{"id":"https://openalex.org/W4391850786","doi":"https://doi.org/10.1016/j.ejcb.2024.151398","title":"Molecular mechanisms of naringenin modulation of mitochondrial permeability transition acting on F1FO-ATPase and counteracting saline load-induced injury in SHRSP cerebral endothelial cells","display_name":"Molecular mechanisms of naringenin modulation of mitochondrial permeability transition acting on F1FO-ATPase and counteracting saline load-induced injury in SHRSP cerebral endothelial cells","publication_year":2024,"publication_date":"2024-02-15","ids":{"openalex":"https://openalex.org/W4391850786","doi":"https://doi.org/10.1016/j.ejcb.2024.151398","pmid":"https://pubmed.ncbi.nlm.nih.gov/38368729"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejcb.2024.151398","doi":"https://doi.org/10.1016/j.ejcb.2024.151398","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejcb.2024.151398","pdf_url":null,"source":{"id":"https://openalex.org/S170067410","display_name":"European Journal of Cell Biology","issn_l":"0171-9335","issn":["0171-9335","1618-1298"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ejcb.2024.151398","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089004786","display_name":"Salvatore Nesci","orcid":"https://orcid.org/0000-0001-8569-7158","observed_orcids":["https://orcid.org/0000-0001-8569-7158"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Salvatore Nesci","raw_affiliation_strings":["Department of Veterinary Medical Sciences, University of Bologna,\u00a0Ozzano Emilia 40064,\u00a0Italy. Electronic address: salvatore.nesci@unibo.it","Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia 40064, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medical Sciences, University of Bologna,\u00a0Ozzano Emilia 40064,\u00a0Italy. Electronic address: salvatore.nesci@unibo.it","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia 40064, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010888549","display_name":"Cristina Algieri","orcid":"https://orcid.org/0000-0002-1742-9378","observed_orcids":["https://orcid.org/0000-0002-1742-9378"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Algieri","raw_affiliation_strings":["Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia 40064, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia 40064, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041998967","display_name":"Matteo Antonio Tallarida","orcid":"https://orcid.org/0000-0002-9590-2861","observed_orcids":["https://orcid.org/0000-0002-9590-2861"]},"institutions":[{"id":"https://openalex.org/I4210095584","display_name":"RINA Consulting - Centro Sviluppo Materiali S.p.A. (Italy)","ror":"https://ror.org/008yqe287","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210095584"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Antonio Tallarida","raw_affiliation_strings":["RINA Consulting - Centro Sviluppo Materiali SpA, Via di Castel Romano 100, Rome, 00128, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RINA Consulting - Centro Sviluppo Materiali SpA, Via di Castel Romano 100, Rome, 00128, Italy","institution_ids":["https://openalex.org/I4210095584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019161572","display_name":"Rosita Stanzione","orcid":"https://orcid.org/0000-0002-3576-4604","observed_orcids":["https://orcid.org/0000-0002-3576-4604"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosita Stanzione","raw_affiliation_strings":["IRCCS Neuromed, Pozzilli 86077, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli 86077, Italy","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087028468","display_name":"Saverio Marchi","orcid":"https://orcid.org/0000-0003-2708-1843","observed_orcids":["https://orcid.org/0000-0003-2708-1843"]},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Saverio Marchi","raw_affiliation_strings":["Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona 60126, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona 60126, Italy","institution_ids":["https://openalex.org/I122534668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093935401","display_name":"Donatella Pietrangelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Donatella Pietrangelo","raw_affiliation_strings":["Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome 00189, Italy","IRCCS Neuromed, Pozzilli 86077, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome 00189, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli 86077, Italy","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035815879","display_name":"Fabiana Trombetti","orcid":"https://orcid.org/0000-0003-1611-8727","observed_orcids":["https://orcid.org/0000-0003-1611-8727"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabiana Trombetti","raw_affiliation_strings":["Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia 40064, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia 40064, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077216663","display_name":"Luca D\u2019Ambrosio","orcid":"https://orcid.org/0000-0002-8196-8069","observed_orcids":["https://orcid.org/0000-0002-8196-8069"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca D\u2019Ambrosio","raw_affiliation_strings":["Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035544791","display_name":"Maurizio Forte","orcid":"https://orcid.org/0000-0003-0739-0534","observed_orcids":["https://orcid.org/0000-0003-0739-0534"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Forte","raw_affiliation_strings":["IRCCS