{"id":"https://openalex.org/W4391925390","doi":"https://doi.org/10.1111/jfd.13932","title":"Unveiling the positive impact of biofloc culture on Vibrio parahaemolyticus infection of Pacific white shrimp by reducing quorum sensing and virulence gene expression and enhancing immunity","display_name":"Unveiling the positive impact of biofloc culture on Vibrio parahaemolyticus infection of Pacific white shrimp by reducing quorum sensing and virulence gene expression and enhancing immunity","publication_year":2024,"publication_date":"2024-02-19","ids":{"openalex":"https://openalex.org/W4391925390","doi":"https://doi.org/10.1111/jfd.13932","pmid":"https://pubmed.ncbi.nlm.nih.gov/38373053"},"language":"en","primary_location":{"id":"doi:10.1111/jfd.13932","doi":"https://doi.org/10.1111/jfd.13932","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jfd.13932","pdf_url":null,"source":{"id":"https://openalex.org/S25518365","display_name":"Journal of Fish Diseases","issn_l":"0140-7775","issn":["0140-7775","1365-2761"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Fish Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004782633","display_name":"Widanarni Widanarni","orcid":"https://orcid.org/0000-0002-0821-3225","observed_orcids":["https://orcid.org/0000-0002-0821-3225"]},"institutions":[{"id":"https://openalex.org/I21881038","display_name":"IPB University","ror":"https://ror.org/05smgpd89","country_code":"ID","type":"education","lineage":["https://openalex.org/I21881038"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Widanarni Widanarni","raw_affiliation_strings":["Department of Aquaculture, Faculty of Fisheries and Marine Sciences, Bogor Agricultural University, Bogor, West Java, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Aquaculture, Faculty of Fisheries and Marine Sciences, Bogor Agricultural University, Bogor, West Java, Indonesia","institution_ids":["https://openalex.org/I21881038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024872900","display_name":"Muhamad Gustilatov","orcid":"https://orcid.org/0000-0003-4807-1249","observed_orcids":["https://orcid.org/0000-0003-4807-1249"]},"institutions":[{"id":"https://openalex.org/I21881038","display_name":"IPB University","ror":"https://ror.org/05smgpd89","country_code":"ID","type":"education","lineage":["https://openalex.org/I21881038"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Muhamad Gustilatov","raw_affiliation_strings":["Department of Aquaculture, Faculty of Fisheries and Marine Sciences, Bogor Agricultural University, Bogor, West Java, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Aquaculture, Faculty of Fisheries and Marine Sciences, Bogor Agricultural University, Bogor, West Java, Indonesia","institution_ids":["https://openalex.org/I21881038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069357721","display_name":"Julie Ekasari","orcid":"https://orcid.org/0000-0002-6179-7629","observed_orcids":["https://orcid.org/0000-0002-6179-7629"]},"institutions":[{"id":"https://openalex.org/I21881038","display_name":"IPB University","ror":"https://ror.org/05smgpd89","country_code":"ID","type":"education","lineage":["https://openalex.org/I21881038"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Julie Ekasari","raw_affiliation_strings":["Department of Aquaculture, Faculty of Fisheries and Marine Sciences, Bogor Agricultural University, Bogor, West Java, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Aquaculture, Faculty of Fisheries and Marine Sciences, Bogor Agricultural University, Bogor, West Java, Indonesia","institution_ids":["https://openalex.org/I21881038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019820908","display_name":"Pande Gde Sasmita Julyantoro","orcid":"https://orcid.org/0000-0003-4917-5429","observed_orcids":["https://orcid.org/0000-0003-4917-5429"]},"institutions":[{"id":"https://openalex.org/I126826664","display_name":"Udayana University","ror":"https://ror.org/035qsg823","country_code":"ID","type":"education","lineage":["https://openalex.org/I126826664"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Pande Gde Sasmita Julyantoro","raw_affiliation_strings":["Department of Aquatic Resources Management, Faculty of Marine Science and Fisheries, University of Udayana, Denpasar, Bali, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Aquatic Resources Management, Faculty of Marine Science and Fisheries, University of Udayana, Denpasar, Bali, Indonesia","institution_ids":["https://openalex.org/I126826664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024910451","display_name":"Diana Elizabeth Waturangi","orcid":"https://orcid.org/0000-0002-6013-7979","observed_orcids":["https://orcid.org/0000-0002-6013-7979"]},"institutions":[{"id":"https://openalex.org/I161010349","display_name":"Atma Jaya Catholic University of Indonesia","ror":"https://ror.org/02hd2zk59","country_code":"ID","type":"education","lineage":["https://openalex.org/I161010349"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Diana Elizabeth Waturangi","raw_affiliation_strings":["Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia","institution_ids":["https://openalex.org/I161010349"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054984117","display_name":"Sukenda