{"id":"https://openalex.org/W4391737814","doi":"https://doi.org/10.1093/bbb/zbae017","title":"Effects of pulsed electrical stimulation on \u03b1-smooth muscle actin and type I collagen expression in human dermal fibroblasts","display_name":"Effects of pulsed electrical stimulation on \u03b1-smooth muscle actin and type I collagen expression in human dermal fibroblasts","publication_year":2024,"publication_date":"2024-02-10","ids":{"openalex":"https://openalex.org/W4391737814","doi":"https://doi.org/10.1093/bbb/zbae017","pmid":"https://pubmed.ncbi.nlm.nih.gov/38341279"},"language":"en","primary_location":{"id":"doi:10.1093/bbb/zbae017","doi":"https://doi.org/10.1093/bbb/zbae017","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bbb/zbae017","pdf_url":"https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbae017/56915838/zbae017.pdf","source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbae017/56915838/zbae017.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079273446","display_name":"Hiroya Urabe","orcid":"https://orcid.org/0000-0003-0145-7005","observed_orcids":["https://orcid.org/0000-0003-0145-7005"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hiroya Urabe","raw_affiliation_strings":["Homer Ion Laboratory Co., Ltd ., Tokyo , Japan"],"raw_orcid":"https://orcid.org/0000-0003-0145-7005","affiliations":[{"raw_affiliation_string":"Homer Ion Laboratory Co., Ltd ., Tokyo , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071038581","display_name":"Ryuji Akimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryuji Akimoto","raw_affiliation_strings":["Homer Ion Laboratory Co., Ltd ., Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Homer Ion Laboratory Co., Ltd ., Tokyo , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035048734","display_name":"Shohei Kamiya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shohei Kamiya","raw_affiliation_strings":["Homer Ion Laboratory Co., Ltd ., Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Homer Ion Laboratory Co., Ltd ., Tokyo , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066925883","display_name":"Katsu Hosoki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katsu Hosoki","raw_affiliation_strings":["Homer Ion Laboratory Co., Ltd ., Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Homer Ion Laboratory Co., Ltd ., Tokyo , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079461343","display_name":"Hideyuki Ichikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideyuki Ichikawa","raw_affiliation_strings":["Homer Ion Laboratory Co., Ltd ., Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Homer Ion Laboratory Co., Ltd ., Tokyo , Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016282860","display_name":"Toshio Nishiyama","orcid":"https://orcid.org/0000-0002-3459-2636","observed_orcids":["https://orcid.org/0000-0002-3459-2636"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshio Nishiyama","raw_affiliation_strings":["Homer Ion Laboratory Co., Ltd ., Tokyo , Japan","Tokyo University of Agriculture and Technology , Fuchu, Tokyo , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Homer Ion Laboratory Co., Ltd ., Tokyo , Japan","institution_ids":[]},{"raw_affiliation_string":"Tokyo University of Agriculture and Technology , Fuchu, Tokyo , Japan","institution_ids":["https://openalex.org/I92614990"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079273446"],"corresponding_institution_ids":[],"apc_list":{"value":3370,"currency":"USD","value_usd":3370},"apc_paid":null,"fwci":3.2955,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.92508216,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"88","issue":"5","first_page":"522","last_page":"528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.11559999734163284,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulsed-electrical-stimulation","display_name":"pulsed electrical stimulation","score":1.0},{"id":"https://openalex.org/keywords/human-dermal-fibroblasts","display_name":"human dermal fibroblasts","score":0.9710000157356262},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9269999861717224},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.9380000233650208},{"id":"https://openalex.org/keywords/pdgf-a","display_name":"PDGF-A","score":0.8700000047683716},{"id":"https://openalex.org/keywords/myofibroblast-differentiation","display_name":"myofibroblast differentiation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.9350000023841858},{"id":"https://openalex.org/keywords/pdgf-receptor-inhibition","display_name":"PDGF receptor inhibition","score":0.8939999938011169},{"id":"https://openalex.org/keywords/collagen-synthesis","display_name":"collagen synthesis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.6566941738128662},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6507839560508728},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5962820649147034},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.5823641419410706},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.5698100924491882},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.5681301355361938},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5146235227584839},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49612006545066833},{"id":"https://openalex.org/C2780644872","wikidata":"https://www.wikidata.org/wiki/Q14881714","display_name":"Type I