{"id":"https://openalex.org/W4391778232","doi":"https://doi.org/10.21203/rs.3.rs-3941004/v1","title":"USP10 activates the FAK pathway by stabilizing RIOK3 in pancreatic ductal adenocarcinoma","display_name":"USP10 activates the FAK pathway by stabilizing RIOK3 in pancreatic ductal adenocarcinoma","publication_year":2024,"publication_date":"2024-02-13","ids":{"openalex":"https://openalex.org/W4391778232","doi":"https://doi.org/10.21203/rs.3.rs-3941004/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-3941004/v1","doi":"https://doi.org/10.21203/rs.3.rs-3941004/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-3941004/v1","pdf_url":"https://www.researchsquare.com/article/rs-3941004/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-3941004/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001341362","display_name":"Henan Qin","orcid":"https://orcid.org/0000-0003-2989-7424","observed_orcids":["https://orcid.org/0000-0003-2989-7424"]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Henan Qin","raw_affiliation_strings":["First Affiliated Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011412144","display_name":"Rui Sun","orcid":"https://orcid.org/0000-0002-8483-3901","observed_orcids":["https://orcid.org/0000-0002-8483-3901"]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Sun","raw_affiliation_strings":["First Affiliated Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100532370","display_name":"Zhen Ning","orcid":"https://orcid.org/0000-0002-2901-2991","observed_orcids":["https://orcid.org/0000-0002-2901-2991"]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Ning","raw_affiliation_strings":["First Affiliated Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111128890","display_name":"Wenhe Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhe Zhang","raw_affiliation_strings":["First Affiliated Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xin Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Guo","raw_affiliation_strings":["First Affiliated Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103206168","display_name":"Lei Fang","orcid":"https://orcid.org/0009-0000-4775-3331","observed_orcids":["https://orcid.org/0009-0000-4775-3331","https://orcid.org/0000-0002-0433-3174"]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Fang","raw_affiliation_strings":["First Affiliated Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kun Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Zou","raw_affiliation_strings":["First Affiliated Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415925","display_name":"Shuang Li","orcid":"https://orcid.org/0000-0002-6828-5925","observed_orcids":["https://orcid.org/0000-0002-6828-5925"]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Li","raw_affiliation_strings":["First Affiliated Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101712942","display_name":"Mengyuan Xu","orcid":"https://orcid.org/0000-0002-0484-0256","observed_orcids":["https://orcid.org/0000-0002-0484-0256"]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyuan Xu","raw_affiliation_strings":["First Affiliated Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082268047","display_name":"Yibin Teng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yibin Teng","raw_affiliation_strings":["First Affiliated Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072913663","display_name":"Peiyuan Yin","orcid":"https://orcid.org/0000-0003-3639-3363","observed_orcids":["https://orcid.org/0000-0003-3639-3363"]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peiyuan Yin","raw_affiliation_strings":["First Affiliated Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090303721","display_name":"Aman Wang","orcid":"https://orcid.org/0009-0009-1741-1395","observed_orcids":["https://orcid.org/0009-0009-1741-1395"]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aman Wang","raw_affiliation_strings":["First Affiliated Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101826858","display_name":"Jiwei Liu","orcid":"https://orcid.org/0000-0001-5040-6242","observed_orcids":["https://orcid.org/0000-0001-5040-6242","https://orcid.org/0009-0009-4755-1970"]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiwei Liu","raw_affiliation_strings":["First Affiliated Hospital of Dalian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Dalian Medical University","institution_ids":["https://openalex.org/I4210140813"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140813"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.7261000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.7261000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.2240000069141388,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/usp10","display_name":"USP10","score":0.9900000095367432},{"id":"https://openalex.org/keywords/riok3","display_name":"RIOK3","score":0.9589999914169312},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9010000228881836},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9440000057220459},{"id":"https://openalex.org/keywords/deubiquitination","display_name":"deubiquitination","score":0.8140000104904175},{"id":"https://openalex.org/keywords/protein-stabilization","display_name":"protein stabilization","score":0.9110000133514404},{"id":"https://openalex.org/keywords/fak-signaling-pathway","display_name":"FAK signaling pathway","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tumor-invasion-and-metastasis","display_name":"tumor invasion and metastasis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8610000014305115},{"id":"https://openalex.org/keywords/fak-inhibitors","display_name":"FAK inhibitors","score":0.628000020980835},{"id":"https://openalex.org/keywords/tumor-growth-and-survival","display_name":"tumor growth and