{"id":"https://openalex.org/W4391679406","doi":"https://doi.org/10.3390/biology13020110","title":"CEBPA Overexpression Enhances \u03b2-Cell Proliferation and Survival","display_name":"CEBPA Overexpression Enhances \u03b2-Cell Proliferation and Survival","publication_year":2024,"publication_date":"2024-02-09","ids":{"openalex":"https://openalex.org/W4391679406","doi":"https://doi.org/10.3390/biology13020110","pmid":"https://pubmed.ncbi.nlm.nih.gov/38392328","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10887016"},"language":"en","primary_location":{"id":"doi:10.3390/biology13020110","doi":"https://doi.org/10.3390/biology13020110","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology13020110","pdf_url":"https://www.mdpi.com/2079-7737/13/2/110/pdf?version=1707472295","source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-7737/13/2/110/pdf?version=1707472295","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103209669","display_name":"Peter N Ellsworth","orcid":"https://orcid.org/0009-0002-0630-5860","observed_orcids":["https://orcid.org/0009-0002-0630-5860"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter N. Ellsworth","raw_affiliation_strings":["Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102807617","display_name":"Jacob A. Herring","orcid":"https://orcid.org/0000-0002-0084-1091","observed_orcids":["https://orcid.org/0000-0002-0084-1091"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob A. Herring","raw_affiliation_strings":["Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA","Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":"https://orcid.org/0000-0002-0084-1091","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]},{"raw_affiliation_string":"Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033905067","display_name":"Aaron H. Leifer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron H. Leifer","raw_affiliation_strings":["Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000087495","display_name":"Jason D. Ray","orcid":"https://orcid.org/0000-0002-2675-2679","observed_orcids":["https://orcid.org/0000-0002-2675-2679"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason D. Ray","raw_affiliation_strings":["Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023223592","display_name":"Weston S. Elison","orcid":"https://orcid.org/0000-0002-5496-2972","observed_orcids":["https://orcid.org/0000-0002-5496-2972"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weston S. Elison","raw_affiliation_strings":["Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029412674","display_name":"Peter Daniel Poulson","orcid":"https://orcid.org/0000-0002-1471-1378","observed_orcids":["https://orcid.org/0000-0002-1471-1378"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Daniel Poulson","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":"https://orcid.org/0000-0002-1471-1378","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018668404","display_name":"Jacqueline E. Crabtree","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline E. Crabtree","raw_affiliation_strings":["Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018931849","display_name":"Pam M. Van Ry","orcid":"https://orcid.org/0000-0003-0195-7229","observed_orcids":["https://orcid.org/0000-0003-0195-7229"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pam M. Van Ry","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023893268","display_name":"Jeffery S. Tessem","orcid":"https://orcid.org/0000-0003-3081-3187","observed_orcids":["https://orcid.org/0000-0003-3081-3187"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffery S. Tessem","raw_affiliation_strings":["Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":"https://orcid.org/0000-0003-3081-3187","affiliations":[{"raw_affiliation_string":"Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023893268"],"corresponding_institution_ids":["https://openalex.org/I100005738"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3069},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3069},"fwci":2.3153,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.88212101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"13","issue":"2","first_page":"110","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cebpa","display_name":"CEBPA","score":0.9919999837875366},{"id":"https://openalex.org/keywords/nkx6-1","display_name":"NKX6.1","score":0.949999988079071},{"id":"https://openalex.org/keywords/beta-cell-proliferation","display_name":"beta-cell proliferation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/beta-cell-survival","display_name":"beta-cell survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/beta-cell-mass","display_name":"beta-cell mass","score":0.7450000047683716},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.6790000200271606},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8650000095367432},{"id":"https://openalex.org/keywords/thapsigargin","display_name":"thapsigargin","score":0.9010000228881836},{"id":"https://openalex.org/keywords/ire1alpha","display_name":"IRE1\u03b1","score":0.7689999938011169},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.8640000224113464},{"id":"https://openalex.org/keywords/nr4a1","display_name":"Nur77","score":0.7960000038146973},{"id":"https://openalex.org/keywords/nr4a3","display_name":"NR4A3","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bzip-transcription-factors","display_name":"bZIP transcription factors","score":0.5879999995231628},{"id":"https://openalex.org/keywords/ins-1-832-13-cells","display_name":"INS-1 832/13 cells","score":0.847000002861023},{"id":"https://openalex.org/keywords/islets","display_name":"islets","score":0.5870000123977661},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8169999718666077},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0}],"concepts":[{"id":"https://openalex.org/C45091340","wikidata":"https://www.wikidata.org/wiki/Q17861031","display_name":"CEBPA","level":4,"score":0.8790228366851807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8702110052108765},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7403045892715454},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7096216082572937},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5615759491920471},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5523157119750977},{"id":"https://openalex.org/C149240914","wikidata":"https://www.wikidata.org/wiki/Q907967","display_name":"Ccaat-enhancer-binding proteins","level":5,"score":0.504114031791687},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3520249128341675},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20816195011138916},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.1658918857574463},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11801663041114807}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/biology13020110","doi":"https://doi.org/10.3390/biology13020110","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology13020110","pdf_url":"https://www.mdpi.com/2079-7737/13/2/110/pdf?version=1707472295","source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10887016","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10887016","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10887016/pdf/biology-13-00110.