{"id":"https://openalex.org/W4391719084","doi":"https://doi.org/10.1038/s41467-024-45553-z","title":"Structural role for DNA Ligase IV in promoting the fidelity of non-homologous end joining","display_name":"Structural role for DNA Ligase IV in promoting the fidelity of non-homologous end joining","publication_year":2024,"publication_date":"2024-02-10","ids":{"openalex":"https://openalex.org/W4391719084","doi":"https://doi.org/10.1038/s41467-024-45553-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/38341432","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10858965"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-024-45553-z","doi":"https://doi.org/10.1038/s41467-024-45553-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-45553-z","pdf_url":"https://www.nature.com/articles/s41467-024-45553-z.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-024-45553-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063556205","display_name":"Benjamin M. Stinson","orcid":"https://orcid.org/0000-0002-3845-8012","observed_orcids":["https://orcid.org/0000-0002-3845-8012"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin M. Stinson","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA","Howard Hughes Medical Institute, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068203539","display_name":"Sean M. Carney","orcid":"https://orcid.org/0000-0002-2674-1064","observed_orcids":["https://orcid.org/0000-0002-2674-1064"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean M. Carney","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080203458","display_name":"Johannes C. Walter","orcid":"https://orcid.org/0000-0002-4186-7570","observed_orcids":["https://orcid.org/0000-0002-4186-7570"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Johannes C. Walter","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA. johannes_walter@hms.harvard.edu","Howard Hughes Medical Institute, Boston, MA, 02115, USA. johannes_walter@hms.harvard.edu","Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA"],"raw_orcid":"https://orcid.org/0000-0002-4186-7570","affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA. johannes_walter@hms.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Boston, MA, 02115, USA. johannes_walter@hms.harvard.edu","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047415642","display_name":"Joseph J. Loparo","orcid":"https://orcid.org/0000-0003-4941-4696","observed_orcids":["https://orcid.org/0000-0003-4941-4696"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph J. Loparo","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA. joseph_loparo@hms.harvard.edu","Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA"],"raw_orcid":"https://orcid.org/0000-0003-4941-4696","affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA. joseph_loparo@hms.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047415642","https://openalex.org/A5080203458"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"],"apc_list":{"value":6790,"currency":"USD","value_usd":6790},"apc_paid":{"value":6790,"currency":"USD","value_usd":6790},"fwci":2.717,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.91757285,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"1250","last_page":"1250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-ligase-iv","display_name":"DNA ligase IV","score":0.9200000166893005},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9990000128746033},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.9700000286102295},{"id":"https://openalex.org/keywords/dna-end-binding","display_name":"DNA end binding","score":0.753000020980835},{"id":"https://openalex.org/keywords/error-prone-polymerase","display_name":"error-prone polymerase","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.8838909864425659},{"id":"https://openalex.org/C179437574","wikidata":"https://www.wikidata.org/wiki/Q15089798","display_name":"Ligation","level":2,"score":0.6569119095802307},{"id":"https://openalex.org/C2908738455","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA Ligases","level":4,"score":0.6240306496620178},{"id":"https://openalex.org/C122917832","wikidata":"https://www.wikidata.org/wiki/Q2065945","display_name":"Non-homologous end joining","level":4,"score":0.6225610971450806},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5727697014808655},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.4799078404903412},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4507293403148651},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44466957449913025},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4282044470310211},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3871018886566162},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37132519483566284},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35027727484703064},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3476043939590454}],"mesh":[{"descriptor_ui":"D000072481","descriptor_name":"DNA Ligase ATP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011088","descriptor_name":"DNA Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059766","descriptor_name":"DNA End-Joining Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-024-45553-z","doi":"https://doi.org/10.1038/s41467-024-45553-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-45553-z","pdf_url":"https://www.nature.com/articles/s41467-024-45553-z.