{"id":"https://openalex.org/W4391766836","doi":"https://doi.org/10.1038/s41467-024-45729-7","title":"The secondary somatosensory cortex gates mechanical and heat sensitivity","display_name":"The secondary somatosensory cortex gates mechanical and heat sensitivity","publication_year":2024,"publication_date":"2024-02-12","ids":{"openalex":"https://openalex.org/W4391766836","doi":"https://doi.org/10.1038/s41467-024-45729-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/37461707","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10350168"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-024-45729-7","doi":"https://doi.org/10.1038/s41467-024-45729-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-45729-7","pdf_url":"https://www.nature.com/articles/s41467-024-45729-7.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-024-45729-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060791449","display_name":"Daniel G. Taub","orcid":"https://orcid.org/0000-0003-0363-6031","observed_orcids":["https://orcid.org/0000-0003-0363-6031"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel G. Taub","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA, USA","F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-0363-6031","affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038499731","display_name":"Qiufen Jiang","orcid":"https://orcid.org/0000-0001-5121-9561","observed_orcids":["https://orcid.org/0000-0001-5121-9561"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiufen Jiang","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA, USA","F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082325224","display_name":"Francesca Pietrafesa","orcid":"https://orcid.org/0009-0007-1458-1677","observed_orcids":["https://orcid.org/0009-0007-1458-1677"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesca Pietrafesa","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA, USA","F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058409605","display_name":"Junfeng Su","orcid":"https://orcid.org/0000-0002-3415-5655","observed_orcids":["https://orcid.org/0000-0002-3415-5655"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junfeng Su","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA, USA","F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3415-5655","affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101564925","display_name":"Aloe Carroll","orcid":"https://orcid.org/0009-0009-2775-9651","observed_orcids":["https://orcid.org/0009-0009-2775-9651"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aloe Carroll","raw_affiliation_strings":["College of Sciences, Northeastern University, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0009-0009-2775-9651","affiliations":[{"raw_affiliation_string":"College of Sciences, Northeastern University, Boston, MA, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109315778","display_name":"Caitlin A. Greene","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlin Greene","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA, USA","F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003058029","display_name":"Michael R. Blanchard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Blanchard","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072814064","display_name":"Aakanksha Jain","orcid":"https://orcid.org/0000-0001-9602-4987","observed_orcids":["https://orcid.org/0000-0001-9602-4987"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aakanksha Jain","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA, USA","F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mahmoud El-Rifai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahmoud El-Rifai","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091992421","display_name":"Alexis Callen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexis Callen","raw_affiliation_strings":["Morrissey College of Arts and Sciences, Boston College, Chestnut Hill, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Morrissey College of Arts and Sciences, Boston College, Chestnut Hill, MA, USA","institution_ids":["https://openalex.org/I103531236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013772564","display_name":"Katherine Yager","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Yager","raw_affiliation_strings":["Morrissey College of Arts and Sciences, Boston College, Chestnut Hill, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Morrissey College of Arts and Sciences, Boston College, Chestnut Hill, MA, USA","institution_ids":["https://openalex.org/I103531236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104118999","display_name":"Clara Chung","orcid":"https://orcid.org/0009-0001-8181-5206","observed_orcids":["https://orcid.org/0009-0001-8181-5206"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clara Chung","raw_affiliation_strings":["Department of Neuroscience, Boston University, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Boston University, Boston, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065624513","display_name":"Zhigang He","orcid":"https://orcid.org/0000-0001-6080-6880","observed_orcids":["https://orcid.org/0000-0001-6080-6880"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhigang He","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA, USA","F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-6080-6880","affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076469919","display_name":"Chinfei Chen","orcid":"https://orcid.org/0000-0002-6486-3097","observed_orcids":["https://orcid.org/0000-0002-6486-3097"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chinfei Chen","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA, USA","F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-6486-3097","affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017534594","display_name":"Clifford J. Woolf","orcid":"https://orcid.org/0000-0002-6636-3897","observed_orcids":["https://orcid.org/0000-0002-6636-3897","https://orcid.org/0000-0001-9840-596X"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clifford J. Woolf","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA, USA. Clifford.Woolf@childrens.harvard.edu","F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA. Clifford.Woolf@childrens.harvard.edu","Department of Neurobiology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-6636-3897","affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA. Clifford.Woolf@childrens.