{"id":"https://openalex.org/W4391745568","doi":"https://doi.org/10.1007/s12032-024-02301-z","title":"CRP inhibits the osteoblastic differentiation of OPCs via the up-regulation of primary cilia and repression of the Hedgehog signaling pathway","display_name":"CRP inhibits the osteoblastic differentiation of OPCs via the up-regulation of primary cilia and repression of the Hedgehog signaling pathway","publication_year":2024,"publication_date":"2024-02-12","ids":{"openalex":"https://openalex.org/W4391745568","doi":"https://doi.org/10.1007/s12032-024-02301-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/38345752"},"language":"en","primary_location":{"id":"doi:10.1007/s12032-024-02301-z","doi":"https://doi.org/10.1007/s12032-024-02301-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12032-024-02301-z","pdf_url":null,"source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-3127350/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072981164","display_name":"Jie Xu","orcid":"https://orcid.org/0000-0003-2435-0382","observed_orcids":["https://orcid.org/0000-0003-2435-0382"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Xu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006809175","display_name":"Xiangmei Wu","orcid":"https://orcid.org/0000-0002-6405-8346","observed_orcids":["https://orcid.org/0000-0002-6405-8346"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangmei Wu","raw_affiliation_strings":["Department of Physiology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101826049","display_name":"Huifang Zhu","orcid":"https://orcid.org/0000-0003-0303-7522","observed_orcids":["https://orcid.org/0000-0003-0303-7522"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huifang Zhu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102179534","display_name":"Yinghua Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210135470","display_name":"Chongqing Emergency Medical Center","ror":"https://ror.org/03xhwyc44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135470"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinghua Zhu","raw_affiliation_strings":["Department of Pre-Hospital Emergency, Chongqing Emergency Medical Center, Central Hospital of Chongqing University, Chongqing, 400014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pre-Hospital Emergency, Chongqing Emergency Medical Center, Central Hospital of Chongqing University, Chongqing, 400014, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210135470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021175765","display_name":"Kailong Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kailong Du","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076420278","display_name":"Xiaoyan Deng","orcid":"https://orcid.org/0000-0003-0207-0769","observed_orcids":["https://orcid.org/0000-0003-0207-0769"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Deng","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102790464","display_name":"Changdong Wang","orcid":"https://orcid.org/0000-0002-2595-1369","observed_orcids":["https://orcid.org/0000-0002-2595-1369","https://orcid.org/0000-0001-5972-559X"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changdong Wang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China. wangchangdong@cqmu.edu.cn","Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":"https://orcid.org/0000-0002-2595-1369","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China. wangchangdong@cqmu.edu.cn","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102790464"],"corresponding_institution_ids":["https://openalex.org/I87780372"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.4448,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.49928362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"41","issue":"3","first_page":"72","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":1.0},{"id":"https://openalex.org/keywords/osteoblast-precursors","display_name":"osteoblast precursors","score":0.8730000257492065},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/primary-cilia","display_name":"primary cilia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9610000252723694},{"id":"https://openalex.org/keywords/gli2","display_name":"GLI2","score":0.6140000224113464},{"id":"https://openalex.org/keywords/suppressor-of-fused","display_name":"SUFU","score":0.8930000066757202},{"id":"https://openalex.org/keywords/g1-s-transition","display_name":"G1/S