{"id":"https://openalex.org/W4391840957","doi":"https://doi.org/10.1158/0008-5472.25224586","title":"Supplementary Figure S4 from A Large-Scale Meta-Analysis Reveals Positive Feedback between Macrophages and T Cells That Sensitizes Tumors to Immunotherapy","display_name":"Supplementary Figure S4 from A Large-Scale Meta-Analysis Reveals Positive Feedback between Macrophages and T Cells That Sensitizes Tumors to Immunotherapy","publication_year":2024,"publication_date":"2024-02-15","ids":{"openalex":"https://openalex.org/W4391840957","doi":"https://doi.org/10.1158/0008-5472.25224586"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.25224586","doi":"https://doi.org/10.1158/0008-5472.25224586","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.25224586","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.25224586","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008449795","display_name":"Jing Yang","orcid":"https://orcid.org/0000-0002-3302-2754","observed_orcids":["https://orcid.org/0000-0002-3302-2754"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3302-2754","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453168","display_name":"Qi Liu","orcid":"https://orcid.org/0000-0001-8892-7078","observed_orcids":["https://orcid.org/0000-0001-8892-7078"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8892-7078","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062656698","display_name":"Yu Shyr","orcid":"https://orcid.org/0000-0003-2086-9670","observed_orcids":["https://orcid.org/0000-0003-2086-9670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Shyr","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2086-9670","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9079999923706055},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7450000047683716},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.753000020980835},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.7149999737739563},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7480000257492065},{"id":"https://openalex.org/keywords/ifngr2","display_name":"IFNGR2","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cxcr3","display_name":"CXCR3","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cxcl11","display_name":"CXCL11","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.9649999737739563},{"id":"https://openalex.org/keywords/irf-1","display_name":"IRF1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/ligand-receptor-interactions","display_name":"ligand-receptor interactions","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6647528409957886},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4043393135070801},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3851314187049866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35385000705718994},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34031176567077637},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.23089027404785156}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.25224586","doi":"https://doi.org/10.1158/0008-5472.25224586","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.25224586","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.25224586.v1","doi":"https://doi.org/10.1158/0008-5472.25224586.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.25224586.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S4_from_A_Large-Scale_Meta-Analysis_Reveals_Positive_Feedback_between_Macrophages_and_T_Cells_That_Sensitizes_Tumors_to_Immunotherapy/25224586/1/files/44555842.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/25224586","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_S4_from_A_Large-Scale_Meta-Analysis_Reveals_Positive_Feedback_between_Macrophages_and_T_Cells_That_Sensitizes_Tumors_to_Immunotherapy/25224586","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.25224586","doi":"https://doi.org/10.1158/0008-5472.25224586","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.25224586","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391840957.pdf","grobid_xml":"https://content.openalex.org/works/W4391840957.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390016261","https://openalex.org/W4391842272","https://openalex.org/W4401428242","https://openalex.org/W7010813992","https://openalex.org/W7152939233","https://openalex.org/W4407141162","https://openalex.org/W4320723494","https://openalex.org/W4414370889","https://openalex.org/W4322771732","https://openalex.org/W4361823399"],"abstract_inverted_index":{"Differential":[0],"expression":[1,15,46],"of":[2,16,40,54],"ICI-related":[3,17],"biomarkers":[4,18],"and":[5,21,35,63],"dysregulated":[6],"ligand-receptor":[7],"in":[8,19,23,66],"the":[9,52],"breast":[10],"cancer":[11],"study.":[12],"A.":[13],"Different":[14],"responders":[20,67],"non-responders":[22],"each":[24,41],"cell":[25],"type.":[26],"Dot":[27],"plot":[28],"for":[29],"IFNG,":[30],"IRF1,":[31],"LAG3,":[32],"CXCL10,":[33],"CXCL11":[34],"CXCR3.":[36],"The":[37],"color":[38],"intensity":[39],"dot":[42],"corresponds":[43],"to":[44,69],"gene":[45],"level,":[47],"with":[48],"dot\u2019s":[49],"size":[50],"indicating":[51],"percentage":[53],"cells":[55],"expressing":[56],"that":[57],"gene.":[58],"B.":[59],"Dysregulated":[60],"IFNG-IFNGR2,":[61],"CXCL10-CXCR3":[62],"CXCL11-CXCR3":[64],"interactions":[65],"compared":[68],"non-responders.":[70]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-02-16T00:00:00"}