collagen","level":2,"score":0.48094767332077026},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4277888536453247},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34905892610549927},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3478511869907379},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3245961666107178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31695473194122314},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2851487398147583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19118046760559082},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18894532322883606},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18560907244682312},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16611427068710327},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017479","descriptor_name":"Receptors, Platelet-Derived Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017479","descriptor_name":"Receptors, Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bbb/zbae017","doi":"https://doi.org/10.1093/bbb/zbae017","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bbb/zbae017","pdf_url":"https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbae017/56915838/zbae017.pdf","source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},{"id":"pmid:38341279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38341279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, biotechnology, and biochemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/bbb/zbae017","doi":"https://doi.org/10.1093/bbb/zbae017","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bbb/zbae017","pdf_url":"https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbae017/56915838/zbae017.pdf","source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391737814.pdf","grobid_xml":"https://content.openalex.org/works/W4391737814.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1146088675","https://openalex.org/W1520880969","https://openalex.org/W1561495212","https://openalex.org/W1594157448","https://openalex.org/W1854163794","https://openalex.org/W1878807841","https://openalex.org/W1925229342","https://openalex.org/W1931315964","https://openalex.org/W1963636573","https://openalex.org/W1965947268","https://openalex.org/W1969696386","https://openalex.org/W1995528629","https://openalex.org/W1998606464","https://openalex.org/W2017988613","https://openalex.org/W2020234367","https://openalex.org/W2023805473","https://openalex.org/W2026671183","https://openalex.org/W2046655679","https://openalex.org/W2062198763","https://openalex.org/W2081473776","https://openalex.org/W2094064713","https://openalex.org/W2098952398","https://openalex.org/W2110121929","https://openalex.org/W2117910395","https://openalex.org/W2154254162","https://openalex.org/W2155214429","https://openalex.org/W2156673166","https://openalex.org/W2160200374","https://openalex.org/W2160698607","https://openalex.org/W2161590177","https://openalex.org/W2170084502","https://openalex.org/W2184817776","https://openalex.org/W2757684426","https://openalex.org/W2783225214","https://openalex.org/W3088147810","https://openalex.org/W3129829621","https://openalex.org/W3162290153","https://openalex.org/W3204891582","https://openalex.org/W6627465751","https://openalex.org/W6630359805"],"related_works":["https://openalex.org/W3088147810","https://openalex.org/W4388540666","https://openalex.org/W1925229342","https://openalex.org/W7065560685","https://openalex.org/W2324005716","https://openalex.org/W2793256411","https://openalex.org/W3136755783","https://openalex.org/W2802304532","https://openalex.org/W1572374327","https://openalex.org/W2371989467"],"abstract_inverted_index":{"Pulsed":[0],"electrical":[1],"stimulation":[2],"(PES)":[3],"is":[4,145,150],"known":[5],"to":[6,14],"affect":[7],"cellular":[8],"activities.":[9],"We":[10],"previously":[11],"found":[12],"PES":[13,36,91,118,123,133],"human":[15],"dermal":[16],"fibroblasts":[17],"(HFs)":[18],"promoted":[19,96],"platelet-derived":[20],"growth":[21],"factor":[22],"subunit":[23],"A":[24],"(PDGFA)":[25],"gene":[26,86],"expression,":[27],"which":[28,144],"enhanced":[29,116],"proliferation.":[30],"In":[31],"this":[32],"study,":[33],"we":[34],"investigated":[35],"effects":[37],"on":[38],"fibroblast":[39],"collagen":[40,81,113,140],"production":[41,109,136],"and":[42,53,80,103,112,139],"differentiation":[43],"into":[44],"myofibroblasts.":[45],"HFs":[46],"were":[47,88],"electrically":[48],"stimulated":[49],"at":[50,127],"4800":[51],"Hz":[52],"5":[54],"V":[55],"for":[56,99],"60":[57],"min.":[58],"Imatinib,":[59],"a":[60],"specific":[61],"inhibitor":[62],"of":[63,73,110,137],"PDGF":[64],"receptors,":[65],"was":[66,115],"treated":[67],"before":[68],"PES.":[69,131,154],"After":[70],"6":[71],"h":[72,129],"PES,":[74],"PDGFA,":[75],"\u03b1-smooth":[76],"muscle":[77],"actin":[78],"(\u03b1-SMA),":[79],"type":[82],"I":[83,114,141],"\u03b11":[84],"chain":[85],"expressions":[87],"upregulated":[89,151],"in":[90,117,122,142],"group.":[92],"Imatinib":[93],"suppressed":[94,121],"the":[95,108,135],"expression":[97],"except":[98],"PDGFA.":[100],"Immunofluorescence":[101],"staining":[102],"enzyme-linked":[104],"immunosorbent":[105],"assay":[106],"showed":[107],"\u03b1-SMA":[111,138],"group":[119,126],"but":[120],"+":[124],"imatinib":[125],"48":[128],"after":[130,153],"Therefore,":[132],"promotes":[134],"fibroblasts,":[143],"triggered":[146],"by":[147],"PDGFA":[148],"that":[149],"early":[152]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-02-12T00:00:00"}
