{"id":"https://openalex.org/W4391821352","doi":"https://doi.org/10.1038/s41392-024-01754-y","title":"Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes","display_name":"Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes","publication_year":2024,"publication_date":"2024-02-14","ids":{"openalex":"https://openalex.org/W4391821352","doi":"https://doi.org/10.1038/s41392-024-01754-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/38355848","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10866945"},"language":"en","primary_location":{"id":"doi:10.1038/s41392-024-01754-y","doi":"https://doi.org/10.1038/s41392-024-01754-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41392-024-01754-y","pdf_url":"https://www.nature.com/articles/s41392-024-01754-y.pdf","source":{"id":"https://openalex.org/S2739142469","display_name":"Signal Transduction and Targeted Therapy","issn_l":"2059-3635","issn":["2059-3635","2095-9907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduction and Targeted Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41392-024-01754-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100762287","display_name":"Xinyi Yang","orcid":"https://orcid.org/0009-0003-2572-4988","observed_orcids":["https://orcid.org/0009-0003-2572-4988"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Yang","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003315105","display_name":"Xu Zheng","orcid":"https://orcid.org/0000-0002-1446-1882","observed_orcids":["https://orcid.org/0000-0002-1446-1882","https://orcid.org/0000-0001-7816-2390"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Zheng","raw_affiliation_strings":["Department of Microbiology, Faculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003163815","display_name":"Yuqi Zhu","orcid":"https://orcid.org/0000-0001-5315-7210","observed_orcids":["https://orcid.org/0000-0001-5315-7210"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqi Zhu","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104026886","display_name":"Xiaying Zhao","orcid":"https://orcid.org/0009-0002-4067-9655","observed_orcids":["https://orcid.org/0009-0002-4067-9655"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaying Zhao","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jun Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Liu","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112731633","display_name":"Jiangna Xun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210106542","display_name":"Shanghai Public Health Clinical Center","ror":"https://ror.org/01nnwyz44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106542"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangna Xun","raw_affiliation_strings":["Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China","State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210106542"]},{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102860372","display_name":"Songhua Yuan","orcid":"https://orcid.org/0000-0003-3351-5134","observed_orcids":["https://orcid.org/0000-0003-3351-5134"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210106542","display_name":"Shanghai Public Health Clinical Center","ror":"https://ror.org/01nnwyz44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106542"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Songhua Yuan","raw_affiliation_strings":["Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210106542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100609297","display_name":"Jun Chen","orcid":"https://orcid.org/0000-0002-3850-4875","observed_orcids":["https://orcid.org/0000-0002-3850-4875"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210106542","display_name":"Shanghai Public Health Clinical Center","ror":"https://ror.org/01nnwyz44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106542"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Chen","raw_affiliation_strings":["Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China","Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210106542"]},{"raw_affiliation_string":"Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210106542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101028886","display_name":"Hanyu Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanyu Pan","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106571446","display_name":"Jin\u2010Long Yang","orcid":"https://orcid.org/0000-0001-7931-8748","observed_orcids":["https://orcid.org/0000-0001-7931-8748"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinlong Yang","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115694897","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0001-7431-8925","observed_orcids":["https://orcid.org/0000-0001-7431-8925"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109301369","display_name":"Zhimin Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhimin Liang","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105404137","display_name":"Xiaoting Shen","orcid":"https://orcid.org/0000-0002-3956-6955","observed_orcids":["https://orcid.org/0000-0002-3956-6955"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoting