{"id":"https://openalex.org/W4391908274","doi":"https://doi.org/10.1117/12.3005610","title":"Methods for modeled bioprinting of hard and soft tissues","display_name":"Methods for modeled bioprinting of hard and soft tissues","publication_year":2024,"publication_date":"2024-02-16","ids":{"openalex":"https://openalex.org/W4391908274","doi":"https://doi.org/10.1117/12.3005610"},"language":"en","primary_location":{"id":"doi:10.1117/12.3005610","doi":"https://doi.org/10.1117/12.3005610","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.3005610","pdf_url":null,"source":{"id":"https://openalex.org/S7407087808","display_name":"SPIE Medical Imaging: Imaging Informatics for Healthcare, Research, and Applications","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2024: Imaging Informatics for Healthcare, Research, and Applications","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093948679","display_name":"Trenton D. Campos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trenton D. Campos","raw_affiliation_strings":["Univ. of Pennsylvania (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pennsylvania (United States)","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093948680","display_name":"Gregory Datto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Datto","raw_affiliation_strings":["Univ. of Pennsylvania (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pennsylvania (United States)","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093948681","display_name":"Andy Tianyu Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andy Liu","raw_affiliation_strings":["Univ. of Pennsylvania (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pennsylvania (United States)","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093948682","display_name":"Carlos Mendez-Cruz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Mendez-Cruz","raw_affiliation_strings":["Univ. of Pennsylvania (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pennsylvania (United States)","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093948683","display_name":"Krunal Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krunal Patel","raw_affiliation_strings":["Univ. of Pennsylvania (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pennsylvania (United States)","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046715485","display_name":"Chet S. Friday","orcid":"https://orcid.org/0009-0008-2628-5063","observed_orcids":["https://orcid.org/0009-0008-2628-5063"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chet Friday","raw_affiliation_strings":["Univ. of Pennsylvania (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pennsylvania (United States)","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029547442","display_name":"Rashad Madi","orcid":"https://orcid.org/0000-0002-7498-3244","observed_orcids":["https://orcid.org/0000-0002-7498-3244"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rashad Madi","raw_affiliation_strings":["Univ. of Pennsylvania (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pennsylvania (United States)","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029372052","display_name":"Michael W. Hast","orcid":"https://orcid.org/0000-0002-0351-9196","observed_orcids":["https://orcid.org/0000-0002-0351-9196"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Hast","raw_affiliation_strings":["Univ. of Pennsylvania (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pennsylvania (United States)","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026804587","display_name":"Yubing Tong","orcid":"https://orcid.org/0000-0002-2133-4910","observed_orcids":["https://orcid.org/0000-0002-2133-4910"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yubing Tong","raw_affiliation_strings":["Univ. of Pennsylvania (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pennsylvania (United States)","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021492844","display_name":"Chamith S. Rajapakse","orcid":"https://orcid.org/0000-0002-9247-833X","observed_orcids":["https://orcid.org/0000-0002-9247-833X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chamith S. Rajapakse","raw_affiliation_strings":["Univ. of Pennsylvania (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pennsylvania (United States)","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02955665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"50","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.7416999936103821,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.7416999936103821,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11984","display_name":"Anatomy and Medical Technology","score":0.1923000067472458,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10783","display_name":"Additive Manufacturing and 3D Printing Technologies","score":0.041600000113248825,"subfield":{"id":"https://openalex.org/subfields/2203","display_name":"Automotive Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioprinting","display_name":"bioprinting","score":0.9559999704360962},{"id":"https://openalex.org/keywords/polycaprolactone","display_name":"polycaprolactone","score":0.7160000205039978},{"id":"https://openalex.org/keywords/hydroxyapatite","display_name":"hydroxyapatite","score":0.968999981880188},{"id":"https://openalex.org/keywords/3d-slicer","display_name":"3D