{"id":"https://openalex.org/W43917258","doi":null,"title":"Subtype of depression as a moderator of response in the treatment of major depression with St John's wort","display_name":"Subtype of depression as a moderator of response in the treatment of major depression with St John's wort","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W43917258","mag":"43917258"},"language":"en","primary_location":{"id":"pmh:oai:drum.lib.umd.edu:1903/11582","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1903/11582","pdf_url":"http://hdl.handle.net/1903/11582","source":{"id":"https://openalex.org/S4306401518","display_name":"University Libraries (University of Maryland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1903/11582","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006605042","display_name":"Christine M. Ulbricht","orcid":"https://orcid.org/0000-0003-3811-1446","observed_orcids":["https://orcid.org/0000-0003-3811-1446"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christine M. Ulbricht","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3811-1446","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5006605042"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.6807000041007996,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.6807000041007996,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.18619999289512634,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.04910000041127205,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.753000020980835},{"id":"https://openalex.org/keywords/depression-subtypes","display_name":"depression subtypes","score":0.828000009059906},{"id":"https://openalex.org/keywords/melancholic-depression","display_name":"endogenous depression","score":0.9929999709129333},{"id":"https://openalex.org/keywords/anxious-depression","display_name":"anxious depression","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hypericum-perforatum","display_name":"Hypericum perforatum","score":0.9779999852180481},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.9089999794960022},{"id":"https://openalex.org/keywords/treatment-moderators","display_name":"treatment moderators","score":0.6510000228881836},{"id":"https://openalex.org/keywords/sertraline","display_name":"sertraline","score":0.9660000205039978},{"id":"https://openalex.org/keywords/placebo","display_name":"placebo","score":0.6729999780654907},{"id":"https://openalex.org/keywords/depression-severity","display_name":"depression severity","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.828420102596283},{"id":"https://openalex.org/C2781044885","wikidata":"https://www.wikidata.org/wiki/Q13512178","display_name":"Melancholic depression","level":4,"score":0.8166769742965698},{"id":"https://openalex.org/C93225998","wikidata":"https://www.wikidata.org/wiki/Q1941972","display_name":"Moderation","level":2,"score":0.5772342681884766},{"id":"https://openalex.org/C2777669559","wikidata":"https://www.wikidata.org/wiki/Q407617","display_name":"Sertraline","level":4,"score":0.5353518128395081},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.5140336751937866},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5111032128334045},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4997837543487549},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4847099781036377},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4811909794807434},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41666683554649353},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4024896025657654},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3993931710720062},{"id":"https://openalex.org/C2780783166","wikidata":"https://www.wikidata.org/wiki/Q192077","display_name":"Melancholia","level":3,"score":0.30154258012771606},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.26975953578948975},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.1775299608707428},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.13017511367797852},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.11642423272132874},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:drum.lib.umd.edu:1903/11582","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1903/11582","pdf_url":"http://hdl.handle.net/1903/11582","source":{"id":"https://openalex.org/S4306401518","display_name":"University Libraries (University of Maryland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:43917258","doi":null,"is_oa":false,"landing_page_url":"https://drum.lib.umd.edu/bitstream/1903/11582/1/Ulbricht_umd_0117N_12245.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:drum.lib.umd.edu:1903/11582","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1903/11582","pdf_url":"http://hdl.handle.net/1903/11582","source":{"id":"https://openalex.org/S4306401518","display_name":"University Libraries (University of Maryland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8700000047683716,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W43917258.pdf","grobid_xml":"https://content.openalex.org/works/W43917258.