{"id":"https://openalex.org/W4391884415","doi":"https://doi.org/10.1158/2767-9764.25233500","title":"FIGURE 4 from Pim Kinase Inhibitors Increase Gilteritinib Cytotoxicity in FLT3-ITD Acute Myeloid Leukemia Through GSK-3\u03b2 Activation and c-Myc and Mcl-1 Proteasomal Degradation","display_name":"FIGURE 4 from Pim Kinase Inhibitors Increase Gilteritinib Cytotoxicity in FLT3-ITD Acute Myeloid Leukemia Through GSK-3\u03b2 Activation and c-Myc and Mcl-1 Proteasomal Degradation","publication_year":2024,"publication_date":"2024-02-16","ids":{"openalex":"https://openalex.org/W4391884415","doi":"https://doi.org/10.1158/2767-9764.25233500"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.25233500","doi":"https://doi.org/10.1158/2767-9764.25233500","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.25233500","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.25233500","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026057477","display_name":"Jonelle K. Lee","orcid":"https://orcid.org/0000-0001-7250-6818","observed_orcids":["https://orcid.org/0000-0001-7250-6818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonelle K. Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7250-6818","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040265273","display_name":"Aditi Chatterjee","orcid":"https://orcid.org/0000-0003-0595-3866","observed_orcids":["https://orcid.org/0000-0003-0595-3866"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aditi Chatterjee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0595-3866","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082280429","display_name":"Mario Scarpa","orcid":"https://orcid.org/0000-0001-6885-6778","observed_orcids":["https://orcid.org/0000-0001-6885-6778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mario Scarpa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6885-6778","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029789482","display_name":"Christopher M. Bailey","orcid":"https://orcid.org/0000-0002-2259-0502","observed_orcids":["https://orcid.org/0000-0002-2259-0502"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher M. Bailey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2259-0502","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054706220","display_name":"Sandrine Niyongere","orcid":"https://orcid.org/0000-0001-9254-0095","observed_orcids":["https://orcid.org/0000-0001-9254-0095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandrine Niyongere","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9254-0095","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084575052","display_name":"Prerna Singh","orcid":"https://orcid.org/0000-0002-7808-6049","observed_orcids":["https://orcid.org/0000-0002-7808-6049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prerna Singh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7808-6049","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020357166","display_name":"Moaath K. Mustafa Ali","orcid":"https://orcid.org/0000-0003-3289-2333","observed_orcids":["https://orcid.org/0000-0003-3289-2333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moaath K. Mustafa Ali","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3289-2333","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064415728","display_name":"Shivani Kapoor","orcid":"https://orcid.org/0009-0003-6060-6637","observed_orcids":["https://orcid.org/0009-0003-6060-6637"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shivani Kapoor","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-6060-6637","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027415109","display_name":"Yin Wang","orcid":"https://orcid.org/0000-0002-4749-3768","observed_orcids":["https://orcid.org/0000-0002-4749-3768"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yin Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4749-3768","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056803476","display_name":"Giovannino Silvestri","orcid":"https://orcid.org/0000-0001-5911-6997","observed_orcids":["https://orcid.org/0000-0001-5911-6997"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giovannino Silvestri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5911-6997","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049910941","display_name":"Maria R. Baer","orcid":"https://orcid.org/0000-0002-9499-1348","observed_orcids":["https://orcid.org/0000-0002-9499-1348"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria R. Baer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9499-1348","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pim-kinase-inhibitors","display_name":"PIM kinase inhibitors","score":0.8899999856948853},{"id":"https://openalex.org/keywords/gilteritinib","display_name":"gilteritinib","score":0.9229999780654907},{"id":"https://openalex.org/keywords/flt3-itd-acute-myeloid-leukemia","display_name":"FLT3-ITD acute myeloid leukemia","score":0.9160000085830688},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9309999942779541},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":1.0},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/azd1208","display_name":"AZD1208","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mv4-11-cells","display_name":"MV4-11 cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7678537368774414},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5940690636634827},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.579387366771698},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.5062174201011658},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4342522919178009},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3003045618534088},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10601505637168884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.092745840549469},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0688970685005188},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2767-9764.25233500","doi":"https://doi.org/10.1158/2767-9764.25233500","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.25233500","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2767-9764.25233500.v1","doi":"https://doi.org/10.1158/2767-9764.25233500.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.25233500.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.25233500","doi":"https://doi.org/10.1158/2767-9764.25233500","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.25233500","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391879140","https://openalex.org/W4391884497","https://openalex.org/W4391884459","https://openalex.org/W4391879170","https://openalex.org/W4391879157","https://openalex.org/W4391879141","https://openalex.org/W4391884481","https://openalex.org/W4391313605","https://openalex.org/W4282920721","https://openalex.org/W4362401588"],"abstract_inverted_index":{"c-Myc":[0,75],"and":[1,10,14,79,89,94,98],"Mcl-1":[2,77],"are":[3,91],"downregulated":[4],"through":[5],"enhanced":[6],"proteasomal":[7],"degradation.":[8],"A":[9,88],"B,":[11],"Ba/F3-ITD,":[12],"MV4-11,":[13],"MOLM-14":[15],"cells":[16],"plated":[17],"at":[18,55,67],"1":[19,30],"\u00d7":[20],"105":[21],"cells/mL":[22],"were":[23,70],"treated":[24],"with":[25,36,51],"100":[26],"\u00b5g/mL":[27],"CHX":[28],"for":[29,72],"hour":[31],"to":[32,49],"inhibit":[33],"protein":[34,83],"synthesis,":[35],"or":[37,62],"without":[38],"addition":[39],"of":[40,74],"the":[41],"proteasome":[42],"inhibitor":[43],"MG-132":[44],"after":[45],"30":[46],"minutes,":[47],"prior":[48],"treatment":[50],"gilteritinib":[52],"and/or":[53],"AZD1208":[54],"same":[56],"concentrations":[57],"as":[58],"in":[59,87,96],"Fig.":[60],"3,":[61],"DMSO":[63],"control.":[64],"Samples":[65],"collected":[66],"serial":[68],"timepoints":[69],"studied":[71],"expression":[73],"(A),":[76],"(B)":[78],"vinculin":[80],"loading":[81],"control":[82],"by":[84],"immunoblotting.":[85],"Data":[86],"B":[90],"shown":[92],"graphically":[93],"numerically":[95],"C":[97],"D,":[99],"respectively.":[100]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-02-17T00:00:00"}