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA. Clifford.Woolf@childrens.harvard.edu","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5017534594"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"],"apc_list":{"value":6790,"currency":"USD","value_usd":6790},"apc_paid":{"value":6790,"currency":"USD","value_usd":6790},"fwci":5.084,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.9625266,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"1289","last_page":"1289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10914","display_name":"Tactile and Sensory Interactions","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10914","display_name":"Tactile and Sensory Interactions","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secondary-somatosensory-cortex","display_name":"secondary somatosensory cortex","score":1.0},{"id":"https://openalex.org/keywords/mechanical-sensitivity","display_name":"mechanical sensitivity","score":0.656000018119812},{"id":"https://openalex.org/keywords/heat-sensitivity","display_name":"heat sensitivity","score":0.9470000267028809},{"id":"https://openalex.org/keywords/top-down-modulation","display_name":"top-down modulation","score":0.5899999737739563},{"id":"https://openalex.org/keywords/somatosensation","display_name":"somatosensory perception","score":0.6919999718666077},{"id":"https://openalex.org/keywords/secondary-motor-cortex","display_name":"secondary motor cortex","score":0.878000020980835},{"id":"https://openalex.org/keywords/cortical-inhibition","display_name":"cortical inhibition","score":0.7139999866485596},{"id":"https://openalex.org/keywords/chemogenetic-inhibition","display_name":"chemogenetic inhibition","score":0.8389999866485596},{"id":"https://openalex.org/keywords/sensory-gating","display_name":"sensory gating","score":0.32100000977516174},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C172497186","wikidata":"https://www.wikidata.org/wiki/Q328835","display_name":"Somatosensory system","level":2,"score":0.9440371990203857},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7447459101676941},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.5932953953742981},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4949626326560974},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.43040895462036133},{"id":"https://openalex.org/C2781347215","wikidata":"https://www.wikidata.org/wiki/Q4863332","display_name":"Barrel cortex","level":3,"score":0.4180411100387573},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.4134070873260498},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34491023421287537},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1038/s41467-024-45729-7","doi":"https://doi.org/10.1038/s41467-024-45729-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-45729-7","pdf_url":"https://www.nature.com/articles/s41467-024-45729-7.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-2976953/v1","doi":"https://doi.org/10.21203/rs.3.rs-2976953/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2976953/v1","pdf_url":"https://www.researchsquare.com/article/rs-2976953/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10861531","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10861531","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10861531/pdf/41467_2024_Article_45729.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:37461707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37461707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research square","raw_type":"Preprint"},{"id":"pmid:38346995","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38346995","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10350168","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10350168","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10350168/pdf/nihpp-rs2976953v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Res Sq","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45729-7","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-024-45729-7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9e073c85d0df4663aabacd3520049eed","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9e073c85d0df4663aabacd3520049eed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-024-45729-7","doi":"https://doi.org/10.1038/s41467-024-45729-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-45729-7","pdf_url":"https://www.nature.com/articles/s41467-024-45729-7.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1820584063","display_name":null,"funder_award_id":"U54HD090255","funder_id":"https://openalex.org/F4320332591","funder_display_name":"Intellectual and Developmental Disabilities Research Center"},{"id":"https://openalex.org/G3186357351","display_name":null,"funder_award_id":"#NS072030","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4267291720","display_name":"HMS/BCH Center for Neuroscience Research","funder_award_id":"P30NS072030","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5160117315","display_name":"Mechanism and Optimization of CBD-mediated analgesic effects","funder_award_id":"R01AT010779","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G5210818642","display_name":"Spinal Cord Nociceptive Circuits that Deliver Outputs to the Brain to Initiate Pain","funder_award_id":"R01AT011447","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G5829768055","display_name":"Boston Intellectual and Developmental Disabilities Research Center","funder_award_id":"U54HD090255","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6971546397","display_name":"TissueCyte 1600FC Whole Mount Tissue Scanner","funder_award_id":"1s10od026866-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G833713954","display_name":null,"funder_award_id":"R01 