{"id":"https://openalex.org/W4391722435","doi":"https://doi.org/10.1038/s41467-024-45439-0","title":"Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage","display_name":"Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage","publication_year":2024,"publication_date":"2024-02-10","ids":{"openalex":"https://openalex.org/W4391722435","doi":"https://doi.org/10.1038/s41467-024-45439-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/38341404","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10858916"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-024-45439-0","doi":"https://doi.org/10.1038/s41467-024-45439-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-45439-0","pdf_url":"https://www.nature.com/articles/s41467-024-45439-0.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-024-45439-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054652451","display_name":"Inmaculada Ruz\u2010Maldonado","orcid":"https://orcid.org/0000-0002-2858-8446","observed_orcids":["https://orcid.org/0000-0002-2858-8446"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inmaculada Ruz-Maldonado","raw_affiliation_strings":["Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA","Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA","Departments of Internal Medicine (Endocrinology) and Cellular & Molecular Physiology, Yale University, New Haven, CT, USA","Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA","Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Departments of Internal Medicine (Endocrinology) and Cellular & Molecular Physiology, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033850312","display_name":"John T. Gonz\u00e1lez","orcid":"https://orcid.org/0000-0002-1020-8783","observed_orcids":["https://orcid.org/0000-0002-1020-8783"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John T. Gonzalez","raw_affiliation_strings":["Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA","Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA","Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA"],"raw_orcid":"https://orcid.org/0000-0002-1020-8783","affiliations":[{"raw_affiliation_string":"Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hanming Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanming Zhang","raw_affiliation_strings":["Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA","Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA","Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA","Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110706038","display_name":"Jonathan Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Sun","raw_affiliation_strings":["Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA","Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA","Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA","Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015917640","display_name":"Alicia Bort","orcid":"https://orcid.org/0000-0003-1490-5823","observed_orcids":["https://orcid.org/0000-0003-1490-5823"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicia Bort","raw_affiliation_strings":["Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA","Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA","Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA","Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084795666","display_name":"Inamul Kabir","orcid":"https://orcid.org/0000-0001-6207-1785","observed_orcids":["https://orcid.org/0000-0001-6207-1785"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inamul Kabir","raw_affiliation_strings":["Department of Genetics, Yale University School of Medicine, New Haven, CT, 06511, USA","Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06511, USA"],"raw_orcid":"https://orcid.org/0000-0001-6207-1785","affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University School of Medicine, New Haven, CT, 06511, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016669746","display_name":"Richard Glenn Kibbey","orcid":"https://orcid.org/0000-0001-6768-3473","observed_orcids":["https://orcid.org/0000-0001-6768-3473"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard G. Kibbey","raw_affiliation_strings":["Departments of Internal Medicine (Endocrinology) and Cellular & Molecular Physiology, Yale University, New Haven, CT, USA","Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine (Endocrinology) and Cellular & Molecular Physiology, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002528642","display_name":"Yajaira Su\u00e1rez","orcid":"https://orcid.org/0000-0003-4549-2953","observed_orcids":["https://orcid.org/0000-0003-4549-2953"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yajaira Su\u00e1rez","raw_affiliation_strings":["Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA","Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA","Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA","Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA"],"raw_orcid":"https://orcid.org/0000-0003-4549-2953","affiliations":[{"raw_affiliation_string":"Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088025612","display_name":"Daniel M. Greif","orcid":"https://orcid.org/0000-0002-9842-3751","observed_orcids":["https://orcid.org/0000-0002-9842-3751"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel M. Greif","raw_affiliation_strings":["Department of Genetics, Yale University School of Medicine, New Haven, CT, 06511, USA","Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06511, USA"],"raw_orcid":"https://orcid.org/0000-0002-9842-3751","affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University School of Medicine, New Haven, CT, 