{"id":"https://openalex.org/W4391932995","doi":"https://doi.org/10.1158/2767-9764.c.7080965.v1","title":"Data from Exhausted Tumor-infiltrating CD39+CD103+ CD8+ T Cells Unveil Potential for Increased Survival in Human Pancreatic Cancer","display_name":"Data from Exhausted Tumor-infiltrating CD39+CD103+ CD8+ T Cells Unveil Potential for Increased Survival in Human Pancreatic Cancer","publication_year":2024,"publication_date":"2024-02-19","ids":{"openalex":"https://openalex.org/W4391932995","doi":"https://doi.org/10.1158/2767-9764.c.7080965.v1"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.c.7080965.v1","doi":"https://doi.org/10.1158/2767-9764.c.7080965.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.c.7080965.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.c.7080965.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005243948","display_name":"Laia Gorchs","orcid":"https://orcid.org/0000-0002-8766-6686","observed_orcids":["https://orcid.org/0000-0002-8766-6686"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laia Gorchs","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8766-6686","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025483481","display_name":"Carlos Fern\u00e1ndez Moro","orcid":"https://orcid.org/0000-0001-6863-5959","observed_orcids":["https://orcid.org/0000-0001-6863-5959"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Fern\u00e1ndez-Moro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6863-5959","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060148877","display_name":"Ebba Asplund","orcid":"https://orcid.org/0000-0002-7649-7901","observed_orcids":["https://orcid.org/0000-0002-7649-7901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ebba Asplund","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7649-7901","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030340691","display_name":"Marlies Oosthoek","orcid":"https://orcid.org/0009-0000-8714-4944","observed_orcids":["https://orcid.org/0009-0000-8714-4944"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marlies Oosthoek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-8714-4944","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004672362","display_name":"Martin Solders","orcid":"https://orcid.org/0000-0001-6951-1958","observed_orcids":["https://orcid.org/0000-0001-6951-1958"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Solders","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6951-1958","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026406913","display_name":"Poya Ghorbani","orcid":"https://orcid.org/0000-0003-2102-7168","observed_orcids":["https://orcid.org/0000-0003-2102-7168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Poya Ghorbani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2102-7168","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032951554","display_name":"Ernesto Sparrelid","orcid":"https://orcid.org/0000-0003-0259-8328","observed_orcids":["https://orcid.org/0000-0003-0259-8328"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ernesto Sparrelid","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0259-8328","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091021109","display_name":"Elena B. Rangelova","orcid":"https://orcid.org/0000-0003-3844-7265","observed_orcids":["https://orcid.org/0000-0003-3844-7265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Rangelova","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3844-7265","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067118869","display_name":"Matthias J. L\u00f6hr","orcid":"https://orcid.org/0000-0002-7647-198X","observed_orcids":["https://orcid.org/0000-0002-7647-198X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthias J. L\u00f6hr","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7647-198X","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023468955","display_name":"Helen Kaipe","orcid":"https://orcid.org/0000-0001-7391-1137","observed_orcids":["https://orcid.org/0000-0001-7391-1137"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen Kaipe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7391-1137","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6279000043869019,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6279000043869019,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.20909999310970306,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.05779999867081642,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8650000095367432},{"id":"https://openalex.org/keywords/desmoplastic-stroma","display_name":"desmoplastic