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology (Basel)","raw_type":"Text"},{"id":"pmid:38392328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38392328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt5fj371c5","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/5fj371c5","pdf_url":"https://escholarship.org/content/qt5fj371c5/qt5fj371c5.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology, vol 13, iss 2","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:acccf53dc7734d41840047ae1c3c5757","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/acccf53dc7734d41840047ae1c3c5757","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology, Vol 13, Iss 2, p 110 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biology13020110","doi":"https://doi.org/10.3390/biology13020110","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology13020110","pdf_url":"https://www.mdpi.com/2079-7737/13/2/110/pdf?version=1707472295","source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1612322819","display_name":null,"funder_award_id":"1-17-IBS-101","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3479060862","display_name":null,"funder_award_id":"1-17-IBS-101","funder_id":"https://openalex.org/F4320306089","funder_display_name":"American Diabetes Association"},{"id":"https://openalex.org/G6108603219","display_name":null,"funder_award_id":"R15DK124835","funder_id":"https://openalex.org/F4320306089","funder_display_name":"American Diabetes Association"},{"id":"https://openalex.org/G8595492468","display_name":"Sex dependent function of the orphan nuclear receptor Nr4a1 in the pancreatic beta cell during Type 2 Diabetes disease progression","funder_award_id":"R15DK124835","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391679406.pdf","grobid_xml":"https://content.openalex.org/works/W4391679406.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1794958687","https://openalex.org/W1914885977","https://openalex.org/W1964269036","https://openalex.org/W1967205770","https://openalex.org/W1975905680","https://openalex.org/W1976862841","https://openalex.org/W1980964148","https://openalex.org/W1981114929","https://openalex.org/W1992319922","https://openalex.org/W1996302662","https://openalex.org/W1997520810","https://openalex.org/W2005205763","https://openalex.org/W2011334284","https://openalex.org/W2020437934","https://openalex.org/W2020649739","https://openalex.org/W2039420809","https://openalex.org/W2040381793","https://openalex.org/W2086915316","https://openalex.org/W2089198803","https://openalex.org/W2095767079","https://openalex.org/W2101951807","https://openalex.org/W2114360920","https://openalex.org/W2122220050","https://openalex.org/W2125871871","https://openalex.org/W2141351124","https://openalex.org/W2142389014","https://openalex.org/W2146846877","https://openalex.org/W2151058113","https://openalex.org/W2157959243","https://openalex.org/W2162695817","https://openalex.org/W2163616479","https://openalex.org/W2164256676","https://openalex.org/W2164599211","https://openalex.org/W2165384604","https://openalex.org/W2167165077","https://openalex.org/W2278493779","https://openalex.org/W2363193728","https://openalex.org/W2403241282","https://openalex.org/W2612212442","https://openalex.org/W2784201854","https://openalex.org/W2897677997","https://openalex.org/W2904492066","https://openalex.org/W2986002996","https://openalex.org/W3110637847","https://openalex.org/W3136988459","https://openalex.org/W3196353619","https://openalex.org/W4200221840","https://openalex.org/W4213180837","https://openalex.org/W4220904119","https://openalex.org/W4362521994","https://openalex.org/W6786741898"],"related_works":["https://openalex.org/W4378674460","https://openalex.org/W4389020555","https://openalex.org/W7045968091","https://openalex.org/W7112852399","https://openalex.org/W3177471423","https://openalex.org/W3176938818","https://openalex.org/W2163616479","https://openalex.org/W4389025420","https://openalex.org/W2363193728","https://openalex.org/W2772482495"],"abstract_inverted_index":{"A":[0],"commonality":[1],"between":[2],"type":[3,6],"1":[4],"and":[5,23,41,47,55,72,92,152],"2":[7],"diabetes":[8],"is":[9,24,76,85,141],"the":[10,42,67,101,128,154],"decline":[11],"in":[12,64,113,121,127],"functional":[13,145],"\u03b2-cell":[14,21,28,51,91,146,150],"mass.":[15],"The":[16],"transcription":[17,69],"factor":[18,70],"Nkx6.1":[19,35,61],"regulates":[20],"development":[22],"integral":[25],"for":[26],"proper":[27],"function.":[29],"We":[30,108],"have":[31],"previously":[32],"demonstrated":[33],"that":[34,60,73,110,139],"depends":[36],"on":[37],"c-Fos":[38,79],"mediated":[39],"upregulation":[40,65],"nuclear":[43],"hormone":[44],"receptors":[45],"Nr4a1":[46],"Nr4a3":[48],"to":[49,87,115,143],"increase":[50],"insulin":[52],"secretion,":[53],"survival,":[54],"replication.":[56],"Here,":[57],"we":[58],"demonstrate":[59,109],"overexpression":[62,84,98],"results":[63],"of":[66,78,103,123],"bZip":[68],"CEBPA":[71,74,83,97,140],"expression":[75,122],"independent":[77],"regulation.":[80],"In":[81],"turn,":[82],"sufficient":[86,142],"enhance":[88,144],"INS-1":[89],"832/13":[90],"primary":[93],"rat":[94],"islet":[95],"proliferation.":[96],"also":[99],"increases":[100],"survival":[102,112],"\u03b2-cells":[104],"treated":[105],"with":[106,119],"thapsigargin.":[107],"increased":[111],"response":[114],"ER":[116],"stress":[117],"corresponds":[118],"changes":[120],"various":[124],"genes":[125],"involved":[126],"unfolded":[129,155],"protein":[130,156],"response,":[131],"including":[132],"decreased":[133],"Ire1a":[134],"expression.":[135],"These":[136],"data":[137],"show":[138],"mass":[147],"by":[148],"increasing":[149],"proliferation":[151],"modulating":[153],"response.":[157]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2024-02-10T00:00:00"}