06511, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048379477","display_name":"Carlos F Fernandez-Hernando","orcid":"https://orcid.org/0000-0002-3950-1924","observed_orcids":["https://orcid.org/0000-0002-3950-1924"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carlos Fern\u00e1ndez-Hernando","raw_affiliation_strings":["Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA. carlos.fernandez@yale.edu","Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA. carlos.fernandez@yale.edu","Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA. carlos.fernandez@yale.edu","Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA. carlos.fernandez@yale.edu","Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA"],"raw_orcid":"https://orcid.org/0000-0002-3950-1924","affiliations":[{"raw_affiliation_string":"Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA. carlos.fernandez@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT, 06520, USA. carlos.fernandez@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA. carlos.fernandez@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA. carlos.fernandez@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048379477"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":6790,"currency":"USD","value_usd":6790},"apc_paid":{"value":6790,"currency":"USD","value_usd":6790},"fwci":6.4617,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.97722178,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"1247","last_page":"1247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.984000027179718},{"id":"https://openalex.org/keywords/hepatocyte-heterogeneity","display_name":"hepatocyte heterogeneity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hepatocellular-hypertrophy","display_name":"hepatocyte hypertrophy","score":0.8230000138282776},{"id":"https://openalex.org/keywords/pericentral-hepatocytes","display_name":"pericentral hepatocytes","score":0.7950000166893005},{"id":"https://openalex.org/keywords/hepatocyte-transdifferentiation","display_name":"hepatocyte transdifferentiation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/galectin-9","display_name":"galectin-9","score":0.7599999904632568},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9459999799728394},{"id":"https://openalex.org/keywords/coronavirus-infection","display_name":"coronavirus infection","score":0.6039999723434448},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.6610000133514404},{"id":"https://openalex.org/keywords/liver-architecture","display_name":"liver architecture","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.8928508162498474},{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.6845734119415283},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6319555044174194},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6052379608154297},{"id":"https://openalex.org/C60870556","wikidata":"https://www.wikidata.org/wiki/Q2300675","display_name":"Transdifferentiation","level":3,"score":0.5740615725517273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5455706119537354},{"id":"https://openalex.org/C2992672570","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Liver cell","level":2,"score":0.42082783579826355},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.4157218933105469},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.24380329251289368},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20604795217514038},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15271618962287903},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10469302535057068},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41467-024-45439-0","doi":"https://doi.org/10.1038/s41467-024-45439-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-45439-0","pdf_url":"https://www.nature.com/articles/s41467-024-45439-0.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10858916","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10858916","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:38341404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38341404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45439-0","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-024-45439-0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:464ecf555656487594404e7c594fa8c7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/464ecf555656487594404e7c594fa8c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-024-45439-0","doi":"https://doi.org/10.1038/s41467-024-45439-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-45439-0","pdf_url":"https://www.nature.com/articles/s41467-024-45439-0.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2340560689","display_name":"Novel insights into the molecular and cellular mechanism regulating lipid metabolism and atherosclerosis","funder_award_id":"R35HL135820","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000858338","display_name":"Insights into the molecular mechanisms regulating vascular and immune metabolism in vascular diseases","funder_award_id":"R35HL155988","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000866473","display_name":"Yale Liver Center","funder_award_id":"P30DK034989","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337612","display_name":"Yale Liver