{"id":"https://openalex.org/W4391925896","doi":"https://doi.org/10.3389/fendo.2024.1309118","title":"Efficacy and safety of Mazdutide on weight loss among diabetic and non-diabetic patients: a systematic review and meta-analysis of randomized controlled trials","display_name":"Efficacy and safety of Mazdutide on weight loss among diabetic and non-diabetic patients: a systematic review and meta-analysis of randomized controlled trials","publication_year":2024,"publication_date":"2024-02-14","ids":{"openalex":"https://openalex.org/W4391925896","doi":"https://doi.org/10.3389/fendo.2024.1309118","pmid":"https://pubmed.ncbi.nlm.nih.gov/38440786","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10911117"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2024.1309118","doi":"https://doi.org/10.3389/fendo.2024.1309118","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2024.1309118","pdf_url":null,"source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4391925896"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fendo.2024.1309118","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031112100","display_name":"David Lubasi Nalisa","orcid":"https://orcid.org/0000-0001-6351-1500","observed_orcids":["https://orcid.org/0000-0001-6351-1500"]},"institutions":[{"id":"https://openalex.org/I167383011","display_name":"Henan University of Science and Technology","ror":"https://ror.org/05d80kz58","country_code":"CN","type":"education","lineage":["https://openalex.org/I167383011"]},{"id":"https://openalex.org/I2802614804","display_name":"University Teaching Hospital","ror":"https://ror.org/03zn9xk79","country_code":"ZM","type":"healthcare","lineage":["https://openalex.org/I2802614804"]},{"id":"https://openalex.org/I4210134906","display_name":"First Affiliated Hospital of Henan University of Science and Technology","ror":"https://ror.org/035zbbv42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134906"]}],"countries":["CN","ZM"],"is_corresponding":false,"raw_author_name":"David Lubasi Nalisa","raw_affiliation_strings":["Adult Hospital Internal Medicine Department, Endocrine Unit, The University Teaching Hospitals, Lusaka, Zambia","Department of Metabolism and Endocrinology, Endocrine and Metabolic Disease Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China","Department of Metabolism and Endocrinology, Endocrine and Metabolic Disease Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adult Hospital Internal Medicine Department, Endocrine Unit, The University Teaching Hospitals, Lusaka, Zambia","institution_ids":["https://openalex.org/I2802614804"]},{"raw_affiliation_string":"Department of Metabolism and Endocrinology, Endocrine and Metabolic Disease Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China","institution_ids":["https://openalex.org/I167383011","https://openalex.org/I4210134906"]},{"raw_affiliation_string":"Department of Metabolism and Endocrinology, Endocrine and Metabolic Disease Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, China","institution_ids":["https://openalex.org/I167383011","https://openalex.org/I4210134906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093471771","display_name":"Nelson Cuboia","orcid":"https://orcid.org/0000-0002-6903-9750","observed_orcids":["https://orcid.org/0000-0002-6903-9750"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210137384","display_name":"Centre for Health Technology and Services Research","ror":"https://ror.org/0434vme59","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210137384"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Nelson Cuboia","raw_affiliation_strings":["Center for Health Technology and Service Research (CINTESIS) & Health Research Network Associated Laboratory (RISE), University of Porto, Porto, Portugal","Center for Health Technology and Service Research (CINTESIS) & Health Research Network Associated Laboratory (RISE), University of Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Health Technology and Service Research (CINTESIS) & Health Research Network Associated Laboratory (RISE), University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210137384"]},{"raw_affiliation_string":"Center for Health Technology and Service Research (CINTESIS) & Health Research Network Associated Laboratory (RISE), University of Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210137384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070461692","display_name":"Eman Ali Dyab","orcid":"https://orcid.org/0000-0002-6451-1331","observed_orcids":["https://orcid.org/0000-0002-6451-1331"]},"institutions":[{"id":"https://openalex.org/I23906160","display_name":"University of Tripoli","ror":"https://ror.org/00taa2s29","country_code":"LY","type":"education","lineage":["https://openalex.org/I23906160"]}],"countries":["LY"],"is_corresponding":false,"raw_author_name":"Eman Dyab","raw_affiliation_strings":["Pharmaceutics Department, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya","Pharmaceutics Department, Faculty of Pharmacy, University of Tripoli, Libya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutics Department, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya","institution_ids":["https://openalex.org/I23906160"]},{"raw_affiliation_string":"Pharmaceutics Department, Faculty of Pharmacy, University of Tripoli, Libya","institution_ids":["https://openalex.org/I23906160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077548115","display_name":"Idongesit Linus