201],"watershed":[203],"cell":[204],"detection,":[205],"they":[207],"classified":[209,272],"negative,":[211],"low-positive,":[212],"medium-positive,":[213],"high-positive":[215],"based":[216,281],"mean":[218,284],"DAB":[219,285],"intensity":[220,286],"calculate":[222,288],"H-score.":[223,289],"An":[224],"average":[225,237,293],"H":[226,294],"score":[227],"computed":[229],"all":[231,307],"sites":[233],"represent":[235],"aquaporin-4":[238],"levels":[240],"samples.":[244,303],"CEA-stained":[246],"tissues,":[247],"images":[248],"entire":[251],"analyzed.":[254],"area":[257],"segmented":[259],"superpixels":[261,270],"simple":[263],"linear":[264],"iterative":[265],"clustering":[266],"(SLIC),":[267],"these":[269],"positive":[274],"(1+,":[275],"2+,":[276],"3+)":[278],"negative":[280],"In":[290],"both":[291],"cases,":[292],"scores":[295],"compared":[297,371],"Results:":[304],"When":[305],"considering":[306],"(secretory":[310],"meningiomas),":[317],"AQP-4":[319,384,404,433,457],"differences":[321],"found":[323],"low":[326,462],"group":[328,333,422,426,452],"high":[331],"(":[334,357,374,395,428],"p":[335,358,375,396,429],"0.02).":[337],"As":[338],"anticipated,":[339],"there":[340],"no":[342],"difference":[344,390,418],"0.21).":[360],"However,":[361,445],"CEA":[362],"significantly":[365,437,455],"elevated":[366],"0.019).":[377],"Although":[378],"increased":[383,411],"relative":[386,442],"controls,":[388],"this":[389],"not":[392,436],"statistically":[393],"0.1014).":[398],"Similarly,":[399],"samples,":[403],"seemed":[406],"correlate":[408],"positively":[409],"index,":[413],"most":[416],"notable":[417],"vs.":[424],"3":[427],"0.06).":[431],"Conclusion:":[432],"associated":[438],"controls.":[444],"(edema":[451],"3)":[453],"more":[456],"than":[459],"edema.":[464],"These":[465],"findings":[466],"contribute":[467],"expanding":[470],"body":[471],"knowledge":[473],"AQP-4's":[475],"involvement":[476],"tumors.":[479],"Fig.":[480,482],"2":[483],"Publication":[484],"History":[485],"Article":[486],"published":[487],"online:":[488],"05":[489],"February":[490],"2024":[491],"\u00a9":[492],"2024.":[493],"Thieme.":[494],"All":[495],"rights":[496],"reserved.":[497],"Georg":[498],"Thieme":[499],"Verlag":[500],"KG":[501],"R\u00fcdigerstra\u00dfe":[502],"14,":[503],"70469":[504],"Stuttgart,":[505],"Germany":[506]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2024-02-22T00:00:00"}