Slicer","score":0.8510000109672546},{"id":"https://openalex.org/keywords/femur","display_name":"femur","score":0.7129999995231628},{"id":"https://openalex.org/keywords/scaffold-stiffness","display_name":"scaffold stiffness","score":0.8970000147819519},{"id":"https://openalex.org/keywords/infill-geometry","display_name":"infill geometry","score":0.9139999747276306},{"id":"https://openalex.org/keywords/compression-test","display_name":"compression testing","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C77331912","wikidata":"https://www.wikidata.org/wiki/Q81095","display_name":"DICOM","level":2,"score":0.8145983219146729},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6286770105361938},{"id":"https://openalex.org/C2780954041","wikidata":"https://www.wikidata.org/wiki/Q25326600","display_name":"Hard tissue","level":2,"score":0.5863167643547058},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.5627174973487854},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.5124926567077637},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.49481910467147827},{"id":"https://openalex.org/C3019308078","wikidata":"https://www.wikidata.org/wiki/Q229367","display_name":"3d printed","level":2,"score":0.46011286973953247},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.43733251094818115},{"id":"https://openalex.org/C199639397","wikidata":"https://www.wikidata.org/wiki/Q1788588","display_name":"Engineering drawing","level":1,"score":0.3236631155014038},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.17961692810058594},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.16626596450805664},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09338164329528809},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.3005610","doi":"https://doi.org/10.1117/12.3005610","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.3005610","pdf_url":null,"source":{"id":"https://openalex.org/S7407087808","display_name":"SPIE Medical Imaging: Imaging Informatics for Healthcare, Research, and Applications","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2024: Imaging Informatics for Healthcare, Research, and Applications","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2779551778","https://openalex.org/W3049364270","https://openalex.org/W4251086906"],"related_works":["https://openalex.org/W2598409683","https://openalex.org/W2972641312","https://openalex.org/W4223980783","https://openalex.org/W2355240698","https://openalex.org/W2210587534","https://openalex.org/W2391100348","https://openalex.org/W2369145011","https://openalex.org/W2183167140","https://openalex.org/W4378231928","https://openalex.org/W2912647879"],"abstract_inverted_index":{"This":[0,161],"study":[1],"presents":[2],"new":[3],"methods":[4],"to":[5,9,97,132,151,166,184,204,223,233,242],"utilize":[6],"bioprinting":[7],"technology":[8],"recreate":[10],"hard":[11,60,110,138,158,195],"and":[12,31,63,104,230],"soft":[13,68,141,153,171,190],"tissue":[14,61,69,111,142,154,159,191,217],"based":[15,156],"on":[16,157,246],"medical":[17,23],"imaging.":[18,160],"Using":[19],"the":[20,59,67,87,109,122,130,167,189,193,209,247],"proposed":[21],"methods,":[22],"DICOM":[24,113,178],"files":[25,30,114,120],"are":[26,115],"converted":[27,116],"into":[28,33,118,227],"STL":[29,119],"bioprinted":[32,74],"PCL:HA":[34,76,213,219],"scaffolds.":[35],"The":[36,126,180,197],"high":[37],"model":[38,62],"precision":[39],"provides":[40],"potential":[41],"for":[42,50,58,66,80,89,95,215],"their":[43,244],"use":[44],"as":[45,174],"image-based,":[46],"implantable":[47],"biological":[48],"scaffolds":[49,96],"musculoskeletal":[51],"applications.":[52],"Initially,":[53],"femur":[54],"segments":[55,129],"were":[56,73,225,239],"recreated":[57],"spinal":[64,175],"discs":[65],"model.":[70],"All":[71],"models":[72,155],"utilizing":[75,121],"ratios":[77,214,220],"of":[78,82,137,169,188,211],"80:20":[79],"ease":[81],"manufacturing.":[83],"Printing":[84],"methodology":[85],"circumvents":[86],"need":[88],"solvents":[90],"in":[91,100,177,202],"PCL":[92],"printing,":[93],"allowing":[94],"be":[98],"created":[99,150],"a":[101,134,144,186],"safer,":[102],"faster,":[103],"more":[105],"cost-effective":[106],"manner.":[107],"For":[108,140],"models,":[112,143,218],"directly":[117,128],"software":[123,127],"3D":[124],"Slicer.":[125],"imaging":[131,148],"print":[133],"specified":[135],"section":[136],"tissue.":[139,196],"protocol":[145,181],"called":[146],"negative":[147],"was":[149],"generate":[152,185],"method":[162],"is":[163,199],"employed":[164],"due":[165],"difficulty":[168],"isolating":[170],"tissue,":[172],"such":[173],"discs,":[176],"files.":[179],"utilizes":[182],"CAD":[183],"mold":[187,198],"from":[192,221],"surrounding":[194],"then":[200],"cleaned":[201],"Meshmixer":[203],"fix":[205],"imperfections.":[206],"To":[207],"gauge":[208],"strength":[210],"various":[212],"future":[216],"90:10":[222],"65:35":[224],"printed":[226],"standardized":[228],"cubes":[229],"compression":[231],"tested":[232,241],"determine":[234],"stiffness.":[235,249],"Various":[236],"infill":[237],"geometries":[238],"also":[240],"see":[243],"effect":[245],"scaffold":[248]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2025-10-10T00:00:00"}
