{"id":"https://openalex.org/W4391879652","doi":"https://doi.org/10.1021/acsanm.3c05999","title":"Sustainable and Well-Dispersed Cu-Doped Magnetic Vortex Nanorings for Highly Specific Separation of His-Rich Proteins","display_name":"Sustainable and Well-Dispersed Cu-Doped Magnetic Vortex Nanorings for Highly Specific Separation of His-Rich Proteins","publication_year":2024,"publication_date":"2024-02-16","ids":{"openalex":"https://openalex.org/W4391879652","doi":"https://doi.org/10.1021/acsanm.3c05999"},"language":"en","primary_location":{"id":"doi:10.1021/acsanm.3c05999","doi":"https://doi.org/10.1021/acsanm.3c05999","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsanm.3c05999","pdf_url":null,"source":{"id":"https://openalex.org/S4210191493","display_name":"ACS Applied Nano Materials","issn_l":"2574-0970","issn":["2574-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Nano Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115588318","display_name":"Xingyan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingyan Wang","raw_affiliation_strings":["School of Chemistry, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710049, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yingying Niu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingying Niu","raw_affiliation_strings":["School of Chemistry, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710049, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100757025","display_name":"Kaili Wang","orcid":"https://orcid.org/0000-0002-7996-5600","observed_orcids":["https://orcid.org/0000-0002-7996-5600"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaili Wang","raw_affiliation_strings":["School of Pharmacy, Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710061, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710061, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100649374","display_name":"Long Zhang","orcid":"https://orcid.org/0000-0002-6701-8147","observed_orcids":["https://orcid.org/0000-0002-6701-8147"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Long Zhang","raw_affiliation_strings":["School of Pharmacy, Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710061, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710061, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101305713","display_name":"Yuheng Liao","orcid":"https://orcid.org/0009-0003-4639-4586","observed_orcids":["https://orcid.org/0009-0003-4639-4586","https://orcid.org/0009-0009-0664-3182"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuheng Liao","raw_affiliation_strings":["Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337551","display_name":"Chen Wang","orcid":"https://orcid.org/0000-0002-1906-7366","observed_orcids":["https://orcid.org/0000-0002-1906-7366"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Wang","raw_affiliation_strings":["Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109683452","display_name":"Chendi Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chendi Lu","raw_affiliation_strings":["Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101967086","display_name":"Yi Hao","orcid":"https://orcid.org/0000-0002-8709-151X","observed_orcids":["https://orcid.org/0000-0002-8709-151X"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi Hao","raw_affiliation_strings":["School of Pharmacy, Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710061, China"],"raw_orcid":"https://orcid.org/0000-0002-8709-151X","affiliations":[{"raw_affiliation_string":"School of Pharmacy, Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710061, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005491871","display_name":"Ruixia Gao","orcid":"https://orcid.org/0000-0002-5617-1509","observed_orcids":["https://orcid.org/0000-0002-5617-1509","https://orcid.org/0009-0004-1617-5865"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ruixia Gao","raw_affiliation_strings":["School of Chemistry, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710049, China"],"raw_orcid":"https://orcid.org/0000-0002-5617-1509","affiliations":[{"raw_affiliation_string":"School of Chemistry, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710049, China","institution_ids":["https://openalex.org/I87445476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005491871","https://openalex.org/A5101967086"],"corresponding_institution_ids":["https://openalex.org/I87445476"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6672,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.59916993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"5","first_page":"5263","last_page":"5271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.19210000336170197,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10016","display_name":"Adsorption and biosorption for pollutant removal","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-hemoglobin","display_name":"bovine hemoglobin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/magnetic-adsorbent","display_name":"magnetic adsorbent","score":0.6850000023841858},{"id":"https://openalex.org/keywords/ligand-free-synthesis","display_name":"ligand-free synthesis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/adsorbent-regeneration","display_name":"adsorbent regeneration","score":0.8569999933242798},{"id":"https://openalex.org/keywords/bovine-blood","display_name":"bovine blood","score":0.5770000219345093},{"id":"https://openalex.org/keywords/protein-enrichment","display_name":"protein enrichment","score":0.3440000116825104}],"concepts":[{"id":"https://openalex.org/C140820882","wikidata":"https://www.wikidata.org/wiki/Q732722","display_name":"Vortex","level":2,"score":0.5387618541717529},{"id":"https://openalex.org/C57863236","wikidata":"https://www.wikidata.org/wiki/Q1130571","display_name":"Doping","level":2,"score":0.5196672677993774},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5062726736068726},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.47599732875823975},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.411360502243042},{"id":"https://openalex.org/C26873012","wikidata":"https://www.wikidata.org/wiki/Q214781","display_name":"Condensed