Shen","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yue Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Liang","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090050559","display_name":"Qinru Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinru Lin","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021897394","display_name":"Huitong Liang","orcid":"https://orcid.org/0009-0006-4248-6557","observed_orcids":["https://orcid.org/0009-0006-4248-6557"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huitong Liang","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100643214","display_name":"Min Li","orcid":"https://orcid.org/0000-0003-1350-9909","observed_orcids":["https://orcid.org/0000-0003-1350-9909"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fei Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Peng","raw_affiliation_strings":["Changzheng Hospital, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changzheng Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100686854","display_name":"Daru Lu","orcid":"https://orcid.org/0000-0001-6748-7966","observed_orcids":["https://orcid.org/0000-0001-6748-7966"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daru Lu","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003298311","display_name":"Jianqing Xu","orcid":"https://orcid.org/0000-0003-0896-9273","observed_orcids":["https://orcid.org/0000-0003-0896-9273"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianqing Xu","raw_affiliation_strings":["Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100694490","display_name":"Hongzhou Lu","orcid":"https://orcid.org/0000-0002-8308-5534","observed_orcids":["https://orcid.org/0000-0002-8308-5534"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210106542","display_name":"Shanghai Public Health Clinical Center","ror":"https://ror.org/01nnwyz44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106542"]},{"id":"https://openalex.org/I4210166055","display_name":"Shenzhen Third People\u2019s Hospital","ror":"https://ror.org/04xfsbk97","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166055"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongzhou Lu","raw_affiliation_strings":["Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China","Department of Infectious Diseases and Nursing Research Institution, National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China","Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210106542"]},{"raw_affiliation_string":"Department of Infectious Diseases and Nursing Research Institution, National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I4210166055"]},{"raw_affiliation_string":"Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210106542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069302796","display_name":"Shibo Jiang","orcid":"https://orcid.org/0000-0001-8283-7135","observed_orcids":["https://orcid.org/0000-0001-8283-7135"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shibo Jiang","raw_affiliation_strings":["Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113260458","display_name":"Ping Zhao","orcid":"https://orcid.org/0009-0009-3392-5468","observed_orcids":["https://orcid.org/0009-0009-3392-5468"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ping Zhao","raw_affiliation_strings":["Department of Microbiology, Faculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China. pnzhao@163.com","Department of Microbiology, Faculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China. pnzhao@163.com","institution_ids":["https://openalex.org/I177933477"]},{"raw_affiliation_string":"Department of Microbiology, Faculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069283665","display_name":"Huanzhang Zhu","orcid":"https://orcid.org/0000-0001-5797-0292","observed_orcids":["https://orcid.org/0000-0001-5797-0292"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huanzhang Zhu","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China. hzzhu@fudan.edu.cn","State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0001-5797-0292","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China. hzzhu@fudan.edu.cn","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]},{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Yiwu Research Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5069283665","https://openalex.org/A5113260458"],"corresponding_institution_ids":["https://openalex.org/I177933477","https://openalex.org/I24943067","https://openalex.org/I4391768242"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":8.5772,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.98716116,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"42","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9490000009536743},{"id":"https://openalex.org/keywords/asgr1","display_name":"ASGR1","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.6880000233650208},{"id":"https://openalex.org/keywords/hepatic-parenchymal-cells","display_name":"hepatic parenchymal cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.7409999966621399},{"id":"https://openalex.org/keywords/ace2","display_name":"ACE2","score":0.6800000071525574},{"id":"https://openalex.org/keywords/spike-protein","display_name":"spike