Center","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391722435.pdf","grobid_xml":"https://content.openalex.org/works/W4391722435.grobid-xml"},"referenced_works_count":107,"referenced_works":["https://openalex.org/W1494211513","https://openalex.org/W1508475810","https://openalex.org/W1628437161","https://openalex.org/W1962220447","https://openalex.org/W1968776144","https://openalex.org/W1969784842","https://openalex.org/W1989832114","https://openalex.org/W1992365936","https://openalex.org/W2000294771","https://openalex.org/W2005044790","https://openalex.org/W2006821600","https://openalex.org/W2016823790","https://openalex.org/W2024592247","https://openalex.org/W2054684099","https://openalex.org/W2059385530","https://openalex.org/W2063738705","https://openalex.org/W2084074847","https://openalex.org/W2085283151","https://openalex.org/W2089140170","https://openalex.org/W2092743512","https://openalex.org/W2096631439","https://openalex.org/W2103036266","https://openalex.org/W2114414056","https://openalex.org/W2115095305","https://openalex.org/W2118363577","https://openalex.org/W2128428920","https://openalex.org/W2132886417","https://openalex.org/W2137799668","https://openalex.org/W2152624886","https://openalex.org/W2155189607","https://openalex.org/W2157173498","https://openalex.org/W2168745358","https://openalex.org/W2171729436","https://openalex.org/W2278793656","https://openalex.org/W2339980262","https://openalex.org/W2346605654","https://openalex.org/W2516129837","https://openalex.org/W2530629623","https://openalex.org/W2551147770","https://openalex.org/W2585175142","https://openalex.org/W2587924565","https://openalex.org/W2591862276","https://openalex.org/W2597129987","https://openalex.org/W2610763259","https://openalex.org/W2614948702","https://openalex.org/W2734880494","https://openalex.org/W2765801445","https://openalex.org/W2793374919","https://openalex.org/W2794622099","https://openalex.org/W2801517459","https://openalex.org/W2803608485","https://openalex.org/W2806924362","https://openalex.org/W2807476445","https://openalex.org/W2896181688","https://openalex.org/W2902652978","https://openalex.org/W2932483334","https://openalex.org/W2932965638","https://openalex.org/W2938341288","https://openalex.org/W2945936487","https://openalex.org/W2948117622","https://openalex.org/W2949177718","https://openalex.org/W2951506174","https://openalex.org/W2959566316","https://openalex.org/W2969794459","https://openalex.org/W2971915501","https://openalex.org/W2979697899","https://openalex.org/W2989057263","https://openalex.org/W2996029077","https://openalex.org/W2996106944","https://openalex.org/W2996555649","https://openalex.org/W3002108456","https://openalex.org/W3006066671","https://openalex.org/W3010637630","https://openalex.org/W3011134208","https://openalex.org/W3011994656","https://openalex.org/W3017517863","https://openalex.org/W3017638747","https://openalex.org/W3023986730","https://openalex.org/W3025219492","https://openalex.org/W3040537541","https://openalex.org/W3045097178","https://openalex.org/W3047433286","https://openalex.org/W3070313547","https://openalex.org/W3080749226","https://openalex.org/W3086401240","https://openalex.org/W3089346069","https://openalex.org/W3096901923","https://openalex.org/W3097961179","https://openalex.org/W3111233897","https://openalex.org/W3122785882","https://openalex.org/W3129561557","https://openalex.org/W3130345333","https://openalex.org/W3131151008","https://openalex.org/W3132549301","https://openalex.org/W3132661792","https://openalex.org/W3133820991","https://openalex.org/W3165409365","https://openalex.org/W3207969561","https://openalex.org/W3217341447","https://openalex.org/W4213224716","https://openalex.org/W4220929336","https://openalex.org/W4226438798","https://openalex.org/W4247878364","https://openalex.org/W4250393576","https://openalex.org/W4281295687","https://openalex.org/W4288054205","https://openalex.org/W4327623063"],"related_works":["https://openalex.org/W2904514484","https://openalex.org/W3133820991","https://openalex.org/W3119048366","https://openalex.org/W4405735222","https://openalex.org/W2021777152","https://openalex.org/W2829125471","https://openalex.org/W2060332785","https://openalex.org/W4385694018","https://openalex.org/W2915464486","https://openalex.org/W2808974142"],"abstract_inverted_index":{"Midlobular":[0],"hepatocytes":[1,73,104],"are":[2],"proposed":[3],"to":[4,37,79,140],"be":[5,119],"the":[6,31,112],"most":[7],"plastic":[8],"hepatic":[9,142],"cell,":[10],"providing":[11],"a":[12,59],"reservoir":[13],"for":[14,50,121],"hepatocyte":[15,35,44],"proliferation":[16],"during":[17,46,111,134],"homeostasis":[18],"and":[19,30,53,64,82,109,115,131],"regeneration.":[20],"However,":[21],"other":[22,34],"mechanisms":[23],"beyond":[24],"hyperplasia":[25],"have":[26],"been":[27,40],"little":[28],"explored":[29],"contribution":[32],"of":[33,55,62],"subpopulations":[36],"regeneration":[38,47,135],"has":[39],"controversial.":[41],"Thus,":[42],"re-examining":[43],"dynamics":[45],"is":[48],"critical":[49,120],"cell":[51,132],"therapy":[52],"treatment":[54],"liver":[56,93],"diseases.":[57],"Using":[58],"mouse":[60],"model":[61],"hepatocyte-":[63],"non-hepatocyte-":[65],"multicolor":[66],"lineage":[67],"tracing,":[68],"we":[69,100,126],"demonstrate":[70,101],"that":[71,88,102,129],"midlobular":[72],"also":[74,91,105,127],"undergo":[75],"hypertrophy":[76],"in":[77,107],"response":[78],"chemical,":[80],"physical,":[81],"viral":[83],"insults.":[84],"Our":[85],"study":[86],"shows":[87],"this":[89],"subpopulation":[90],"combats":[92],"impairment":[94],"after":[95,136],"infection":[96],"with":[97],"coronavirus.":[98],"Furthermore,":[99],"pericentral":[103],"expand":[106],"number":[108],"size":[110],"repair":[113],"process":[114],"Galectin-9-CD44":[116],"pathway":[117],"may":[118],"driving":[122],"these":[123],"processes.":[124],"Notably,":[125],"identified":[128],"transdifferentiation":[130],"fusion":[133],"severe":[137],"injury":[138],"contribute":[139],"recover":[141],"function.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-02-11T00:00:00"}