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W86284402","https://openalex.org/W175853064","https://openalex.org/W1490057971","https://openalex.org/W1505466667","https://openalex.org/W1600943356","https://openalex.org/W1707183381","https://openalex.org/W1733837299","https://openalex.org/W1742833546","https://openalex.org/W1759151863","https://openalex.org/W1964640782","https://openalex.org/W1975261575","https://openalex.org/W1975916217","https://openalex.org/W1975970212","https://openalex.org/W1982617731","https://openalex.org/W1987271832","https://openalex.org/W1988237057","https://openalex.org/W1990583042","https://openalex.org/W1990985452","https://openalex.org/W1991085765","https://openalex.org/W1994725383","https://openalex.org/W1996437928","https://openalex.org/W1997413626","https://openalex.org/W2006099107","https://openalex.org/W2008981696","https://openalex.org/W2017734181","https://openalex.org/W2020564889","https://openalex.org/W2021355104","https://openalex.org/W2022236488","https://openalex.org/W2022694772","https://openalex.org/W2028306465","https://openalex.org/W2030263867","https://openalex.org/W2032601397","https://openalex.org/W2036537363","https://openalex.org/W2037577652","https://openalex.org/W2042944469","https://openalex.org/W2049165791","https://openalex.org/W2049189688","https://openalex.org/W2055332375","https://openalex.org/W2059939716","https://openalex.org/W2060936341","https://openalex.org/W2061378977","https://openalex.org/W2066834831","https://openalex.org/W2069151316","https://openalex.org/W2071214152","https://openalex.org/W2072358421","https://openalex.org/W2072459990","https://openalex.org/W2074943169","https://openalex.org/W2080503049","https://openalex.org/W2081771792","https://openalex.org/W2088807767","https://openalex.org/W2090245673","https://openalex.org/W2093618613","https://openalex.org/W2095847653","https://openalex.org/W2096458622","https://openalex.org/W2097205417","https://openalex.org/W2099564543","https://openalex.org/W2100122991","https://openalex.org/W2105510555","https://openalex.org/W2108595957","https://openalex.org/W2111762674","https://openalex.org/W2113823824","https://openalex.org/W2114613490","https://openalex.org/W2123275168","https://openalex.org/W2124136543","https://openalex.org/W2124295269","https://openalex.org/W2126856618","https://openalex.org/W2131711107","https://openalex.org/W2138255666","https://openalex.org/W2140669914","https://openalex.org/W2141463470","https://openalex.org/W2145151017","https://openalex.org/W2146659162","https://openalex.org/W2148933229","https://openalex.org/W2150041936","https://openalex.org/W2153403353","https://openalex.org/W2157877920","https://openalex.org/W2163267194","https://openalex.org/W2170022513","https://openalex.org/W2170684975","https://openalex.org/W2171092546","https://openalex.org/W2226062431","https://openalex.org/W2275487654","https://openalex.org/W2397865677","https://openalex.org/W2398859736","https://openalex.org/W2400172486","https://openalex.org/W2400600349","https://openalex.org/W2403845770","https://openalex.org/W2405023425","https://openalex.org/W2417284288","https://openalex.org/W2486183228","https://openalex.org/W3090293687"],"related_works":["https://openalex.org/W1972105422","https://openalex.org/W2160932566","https://openalex.org/W2040090698","https://openalex.org/W2165707326","https://openalex.org/W2605882613","https://openalex.org/W2019714241","https://openalex.org/W2570529618","https://openalex.org/W7100655188","https://openalex.org/W1970962912","https://openalex.org/W1770079579"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"evaluate":[2],"the":[3,6,17,40,75],"effect":[4],"of":[5,11,42,53,77],"melancholic":[7,56,69,82,129],"and":[8,35,45,58,74,80,100,125],"anxious":[9,61,101,131],"subtypes":[10,133],"depression":[12,25,30,43,57,70,88,102,107,111,132],"on":[13,48,87,106],"treatment":[14,46,49,78,99,139],"response":[15,137],"in":[16],"Hypericum":[18],"Depression":[19],"Trial.":[20],"Methods:":[21],"340":[22],"adults":[23],"with":[24,140],"were":[26],"classified":[27],"according":[28],"to":[29,114,117,134,138],"subtype":[31,44,112],"at":[32,72,104],"baseline.":[33],"Linear":[34],"logistic":[36],"regression":[37,65,92],"models":[38],"examined":[39],"effects":[41,86,96],"assignment":[47,79],"response.":[50],"Results:":[51],"64.41%":[52],"participants":[54],"had":[55,60,84],"71.76%":[59],"depression.":[62],"The":[63,90],"linear":[64,91],"model":[66,93],"demonstrated":[67],"that":[68],"status":[71,83,103],"baseline":[73,81,105],"interaction":[76],"significant":[85,95],"severity.":[89,108],"showed":[94],"only":[97],"for":[98],"Conclusion:":[109],"While":[110],"appears":[113],"be":[115],"related":[116],"certain":[118],"clinical":[119],"characteristics,":[120],"this":[121],"study":[122],"was":[123],"inconclusive":[124],"did":[126],"not":[127],"find":[128],"or":[130,145],"significantly":[135],"moderate":[136],"St":[141],"John's":[142],"wort,":[143],"placebo,":[144],"sertraline.":[146]},"counts_by_year":[],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2016-06-24T00:00:00"}
