{"id":"https://openalex.org/W4391658752","doi":"https://doi.org/10.1016/j.bpj.2023.11.2326","title":"Ca2+-mediated synaptotagmin C2 domain binding to target membranes changes the physical properties of the lipid bilayer","display_name":"Ca2+-mediated synaptotagmin C2 domain binding to target membranes changes the physical properties of the lipid bilayer","publication_year":2024,"publication_date":"2024-02-01","ids":{"openalex":"https://openalex.org/W4391658752","doi":"https://doi.org/10.1016/j.bpj.2023.11.2326"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2023.11.2326","doi":"https://doi.org/10.1016/j.bpj.2023.11.2326","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2023.11.2326","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.bpj.2023.11.2326","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057271812","display_name":"Volker Kiessling","orcid":"https://orcid.org/0000-0002-9388-5703","observed_orcids":["https://orcid.org/0000-0002-9388-5703"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Volker Kiessling","raw_affiliation_strings":["Department of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055081143","display_name":"Connor R. Sandall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connor R. Sandall","raw_affiliation_strings":["Department of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018864949","display_name":"Akosua P. Ofosuhene","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akosua Ofosuhene","raw_affiliation_strings":["Department of Chemistry, University of Virginia, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Virginia, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080750032","display_name":"Mark A. B. Kreutzberger","orcid":"https://orcid.org/0000-0002-1269-2089","observed_orcids":["https://orcid.org/0000-0002-1269-2089"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A.B. Kreutzberger","raw_affiliation_strings":["Department of Biochemistry, University of Virginia, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Virginia, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063148645","display_name":"Weronika Tomaka","orcid":"https://orcid.org/0009-0009-3742-4214","observed_orcids":["https://orcid.org/0009-0009-3742-4214"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weronika Tomaka","raw_affiliation_strings":["Department of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077004323","display_name":"M. Neal Waxham","orcid":"https://orcid.org/0000-0003-4801-1190","observed_orcids":["https://orcid.org/0000-0003-4801-1190"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal Waxham","raw_affiliation_strings":["Department of Neurobiology, McGovern Medical School, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, McGovern Medical School, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015058477","display_name":"Frederick A. Heberle","orcid":"https://orcid.org/0000-0002-0424-3240","observed_orcids":["https://orcid.org/0000-0002-0424-3240"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick A. Heberle","raw_affiliation_strings":["Department of Chemistry, University of Tennessee, Knoxville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Tennessee, Knoxville, TN, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028973291","display_name":"David S. Cafiso","orcid":"https://orcid.org/0000-0002-3813-8721","observed_orcids":["https://orcid.org/0000-0002-3813-8721"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Cafiso","raw_affiliation_strings":["Department of Chemistry, University of Virginia, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Virginia, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021277644","display_name":"Lukas K. Tamm","orcid":"https://orcid.org/0000-0002-1674-4464","observed_orcids":["https://orcid.org/0000-0002-1674-4464"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lukas K. Tamm","raw_affiliation_strings":["Department of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I2799765794"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01681369,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"123","issue":"3","first_page":"381a","last_page":"381a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.1387999951839447,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synaptotagmin-1","display_name":"synaptotagmin-1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/c2-domain","display_name":"C2 domain","score":0.9620000123977661},{"id":"https://openalex.org/keywords/calcium-binding","display_name":"calcium binding","score":0.7149999737739563},{"id":"https://openalex.org/keywords/membrane-perturbation","display_name":"membrane perturbation","score":0.527999997138977},{"id":"https://openalex.org/keywords/syntaxin-1a","display_name":"syntaxin 1A","score":0.796999990940094},{"id":"https://openalex.org/keywords/snare-proteins","display_name":"SNARE proteins","score":0.7390000224113464},{"id":"https://openalex.org/keywords/linker-conformation","display_name":"linker conformation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/membrane-fusion","display_name":"membrane fusion","score":0.7580000162124634},{"id":"https://openalex.org/keywords/fluorescence-anisotropy","display_name":"fluorescence anisotropy","score":0.8130000233650208},{"id":"https://openalex.org/keywords/lipid-packing","display_name":"lipid packing","score":0.3930000066757202},{"id":"https://openalex.org/keywords/acyl-chain-saturation","display_name":"acyl chain saturation","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C86473631","wikidata":"https://www.wikidata.org/wiki/Q18031809","display_name":"Synaptotagmin 1","level":5,"score":0.8642569780349731},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.7041509747505188},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5901004672050476},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.543144166469574},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.520825982093811},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.506758987903595},{"id":"https://openalex.org/C143840085","wikidata":"https://www.wikidata.org/wiki/Q5008102","display_name":"C2 domain","level":3,"score":0.46125543117523193},{"id":"https://openalex.org/C76564549","wikidata":"https://www.wikidata.org/wiki/Q17154515","display_name":"Lipid bilayer phase behavior","level":4,"score":0.4137704372406006},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21919551491737366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14634931087493896},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.08146616816520691},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.04713037610054016}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2023.11.2326","doi":"https://doi.org/10.1016/j.bpj.2023.11.2326","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2023.11.2326","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2023.11.2326","doi":"https://doi.org/10.1016/j.bpj.2023.11.2326","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2023.11.2326","pdf_url":null,"source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4319880440","https://openalex.org/W2050367367","https://openalex.org/W2002239312","https://openalex.org/W2036658478","https://openalex.org/W2026886026","https://openalex.org/W6963841035","https://openalex.org/W2069247643","https://openalex.org/W2019227358","https://openalex.org/W1978472231","https://openalex.org/W2011889479"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-02-09T00:00:00"}