protein","score":0.5740000009536743},{"id":"https://openalex.org/keywords/receptor-binding-domain","display_name":"receptor binding domain","score":0.9890000224113464},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pseudovirus-infection","display_name":"pseudovirus infection","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C11569505","wikidata":"https://www.wikidata.org/wiki/Q727265","display_name":"Asialoglycoprotein receptor","level":4,"score":0.8589589595794678},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6029874682426453},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.5719204545021057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5545974373817444},{"id":"https://openalex.org/C35693153","wikidata":"https://www.wikidata.org/wiki/Q239762","display_name":"Tropism","level":3,"score":0.5507567524909973},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5441078543663025},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5223144888877869},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.5155575275421143},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5094423890113831},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4896309971809387},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4681447148323059},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.4637290835380554},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.45044034719467163},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.4300634264945984},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37910202145576477},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.18813684582710266},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09516090154647827},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07800161838531494},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07159748673439026},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037263","descriptor_name":"Asialoglycoprotein Receptor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41392-024-01754-y","doi":"https://doi.org/10.1038/s41392-024-01754-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41392-024-01754-y","pdf_url":"https://www.nature.com/articles/s41392-024-01754-y.pdf","source":{"id":"https://openalex.org/S2739142469","display_name":"Signal Transduction and Targeted Therapy","issn_l":"2059-3635","issn":["2059-3635","2095-9907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduction and Targeted Therapy","raw_type":"journal-article"},{"id":"doi:10.1101/2022.01.15.476426","doi":"https://doi.org/10.1101/2022.01.15.476426","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.01.15.476426","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/01/18/2022.01.15.476426.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10866945","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10866945","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10866945/pdf/41392_2024_Article_1754.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduct Target Ther","raw_type":"Text"},{"id":"pmid:38355848","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38355848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal transduction and targeted therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:328ac007c7894de5abb7b72a389413cd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/328ac007c7894de5abb7b72a389413cd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-10 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41392-024-01754-y","doi":"https://doi.org/10.1038/s41392-024-01754-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41392-024-01754-y","pdf_url":"https://www.nature.com/articles/s41392-024-01754-y.pdf","source":{"id":"https://openalex.org/S2739142469","display_name":"Signal Transduction and Targeted Therapy","issn_l":"2059-3635","issn":["2059-3635","2095-9907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduction and Targeted Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3576302673","display_name":null,"funder_award_id":"92169112","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7495895881","display_name":null,"funder_award_id":"31771484","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8673551834","display_name":null,"funder_award_id":"82041001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8874330897","display_name":null,"funder_award_id":"81761128020","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391821352.pdf","grobid_xml":"https://content.openalex.org/works/W4391821352.