Sukenda","orcid":"https://orcid.org/0000-0001-9465-8329","observed_orcids":["https://orcid.org/0000-0001-9465-8329"]},"institutions":[{"id":"https://openalex.org/I21881038","display_name":"IPB University","ror":"https://ror.org/05smgpd89","country_code":"ID","type":"education","lineage":["https://openalex.org/I21881038"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Sukenda Sukenda","raw_affiliation_strings":["Department of Aquaculture, Faculty of Fisheries and Marine Sciences, Bogor Agricultural University, Bogor, West Java, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-9465-8329","affiliations":[{"raw_affiliation_string":"Department of Aquaculture, Faculty of Fisheries and Marine Sciences, Bogor Agricultural University, Bogor, West Java, Indonesia","institution_ids":["https://openalex.org/I21881038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019820908","https://openalex.org/A5069357721"],"corresponding_institution_ids":["https://openalex.org/I126826664","https://openalex.org/I21881038"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":2.7727,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.90864458,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"47","issue":"6","first_page":"e13932","last_page":"e13932"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biofloc-technology","display_name":"biofloc technology","score":0.9850000143051147},{"id":"https://openalex.org/keywords/vibrio-parahaemolyticus","display_name":"Vibrio parahaemolyticus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/litopenaeus-vannamei","display_name":"Litopenaeus vannamei","score":0.9929999709129333},{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"quorum sensing","score":0.7049999833106995},{"id":"https://openalex.org/keywords/virulence-gene-expression","display_name":"virulence gene expression","score":0.9520000219345093},{"id":"https://openalex.org/keywords/shrimp-immunity","display_name":"shrimp immunity","score":0.9139999747276306},{"id":"https://openalex.org/keywords/biofilm-inhibition","display_name":"biofilm inhibition","score":0.6650000214576721},{"id":"https://openalex.org/keywords/exoenzyme-activity","display_name":"exoenzyme activity","score":0.8389999866485596},{"id":"https://openalex.org/keywords/type-vi-secretion-system","display_name":"type VI secretion system","score":0.8529999852180481},{"id":"https://openalex.org/keywords/shrimp-survival","display_name":"shrimp survival","score":0.4659999907016754},{"id":"https://openalex.org/keywords/aquaculture-disease-management","display_name":"aquaculture disease control","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2776575720","wikidata":"https://www.wikidata.org/wiki/Q134280","display_name":"Vibrio parahaemolyticus","level":3,"score":0.9668980240821838},{"id":"https://openalex.org/C2776841996","wikidata":"https://www.wikidata.org/wiki/Q1517781","display_name":"Shrimp","level":2,"score":0.9643075466156006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8520475625991821},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7881675362586975},{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.7462513446807861},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.730594277381897},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.5778562426567078},{"id":"https://openalex.org/C2777013287","wikidata":"https://www.wikidata.org/wiki/Q3007441","display_name":"Litopenaeus","level":3,"score":0.5244550704956055},{"id":"https://openalex.org/C2779771762","wikidata":"https://www.wikidata.org/wiki/Q3143049","display_name":"White spot syndrome","level":3,"score":0.5025806427001953},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3367202877998352},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.16141805052757263},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.13914567232131958},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08050432801246643}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014736","descriptor_name":"Vibrio parahaemolyticus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D014736","descriptor_name":"Vibrio parahaemolyticus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017756","descriptor_name":"Aquaculture","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033561","descriptor_name":"Penaeidae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D033561","descriptor_name":"Penaeidae","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053038","descriptor_name":"Quorum Sensing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/jfd.13932","doi":"https://doi.org/10.1111/jfd.13932","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jfd.13932","pdf_url":null,"source":{"id":"https://openalex.org/S25518365","display_name":"Journal of Fish Diseases","issn_l":"0140-7775","issn":["0140-7775","1365-2761"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Fish Diseases","raw_type":"journal-article"},{"id":"pmid:38373053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38373053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of