Jackson","orcid":"https://orcid.org/0000-0003-3460-7233","observed_orcids":["https://orcid.org/0000-0003-3460-7233"]},"institutions":[{"id":"https://openalex.org/I37797678","display_name":"University of Uyo","ror":"https://ror.org/0127mpp72","country_code":"NG","type":"education","lineage":["https://openalex.org/I37797678"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Idongesit Linus Jackson","raw_affiliation_strings":["Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom State, Nigeria","Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Uyo, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom State, Nigeria","institution_ids":["https://openalex.org/I37797678"]},{"raw_affiliation_string":"Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Uyo, Nigeria","institution_ids":["https://openalex.org/I37797678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045298706","display_name":"Habimana Jean Felix","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Habimana Jean Felix","raw_affiliation_strings":["Directorate of Research and Community Health-Ruli Higher Institute of Health -Saint Rose de Lima (RHIH), Kigali, Rwanda","Directorate of Research and Community Health-Ruli Higher Institute of Health -Saint Rose de Lima (RHIH), Rwanda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Directorate of Research and Community Health-Ruli Higher Institute of Health -Saint Rose de Lima (RHIH), Kigali, Rwanda","institution_ids":[]},{"raw_affiliation_string":"Directorate of Research and Community Health-Ruli Higher Institute of Health -Saint Rose de Lima (RHIH), Rwanda","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093953375","display_name":"Pantaleon Shoki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pantaleon Shoki","raw_affiliation_strings":["Business Development and Partnership, CLM Consultants Ltd., Dar es Salaam, Tanzania","Business Development and Partnership, CLM Consultants Ltd., Tanzania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Business Development and Partnership, CLM Consultants Ltd., Dar es Salaam, Tanzania","institution_ids":[]},{"raw_affiliation_string":"Business Development and Partnership, CLM Consultants Ltd., Tanzania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105957280","display_name":"Mary Mubiana","orcid":"https://orcid.org/0009-0004-9231-8987","observed_orcids":["https://orcid.org/0009-0004-9231-8987"]},"institutions":[{"id":"https://openalex.org/I33278361","display_name":"University of Zambia","ror":"https://ror.org/03gh19d69","country_code":"ZM","type":"education","lineage":["https://openalex.org/I33278361"]}],"countries":["ZM"],"is_corresponding":false,"raw_author_name":"Mary Mubiana","raw_affiliation_strings":["Department of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia","Department of Disease Control, School of Veterinary Medicine, University of Zambia, Zambia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia","institution_ids":["https://openalex.org/I33278361"]},{"raw_affiliation_string":"Department of Disease Control, School of Veterinary Medicine, University of Zambia, Zambia","institution_ids":["https://openalex.org/I33278361"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110798323","display_name":"Mariam Oyefunke Oyedeji-Amusa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24027795","display_name":"University of Johannesburg","ror":"https://ror.org/04z6c2n17","country_code":"ZA","type":"education","lineage":["https://openalex.org/I24027795"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Mariam Oyedeji-Amusa","raw_affiliation_strings":["Department of Botany and Plant Biotechnology, University of Johannesburg, Johannesburg, South Africa","Department of Botany and Plant Biotechnology, University of Johannesburg, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany and Plant Biotechnology, University of Johannesburg, Johannesburg, South Africa","institution_ids":["https://openalex.org/I24027795"]},{"raw_affiliation_string":"Department of Botany and Plant Biotechnology, University of Johannesburg, South Africa","institution_ids":["https://openalex.org/I24027795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022418451","display_name":"Lu\u00eds Filipe Azevedo","orcid":"https://orcid.org/0000-0002-8421-2937","observed_orcids":["https://orcid.org/0000-0002-8421-2937"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210137384","display_name":"Centre for Health Technology and Services Research","ror":"https://ror.org/0434vme59","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210137384"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Lu\u00eds Azevedo","raw_affiliation_strings":["Center for Health Technology and Service Research (CINTESIS) & Health Research Network Associated Laboratory (RISE), University of Porto, Porto, Portugal","Center for Health Technology and Service Research (CINTESIS) & Health Research Network Associated Laboratory (RISE), University of Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Health Technology and Service Research (CINTESIS) & Health Research Network Associated Laboratory (RISE), University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210137384"]},{"raw_affiliation_string":"Center for Health Technology and Service Research (CINTESIS) & Health Research Network Associated Laboratory (RISE), University of Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210137384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056125499","display_name":"Hongwei\ufffd