Neuromed, Pozzilli 86077, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli 86077, Italy","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072021112","display_name":"Maria Cotugno","orcid":"https://orcid.org/0000-0003-0061-1154","observed_orcids":["https://orcid.org/0000-0003-0061-1154"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Cotugno","raw_affiliation_strings":["IRCCS Neuromed, Pozzilli 86077, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli 86077, Italy","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104801477","display_name":"Ilaria Nunzi","orcid":"https://orcid.org/0009-0008-7369-6156","observed_orcids":["https://orcid.org/0009-0008-7369-6156"]},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Nunzi","raw_affiliation_strings":["Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona 60126, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona 60126, Italy","institution_ids":["https://openalex.org/I122534668"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rachele Bigi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rachele Bigi","raw_affiliation_strings":["Department of Neuroscience, Mental Health, and Sensory Organs, Sapienza University, Rome 00189, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mental Health, and Sensory Organs, Sapienza University, Rome 00189, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023691791","display_name":"Loredana Maiuolo","orcid":"https://orcid.org/0000-0002-8936-4454","observed_orcids":["https://orcid.org/0000-0002-8936-4454"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Loredana Maiuolo","raw_affiliation_strings":["Department of Chemistry and Chemical Technologies, University of Calabria, Cosenza 87036, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Technologies, University of Calabria, Cosenza 87036, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030960061","display_name":"Antonio De Nino","orcid":"https://orcid.org/0000-0002-9513-5199","observed_orcids":["https://orcid.org/0000-0002-9513-5199"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio De Nino","raw_affiliation_strings":["Department of Chemistry and Chemical Technologies, University of Calabria, Cosenza 87036, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Technologies, University of Calabria, Cosenza 87036, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070894673","display_name":"Paolo Pinton","orcid":"https://orcid.org/0000-0001-7108-6508","observed_orcids":["https://orcid.org/0000-0001-7108-6508"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]},{"id":"https://openalex.org/I4210100680","display_name":"Maria Cecilia Hospital","ror":"https://ror.org/01wxb8362","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210100680"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Pinton","raw_affiliation_strings":["Translational Research Center, Maria Cecilia Hospital GVM Care & Research,\u00a0Cotignola 48033,\u00a0Italy; Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara 44121, Italy","Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara 44121, Italy","Translational Research Center, Maria Cecilia Hospital GVM Care & Research, 48033 Cotignola, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Research Center, Maria Cecilia Hospital GVM Care & Research,\u00a0Cotignola 48033,\u00a0Italy; Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara 44121, Italy","institution_ids":["https://openalex.org/I201324441","https://openalex.org/I4210100680"]},{"raw_affiliation_string":"Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara 44121, Italy","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"Translational Research Center, Maria Cecilia Hospital GVM Care & Research, 48033 Cotignola, Italy","institution_ids":["https://openalex.org/I4210100680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103853009","display_name":"Giovanni Romeo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Romeo","raw_affiliation_strings":["Medical Genetics Unit, Sant'Orsola-Malpighi University Hospital, Bologna 40126, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Genetics Unit, Sant'Orsola-Malpighi University Hospital, Bologna 40126, Italy","institution_ids":["https://openalex.org/I4210097083"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102774123","display_name":"Speranza Donatella Rubattu","orcid":"https://orcid.org/0000-0002-9808-7970","observed_orcids":["https://orcid.org/0000-0002-9808-7970"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Speranza Rubattu","raw_affiliation_strings":["IRCCS Neuromed, Pozzilli 86077, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome 00189, Italy","Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome 00189, Italy","IRCCS Neuromed, Pozzilli 86077, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli 86077, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome 00189, Italy","institution_ids":["https://openalex.org/I3018288129","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome 00189, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli 86077, Italy","institution_ids":["https://openalex.org/I3018288129"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5089004786"],"corresponding_institution_ids":["https://openalex.org/I9360294"],"apc_list":{"value":2780,"currency":"USD","value_usd":2780},"apc_paid":{"value":2780,"currency":"USD","value_usd":2780},"fwci":1.6681,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.8378211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"103","issue":"2","first_page":"151398","last_page":"151398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.5313000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.5313000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.4066999852657318,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naringenin","display_name":"naringenin","score":1.0},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition","display_name":"mitochondrial permeability transition","score":0.9430000185966492},{"id":"https://openalex.org/keywords/atp-synthase","display_name":"ATP synthase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/atpase-inhibition","display_name":"ATPase inhibition","score":0.5519999861717224},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.8370000123977661},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8410000205039978},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6790000200271606},{"id":"https://openalex.org/keywords/brain-endothelial-cells","display_name":"brain endothelial cells","score":0.8460000157356262},{"id":"https://openalex.org/keywords/stroke-prone-spontaneously-hypertensive-rats","display_name":"stroke-prone spontaneously hypertensive rats","score":0.8970000147819519},{"id":"https://openalex.org/keywords/complex-i-activity","display_name":"complex I activity","score":0.75},{"id":"https://openalex.org/keywords/endothelial-tube-formation","display_name":"endothelial tube formation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C13591479","wikidata":"https://www.wikidata.org/wiki/Q6881880","display_name":"Mitochondrial permeability transition pore","level":4,"score":0.835873544216156},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.5135488510131836},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5075558423995972},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45697104930877686},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4556846618652344},{"id":"https://openalex.org/C2776848411","wikidata":"https://www.wikidata.org/wiki/Q418374","display_name":"Naringenin","level":4,"score":0.4287320077419281},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24213245511054993},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21765872836112976},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17762255668640137},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.10378769040107727},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.06110253930091858},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000083162","descriptor_name":"Mitochondrial Permeability Transition Pore","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006180","descriptor_name":"Proton-Translocating ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D033681","descriptor_name":"Mitochondrial Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044950","descriptor_name":"Flavanones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.ejcb.2024.151398","doi":"https://doi.org/10.1016/j.ejcb.2024.151398","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejcb.2024.151398","pdf_url":null,"source":{"id":"https://openalex.org/S170067410","display_name":"European Journal of Cell Biology","issn_l":"0171-9335","issn":["0171-9335","1618-1298"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmid:38368729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38368729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:cris.unibo.it:11585/958841","doi":null,"is_oa":true,"landing_page_url":"https://www.sciencedirect.com/science/article/pii/S0171933524000153?via=ihub","pdf_url":"https://cris.unibo.it/bitstream/11585/958841/1/Molecular%20mechanisms%20of%20naringenin%20modulation%20of%20MPT%20acting%20on%20F1FO-ATPase%20and%20counteracting%20saline%20load-induced%20injury%20in%20SHRSP.pdf","source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1701914","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11573/1701914","pdf_url":"https://iris.uniroma1.it/bitstream/11573/1701914/4/Nesci_Molecular_2024.pdf","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:fa6f92a0d76e4bf882977013dbb4485a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/fa6f92a0d76e4bf882977013dbb4485a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Cell Biology, Vol 103, Iss 2, Pp 151398- (2024)","raw_type":"article"},{"id":"pmh:oai:iris.unical.it:20.500.11770/364878","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.11770/364878","pdf_url":null,"source":{"id":"https://openalex.org/S4377196898","display_name":"Archive of Doctoral Theses and Digital Collections (University of Calabria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45204951","host_organization_name":"University of Calabria","host_organization_lineage":["https://openalex.org/I45204951"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.ejcb.2024.151398","doi":"https://doi.org/10.1016/j.ejcb.2024.151398","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejcb.2024.151398","pdf_url":null,"source":{"id":"https://openalex.org/S170067410","display_name":"European Journal of Cell Biology","issn_l":"0171-9335","issn":["0171-9335","1618-1298"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cell Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1542558716","display_name":null,"funder_award_id":"CUP B53C22004000006","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G1993633068","display_name":null,"funder_award_id":"PE_00000019","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G955607112","display_name":null,"funder_award_id":"RFO2021","funder_id":"https://openalex.org/F4320323553","funder_display_name":"Universit\u00e0 di Bologna"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320323553","display_name":"Universit\u00e0 di Bologna","ror":"https://ror.org/01111rn36"},{"id":"https://openalex.org/F5497039910","display_name":"Ministero dell'Istruzione e del Merito","ror":"https://ror.org/01ehyh486"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391850786.pdf","grobid_xml":"https://content.openalex.org/works/W4391850786.