fish diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","score":0.5769000053405762,"display_name":"Life below water"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326442","display_name":"Kementerian Riset, Teknologi dan Pendidikan Tinggi","ror":"https://ror.org/032fbvt27"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W850294230","https://openalex.org/W1485812022","https://openalex.org/W1529661949","https://openalex.org/W1602549455","https://openalex.org/W1897635105","https://openalex.org/W1975162099","https://openalex.org/W1975525621","https://openalex.org/W1982417853","https://openalex.org/W1983993275","https://openalex.org/W1986070597","https://openalex.org/W1991211859","https://openalex.org/W2006151445","https://openalex.org/W2006265862","https://openalex.org/W2030913424","https://openalex.org/W2060412085","https://openalex.org/W2061911708","https://openalex.org/W2078161829","https://openalex.org/W2090412782","https://openalex.org/W2092961312","https://openalex.org/W2107277218","https://openalex.org/W2118521369","https://openalex.org/W2119243755","https://openalex.org/W2125535993","https://openalex.org/W2130690514","https://openalex.org/W2154308883","https://openalex.org/W2156564391","https://openalex.org/W2158683791","https://openalex.org/W2170483035","https://openalex.org/W2280556315","https://openalex.org/W2326770912","https://openalex.org/W2330697701","https://openalex.org/W2575606227","https://openalex.org/W2578718150","https://openalex.org/W2606052800","https://openalex.org/W2773077324","https://openalex.org/W2799823799","https://openalex.org/W2801068067","https://openalex.org/W2801276194","https://openalex.org/W2810454926","https://openalex.org/W2884415646","https://openalex.org/W2909320716","https://openalex.org/W2921015205","https://openalex.org/W2921347424","https://openalex.org/W2966539757","https://openalex.org/W2972146651","https://openalex.org/W2997672651","https://openalex.org/W3005146126","https://openalex.org/W3024334242","https://openalex.org/W3043863742","https://openalex.org/W3080091042","https://openalex.org/W3081625944","https://openalex.org/W3094414953","https://openalex.org/W3105452301","https://openalex.org/W3118786354","https://openalex.org/W3198533269","https://openalex.org/W3198998639","https://openalex.org/W4200494302","https://openalex.org/W4221049506","https://openalex.org/W4221063875","https://openalex.org/W4292819539","https://openalex.org/W4304957600","https://openalex.org/W4377103763","https://openalex.org/W4381186707"],"related_works":["https://openalex.org/W4412450459","https://openalex.org/W4221049506","https://openalex.org/W4410476882","https://openalex.org/W7118835375","https://openalex.org/W4399770407","https://openalex.org/W4377103763","https://openalex.org/W4402143350","https://openalex.org/W4387779466","https://openalex.org/W7124728569","https://openalex.org/W3044777505"],"abstract_inverted_index":{"Abstract":[0],"This":[1],"study":[2],"aimed":[3],"to":[4],"evaluate":[5],"and":[6,27,31,59,86,107,125,138,161,167,173,190,192],"unveil":[7],"the":[8,115,133,144,149,152,157,162,181,193],"positive":[9],"impact":[10],"of":[11,18,42,54,62,84,104,114,140,151,183,196],"biofloc":[12,77,121,145,177],"culture":[13],"on":[14],"Vibrio":[15],"parahaemolyticus":[16,101],"infection":[17],"Pacific":[19],"white":[20,197],"shrimp":[21,36,64,67,184,198],"by":[22,93],"reducing":[23],"quorum":[24],"sensing":[25],"(QS)":[26],"virulence":[28,163],"gene":[29,155],"expression":[30,150,182],"enhancing":[32],"shrimp's":[33],"immunity.":[34],"The":[35,66,112,176],"with":[37,51,73,80,200],"an":[38],"average":[39],"body":[40],"weight":[41],"0.50":[43],"\u00b1":[44],"0.09":[45],"g":[46],"were":[47,68],"reared":[48],"in":[49,116,169,171,174],"containers":[50],"a":[52,60,81,87,94],"volume":[53],"2.5":[55],"L,":[56],"21":[57],"units,":[58],"density":[61],"20":[63],"L\u22121.":[65],"cultured":[69],"for":[70],"5":[71],"days,":[72],"each":[74],"treatment":[75,89,146],"including":[76],"system":[78,178],"maintenance":[79],"C/N":[82],"ratio":[83],"10":[85],"control":[88],"without":[90],"biofloc,":[91],"followed":[92],"challenge":[95],"test":[96],"through":[97],"immersion":[98],"using":[99],"V.":[100,141,201],"at":[102],"densities":[103],"103,":[105],"105,":[106],"107":[108],"CFU":[109],"mL\u22121":[110],"initially.":[111],"results":[113],"vitro":[117,172],"experiment":[118],"showed":[119],"that":[120],"suspension":[122],"can":[123],"inhibit":[124],"disperse":[126],"biofilm":[127],"formation,":[128],"as":[129,131],"well":[130],"reduce":[132],"exo\u2010enzyme":[134],"activity":[135],"(amylase,":[136],"protease,":[137],"chitinase)":[139],"parahaemolyticus.":[142,202],"Furthermore,":[143],"significantly":[147],"reduced":[148],"QS":[153],"regulatory":[154],"OpaR,":[156],"PirB":[158],"toxin":[159],"gene,":[160],"factor":[164],"genes":[165,186],"T6SS1":[166],"T6SS2":[168],"both":[170],"vivo.":[175],"also":[179],"increased":[180],"immunity\u2010related":[185],"(LGBP,":[187],"proPO,":[188],"SP,":[189],"PE)":[191],"survival":[194],"rate":[195],"challenged":[199]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-02-20T00:00:00"}