Jiang","orcid":"https://orcid.org/0000-0003-3807-7989","observed_orcids":["https://orcid.org/0000-0003-3807-7989"]},"institutions":[{"id":"https://openalex.org/I167383011","display_name":"Henan University of Science and Technology","ror":"https://ror.org/05d80kz58","country_code":"CN","type":"education","lineage":["https://openalex.org/I167383011"]},{"id":"https://openalex.org/I4210134906","display_name":"First Affiliated Hospital of Henan University of Science and Technology","ror":"https://ror.org/035zbbv42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134906"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongwei Jiang","raw_affiliation_strings":["Department of Metabolism and Endocrinology, Endocrine and Metabolic Disease Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China","Department of Metabolism and Endocrinology, Endocrine and Metabolic Disease Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolism and Endocrinology, Endocrine and Metabolic Disease Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China","institution_ids":["https://openalex.org/I167383011","https://openalex.org/I4210134906"]},{"raw_affiliation_string":"Department of Metabolism and Endocrinology, Endocrine and Metabolic Disease Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, China","institution_ids":["https://openalex.org/I167383011","https://openalex.org/I4210134906"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5056125499"],"corresponding_institution_ids":["https://openalex.org/I167383011","https://openalex.org/I4210134906"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.5186,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.81848185,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"15","issue":null,"first_page":"1309118","last_page":"1309118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0640999972820282,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mazdutide","display_name":"mazdutide","score":0.9660000205039978},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.8059999942779541},{"id":"https://openalex.org/keywords/dual-agonist","display_name":"dual agonist","score":0.6150000095367432},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.9179999828338623},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9750000238418579},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9369999766349792},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.7289999723434448},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.5649999976158142},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8209999799728394},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.8980000019073486},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.699999988079071},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7269999980926514},{"id":"https://openalex.org/keywords/placebo-controlled-comparison","display_name":"placebo comparison","score":0.44600000977516174},{"id":"https://openalex.org/keywords/overweight-adults","display_name":"overweight adults","score":0.5989999771118164},{"id":"https://openalex.org/keywords/gip-glp-1-receptor-agonist","display_name":"GIP/GLP-1 receptor agonist","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8039038181304932},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.6157158017158508},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6063652634620667},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.6000295281410217},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5829517841339111},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5739485025405884},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5548327565193176},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5399060845375061},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4653967320919037},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.42843422293663025},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.3663242757320404},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.173059344291687},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.08063152432441711},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0566573441028595}],"mesh":[{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fendo.2024.1309118","doi":"https://doi.org/10.3389/fendo.2024.1309118","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2024.1309118","pdf_url":null,"source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10911117","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10911117","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10911117/pdf/fendo-15-1309118.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmid:38440786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38440786","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:609acbe8420a4807b69d6bebfc88d752","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/609acbe8420a4807b69d6bebfc88d752","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2024.1309118","doi":"https://doi.org/10.3389/fendo.2024.1309118","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2024.1309118","pdf_url":null,"source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391925896.pdf","grobid_xml":"https://content.openalex.org/works/W4391925896.