{"id":"https://openalex.org/W4391699208","doi":"https://doi.org/10.35975/apic.v27i3.2230","title":"Preemptive analgesia with tapentadol in inguinal surgery; a randomized controlled trial","display_name":"Preemptive analgesia with tapentadol in inguinal surgery; a randomized controlled trial","publication_year":2023,"publication_date":"2023-06-02","ids":{"openalex":"https://openalex.org/W4391699208","doi":"https://doi.org/10.35975/apic.v27i3.2230"},"language":"en","primary_location":{"id":"doi:10.35975/apic.v27i3.2230","doi":"https://doi.org/10.35975/apic.v27i3.2230","is_oa":true,"landing_page_url":"http://dx.doi.org/10.35975/apic.v27i3.2230","pdf_url":"https://www.apicareonline.com/index.php/APIC/article/download/2230/3354","source":{"id":"https://openalex.org/S4210188766","display_name":"Anaesthesia Pain & Intensive Care","issn_l":"1607-8322","issn":["1607-8322","2220-5799"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319305","host_organization_name":"Anaesthesia, Pain & Intensive Care","host_organization_lineage":["https://openalex.org/P4310319305"],"host_organization_lineage_names":["Anaesthesia, Pain & Intensive Care"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia, Pain &amp; Intensive Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.apicareonline.com/index.php/APIC/article/download/2230/3354","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028474330","display_name":"Prasanna Vadhanan C","orcid":"https://orcid.org/0000-0001-6060-3880","observed_orcids":["https://orcid.org/0000-0001-6060-3880"]},"institutions":[{"id":"https://openalex.org/I175548057","display_name":"Vinayaka Missions University","ror":"https://ror.org/03wt62c10","country_code":"IN","type":"education","lineage":["https://openalex.org/I175548057"]},{"id":"https://openalex.org/I4210138697","display_name":"Vinayaka Missions Medical College and Hospitals","ror":"https://ror.org/04p18ec14","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210138697"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prasanna Vadhanan","raw_affiliation_strings":["Department of Anesthesiology, Vinayaka Missions Medical College, Vinayaka Missions Research Foundation, Karaikal, India 609609;","Department of Anesthesiology, Vinayaka Missions Medical College, Karaikal, lndia 609609;","Vinayaka Mission KV Medical College, Salem, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Vinayaka Missions Medical College, Vinayaka Missions Research Foundation, Karaikal, India 609609;","institution_ids":["https://openalex.org/I175548057","https://openalex.org/I4210138697"]},{"raw_affiliation_string":"Department of Anesthesiology, Vinayaka Missions Medical College, Karaikal, lndia 609609;","institution_ids":["https://openalex.org/I4210138697"]},{"raw_affiliation_string":"Vinayaka Mission KV Medical College, Salem, India;","institution_ids":["https://openalex.org/I4210138697"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Iniya Rajendran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175548057","display_name":"Vinayaka Missions University","ror":"https://ror.org/03wt62c10","country_code":"IN","type":"education","lineage":["https://openalex.org/I175548057"]},{"id":"https://openalex.org/I4210138697","display_name":"Vinayaka Missions Medical College and Hospitals","ror":"https://ror.org/04p18ec14","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210138697"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Iniya Rajendran","raw_affiliation_strings":["Department of Anesthesiology, Vinayaka Missions Medical College, Vinayaka Missions Research Foundation, Karaikal, India 609609;","Department of Anesthesiology, Vinayaka Missions Medical College, Karaikal, lndia 609609;","Vinayaka Mission KV Medical College, Salem, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Vinayaka Missions Medical College, Vinayaka Missions Research Foundation, Karaikal, India 609609;","institution_ids":["https://openalex.org/I175548057","https://openalex.org/I4210138697"]},{"raw_affiliation_string":"Department of Anesthesiology, Vinayaka Missions Medical College, Karaikal, lndia 609609;","institution_ids":["https://openalex.org/I4210138697"]},{"raw_affiliation_string":"Vinayaka Mission KV Medical College, Salem, India;","institution_ids":["https://openalex.org/I4210138697"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101366830","display_name":"Vinith Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175548057","display_name":"Vinayaka Missions