transition","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.7590000033378601},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.6741369962692261},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.618322491645813},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.5868616104125977},{"id":"https://openalex.org/C2777605378","wikidata":"https://www.wikidata.org/wiki/Q3271319","display_name":"Cyclopamine","level":4,"score":0.5777654647827148},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.5772663354873657},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.525792121887207},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5237022638320923},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.4900616407394409},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45426836609840393},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3847159743309021},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37318557500839233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3621680438518524},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19852066040039062},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17527168989181519},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09396800398826599},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09330770373344421}],"mesh":[{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s12032-024-02301-z","doi":"https://doi.org/10.1007/s12032-024-02301-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12032-024-02301-z","pdf_url":null,"source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-3127350/v1","doi":"https://doi.org/10.21203/rs.3.rs-3127350/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-3127350/v1","pdf_url":"https://www.researchsquare.com/article/rs-3127350/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:38345752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38345752","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical oncology (Northwood, London, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-3127350/v1","doi":"https://doi.org/10.21203/rs.3.rs-3127350/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-3127350/v1","pdf_url":"https://www.researchsquare.com/article/rs-3127350/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9484000205993652,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1224204252","display_name":null,"funder_award_id":"cstc2014jcyjA10024","funder_id":"https://openalex.org/F4320313612","funder_display_name":"Chongqing Postdoctoral Science Foundation"},{"id":"https://openalex.org/G1512705883","display_name":null,"funder_award_id":"CY170402","funder_id":"https://openalex.org/F4320336837","funder_display_name":"Key Laboratory of Industrial Internet of Things and Networked Control, Ministry of Education"},{"id":"https://openalex.org/G6581546073","display_name":null,"funder_award_id":"20125503120015","funder_id":"https://openalex.org/F4320336024","funder_display_name":"Specialized Research Fund for the Doctoral Program of Higher Education of China"},{"id":"https://openalex.org/G7708559189","display_name":null,"funder_award_id":"CYS19204","funder_id":"https://openalex.org/F4320327600","funder_display_name":"Jiangsu Agricultural Science and Technology Independent Innovation Fund"}],"funders":[{"id":"https://openalex.org/F4320313612","display_name":"Chongqing Postdoctoral Science Foundation","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327600","display_name":"Jiangsu Agricultural Science and Technology Independent Innovation Fund","ror":null},{"id":"https://openalex.org/F4320327639","display_name":"Centre Scientifique et Technique du B\u00e2timent","ror":"https://ror.org/02fsd1928"},{"id":"https://openalex.org/F4320336024","display_name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","ror":null},{"id":"https://openalex.org/F4320336837","display_name":"Key Laboratory of Industrial Internet of Things and Networked Control, Ministry of Education","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391745568.pdf","grobid_xml":"https://content.openalex.org/works/W4391745568.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1492235284","https://openalex.org/W1503876310","https://openalex.org/W1541949755","https://openalex.org/W1568175712","https://openalex.org/W1944656442","https://openalex.org/W1964188104","https://openalex.org/W1968904141","https://openalex.org/W1981738322","https://openalex.org/W1982833361","https://openalex.org/W1984953412","https://openalex.org/W1989465440","https://openalex.org/W1989789921","https://openalex.org/W1992816628","https://openalex.org/W1993569127","https://openalex.org/W1999703499","https://openalex.org/W2006353464","https://openalex.org/W2024886564","https://openalex.org/W2031165650","https://openalex.org/W2032792789","https://openalex.org/W2035252153","https://openalex.org/W2040553528","https://openalex.org/W2044845092","https://openalex.org/W2048521619","https://openalex.org/W2058517860","https://openalex.org/W2059761434","https://openalex.org/W2060505600","https://openalex.org/W2070184849","https://openalex.org/W2074542365","https://openalex.org/W2075840772","https://openalex.org/W2077182790","https://openalex.org/W2077300740","https://openalex.org/W2079037416","https://openalex.org/W2088778855","https://openalex.org/W2089041604","https://openalex.org/W2092902622","https://openalex.org/W2095869636","https://openalex.org/W2098176608","https://openalex.org/W2117846745","https://openalex.org/W2118799944","https://openalex.org/W2123510004","https://openalex.org/W2131999768","https://openalex.org/W2133980038","https://openalex.org/W2138621885","https://openalex.org/W2139422038","https://openalex.org/W2144226194","https://openalex.org/W2152072269","https://openalex.org/W2158899787","https://openalex.org/W2163007274","https://openalex.org/W2163838718","https://openalex.org/W2166311068","https://openalex.org/W2167927701","https://openalex.org/W2168056473","https://openalex.org/W2205574727","https://openalex.org/W2212252333","https://openalex.org/W2291522985","https://openalex.org/W2401201457","https://openalex.org/W2789900897","https://openalex.org/W2792265902","https://openalex.org/W2888222789","https://openalex.org/W2896746371","https://openalex.org/W2999774180","https://openalex.org/W3005483250","https://openalex.org/W3017049470","https://openalex.org/W3026451844","https://openalex.org/W4241982263","https://openalex.org/W7038147196"],"related_works":["https://openalex.org/W2212252333","https://openalex.org/W2001888792","https://openalex.org/W2792265902","https://openalex.org/W2155951638","https://openalex.org/W2470341215","https://openalex.org/W2299706416","https://openalex.org/W4226144330","https://openalex.org/W2100898690","https://openalex.org/W4221114575","https://openalex.org/W4360938123"],"abstract_inverted_index":{"Abstract":[0],"Inflammation":[1],"disrupts":[2],"bone":[3,7],"metabolism":[4],"and":[5,59,98,196,220,237],"causes":[6],"damage.":[8],"C-reactive":[9,79],"protein":[10],"(CRP)":[11],"is":[12],"a":[13,82],"typical":[14],"marker":[15],"of":[16,21,36,50,84,94,102,113,118,123,127,136,138,147,153,157,191,193,200,205,223,234,239],"inflammation.":[17],"Although":[18],"the":[19,29,33,48,61,92,99,103,116,124,128,133,145,151,189,198,203,218,232,240],"measurement":[20],"CRP":[22,51,90,114,215],"has":[23],"been":[24],"conducted":[25],"for":[26],"many":[27],"decades,":[28],"precise":[30],"influence":[31],"on":[32,52,115,140,159],"molecular":[34,63],"mechanisms":[35],"osteoblastic":[37,96,221],"differentiation":[38,222],"remains":[39],"largely":[40],"unknown.":[41],"The":[42,110,225],"present":[43],"study":[44],"aimed":[45],"to":[46,231],"investigate":[47],"effects":[49],"primary":[53,154,186,235],"cultured":[54],"osteoblast":[55],"precursor":[56],"cells":[57],"(OPCs)":[58],"elucidate":[60],"underlying":[62,226],"mechanisms.":[64],"OPCs":[65,72,108,119,160],"were":[66,73],"isolated":[67],"from":[68,144,149],"suckling":[69],"Sprague-Dawleyrats.":[70],"Fewer":[71],"observed":[74],"after":[75],"treatment":[76],"with":[77],"recombinant":[78],"protein.":[80],"In":[81,131],"series":[83],"experiments,":[85],"it":[86],"was":[87,142,161,177],"found":[88],"that":[89,176,214],"inhibited":[91,178,188],"proliferation":[93,117,219],"OPCs,":[95],"differentiation,":[97],"gene":[100],"expression":[101],"hedgehog(Hh)":[104],"signaling":[105,171],"pathway":[106],"in":[107,163,164],"cells.":[109],"inhibitory":[111],"effect":[112,135,152],"occurred":[120],"via":[121],"blockade":[122],"G1-S":[125],"transition":[126],"cell":[129],"cycle.":[130],"addition,":[132],"regulation":[134,137],"protocilium":[139],"osteoblasticdifferentiation":[141,175],"analyzed":[143],"perspective":[146],"bioinformatics,":[148],"which":[150,184],"cilia":[155,236],"activation":[156,233],"recombinantCRP":[158],"revealed":[162],"vitro":[165],"experiments.":[166],"A":[167],"specific":[168],"Sonic":[169],"Hedgehog":[170],"agonist":[172],"(SAG)":[173],"rescued":[174],"by":[179,208],"recombinantCRP.":[180],"Moreover,":[181],"chloral":[182],"hydrate,":[183],"removes":[185],"cilia,":[187],"formation":[190],"Suppressor":[192],"Fused":[194],"(SUFU)":[195],"blocked":[197],"degradation":[199],"Gli2,":[201],"counteracting":[202],"inhibition":[204],"osteogenesis":[206],"caused":[207],"CRP.":[209],"Thus,":[210],"these":[211],"data":[212],"indicate":[213],"can":[216],"inhibit":[217],"OPCs.":[224],"mechanism":[227],"may":[228],"be":[229],"related":[230],"repression":[238],"Hh":[241],"pathway.":[242]},"counts_by_year":[{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-02-13T00:00:00"}