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1773084519","https://openalex.org/W1977572334","https://openalex.org/W1993582432","https://openalex.org/W2077024838","https://openalex.org/W2086177834","https://openalex.org/W2119605658","https://openalex.org/W2126930838","https://openalex.org/W2148275037","https://openalex.org/W2148623180","https://openalex.org/W2149200710","https://openalex.org/W2521000591","https://openalex.org/W2574032118","https://openalex.org/W2584275000","https://openalex.org/W2763071190","https://openalex.org/W2795481136","https://openalex.org/W2808302800","https://openalex.org/W2808958607","https://openalex.org/W2917171794","https://openalex.org/W2970684805","https://openalex.org/W2975424845","https://openalex.org/W3088932025","https://openalex.org/W3107005150","https://openalex.org/W3120876049","https://openalex.org/W3121704649","https://openalex.org/W3126226315","https://openalex.org/W3194756735","https://openalex.org/W3217337816","https://openalex.org/W4200404948","https://openalex.org/W4225300035","https://openalex.org/W4244546717","https://openalex.org/W4283383180","https://openalex.org/W4289550446","https://openalex.org/W4297900377","https://openalex.org/W4303414894","https://openalex.org/W4310711873","https://openalex.org/W4311890439","https://openalex.org/W4380631434","https://openalex.org/W4388539816","https://openalex.org/W4389741339"],"related_works":["https://openalex.org/W7134803809","https://openalex.org/W7167462053","https://openalex.org/W7196931080","https://openalex.org/W4415412750","https://openalex.org/W7164162324","https://openalex.org/W7170892886","https://openalex.org/W4413357196","https://openalex.org/W7204752369","https://openalex.org/W4411292763","https://openalex.org/W4417436030"],"abstract_inverted_index":{"Background":[0],"Overweight":[1],"and":[2,22,35,52,65,74,96,99,239,264,277,290,337,340],"obesity":[3],"are":[4],"increasing":[5],"global":[6],"public":[7],"health":[8],"problems.":[9],"Mazdutide":[10,55,142,256,312],"is":[11,40],"a":[12,71,111,295,314],"new":[13],"dual":[14],"agonist":[15],"drug":[16,39],"that":[17],"can":[18],"potentially":[19],"reduce":[20],"weight":[21,60,149,280,332],"blood":[23,166,183],"glucose":[24,267],"levels":[25],"simultaneously.":[26],"However,":[27,349],"the":[28,33,50,103,120,125,275],"synthesis":[29],"of":[30,37,54,76,90,131,317],"evidence":[31,48],"on":[32,49,59,304],"efficacy":[34,51],"safety":[36,53],"this":[38,43,140],"scarce.":[41],"Therefore,":[42],"study":[44],"aimed":[45],"to":[46,57,159,175,192,207,220,233,248,288,328],"synthesize":[47],"compared":[56,287],"placebo":[58],"reduction":[61,281,333],"among":[62,334],"adults":[63],"with":[64,259,270,336,353],"without":[66,338],"diabetes.":[67,273],"Methods":[68],"We":[69],"conducted":[70],"systematic":[72],"review":[73,361],"meta-analysis":[75],"randomized":[77],"controlled":[78],"trials":[79],"(RCTs).":[80],"Data":[81],"were":[82,108,137],"retrieved":[83],"from":[84,102],"six":[85],"electronic":[86],"databases:":[87],"PubMed,":[88],"Web":[89],"Science,":[91],"Scopus,":[92],"Cochrane":[93],"Library,":[94],"ClinicalTrial.gov,":[95],"Google":[97],"Scholar,":[98],"manually":[100],"searched":[101],"included":[104,138],"references.":[105],"The":[106],"data":[107],"synthesized":[109],"using":[110,124],"random":[112],"effect":[113],"model.":[114],"This":[115],"analysis":[116],"was":[117,143,257,282,351],"performed":[118],"in":[119,139,146,268,285,291,302,331],"R":[121],"programming":[122],"language":[123],"Meta":[126],"package.":[127],"Results":[128],"A":[129],"total":[130,199],"seven":[132],"RCTs":[133],"involving":[134],"680":[135],"participants":[136,269],"study.":[141],"more":[144,283],"effective":[145,330],"reducing":[147],"body":[148],"(mean":[150],"difference":[151],"[MD]=":[152],"-6.22%,":[153],"95%":[154,172,189,204,217,230,245],"confidence":[155],"interval":[156],"[CI]:":[157],"-8.02%":[158],"-4.41%,":[160],"I":[161,178,195,209,222,235,250],"2":[162,179,196,210,223,236,251,272],"=":[163,169,180,186,197,202,211,215,224,237,243,252],"90.0%),":[164],"systolic":[165],"pressure":[167,184],"(MD":[168,185,201,214,242],"-7.57":[170],"mmHg,":[171,177,188,194],"CI:":[173,190,205,218,231,246],"-11.17":[174],"-3.98":[176],"46%),":[181],"diastolic":[182],"-2.98":[187],"-5.74":[191],"-0.22":[193],"56%),":[198],"cholesterol":[200],"-16.82%,":[203],"-24.52":[206],"-9.13%,":[208],"61%),":[212],"triglycerides":[213],"-43.29%,":[216],"-61.57":[219],"-25.01%,":[221],"68%),":[225],"low-density":[226],"lipoprotein":[227,241],"(MD=":[228],"-17.07%,":[229],"-25.54":[232],"-8.60%,":[234],"53%),":[238],"high-density":[240],"-7.54%,":[244],"-11.26":[247],"-3.83%,":[249],"0%)":[253],"than":[254,301],"placebo.":[255],"associated":[258,347,352],"reduced":[260],"hemoglobin":[261],"A1c":[262],"(HbA1c)":[263],"fasting":[265],"plasma":[266],"type":[271],"In":[274],"subgroup":[276],"meta-regression":[278],"analyses,":[279],"significant":[284],"non-diabetics":[286],"diabetics,":[289],"those":[292,303],"who":[293,310],"received":[294,311],"longer":[296],"treatment":[297],"duration":[298],"(24":[299],"weeks)":[300],"shorter":[305],"durations":[306],"(12-20":[307],"weeks).":[308],"Participants":[309],"had":[313],"higher":[315],"risk":[316],"transient":[318],"mild":[319,354],"or":[320,355],"moderate":[321,356],"gastrointestinal":[322,357],"side":[323,358],"effects.":[324,359],"Conclusion":[325],"Mazdutite":[326],"appears":[327],"be":[329],"patients":[335],"diabetes,":[339],"it":[341,350],"has":[342],"an":[343],"advantage":[344],"over":[345],"other":[346],"comorbidities.":[348],"Systematic":[360],"registration":[362],"https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=403859":[363],",":[364],"identifier":[365],"CRD42023403859.":[366]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-02-20T00:00:00"}