{"id":"https://openalex.org/W4391776296","doi":"https://doi.org/10.1134/s1068162024010114","title":"Synthesis of Novel N-Acylhydrazones Derived from 3,5-Dinitrobenzohydrazide and Evaluation of Their Anticholinesterase and Antioxidant Activities","display_name":"Synthesis of Novel N-Acylhydrazones Derived from 3,5-Dinitrobenzohydrazide and Evaluation of Their Anticholinesterase and Antioxidant Activities","publication_year":2024,"publication_date":"2024-02-01","ids":{"openalex":"https://openalex.org/W4391776296","doi":"https://doi.org/10.1134/s1068162024010114"},"language":"en","primary_location":{"id":"doi:10.1134/s1068162024010114","doi":"https://doi.org/10.1134/s1068162024010114","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1068162024010114","pdf_url":null,"source":{"id":"https://openalex.org/S68845364","display_name":"Russian Journal of Bioorganic Chemistry","issn_l":"1068-1620","issn":["1068-1620","1573-9163","1608-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Bioorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023522299","display_name":"Re\u015fit \u00c7akmak","orcid":"https://orcid.org/0000-0003-0401-7419","observed_orcids":["https://orcid.org/0000-0003-0401-7419"]},"institutions":[{"id":"https://openalex.org/I32481161","display_name":"Batman University","ror":"https://ror.org/051tsqh55","country_code":"TR","type":"education","lineage":["https://openalex.org/I32481161"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Re\u015fit \u00c7akmak","raw_affiliation_strings":["Medical Laboratory Techniques Program, Vocational School of Health Services, Batman University, 72000, Batman, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Laboratory Techniques Program, Vocational School of Health Services, Batman University, 72000, Batman, Turkey","institution_ids":["https://openalex.org/I32481161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069466970","display_name":"Ercan \u00c7\u0131nar","orcid":"https://orcid.org/0000-0003-0419-7798","observed_orcids":["https://orcid.org/0000-0003-0419-7798"]},"institutions":[{"id":"https://openalex.org/I32481161","display_name":"Batman University","ror":"https://ror.org/051tsqh55","country_code":"TR","type":"education","lineage":["https://openalex.org/I32481161"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ercan \u00c7\u0131nar","raw_affiliation_strings":["Department of Nursing, Faculty of Health Sciences, Batman University, 72000, Batman, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Faculty of Health Sciences, Batman University, 72000, Batman, Turkey","institution_ids":["https://openalex.org/I32481161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072932384","display_name":"Ey\u00fcp Ba\u015faran","orcid":"https://orcid.org/0000-0002-7840-5919","observed_orcids":["https://orcid.org/0000-0002-7840-5919"]},"institutions":[{"id":"https://openalex.org/I32481161","display_name":"Batman University","ror":"https://ror.org/051tsqh55","country_code":"TR","type":"education","lineage":["https://openalex.org/I32481161"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ey\u00fcp Ba\u015faran","raw_affiliation_strings":["Department of Chemistry and Chemical Processing Technologies, Vocational School of Technical Sciences, Batman University, 72000, Batman, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Processing Technologies, Vocational School of Technical Sciences, Batman University, 72000, Batman, Turkey","institution_ids":["https://openalex.org/I32481161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093919696","display_name":"G\u00fcls\u00fcm Tune\u011f","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G\u00fcls\u00fcm Tune\u011f","raw_affiliation_strings":["Department of Medical Biology, Faculty of Medicine, Dicle University, 21280, Diyarbak\u0131r, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Faculty of Medicine, Dicle University, 