AT011447","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G9000235680","display_name":null,"funder_award_id":"NS072030","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000863310","display_name":"Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center","funder_award_id":"P50HD105351","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000910892","display_name":"Plasticity of the Retinogeniculate Synapse","funder_award_id":"R01EY013613","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000912614","display_name":"CORE GRANT FOR VISION RESEARCH","funder_award_id":"P30EY012196","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320309356","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332591","display_name":"Intellectual and Developmental Disabilities Research Center","ror":"https://ror.org/02pttbw34"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391766836.pdf","grobid_xml":"https://content.openalex.org/works/W4391766836.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W1530897438","https://openalex.org/W1584279891","https://openalex.org/W1784320901","https://openalex.org/W1966403223","https://openalex.org/W1968830866","https://openalex.org/W1973865009","https://openalex.org/W1975389666","https://openalex.org/W1986028388","https://openalex.org/W1997982013","https://openalex.org/W2009759904","https://openalex.org/W2011102093","https://openalex.org/W2014007136","https://openalex.org/W2031215175","https://openalex.org/W2040707073","https://openalex.org/W2053917358","https://openalex.org/W2054580619","https://openalex.org/W2054870083","https://openalex.org/W2060810779","https://openalex.org/W2069139751","https://openalex.org/W2070125981","https://openalex.org/W2075293125","https://openalex.org/W2081387606","https://openalex.org/W2081432059","https://openalex.org/W2084179820","https://openalex.org/W2086871516","https://openalex.org/W2106375468","https://openalex.org/W2108008975","https://openalex.org/W2121379737","https://openalex.org/W2122735346","https://openalex.org/W2137801136","https://openalex.org/W2143588109","https://openalex.org/W2145677511","https://openalex.org/W2165728411","https://openalex.org/W2171332611","https://openalex.org/W2174853638","https://openalex.org/W2211009999","https://openalex.org/W2330523319","https://openalex.org/W2409353631","https://openalex.org/W2546515806","https://openalex.org/W2565787560","https://openalex.org/W2569704302","https://openalex.org/W2583553931","https://openalex.org/W2757601258","https://openalex.org/W2765507708","https://openalex.org/W2792369947","https://openalex.org/W2792890104","https://openalex.org/W2794408934","https://openalex.org/W2802223125","https://openalex.org/W2802537338","https://openalex.org/W2804230025","https://openalex.org/W2806717727","https://openalex.org/W2890125899","https://openalex.org/W2893492543","https://openalex.org/W2916403685","https://openalex.org/W2920824900","https://openalex.org/W2950976066","https://openalex.org/W2975543563","https://openalex.org/W2976024218","https://openalex.org/W2981227605","https://openalex.org/W2982557070","https://openalex.org/W2983991572","https://openalex.org/W2984612860","https://openalex.org/W3002982124","https://openalex.org/W3011705488","https://openalex.org/W3013836352","https://openalex.org/W3021105102","https://openalex.org/W3024181690","https://openalex.org/W3037059423","https://openalex.org/W3037147769","https://openalex.org/W3039872703","https://openalex.org/W3097918738","https://openalex.org/W3137481645","https://openalex.org/W3152373240","https://openalex.org/W3155743912","https://openalex.org/W3156516045","https://openalex.org/W3165176743","https://openalex.org/W3198002666","https://openalex.org/W3212930417","https://openalex.org/W4225634426","https://openalex.org/W4245057219","https://openalex.org/W4282941395","https://openalex.org/W4297498240","https://openalex.org/W4311505626","https://openalex.org/W4319591963","https://openalex.org/W4380052797"],"related_works":["https://openalex.org/W4377233014","https://openalex.org/W4211151938","https://openalex.org/W2093085120","https://openalex.org/W2073898520","https://openalex.org/W3210842601","https://openalex.org/W3152373240","https://openalex.org/W4238048928","https://openalex.org/W7006399017","https://openalex.org/W4388363642","https://openalex.org/W4239589000"],"abstract_inverted_index":{"The":[0],"cerebral":[1],"cortex":[2,100],"is":[3,18],"vital":[4],"for":[5],"the":[6,14,24,97],"perception":[7],"and":[8,27,40,53,58,74,104,139],"processing":[9],"of":[10,69,87],"sensory":[11,122],"stimuli.":[12],"In":[13],"somatosensory":[15,30,137,141],"axis,":[16],"information":[17],"received":[19],"by":[20],"two":[21],"distinct":[22,129],"regions,":[23],"primary":[25],"(S1)":[26],"secondary":[28,98],"(S2)":[29],"cortices.":[31],"Top-down":[32],"circuits":[33],"stemming":[34],"from":[35],"S1":[36],"can":[37],"modulate":[38,133],"mechanical":[39,52,73,103],"cooling":[41,54,78],"but":[42,76],"not":[43,77],"heat":[44],"stimuli":[45,138],"such":[46],"that":[47,62,93,115,124,140],"circuit":[48],"inhibition":[49,68,86],"causes":[50],"blunted":[51],"perception.":[55],"Using":[56],"optogenetics":[57],"chemogenetics,":[59],"we":[60,91],"find":[61],"in":[63,145],"contrast":[64],"to":[65,96,132,135],"S1,":[66,119],"an":[67],"S2":[70,89,94,125],"output":[71],"increases":[72],"heat,":[75],"sensitivity.":[79],"Combining":[80],"2-photon":[81],"anatomical":[82],"reconstruction":[83],"with":[84],"chemogenetic":[85],"specific":[88,121],"circuits,":[90],"discover":[92],"projections":[95],"motor":[99,109],"(M2)":[101],"govern":[102],"thermal":[105],"sensitivity":[106],"without":[107],"affecting":[108],"or":[110],"cognitive":[111],"function.":[112],"This":[113],"suggests":[114],"while":[116],"S2,":[117],"like":[118],"encodes":[120],"information,":[123],"operates":[126],"through":[127],"quite":[128],"neural":[130],"substrates":[131],"responsiveness":[134],"particular":[136],"cortical":[142],"encoding":[143],"occurs":[144],"a":[146],"largely":[147],"parallel":[148],"fashion.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-02-13T00:00:00"}
