{"id":"https://openalex.org/W4391884459","doi":"https://doi.org/10.1158/2767-9764.25233497","title":"FIGURE 5 from Pim Kinase Inhibitors Increase Gilteritinib Cytotoxicity in FLT3-ITD Acute Myeloid Leukemia Through GSK-3\u03b2 Activation and c-Myc and Mcl-1 Proteasomal Degradation","display_name":"FIGURE 5 from Pim Kinase Inhibitors Increase Gilteritinib Cytotoxicity in FLT3-ITD Acute Myeloid Leukemia Through GSK-3\u03b2 Activation and c-Myc and Mcl-1 Proteasomal Degradation","publication_year":2024,"publication_date":"2024-02-16","ids":{"openalex":"https://openalex.org/W4391884459","doi":"https://doi.org/10.1158/2767-9764.25233497"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.25233497","doi":"https://doi.org/10.1158/2767-9764.25233497","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.25233497","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.25233497","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026057477","display_name":"Jonelle K. Lee","orcid":"https://orcid.org/0000-0001-7250-6818","observed_orcids":["https://orcid.org/0000-0001-7250-6818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonelle K. Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7250-6818","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040265273","display_name":"Aditi Chatterjee","orcid":"https://orcid.org/0000-0003-0595-3866","observed_orcids":["https://orcid.org/0000-0003-0595-3866"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aditi Chatterjee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0595-3866","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082280429","display_name":"Mario Scarpa","orcid":"https://orcid.org/0000-0001-6885-6778","observed_orcids":["https://orcid.org/0000-0001-6885-6778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mario Scarpa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6885-6778","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029789482","display_name":"Christopher M. Bailey","orcid":"https://orcid.org/0000-0002-2259-0502","observed_orcids":["https://orcid.org/0000-0002-2259-0502"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher M. Bailey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2259-0502","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054706220","display_name":"Sandrine Niyongere","orcid":"https://orcid.org/0000-0001-9254-0095","observed_orcids":["https://orcid.org/0000-0001-9254-0095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandrine Niyongere","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9254-0095","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084575052","display_name":"Prerna Singh","orcid":"https://orcid.org/0000-0002-7808-6049","observed_orcids":["https://orcid.org/0000-0002-7808-6049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prerna Singh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7808-6049","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020357166","display_name":"Moaath K. Mustafa Ali","orcid":"https://orcid.org/0000-0003-3289-2333","observed_orcids":["https://orcid.org/0000-0003-3289-2333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moaath K. Mustafa Ali","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3289-2333","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064415728","display_name":"Shivani Kapoor","orcid":"https://orcid.org/0009-0003-6060-6637","observed_orcids":["https://orcid.org/0009-0003-6060-6637"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shivani Kapoor","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-6060-6637","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027415109","display_name":"Yin Wang","orcid":"https://orcid.org/0000-0002-4749-3768","observed_orcids":["https://orcid.org/0000-0002-4749-3768"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yin Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4749-3768","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056803476","display_name":"Giovannino Silvestri","orcid":"https://orcid.org/0000-0001-5911-6997","observed_orcids":["https://orcid.org/0000-0001-5911-6997"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giovannino Silvestri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5911-6997","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049910941","display_name":"Maria R. Baer","orcid":"https://orcid.org/0000-0002-9499-1348","observed_orcids":["https://orcid.org/0000-0002-9499-1348"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria R. Baer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9499-1348","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/azd1208","display_name":"AZD1208","score":0.9129999876022339},{"id":"https://openalex.org/keywords/flt3-itd-mutation","display_name":"FLT3-ITD","score":0.8790000081062317},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9240000247955322},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/pim-kinase-inhibitors","display_name":"PIM kinase inhibitors","score":0.7250000238418579},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.7870000004768372},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.7179999947547913},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6549999713897705},{"id":"https://openalex.org/keywords/ba-f3-cells","display_name":"Ba/F3 cells","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7551818490028381},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.6834186315536499},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5904061198234558},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5219739675521851},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47589075565338135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22147220373153687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16129335761070251},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06061902642250061},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.056539177894592285},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.04536682367324829}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2767-9764.25233497","doi":"https://doi.org/10.1158/2767-9764.25233497","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.25233497","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2767-9764.25233497.v1","doi":"https://doi.org/10.1158/2767-9764.25233497.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.25233497.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.25233497","doi":"https://doi.org/10.1158/2767-9764.25233497","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.25233497","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391879170","https://openalex.org/W4391879140","https://openalex.org/W4391884514","https://openalex.org/W4391884497","https://openalex.org/W4391313605","https://openalex.org/W4391884481","https://openalex.org/W4391879141","https://openalex.org/W4391879157","https://openalex.org/W4282920721","https://openalex.org/W2954825813"],"abstract_inverted_index":{"T58A-mutated":[0],"c-Myc":[1,5,24,61,74,102,110,143],"confers":[2],"resistance":[3],"to":[4,8,30,113,122],"downregulation":[6],"and":[7,13,50,55,62,85,90,103,115,130,144,176,184],"apoptosis":[9,177],"induction":[10,181],"by":[11,182],"gilteritinib":[12,49,89,129,167,183],"AZD1208":[14,51,91,131,185],"combination":[15,186],"treatment.":[16],"A,":[17],"Ba/F3-ITD":[18],"cells":[19,77,191],"infected":[20,156,192],"with":[21,25,47,80,88,157,166,193,197],"pCDH-MSCV-MycT58A-EF1a-copGFP,":[22,158],"containing":[23,38],"a":[26],"mutation":[27],"changing":[28],"threonine":[29],"alanine":[31],"at":[32],"residue":[33],"58,":[34],"preventing":[35],"phosphorylation,":[36],"pCDH-MSCV-Myc(WT)-EF1a-copGFP,":[37],"wild-type":[39,142],"c-Myc,":[40],"or":[41,52,93,160,170],"pCDH-MSCV-MCS-EF1-copGFP":[42,161],"empty":[43,136,162,198],"vector":[44,163,199],"were":[45,58,78,99,120,164],"treated":[46,87,165],"either":[48],"DMSO":[53,94,133,171],"control":[54,95,134,200],"serial":[56],"samples":[57,98],"immunoblotted":[59,100],"for":[60,82,101,128,135,141,149,151,173],"vinculin":[63,104,114],"loading":[64,105],"control.":[65,106],"Densitometric":[66],"analysis":[67],"is":[68],"also":[69],"shown.":[70],"B,":[71],"To":[72],"measure":[73],"protein":[75,117],"turnover,":[76],"pretreated":[79],"CHX":[81],"1":[83],"hour":[84],"then":[86],"(+)":[92],"(\u2212).":[96],"Serial":[97],"Densitometry":[107],"was":[108,111,178,187],"performed.":[109],"normalized":[112],"50%":[116],"turnover":[118],"timepoints":[119],"determined":[121],"be":[123],"1.035":[124],"versus":[125,132,139],"1.2":[126],"hours":[127,148],"vector,":[137],"0.6":[138],"0.72":[140],"more":[145],"than":[146],"2":[147],"both":[150],"T58A":[152],"c-Myc.":[153],"C,":[154],"Cells":[155],"pCDH-MSCV-Myc(WT)-EF1a-copGFP":[159],"and/or":[168],"AZD1208,":[169],"control,":[172],"48":[174],"hours,":[175],"measured.":[179],"Apoptosis":[180],"significantly":[188],"reduced":[189],"in":[190],"pMSCVpuro-Flag-cMyc":[194],"T58A,":[195],"compared":[196],"(***,":[201],"P":[202],"<0.0001).":[203]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-02-17T00:00:00"}