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2022.10.26.513880","doi":"https://doi.org/10.1101/2022.10.26.513880","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.10.26.513880","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/10/26/2022.10.26.513880.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10858965","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10858965","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10858965/pdf/41467_2024_Article_45553.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:38341432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38341432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45553-z","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-024-45553-z","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:7f144421046948c4965c6d45b0ca0c4a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7f144421046948c4965c6d45b0ca0c4a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-024-45553-z","doi":"https://doi.org/10.1038/s41467-024-45553-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-45553-z","pdf_url":"https://www.nature.com/articles/s41467-024-45553-z.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1562788791","display_name":null,"funder_award_id":"R01GM115487","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G1780898055","display_name":"Visualizing DNA break repair: single-molecule studies of non-homologous end joining","funder_award_id":"R01GM115487","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391719084.pdf","grobid_xml":"https://content.openalex.org/works/W4391719084.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W142384410","https://openalex.org/W1987988513","https://openalex.org/W1999037466","https://openalex.org/W2013580891","https://openalex.org/W2028128317","https://openalex.org/W2034880487","https://openalex.org/W2051148032","https://openalex.org/W2057636694","https://openalex.org/W2072868547","https://openalex.org/W2079991169","https://openalex.org/W2082910780","https://openalex.org/W2096782300","https://openalex.org/W2102603170","https://openalex.org/W2118844567","https://openalex.org/W2121070277","https://openalex.org/W2133674300","https://openalex.org/W2142844453","https://openalex.org/W2143842681","https://openalex.org/W2158099110","https://openalex.org/W2160752868","https://openalex.org/W2162412306","https://openalex.org/W2168493348","https://openalex.org/W2297808341","https://openalex.org/W2560312390","https://openalex.org/W2612348275","https://openalex.org/W2614950905","https://openalex.org/W2745840994","https://openalex.org/W2754135562","https://openalex.org/W2798263777","https://openalex.org/W2804261193","https://openalex.org/W2810963777","https://openalex.org/W2888681388","https://openalex.org/W2891034002","https://openalex.org/W2955620588","https://openalex.org/W2995349514","https://openalex.org/W3080185191","https://openalex.org/W3112685950","https://openalex.org/W3114767519","https://openalex.org/W3127347270","https://openalex.org/W3155078366","https://openalex.org/W3187829407","https://openalex.org/W4200540683","https://openalex.org/W4306871069"],"related_works":["https://openalex.org/W2995349514","https://openalex.org/W2754135562","https://openalex.org/W4385652349","https://openalex.org/W2007451306","https://openalex.org/W2560312390","https://openalex.org/W2057636694","https://openalex.org/W4306871069","https://openalex.org/W2038596673","https://openalex.org/W7112444368","https://openalex.org/W3203755377"],"abstract_inverted_index":{"Nonhomologous":[0],"end":[1,53,59,84],"joining":[2],"(NHEJ),":[3],"the":[4,63,94,101,122,138,155,168],"primary":[5],"pathway":[6],"of":[7,78,93,140,154,170],"vertebrate":[8],"DNA":[9,16,71,96,118,135],"double-strand-break":[10],"(DSB)":[11],"repair,":[12],"directly":[13],"re-ligates":[14],"broken":[15],"ends.":[17],"Damaged":[18],"DSB":[19,41],"ends":[20,42,80,119,136,150],"that":[21,43,68,104,114,129],"cannot":[22],"be":[23],"immediately":[24],"re-ligated":[25],"are":[26,44,49],"modified":[27],"by":[28],"NHEJ":[29,109],"processing":[30,60],"enzymes,":[31],"including":[32],"error-prone":[33,159],"polymerases":[34],"and":[35,58,107],"nucleases,":[36],"to":[37,120,147],"enable":[38],"ligation.":[39],"However,":[40],"initially":[45],"compatible":[46,79,149],"for":[47,167],"re-ligation":[48],"typically":[50],"joined":[51],"without":[52],"processing.":[54,85,160],"As":[55],"both":[56,134],"ligation":[57,77,106],"occur":[61],"in":[62],"short-range":[64],"(SR)":[65],"synaptic":[66],"complex":[67,103,157],"closely":[69],"aligns":[70],"ends,":[72],"it":[73],"remains":[74],"unclear":[75],"how":[76],"is":[81,145],"prioritized":[82],"over":[83],"In":[86],"this":[87],"study,":[88],"we":[89],"identify":[90],"structural":[91],"interactions":[92],"NHEJ-specific":[95],"Ligase":[97],"IV":[98],"(Lig4)":[99],"within":[100],"SR":[102,123,141,156],"prioritize":[105],"promote":[108],"fidelity.":[110],"Mutational":[111],"analysis":[112],"demonstrates":[113],"Lig4":[115,132,144],"must":[116],"bind":[117],"form":[121],"complex.":[124],"Furthermore,":[125],"single-molecule":[126],"experiments":[127],"show":[128],"a":[130,164],"single":[131],"binds":[133],"at":[137],"instant":[139],"synapsis.":[142],"Thus,":[143],"poised":[146],"ligate":[148],"upon":[151],"initial":[152],"formation":[153],"before":[158],"Our":[161],"results":[162],"provide":[163],"molecular":[165],"basis":[166],"fidelity":[169],"NHEJ.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-02-11T00:00:00"}