stroma","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.902999997138977},{"id":"https://openalex.org/keywords/tim-3","display_name":"TIM-3","score":1.0},{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cxcr6","display_name":"CXCR6","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chemokine-receptor-expression","display_name":"chemokine receptor expression","score":0.781000018119812},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5879541635513306},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5128045678138733},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.43051719665527344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2942734360694885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1690223217010498},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12393316626548767}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2767-9764.c.7080965.v1","doi":"https://doi.org/10.1158/2767-9764.c.7080965.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.c.7080965.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.c.7080965.v1","doi":"https://doi.org/10.1158/2767-9764.c.7080965.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.c.7080965.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391677791","https://openalex.org/W4391943858","https://openalex.org/W4391943323","https://openalex.org/W4391926482","https://openalex.org/W2760259607","https://openalex.org/W4391932616","https://openalex.org/W4391945995","https://openalex.org/W4391989067","https://openalex.org/W2042155372","https://openalex.org/W3136616749"],"abstract_inverted_index":{"Abstract":[0],"In":[1,135],"pancreatic":[2,45,66,197,213,220],"ductal":[3],"adenocarcinoma,":[4],"the":[5,12,31,146],"infiltration":[6],"of":[7,24,54,80,125,145,157,165,188,190,201,226],"CD8+":[8,55,85,109,132,138,167,181,203,228],"T":[9,26,56,86,110,133,139,168,182,192,204,229],"cells":[10,27,87,111,140,169,183,193,205,230],"within":[11,30],"tumor":[13,36,75,92,98],"microenvironment":[14],"correlates":[15],"with":[16,95,104,130,172,184,219,222],"a":[17,21,52,162,185,223,232],"favorable":[18],"prognosis.":[19],"However,":[20],"significant":[22],"proportion":[23,164,225],"tumor-infiltrating":[25],"become":[28],"trapped":[29],"desmoplastic":[32],"stroma":[33],"and":[34,47,63,99,116,127,151,159],"lack":[35],"reactivity.":[37],"Here,":[38],"we":[39],"explored":[40],"different":[41],"T-cell":[42],"subsets":[43],"in":[44,65,77,90,196,209,243],"tumors":[46],"adjacent":[48,100],"tissues.":[49,102],"We":[50],"identified":[51],"subset":[53],"cells,":[57],"double":[58],"positive":[59],"(DP)":[60],"for":[61,212,246],"CD39":[62],"CD103":[64],"tumors,":[67],"which":[68],"has":[69],"recently":[70],"been":[71],"described":[72],"to":[73],"display":[74],"reactivity":[76],"other":[78],"types":[79],"solid":[81],"tumors.":[82,198],"Interestingly,":[83],"DP":[84,108,137,166,180,202],"preferentially":[88],"accumulated":[89],"central":[91],"tissues":[93],"compared":[94,129],"paired":[96],"peripheral":[97],"non-tumor":[101],"Consistent":[103],"an":[105,118],"antigen":[106],"encounter,":[107],"demonstrated":[112],"higher":[113,142],"proliferative":[114],"rates":[115],"displayed":[117],"exhausted":[119],"phenotype,":[120],"characterized":[121],"by":[122],"elevated":[123],"expression":[124,143],"PD-1":[126],"TIM-3,":[128],"CD39\u2212CD103\u2212":[131],"cells.":[134],"addition,":[136],"exhibited":[141],"levels":[144,156],"tissue":[147],"trafficking":[148],"receptors":[149],"CCR5":[150],"CXCR6,":[152],"while":[153],"displaying":[154],"lower":[155],"CXCR3":[158],"CXCR4.":[160],"Importantly,":[161],"high":[163,224],"is":[170],"associated":[171],"increased":[173],"patient":[174],"survival.":[175],"These":[176],"findings":[177],"suggest":[178],"that":[179,189],"phenotype":[186,234],"reminiscent":[187],"tumor-reactive":[191,233],"are":[194],"present":[195],"The":[199],"abundance":[200],"could":[206],"potentially":[207],"aid":[208],"selecting":[210,244],"patients":[211],"cancer":[214,221],"immunotherapy":[215,247],"trials.":[216,248],"Significance:":[217],"Patients":[218],"CD39+CD103+":[227],"exhibiting":[231],"have":[235],"improved":[236],"survival":[237],"rates,":[238],"suggesting":[239],"their":[240],"potential":[241],"utility":[242],"candidates":[245]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2024-02-20T00:00:00"}