21280, Diyarbak\u0131r, Turkey","institution_ids":["https://openalex.org/I123466251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040013722","display_name":"Sevcan \u0130zgi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59738393","display_name":"Gaziantep University","ror":"https://ror.org/020vvc407","country_code":"TR","type":"education","lineage":["https://openalex.org/I59738393"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sevcan \u0130zgi","raw_affiliation_strings":["Department of Medical Biology, Faculty of Medicine, Gaziantep University, 27410, Gaziantep, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Faculty of Medicine, Gaziantep University, 27410, Gaziantep, Turkey","institution_ids":["https://openalex.org/I59738393"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046879369","display_name":"Mehmet Bo\u011fa","orcid":"https://orcid.org/0000-0003-4163-9962","observed_orcids":["https://orcid.org/0000-0003-4163-9962"]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Bo\u011fa","raw_affiliation_strings":["Department of Analytical Chemistry, Faculty of Pharmacy, Dicle University, 21280, Diyarbak\u0131r, Turkey","Dicle University Health Sciences Application and Research Center (D\u00dcSAM), 21280, Diyarbak\u0131r, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Faculty of Pharmacy, Dicle University, 21280, Diyarbak\u0131r, Turkey","institution_ids":["https://openalex.org/I123466251"]},{"raw_affiliation_string":"Dicle University Health Sciences Application and Research Center (D\u00dcSAM), 21280, Diyarbak\u0131r, Turkey","institution_ids":["https://openalex.org/I123466251"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072932384"],"corresponding_institution_ids":["https://openalex.org/I32481161"],"apc_list":null,"apc_paid":null,"fwci":2.0592,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.84862219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"50","issue":"1","first_page":"76","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-acylhydrazones","display_name":"N-acylhydrazones","score":0.996999979019165},{"id":"https://openalex.org/keywords/anticholinesterase-activity","display_name":"anticholinesterase activity","score":0.906000018119812},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibition","display_name":"acetylcholinesterase inhibition","score":0.9210000038146973},{"id":"https://openalex.org/keywords/butyrylcholinesterase-inhibition","display_name":"butyrylcholinesterase inhibition","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.7649999856948853},{"id":"https://openalex.org/keywords/galantamine","display_name":"galantamine","score":0.5720000267028809},{"id":"https://openalex.org/keywords/alzheimer-s-disease-drug-candidates","display_name":"Alzheimer's disease drug candidates","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C113253001","wikidata":"https://www.wikidata.org/wiki/Q864640","display_name":"Bioorganic chemistry","level":3,"score":0.8372474908828735},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5914271473884583},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49424245953559875},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3107144236564636},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09578555822372437}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1134/s1068162024010114","doi":"https://doi.org/10.1134/s1068162024010114","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1068162024010114","pdf_url":null,"source":{"id":"https://openalex.org/S68845364","display_name":"Russian Journal of Bioorganic