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W70110460","https://openalex.org/W1965531501","https://openalex.org/W1993577573","https://openalex.org/W2027463801","https://openalex.org/W2057939270","https://openalex.org/W2104548316","https://openalex.org/W2127862779","https://openalex.org/W2166867592","https://openalex.org/W2178661404","https://openalex.org/W2562740476","https://openalex.org/W2565680402","https://openalex.org/W2765408218","https://openalex.org/W3001897055","https://openalex.org/W3004280078","https://openalex.org/W3006961006","https://openalex.org/W3008827533","https://openalex.org/W3009912996","https://openalex.org/W3011483298","https://openalex.org/W3013093478","https://openalex.org/W3013151148","https://openalex.org/W3014288757","https://openalex.org/W3015134137","https://openalex.org/W3016829967","https://openalex.org/W3016923936","https://openalex.org/W3020828664","https://openalex.org/W3020909574","https://openalex.org/W3023986730","https://openalex.org/W3024126428","https://openalex.org/W3029397768","https://openalex.org/W3036500399","https://openalex.org/W3043649968","https://openalex.org/W3044482768","https://openalex.org/W3083618704","https://openalex.org/W3084083094","https://openalex.org/W3086046890","https://openalex.org/W3087094782","https://openalex.org/W3093867667","https://openalex.org/W3093900830","https://openalex.org/W3094294876","https://openalex.org/W3094419073","https://openalex.org/W3094597057","https://openalex.org/W3105847615","https://openalex.org/W3107235131","https://openalex.org/W3110655041","https://openalex.org/W3110976643","https://openalex.org/W3120758145","https://openalex.org/W3120857229","https://openalex.org/W3128335178","https://openalex.org/W3134682809","https://openalex.org/W3154339996","https://openalex.org/W3184589449","https://openalex.org/W3215783656","https://openalex.org/W4221014433","https://openalex.org/W4283522600","https://openalex.org/W4292262037","https://openalex.org/W4293565853","https://openalex.org/W4293757746","https://openalex.org/W4296046282","https://openalex.org/W4307350133","https://openalex.org/W4309269535","https://openalex.org/W4310774393","https://openalex.org/W4311436944","https://openalex.org/W4383533212","https://openalex.org/W4385282677","https://openalex.org/W6777308275","https://openalex.org/W6779115729","https://openalex.org/W6839402291","https://openalex.org/W6846690823"],"related_works":["https://openalex.org/W4206416007","https://openalex.org/W3154339996","https://openalex.org/W4406211752","https://openalex.org/W4401827705","https://openalex.org/W4391310232","https://openalex.org/W4328026586","https://openalex.org/W4292262037","https://openalex.org/W3215783656","https://openalex.org/W3183621565","https://openalex.org/W4393125203"],"abstract_inverted_index":{"Severe":[0],"acute":[1],"respiratory":[2],"syndrome":[3],"coronavirus":[4],"2":[5,28],"(SARS-CoV-2)":[6],"causes":[7],"multi-organ":[8],"damage,":[9],"which":[10,134,182],"includes":[11],"hepatic":[12,129,165,208,216,246],"dysfunction,":[13],"as":[14],"observed":[15],"in":[16,50,214],"over":[17],"50%":[18],"of":[19,46,73,77,104,112,133,224,245],"COVID-19":[20],"patients.":[21],"Angiotensin":[22],"I":[23],"converting":[24],"enzyme":[25],"(peptidyl-dipeptidase":[26],"A)":[27],"(ACE2)":[29],"is":[30,236],"the":[31,44,75,121,155,221,225],"primary":[32,128,207,215],"receptor":[33,97,185,239],"for":[34,240],"SARS-CoV-2":[35,78,101,117,138,162,204,241],"entry":[36,76],"into":[37,79],"host":[38],"cells,":[39,109,131],"and":[40,93,114,127,189,198],"studies":[41],"have":[42],"shown":[43],"presence":[45],"intracellular":[47],"virus":[48,227],"particles":[49],"human":[51],"hepatocytes":[52,65],"that":[53,95,161,175,203,234,242],"express":[54,67],"ACE2,":[55,137],"but":[56],"at":[57],"extremely":[58],"low":[59],"levels.":[60],"Consequently,":[61],"we":[62,85,194],"asked":[63],"if":[64],"might":[66],"receptors":[68],"other":[69],"than":[70],"ACE2":[71,113],"capable":[72],"promoting":[74],"cells.":[80,106,210,248],"To":[81],"address":[82],"this":[83],"question,":[84],"performed":[86],"a":[87,237],"genome-wide":[88],"CRISPR-Cas9":[89],"activation":[90],"library":[91],"screening":[92],"found":[94],"Asialoglycoprotein":[96],"1":[98],"(ASGR1)":[99],"promoted":[100],"pseudovirus":[102,118,139,163],"infection":[103,156,222,244],"HeLa":[105],"In":[107,120],"Huh-7":[108],"simultaneous":[110],"knockout":[111],"ASGR1":[115,149,176,213,235],"prevented":[116],"infection.":[119,144],"immortalized":[122],"THLE-2":[123],"hepatocyte":[124],"cell":[125],"line":[126],"parenchymal":[130,166,209,217,247],"both":[132],"barely":[135],"expressed":[136],"could":[140,177,205],"successfully":[141],"establish":[142],"an":[143,170],"However,":[145],"after":[146],"treatment":[147],"with":[148,179],"antibody":[150],"or":[151],"siRNA":[152],"targeting":[153],"ASGR1,":[154],"rate":[157],"significantly":[158],"dropped,":[159],"suggesting":[160],"infects":[164],"cells":[167,218],"mainly":[168],"through":[169],"ASGR1-dependent":[171],"mechanism.":[172],"We":[173],"confirmed":[174],"interact":[178],"Spike":[180],"protein,":[181],"depends":[183],"on":[184],"binding":[186],"domain":[187,191],"(RBD)":[188],"N-terminal":[190],"(NTD).":[192],"Finally,":[193],"also":[195],"used":[196],"Immunohistochemistry":[197],"electron":[199],"microscopy":[200],"to":[201],"verify":[202],"infect":[206],"After":[211],"inhibiting":[212],"by":[219],"siRNA,":[220],"efficiency":[223],"live":[226],"decreased":[228],"significantly.":[229],"Collectively,":[230],"these":[231],"findings":[232],"indicate":[233],"candidate":[238],"promotes":[243]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-02-15T00:00:00"}