University","ror":"https://ror.org/03wt62c10","country_code":"IN","type":"education","lineage":["https://openalex.org/I175548057"]},{"id":"https://openalex.org/I4210138697","display_name":"Vinayaka Missions Medical College and Hospitals","ror":"https://ror.org/04p18ec14","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210138697"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vinith Kumar","raw_affiliation_strings":["Department of Anesthesiology, Vinayaka Missions Medical College, Karaikal, lndia 609609;","Department of Anesthesiology, Vinayaka Missions Medical College, Vinayaka Missions Research Foundation, Karaikal, India 609609;","Vinayaka Mission KV Medical College, Salem, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Vinayaka Missions Medical College, Karaikal, lndia 609609;","institution_ids":["https://openalex.org/I4210138697"]},{"raw_affiliation_string":"Department of Anesthesiology, Vinayaka Missions Medical College, Vinayaka Missions Research Foundation, Karaikal, India 609609;","institution_ids":["https://openalex.org/I175548057","https://openalex.org/I4210138697"]},{"raw_affiliation_string":"Vinayaka Mission KV Medical College, Salem, India;","institution_ids":["https://openalex.org/I4210138697"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":190,"currency":"USD","value_usd":190},"apc_paid":{"value":190,"currency":"USD","value_usd":190},"fwci":0.2811,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.47579032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"27","issue":"3","first_page":"356","last_page":"359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preemptive-analgesia","display_name":"preemptive analgesia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tapentadol","display_name":"tapentadol","score":1.0},{"id":"https://openalex.org/keywords/inguinal-hernia-repair","display_name":"inguinal hernia repair","score":0.9909999966621399},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.9210000038146973},{"id":"https://openalex.org/keywords/analgesic-use","display_name":"analgesic use","score":0.8579999804496765},{"id":"https://openalex.org/keywords/diclofenac","display_name":"diclofenac","score":0.9750000238418579},{"id":"https://openalex.org/keywords/spinal-anesthesia","display_name":"spinal anesthesia","score":0.9390000104904175},{"id":"https://openalex.org/keywords/central-sensitization","display_name":"central sensitization","score":0.8700000047683716},{"id":"https://openalex.org/keywords/opioid-analgesics","display_name":"opioid analgesics","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2780505013","wikidata":"https://www.wikidata.org/wiki/Q414463","display_name":"Tapentadol","level":4,"score":0.9139623641967773},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.7937296628952026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7745660543441772},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5506429672241211},{"id":"https://openalex.org/C2781132756","wikidata":"https://www.wikidata.org/wiki/Q1144039","display_name":"Inguinal hernia","level":3,"score":0.47453224658966064},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3922067880630493},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.297783762216568},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10509049892425537},{"id":"https://openalex.org/C2779096551","wikidata":"https://www.wikidata.org/wiki/Q133076","display_name":"Hernia","level":2,"score":0.0708351731300354},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.35975/apic.v27i3.2230","doi":"https://doi.org/10.35975/apic.v27i3.2230","is_oa":true,"landing_page_url":"http://dx.doi.org/10.35975/apic.v27i3.2230","pdf_url":"https://www.apicareonline.com/index.php/APIC/article/download/2230/3354","source":{"id":"https://openalex.org/S4210188766","display_name":"Anaesthesia Pain & Intensive Care","issn_l":"1607-8322","issn":["1607-8322","2220-5799"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319305","host_organization_name":"Anaesthesia, Pain & Intensive Care","host_organization_lineage":["https://openalex.org/P4310319305"],"host_organization_lineage_names":["Anaesthesia, Pain & Intensive Care"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia, Pain &amp; Intensive Care","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.35975/apic.v27i3.2230","doi":"https://doi.org/10.35975/apic.v27i3.2230","is_oa":true,"landing_page_url":"http://dx.doi.org/10.35975/apic.v27i3.2230","pdf_url":"https://www.apicareonline.com/index.php/APIC/article/download/2230/3354","source":{"id":"https://openalex.org/S4210188766","display_name":"Anaesthesia Pain & Intensive Care","issn_l":"1607-8322","issn":["1607-8322","2220-5799"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319305","host_organization_name":"Anaesthesia, Pain & Intensive Care","host_organization_lineage":["https://openalex.org/P4310319305"],"host_organization_lineage_names":["Anaesthesia, Pain & Intensive Care"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia, Pain &amp; Intensive Care","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391699208.pdf","grobid_xml":"https://content.openalex.org/works/W4391699208.