Chemistry","issn_l":"1068-1620","issn":["1068-1620","1573-9163","1608-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Bioorganic Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1562859000","https://openalex.org/W1971048984","https://openalex.org/W1972736369","https://openalex.org/W1988770396","https://openalex.org/W1992544322","https://openalex.org/W2012991711","https://openalex.org/W2021720310","https://openalex.org/W2025543844","https://openalex.org/W2031596649","https://openalex.org/W2041379622","https://openalex.org/W2096401930","https://openalex.org/W2115187133","https://openalex.org/W2782358406","https://openalex.org/W2896257467","https://openalex.org/W3014251530","https://openalex.org/W4200296585","https://openalex.org/W4200528297","https://openalex.org/W4211016192","https://openalex.org/W4211139529","https://openalex.org/W4211156109","https://openalex.org/W4220663708","https://openalex.org/W4220973962","https://openalex.org/W4280569219","https://openalex.org/W4281555913","https://openalex.org/W4281762860","https://openalex.org/W4283583504","https://openalex.org/W4285676824","https://openalex.org/W4289711531","https://openalex.org/W4294204319","https://openalex.org/W4298105218","https://openalex.org/W4312190881","https://openalex.org/W4318203607","https://openalex.org/W4320037611"],"related_works":["https://openalex.org/W4313329087","https://openalex.org/W4403524371","https://openalex.org/W3093846538","https://openalex.org/W4318203607","https://openalex.org/W4368366430","https://openalex.org/W3209089617","https://openalex.org/W4294204319","https://openalex.org/W3009161507","https://openalex.org/W4402830792","https://openalex.org/W4385496935"],"abstract_inverted_index":{"Abstract":[0],"Objective:":[1],"In":[2,61,127],"this":[3,30,198],"study,":[4],"it":[5],"was":[6,41],"aimed":[7],"to":[8,143,155,202],"determine":[9],"the":[10,44,83,87,115,140,144,162,204],"antioxidant":[11,84,103,124,169],"activities":[12,64],"and":[13,47,55,58,73,76,99,123,157,188,194],"enzyme":[14,121,128],"inhibition":[15,122,129,134,149],"properties":[16],"of":[17,34,65,86,114,161],"newly":[18],"synthesized":[19,42],"N-acylhydrazone":[20],"compounds":[21,118],"(IIIa\u2013IIIp)":[22],"bearing":[23],"an":[24],"aryl":[25],"sulfonate":[26],"moiety.":[27],"Methods:":[28],"For":[29],"purpose,":[31],"a":[32],"series":[33],"hydrazone":[35,67,117],"derivatives":[36,68],"based":[37],"on":[38],"3,5-dinitrobenzohydrazide":[39],"(I)":[40],"for":[43],"first":[45],"time":[46],"characterized":[48],"by":[49,92],"spectrometric":[50],"methods":[51],"(FT-IR,":[52],"1H":[53],"NMR":[54],"13C":[56],"NMR)":[57],"elemental":[59],"analysis.":[60],"vitro":[62],"anticholinesterase":[63],"novel":[66],"were":[69,90,200],"evaluated":[70],"against":[71],"acetyl-":[72],"butyrylcholinesterase":[74],"(AChE":[75],"BChE)":[77],"at":[78],"200":[79],"\u00b5M":[80],"concentration.":[81],"Moreover,":[82],"potentials":[85],"same":[88],"molecules":[89,163,172,185],"determined":[91,201],"2,2\u2032-azino-bis(3-ethylbenzthiazoline-6-sulfonic":[93],"acid)":[94],"(ABTS)":[95],"radical":[96],"scavenging":[97],"activity":[98,142,182],"cupric":[100],"ion":[101],"reducing":[102],"capacity":[104],"(CUPRAC)":[105],"assays.":[106],"Results:":[107],"The":[108,171],"obtained":[109],"results":[110],"displayed":[111],"that":[112],"some":[113],"tested":[116,164,173],"had":[119],"varying":[120],"activities.":[125,170],"Discussion:":[126],"studies,":[130],"N\u2032-[2-{[4-fluorobenzensulfonyl]oxy}benzylidene]-3,5-dinitrobenzohydrazide":[131],"(IIIb)":[132],"with":[133,148],"value":[135,150],"77.13":[136],"\u00b1":[137,152],"0.14%":[138],"showed":[139,168],"closest":[141],"standard":[145,184],"compound":[146],"galanthamine":[147],"78.14":[151],"0.65%.":[153],"Compared":[154],"DPPH":[156],"ABTS":[158],"assays,":[159],"all":[160],"in":[165,174,197],"CUPRAC":[166,175],"assay":[167,176,199],"did":[177],"not":[178],"show":[179],"as":[180,183],"much":[181],"(BHA,":[186],"BHT":[187],"\u03b1-TOC).":[189],"Conclusions:":[190],"Compounds":[191],"N\u2032-[4-{[4-fluorobenzensulfonyl]oxy}benzylidene]-3,5-dinitrobenzohydrazide":[192],"(IIIf)":[193],"N\u2032-[4-{[4-methoxybenzensulfonyl]oxy}benzylidene]-3,5dinitrobenzohydrazide":[195],"(IIIh)":[196],"be":[203],"most":[205],"active":[206],"molecules.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-02-14T00:00:00"}
