{"id":"https://openalex.org/W4391657147","doi":"https://doi.org/10.1016/j.bpj.2023.11.942","title":"Investigation of HDAC7-MEF2A interactions using molecular simulations","display_name":"Investigation of HDAC7-MEF2A interactions using molecular simulations","publication_year":2024,"publication_date":"2024-02-01","ids":{"openalex":"https://openalex.org/W4391657147","doi":"https://doi.org/10.1016/j.bpj.2023.11.942"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2023.11.942","doi":"https://doi.org/10.1016/j.bpj.2023.11.942","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2023.11.942","pdf_url":"http://www.cell.com/article/S0006349523016429/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349523016429/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Narayan Gautam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155028946","display_name":"Tribhuvan University","ror":"https://ror.org/02rg1r889","country_code":"NP","type":"education","lineage":["https://openalex.org/I155028946"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Narayan Gautam","raw_affiliation_strings":["Central Department of Physics, Tribhuvan University, Kirtipur, Kathmandu, Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Department of Physics, Tribhuvan University, Kirtipur, Kathmandu, Nepal","institution_ids":["https://openalex.org/I155028946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071186045","display_name":"Prem P. Chapagain","orcid":"https://orcid.org/0000-0002-0999-4975","observed_orcids":["https://orcid.org/0000-0002-0999-4975"]},"institutions":[{"id":"https://openalex.org/I19700959","display_name":"Florida International University","ror":"https://ror.org/02gz6gg07","country_code":"US","type":"education","lineage":["https://openalex.org/I19700959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prem P. Chapagain","raw_affiliation_strings":["Department of Physics, Florida International University, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Florida International University, Miami, FL, USA","institution_ids":["https://openalex.org/I19700959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084898918","display_name":"Narayan Prasad Adhikari","orcid":"https://orcid.org/0000-0003-4535-1368","observed_orcids":["https://orcid.org/0000-0003-4535-1368","https://orcid.org/0009-0001-6083-2269"]},"institutions":[{"id":"https://openalex.org/I155028946","display_name":"Tribhuvan University","ror":"https://ror.org/02rg1r889","country_code":"NP","type":"education","lineage":["https://openalex.org/I155028946"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Narayan P. Adhikari","raw_affiliation_strings":["Central Department of Physics, Tribhuvan University, Kirtipur, Kathmandu, Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Department of Physics, Tribhuvan University, Kirtipur, Kathmandu, Nepal","institution_ids":["https://openalex.org/I155028946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042934564","display_name":"Purushottam Babu Tiwari","orcid":"https://orcid.org/0000-0002-3140-0723","observed_orcids":["https://orcid.org/0000-0002-3140-0723"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Purushottam B. Tiwari","raw_affiliation_strings":["Department of Oncology, Georgetown University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Georgetown University, Washington, DC, USA","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01413358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"123","issue":"3","first_page":"136a","last_page":"136a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.03709999844431877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac7","display_name":"HDAC7","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mef2a","display_name":"MEF2A","score":0.9950000047683716},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.925000011920929},{"id":"https://openalex.org/keywords/complex-formation","display_name":"complex formation","score":0.703000009059906},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.8610000014305115},{"id":"https://openalex.org/keywords/salt-bridges","display_name":"salt bridges","score":0.847000002861023},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.8809999823570251},{"id":"https://openalex.org/keywords/amino-acid-residues","display_name":"amino acid residues","score":0.7639999985694885},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.4480000138282776},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C51183755","wikidata":"https://www.wikidata.org/wiki/Q83166919","display_name":"Mef2","level":5,"score":0.7053705453872681},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.6227102875709534},{"id":"https://openalex.org/C30765947","wikidata":"https://www.wikidata.org/wiki/Q899119","display_name":"Salt bridge","level":4,"score":0.603225827217102},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.5721803307533264},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.42515209317207336},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42053383588790894},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.2530791163444519},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.20642361044883728},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19485437870025635},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.15729564428329468},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2023.11.942","doi":"https://doi.org/10.1016/j.bpj.2023.11.942","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2023.11.942","pdf_url":"http://www.cell.com/article/S0006349523016429/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2023.11.942","doi":"https://doi.org/10.1016/j.bpj.2023.11.942","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2023.11.942","pdf_url":"http://www.cell.com/article/S0006349523016429/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391657147.pdf","grobid_xml":"https://content.openalex.org/works/W4391657147.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405289820","https://openalex.org/W4407477983","https://openalex.org/W4411088593","https://openalex.org/W7130616261","https://openalex.org/W4392884147","https://openalex.org/W2121434446","https://openalex.org/W7130600315","https://openalex.org/W2074354557","https://openalex.org/W4410784296","https://openalex.org/W2084595283"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2024-02-09T00:00:00"}