{"id":"https://openalex.org/W4391909609","doi":"https://doi.org/10.1158/1078-0432.25232177","title":"Supplementary Table S3 from Phase Ia/b Study of Giredestrant \u00b1 Palbociclib and \u00b1 Luteinizing Hormone-Releasing Hormone Agonists in Estrogen Receptor\u2013Positive, HER2-Negative, Locally Advanced/Metastatic Breast Cancer","display_name":"Supplementary Table S3 from Phase Ia/b Study of Giredestrant \u00b1 Palbociclib and \u00b1 Luteinizing Hormone-Releasing Hormone Agonists in Estrogen Receptor\u2013Positive, HER2-Negative, Locally Advanced/Metastatic Breast Cancer","publication_year":2024,"publication_date":"2024-02-16","ids":{"openalex":"https://openalex.org/W4391909609","doi":"https://doi.org/10.1158/1078-0432.25232177"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.25232177","doi":"https://doi.org/10.1158/1078-0432.25232177","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.25232177","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Table_S3_from_Phase_Ia_b_Study_of_Giredestrant_Palbociclib_and_Luteinizing_Hormone-Releasing_Hormone_Agonists_in_Estrogen_Receptor_Positive_HER2-Negative_Locally_Advanced_Metastatic_Breast_Cancer/25232177/1/files/44570486.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Table_S3_from_Phase_Ia_b_Study_of_Giredestrant_Palbociclib_and_Luteinizing_Hormone-Releasing_Hormone_Agonists_in_Estrogen_Receptor_Positive_HER2-Negative_Locally_Advanced_Metastatic_Breast_Cancer/25232177/1/files/44570486.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042743608","display_name":"Komal L. Jhaveri","orcid":"https://orcid.org/0000-0003-0472-1254","observed_orcids":["https://orcid.org/0000-0003-0472-1254"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Komal L. Jhaveri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0472-1254","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025238669","display_name":"Meritxell Bellet","orcid":"https://orcid.org/0000-0001-8859-8307","observed_orcids":["https://orcid.org/0000-0001-8859-8307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meritxell Bellet","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8859-8307","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060044961","display_name":"Nicholas C. Turner","orcid":"https://orcid.org/0000-0001-8937-0873","observed_orcids":["https://orcid.org/0000-0001-8937-0873"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas C. Turner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8937-0873","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010278367","display_name":"Sherene Loi","orcid":"https://orcid.org/0000-0001-6137-9171","observed_orcids":["https://orcid.org/0000-0001-6137-9171"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sherene Loi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6137-9171","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034972183","display_name":"Aditya Bardia","orcid":"https://orcid.org/0000-0003-4885-1157","observed_orcids":["https://orcid.org/0000-0003-4885-1157"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aditya Bardia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4885-1157","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020352800","display_name":"Valentina Boni","orcid":"https://orcid.org/0000-0002-8675-0018","observed_orcids":["https://orcid.org/0000-0002-8675-0018"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valentina Boni","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8675-0018","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030577122","display_name":"Joohyuk Sohn","orcid":"https://orcid.org/0000-0002-2303-2764","observed_orcids":["https://orcid.org/0000-0002-2303-2764"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joohyuk Sohn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2303-2764","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087164932","display_name":"Tomas G. Neilan","orcid":"https://orcid.org/0000-0002-1513-8833","observed_orcids":["https://orcid.org/0000-0002-1513-8833","https://orcid.org/0000-0003-4356-8176"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomas G. Neilan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1513-8833","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081825777","display_name":"Rafael Villanueva-V\u00e1zquez","orcid":"https://orcid.org/0000-0003-4730-6886","observed_orcids":["https://orcid.org/0000-0003-4730-6886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rafael Villanueva-V\u00e1zquez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4730-6886","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020149153","display_name":"Peter Kabos","orcid":"https://orcid.org/0000-0003-1500-471X","observed_orcids":["https://orcid.org/0000-0003-1500-471X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Kabos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1500-471X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062581318","display_name":"Laura Garc\u00eda\u2010Est\u00e9vez","orcid":"https://orcid.org/0000-0002-1709-8097","observed_orcids":["https://orcid.org/0000-0002-1709-8097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Garc\u00eda-Est\u00e9vez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1709-8097","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061314243","display_name":"Elena L\u00f3pez-Miranda","orcid":"https://orcid.org/0000-0002-2253-739X","observed_orcids":["https://orcid.org/0000-0002-2253-739X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena L\u00f3pez-Miranda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2253-739X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062635658","display_name":"Jos\u00e9 Alejandro P\u00e9rez Fidalgo","orcid":"https://orcid.org/0000-0003-3568-4345","observed_orcids":["https://orcid.org/0000-0003-3568-4345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Alejandro P\u00e9rez-Fidalgo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3568-4345","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090108117","display_name":"Jos\u00e9 Manuel P\u00e9rez-Garc\u00eda","orcid":"https://orcid.org/0000-0003-4238-2046","observed_orcids":["https://orcid.org/0000-0003-4238-2046","https://orcid.org/0009-0004-2204-2014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jose M. P\u00e9rez-Garc\u00eda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100638999","display_name":"Jiajie