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1545450702","https://openalex.org/W1887971648","https://openalex.org/W1976133507","https://openalex.org/W1979493659","https://openalex.org/W1993418135","https://openalex.org/W2006557290","https://openalex.org/W2009037349","https://openalex.org/W2029961407","https://openalex.org/W2034448321","https://openalex.org/W2037998901","https://openalex.org/W2052737683","https://openalex.org/W2059061809","https://openalex.org/W2081303452","https://openalex.org/W2091047906","https://openalex.org/W2105668062","https://openalex.org/W2128635872","https://openalex.org/W2134967712","https://openalex.org/W2150697053","https://openalex.org/W2308516605","https://openalex.org/W2340940993","https://openalex.org/W2345712655","https://openalex.org/W2516797805","https://openalex.org/W2613068463","https://openalex.org/W2647490639","https://openalex.org/W2738982574","https://openalex.org/W2766181443","https://openalex.org/W2810279664","https://openalex.org/W2889077368","https://openalex.org/W2908117805","https://openalex.org/W2908708255","https://openalex.org/W2911374797","https://openalex.org/W2969770706","https://openalex.org/W2970506751","https://openalex.org/W2976241964","https://openalex.org/W2981063024","https://openalex.org/W2989495965","https://openalex.org/W2995516783","https://openalex.org/W2999299852","https://openalex.org/W3000062473","https://openalex.org/W3015670160","https://openalex.org/W3027530623","https://openalex.org/W3028350492","https://openalex.org/W3042689819","https://openalex.org/W3084086545","https://openalex.org/W3086511947","https://openalex.org/W3087446765","https://openalex.org/W3100278434","https://openalex.org/W3112432376","https://openalex.org/W3113822643","https://openalex.org/W3130965195","https://openalex.org/W3200623262","https://openalex.org/W4221029211","https://openalex.org/W4224233686","https://openalex.org/W4290999892","https://openalex.org/W4307726921","https://openalex.org/W4309664551","https://openalex.org/W4319003537","https://openalex.org/W4323665378","https://openalex.org/W4360861757","https://openalex.org/W4362657000","https://openalex.org/W4389669102"],"related_works":["https://openalex.org/W3176765404","https://openalex.org/W3020896806","https://openalex.org/W2172196417","https://openalex.org/W7030397911","https://openalex.org/W6967428769","https://openalex.org/W3040019699","https://openalex.org/W2969770706","https://openalex.org/W1969540386","https://openalex.org/W7170048854","https://openalex.org/W4386955673"],"abstract_inverted_index":{"Naringenin":[0],"(NRG)":[1],"was":[2,55],"characterized":[3],"for":[4],"its":[5],"ability":[6],"to":[7,14,127,142,158,166],"counteract":[8],"mitochondrial":[9,148],"dysfunction":[10],"which":[11],"is":[12],"linked":[13,165],"cardiovascular":[15],"diseases.":[16],"The":[17,27,93,139],"F1FO-ATPase":[18,110,136],"can":[19,34,131],"act":[20],"as":[21,51,155,157],"a":[22,56,65,91,190],"molecular":[23],"target":[24],"of":[25,29,40,47,59,75,96,122,135,161],"NRG.":[26],"interaction":[28],"NRG":[30,54,100,123,130,154,168,188],"with":[31,69,171],"this":[32],"enzyme":[33,103],"avoid":[35],"the":[36,45,60,72,80,84,102,109,113,118,125,133,143,147,159,167],"energy":[37],"transmission":[38],"mechanism":[39,121],"ATP":[41],"hydrolysis,":[42],"especially":[43],"in":[44,71,90,146,175],"presence":[46],"Ca2+":[48,106],"cation":[49],"used":[50],"cofactor.":[52],"Indeed,":[53],"selective":[57],"inhibitor":[58],"hydrophilic":[61],"F1":[62],"domain":[63],"displaying":[64],"binding":[66],"site":[67],"overlapped":[68],"quercetin":[70],"inside":[73],"surface":[74],"an":[76],"annulus":[77],"made":[78],"by":[79,105,112,137,153,196],"three":[81,85],"\u03b1":[82],"and":[83,200],"\u03b2":[86],"subunits":[87],"arranged":[88],"alternatively":[89],"hexamer.":[92],"kinetic":[94],"constant":[95],"inhibition":[97,119],"suggested":[98],"that":[99,129],"preferred":[101],"activated":[104,111],"rather":[107],"than":[108],"natural":[114],"cofactor":[115],"Mg2+.":[116],"From":[117],"type":[120],"stemmed":[124],"possibility":[126],"speculate":[128],"prevent":[132],"activation":[134],"Ca2+.":[138],"event":[140],"correlated":[141],"protective":[144,191],"role":[145],"permeability":[149],"transition":[150],"pore":[151],"opening":[152],"well":[156],"reduction":[160],"ROS":[162],"production":[163],"probably":[164],"chemical":[169],"structure":[170],"antioxidant":[172],"action.":[173],"Moreover,":[174],"primary":[176],"cerebral":[177],"endothelial":[178,201],"cells":[179],"(ECs)":[180],"obtained":[181],"from":[182],"stroke":[183],"prone":[184],"spontaneously":[185],"hypertensive":[186],"rats":[187],"had":[189],"effect":[192],"on":[193],"salt-induced":[194],"injury":[195],"restoring":[197],"cell":[198,202],"viability":[199],"tube":[203],"formation":[204],"while":[205],"also":[206],"rescuing":[207],"complex":[208],"I":[209],"activity.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-02-16T00:00:00"}