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1809058072","https://openalex.org/W2042809547","https://openalex.org/W2043727245","https://openalex.org/W2113642820","https://openalex.org/W2158017724","https://openalex.org/W2558963827","https://openalex.org/W2795874757","https://openalex.org/W2923860713","https://openalex.org/W2965490057","https://openalex.org/W3003729541","https://openalex.org/W3121829725","https://openalex.org/W3206427016","https://openalex.org/W4328111571"],"related_works":["https://openalex.org/W7137344332","https://openalex.org/W4283716283","https://openalex.org/W1994663176","https://openalex.org/W2159343331","https://openalex.org/W4256044427","https://openalex.org/W4389050428","https://openalex.org/W4415760118","https://openalex.org/W4312998349","https://openalex.org/W2558963827","https://openalex.org/W7098640727"],"abstract_inverted_index":{"Background":[0],"&":[1],"Objective:":[2],"Preemptive":[3,199,236],"analgesia":[4,59,116,237],"aims":[5],"at":[6],"minimizing":[7,205],"the":[8,51,112,121,131,164,175],"development":[9],"of":[10,45,53,85,114,168],"central":[11],"sensitization":[12],"thereby":[13],"decreasing":[14],"postoperative":[15,58,115,123,206],"pain":[16,207,248],"and":[17,60,93,111,117,163,208],"analgesic":[18,34,61,118,139,166,209],"requirements.":[19],"Various":[20],"drugs":[21],"have":[22],"been":[23],"used":[24],"for":[25,137,204],"this":[26,46],"purpose.":[27],"Tapentadol,":[28],"is":[29,36,202],"a":[30,243],"newer":[31],"centrally":[32],"acting":[33],"which":[35],"effective":[37,203],"in":[38,63,120,144,174,195,211,240],"moderate":[39],"to":[40,49,149],"severe":[41],"pain.":[42],"The":[43],"aim":[44],"study":[47],"was":[48,125,128,141,170],"analyze":[50],"effect":[52],"preoperative":[54],"oral":[55,200],"tapentadol":[56,97,201,239],"upon":[57],"requirements":[62],"patients":[64,73,107,132,212],"undergoing":[65,74,213],"inguinal":[66,77,214,241],"hernia":[67,78,215],"surgeries.":[68],"Methodology:":[69],"One":[70],"hundred":[71],"adult":[72],"elective":[75],"unilateral":[76],"repair":[79],"were":[80,193],"randomized":[81,244],"into":[82],"two":[83],"groups":[84],"fifty":[86],"each.":[87],"Group":[88,94,145,150],"P":[89,151,160,187],"received":[90,96,108],"placebo":[91,176],"tablets":[92,100],"T":[95,146],"(100":[98],"mg)":[99],"orally":[101],"30":[102],"min":[103],"before":[104],"anesthesia.":[105,219],"All":[106],"spinal":[109,218],"anesthesia":[110],"duration":[113],"consumption":[119,167],"first":[122,138],"day":[124],"recorded.":[126],"Diclofenac":[127],"administered":[129],"when":[130],"demanded":[133],"analgesia.":[134],"Results:":[135],"Time":[136],"demand":[140],"significantly":[142],"delayed":[143],"as":[147],"compared":[148],"(328.00":[152],"\u00b1":[153,157,179,184],"129.71":[154],"vs.":[155,182],"252.00":[156],"101.38":[158],"min,":[159],"=":[161,188],"0.017)":[162],"total":[165],"diclofenac":[169],"also":[171],"less":[172],"than":[173],"group":[177],"(73.33":[178],"28.57":[180],"mg":[181],"95.00":[183],"31.30":[185],"mg;":[186],"0.006).":[189],"No":[190],"adverse":[191],"events":[192],"observed":[194],"either":[196],"group.":[197],"Conclusion:":[198],"requirement":[210],"surgeries":[216],"under":[217],"Key":[220],"words:":[221],"Anesthesia,":[222],"Spinal;":[223],"Tapentadol;":[224],"Hernia":[225],"surgery;":[226,242],"Analgesia,":[227],"Postoperative":[228],"Citation:":[229],"Vadhanan":[230],"P,":[231],"Rajendran":[232],"I,":[233],"Kumar":[234],"V.":[235],"with":[238],"controlled":[245],"trial.":[246],"Anaesth.":[247],"intensive":[249],"care":[250],"2023;27(3):356\u2212359;":[251],"DOI:":[252],"10.35975/apic.v27i3.2230":[253],"Received:":[254],"April":[255,259],"15,":[256],"2023;":[257,261],"Reviewed:":[258],"29,":[260],"Accepted:":[262],"May":[263],"10,":[264],"2023":[265]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2024-02-10T00:00:00"}