Yu","orcid":"https://orcid.org/0000-0001-6975-5047","observed_orcids":["https://orcid.org/0000-0001-6975-5047"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiajie Yu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6975-5047","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044122805","display_name":"Jill O. Fredrickson","orcid":"https://orcid.org/0000-0002-2693-4309","observed_orcids":["https://orcid.org/0000-0002-2693-4309"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jill Fredrickson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2693-4309","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072689892","display_name":"Heather M. Moore","orcid":"https://orcid.org/0000-0002-7098-3888","observed_orcids":["https://orcid.org/0000-0002-7098-3888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heather M. Moore","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7098-3888","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071439910","display_name":"Ching\u2010Wei Chang","orcid":"https://orcid.org/0000-0001-9239-4403","observed_orcids":["https://orcid.org/0000-0001-9239-4403"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ching-Wei Chang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9239-4403","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"John W. Bond","orcid":"https://orcid.org/0009-0005-6258-9644","observed_orcids":["https://orcid.org/0009-0005-6258-9644"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John W. Bond","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-6258-9644","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070905626","display_name":"Jennifer Eng\u2010Wong","orcid":"https://orcid.org/0000-0002-6049-6170","observed_orcids":["https://orcid.org/0000-0002-6049-6170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Eng-Wong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6049-6170","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034301580","display_name":"Mary R. Gates","orcid":"https://orcid.org/0009-0006-8576-2769","observed_orcids":["https://orcid.org/0009-0006-8576-2769"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary R. Gates","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-8576-2769","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088828593","display_name":"Elgene Lim","orcid":"https://orcid.org/0000-0001-8065-8838","observed_orcids":["https://orcid.org/0000-0001-8065-8838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elgene Lim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8065-8838","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/giredestrant","display_name":"giredestrant","score":0.9980000257492065},{"id":"https://openalex.org/keywords/palbociclib","display_name":"palbociclib","score":1.0},{"id":"https://openalex.org/keywords/gnrh-agonist","display_name":"GnRH agonist","score":0.9850000143051147},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.9190000295639038},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/locally-advanced-or-metastatic-breast-cancer","display_name":"locally advanced or metastatic breast cancer","score":0.9129999876022339},{"id":"https://openalex.org/keywords/heart-rate-reduction","display_name":"heart rate reduction","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.7770000100135803},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2779744173","wikidata":"https://www.wikidata.org/wiki/Q15269707","display_name":"Palbociclib","level":5,"score":0.6733508706092834},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6391767263412476},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.589788556098938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5842822790145874},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.5306975245475769},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.5192773342132568},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5004854202270508},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.48720043897628784},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.47776949405670166},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43768197298049927},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4285026490688324},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4272039532661438},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33149242401123047},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.25232177","doi":"https://doi.org/10.1158/1078-0432.25232177","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.25232177","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Table_S3_from_Phase_Ia_b_Study_of_Giredestrant_Palbociclib_and_Luteinizing_Hormone-Releasing_Hormone_Agonists_in_Estrogen_Receptor_Positive_HER2-Negative_Locally_Advanced_Metastatic_Breast_Cancer/25232177/1/files/44570486.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.25232177.v1","doi":"https://doi.org/10.1158/1078-0432.25232177.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.25232177.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/25232177","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Table_S3_from_Phase_Ia_b_Study_of_Giredestrant_Palbociclib_and_Luteinizing_Hormone-Releasing_Hormone_Agonists_in_Estrogen_Receptor_Positive_HER2-Negative_Locally_Advanced_Metastatic_Breast_Cancer/25232177","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.25232177","doi":"https://doi.org/10.1158/1078-0432.25232177","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.25232177","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Table_S3_from_Phase_Ia_b_Study_of_Giredestrant_Palbociclib_and_Luteinizing_Hormone-Releasing_Hormone_Agonists_in_Estrogen_Receptor_Positive_HER2-Negative_Locally_Advanced_Metastatic_Breast_Cancer/25232177/1/files/44570486.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391909609.pdf","grobid_xml":"https://content.openalex.org/works/W4391909609.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4220714215","https://openalex.org/W4391910394","https://openalex.org/W4388302567","https://openalex.org/W3171075867","https://openalex.org/W4396591934","https://openalex.org/W4282028151","https://openalex.org/W4389783358","https://openalex.org/W7129508848","https://openalex.org/W4295816936","https://openalex.org/W4389817403"],"abstract_inverted_index":{"Table":[0],"S3.":[1],"Maximum":[2],"post-baseline":[3],"reduction":[4],"of":[5],"heart":[6],"rate":[7],"in":[8],"the":[9],"safety-evaluable":[10],"population.":[11]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-02-18T00:00:00"}