survival","score":0.4230000078678131},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.6890000104904175},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.8483204245567322},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45747849345207214},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36499062180519104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3512687087059021},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3323286175727844},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.2880869507789612},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2815006971359253},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21281909942626953},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11244821548461914}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-3941004/v1","doi":"https://doi.org/10.21203/rs.3.rs-3941004/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-3941004/v1","pdf_url":"https://www.researchsquare.com/article/rs-3941004/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-3941004/v1","doi":"https://doi.org/10.21203/rs.3.rs-3941004/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-3941004/v1","pdf_url":"https://www.researchsquare.com/article/rs-3941004/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G975321988","display_name":"USP22\u901a\u8fc7\u53bb\u6cdb\u7d20\u5316SND1\u4ecb\u5bfc\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u6781\u5316\u5e76\u4fc3\u8fdb\u80f0\u817a\u764c\u751f\u957f\u548c\u8f6c\u79fb\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"81502024","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391778232.pdf","grobid_xml":"https://content.openalex.org/works/W4391778232.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1968812902","https://openalex.org/W2007979842","https://openalex.org/W2021705436","https://openalex.org/W2044895919","https://openalex.org/W2068652698","https://openalex.org/W2084178659","https://openalex.org/W2086570115","https://openalex.org/W2128652401","https://openalex.org/W2135604793","https://openalex.org/W2243111489","https://openalex.org/W2254311951","https://openalex.org/W2293821951","https://openalex.org/W2325225342","https://openalex.org/W2333587048","https://openalex.org/W2618395638","https://openalex.org/W2750640253","https://openalex.org/W2774907925","https://openalex.org/W2800295319","https://openalex.org/W2883790769","https://openalex.org/W2938700958","https://openalex.org/W2944210961","https://openalex.org/W2949922878","https://openalex.org/W2983412675","https://openalex.org/W3013329375","https://openalex.org/W3022337093","https://openalex.org/W3108801782","https://openalex.org/W3173746096","https://openalex.org/W3193372782","https://openalex.org/W4212834395","https://openalex.org/W4223640931","https://openalex.org/W4283078749","https://openalex.org/W4289642452","https://openalex.org/W4315754639"],"related_works":["https://openalex.org/W4289642452","https://openalex.org/W7162658951","https://openalex.org/W4403546110","https://openalex.org/W6908407569","https://openalex.org/W2624399612","https://openalex.org/W2796129717","https://openalex.org/W4398203669","https://openalex.org/W2809847889","https://openalex.org/W3087563071","https://openalex.org/W2330332381"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2],"aberrant":[3],"activation":[4],"of":[5,36,44,48,70,139,174,184,226,246],"FAK":[6,27,38,49,54,75,253,283,313],"(Focal":[7],"Adhesion":[8],"Kinase)":[9],"serves":[10],"as":[11,258],"a":[12,179,208,259,292,325],"critical":[13],"mechanism":[14,47],"leading":[15],"to":[16,88,134,157],"heightened":[17],"invasiveness":[18,67],"and":[19,68,78,86,95,103,108,117,124,145,150,165,186,197,224,231,244,254,263,267,288,307,310],"metastatic":[20],"potential":[21,326],"in":[22,39,98,143,146,211,235,282,299],"pancreatic":[23],"ductal":[24],"adenocarcinoma":[25],"(PDAC).":[26],"inhibitors":[28],"have":[29],"entered":[30],"clinical":[31],"trials,":[32],"underscoring":[33],"the":[34,45,66,136,159,171,221,242,278,300,312],"significance":[35],"targeting":[37],"treating":[40],"PDAC.":[41,212],"Further":[42],"exploration":[43],"regulation":[46],"is":[50,291],"crucial":[51],"for":[52,277,329],"advancing":[53],"inhibitors.":[55],"Our":[56],"previous":[57],"study":[58],"suggests":[59],"that":[60,217,239,321],"RIO":[61],"Kinase":[62],"3":[63],"(RIOK3)":[64],"facilitates":[65],"metastasis":[69,233,245],"PDAC":[71,99,105,110,132,193,227,247,301,318],"cells":[72,133],"by":[73],"stabilizing":[74],"protein":[76,96,284],"expression":[77,97],"upregulating":[79],"its":[80],"phosphorylation.":[81],"Methods":[82],"We":[83],"used":[84],"bioinformatics":[85],"IHC":[87],"measure":[89],"Ubiquitin-specific":[90],"protease":[91],"10":[92],"(USP10)":[93],"mRNA":[94,106],"based":[100],"on":[101,129,176],"TCGA":[102],"GTEx":[104],"databases":[107],"two":[109],"tissue":[111],"chips":[112],"from":[113],"independent":[114],"medical":[115],"centers,":[116],"survival":[118,194,298],"analysis":[119],"was":[120,195,205],"performed.":[121],"Stable":[122],"knockdown":[123],"overexpression":[125,273],"experiments":[126,153,168,215],"were":[127,154],"performed":[128],"three":[130],"different":[131],"elucidate":[135],"carcinogenic":[137],"effect":[138,173],"USP10":[140,175,185,204,218,240,250,262,265,279,287,305],"through":[141],"both":[142],"vivo":[144],"vitro":[147,214],"experiments.":[148],"Co-IP":[149],"laser":[151],"confocal":[152],"carried":[155],"out":[156],"confirm":[158],"interaction":[160],"modes":[161],"between":[162,261],"USP10,":[163],"FAK,":[164],"RIOK3.":[166,177,255,269],"Deubiquitination":[167],"further":[169],"validated":[170,198],"deubiquitination":[172],"Finally,":[178],"prognostic":[180,302],"model":[181],"incorporating":[182],"co-expression":[183,290],"RIOK3":[187,256,272,289,309],"along":[188],"with":[189,207,252,296],"other":[190],"factors":[191],"influencing":[192],"established":[196],"using":[199],"COX":[200],"regression":[201],"analysis.":[202],"Results":[203],"associated":[206,295],"poor":[209,297],"prognosis":[210],"In":[213,270],"found":[216],"significantly":[219,275],"promotes":[220],"proliferation,":[222],"invasion,":[223],"migration":[225],"cells.":[228,248],"Xenografted":[229],"tumor":[230],"lung":[232],"models":[234],"nude":[236],"mice":[237],"demonstrated":[238],"promoted":[241],"growth":[243],"Mechanically,":[249],"interacts":[251],"acts":[257],"bridge":[260],"FAK.":[264],"deubiquitinates":[266,306],"stabilizes":[268,308],"addition,":[271],"can":[274],"compensate":[276],"knockdown-mediated":[280],"decline":[281],"expression.":[285],"Moreover,":[286],"significant":[293],"factor":[294],"model.":[303],"Conclusion":[304],"activates":[311],"signaling":[314],"pathway,":[315],"thereby":[316],"inhibiting":[317],"tumorigenesis,":[319],"indicating":[320],"it":[322],"may":[323],"be":[324],"drug":[327],"target":[328],"cancer":[330],"treatment.":[331]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-02-14T00:00:00"}