matter physics","level":1,"score":0.3868752121925354},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.38110193610191345},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32564765214920044},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1725323498249054},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.16862526535987854},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.08843910694122314},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07227113842964172}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acsanm.3c05999","doi":"https://doi.org/10.1021/acsanm.3c05999","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsanm.3c05999","pdf_url":null,"source":{"id":"https://openalex.org/S4210191493","display_name":"ACS Applied Nano Materials","issn_l":"2574-0970","issn":["2574-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Nano Materials","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1911577398","display_name":null,"funder_award_id":"No. 2023-YBNY-233","funder_id":"https://openalex.org/F4320324173","funder_display_name":"Natural Science Foundation of Shaanxi Province"},{"id":"https://openalex.org/G7085076260","display_name":null,"funder_award_id":"No. 22250410261","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324173","display_name":"Natural Science Foundation of Shaanxi Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1989722007","https://openalex.org/W2022688069","https://openalex.org/W2068794150","https://openalex.org/W2108341748","https://openalex.org/W2150772197","https://openalex.org/W2327095779","https://openalex.org/W2405653883","https://openalex.org/W2743065978","https://openalex.org/W2768588919","https://openalex.org/W2783908120","https://openalex.org/W2791200641","https://openalex.org/W2887138069","https://openalex.org/W2900836949","https://openalex.org/W2942764302","https://openalex.org/W2946224380","https://openalex.org/W2950726033","https://openalex.org/W2964274846","https://openalex.org/W2977719974","https://openalex.org/W3002196606","https://openalex.org/W3005185138","https://openalex.org/W3037864844","https://openalex.org/W3040618843","https://openalex.org/W3041508844","https://openalex.org/W3045526107","https://openalex.org/W3045627749","https://openalex.org/W3093539315","https://openalex.org/W3147354265","https://openalex.org/W3177173937","https://openalex.org/W3185760301","https://openalex.org/W4226413004","https://openalex.org/W4229441242","https://openalex.org/W4282827133","https://openalex.org/W4282945209","https://openalex.org/W4291465401","https://openalex.org/W4292622655","https://openalex.org/W4307179692","https://openalex.org/W4307814778","https://openalex.org/W4324117779","https://openalex.org/W4366534505","https://openalex.org/W4368363132"],"related_works":["https://openalex.org/W4226413004","https://openalex.org/W4408962649","https://openalex.org/W2327095779","https://openalex.org/W2404659921","https://openalex.org/W2051050178","https://openalex.org/W3133373405","https://openalex.org/W2743065978","https://openalex.org/W3041508844","https://openalex.org/W3031085669","https://openalex.org/W2105522853"],"abstract_inverted_index":{"The":[0],"combination":[1],"of":[2,66,133,180,206],"magnetic":[3,30,53,96,137],"nanomaterials":[4],"with":[5,32,77,150],"the":[6,62,70,104,134,175,190,204],"immobilized":[7],"metal":[8],"affinity":[9],"(IMA)":[10],"technique":[11],"has":[12],"emerged":[13],"as":[14],"a":[15,26,40,46,94,112,163],"powerful":[16],"method":[17,49],"to":[18,50,170,196,213],"specifically":[19],"separate":[20],"histidine":[21],"(His)-rich":[22],"proteins.":[23,68],"However,":[24],"obtaining":[25],"high-performance":[27],"and":[28,35,121,160,178,199],"sustainable":[29],"adsorbent":[31],"good":[33],"dispersibility":[34],"minimal":[36],"copper":[37,152],"leakage":[38,154],"remains":[39],"major":[41],"challenge.":[42],"Herein,":[43],"we":[44],"propose":[45],"simple":[47],"ligand-free":[48],"acquire":[51],"Cu-doped":[52],"nanorings":[54],"(Fe":[55],"3":[56,72,106,141,182,208],"O":[57,73,107,142,183,209],"4":[58,74,108,143,184,210],"\u2013Cu":[59,75,109,144,185,211],"NR)":[60],"for":[61,89,127,168,187],"highly":[63],"selective":[64],"enrichment":[65],"His-rich":[67,90],"Importantly,":[69],"Fe":[71,105,140,181,207],"NR":[76,110,145,186,212],"unique":[78],"ring-like":[79],"structural":[80],"features":[81],"offers":[82],"numerous":[83],"exposed":[84],"Cu":[85],"2+":[86],"binding":[87],"sites":[88],"proteins":[91],"while":[92],"maintaining":[93],"high":[95,122],"behavior":[97],"(61.7":[98],"emu":[99],"g":[100,118],"\u20131":[101,119,158],").":[102],"Thus,":[103],"exhibits":[111],"remarkable":[113],"adsorption":[114],"capacity":[115],"(932.2":[116],"mg":[117],")":[120,159],"selectivity":[123],"(SF":[124],"<":[125],"0.1)":[126],"bovine":[128,192],"hemoglobin":[129],"(BHb),":[130],"surpassing":[131],"most":[132],"reported":[135],"IMA":[136],"adsorbents.":[138],"Moreover,":[139],"can":[146],"be":[147,197],"easily":[148],"regenerated":[149],"negligible":[151],"ion":[153],"(<0.1":[155],"\u03bcmol":[156],"L":[157],"without":[161],"requiring":[162],"reincubation":[164],"step,":[165],"demonstrating":[166],"reusability":[167],"up":[169],"six":[171],"cycles.":[172],"In":[173],"addition,":[174],"removal":[176],"efficiency":[177],"recovery":[179],"BHb":[188,214],"in":[189,215],"diluted":[191],"blood":[193],"were":[194],"found":[195],"89.79":[198],"70.25%,":[200],"respectively,":[201],"further":[202],"indicating":[203],"specificity":[205],"complex":[216],"biological":[217],"samples.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-02-17T00:00:00"}