{"id":"https://openalex.org/W4391656494","doi":"https://doi.org/10.1016/j.bpj.2023.11.463","title":"Pathogenic COPA mutations decrease binding of dilysine motifs through allosteric effects","display_name":"Pathogenic COPA mutations decrease binding of dilysine motifs through allosteric effects","publication_year":2024,"publication_date":"2024-02-01","ids":{"openalex":"https://openalex.org/W4391656494","doi":"https://doi.org/10.1016/j.bpj.2023.11.463"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2023.11.463","doi":"https://doi.org/10.1016/j.bpj.2023.11.463","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2023.11.463","pdf_url":"http://www.cell.com/article/S0006349523011633/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349523011633/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008615918","display_name":"\u00c0nna Pavlova","orcid":"https://orcid.org/0000-0002-6527-944X","observed_orcids":["https://orcid.org/0000-0002-6527-944X","https://orcid.org/0000-0002-1553-9012"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Pavlova","raw_affiliation_strings":["Department of Physics, Georgia Tech, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Georgia Tech, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104299839","display_name":"Sasthi C. Mandal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70983195","display_name":"Syracuse University","ror":"https://ror.org/025r5qe02","country_code":"US","type":"education","lineage":["https://openalex.org/I70983195"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sasthi C. Mandal","raw_affiliation_strings":["BioInspired Syracuse and Department of Chemistry, Syracuse University, Syracuse, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioInspired Syracuse and Department of Chemistry, Syracuse University, Syracuse, NY, USA","institution_ids":["https://openalex.org/I70983195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092511255","display_name":"Noa Simchoni","orcid":"https://orcid.org/0000-0002-1093-3950","observed_orcids":["https://orcid.org/0000-0002-1093-3950"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noa Simchoni","raw_affiliation_strings":["Department of Medicine, University of California San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046117875","display_name":"Christopher S. Law","orcid":"https://orcid.org/0009-0005-4516-3844","observed_orcids":["https://orcid.org/0009-0005-4516-3844"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher S. Law","raw_affiliation_strings":["Department of Medicine, University of California San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002050144","display_name":"Atanu Acharya","orcid":"https://orcid.org/0000-0002-6960-7789","observed_orcids":["https://orcid.org/0000-0002-6960-7789"]},"institutions":[{"id":"https://openalex.org/I70983195","display_name":"Syracuse University","ror":"https://ror.org/025r5qe02","country_code":"US","type":"education","lineage":["https://openalex.org/I70983195"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atanu Acharya","raw_affiliation_strings":["BioInspired Syracuse and Department of Chemistry, Syracuse University, Syracuse, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioInspired Syracuse and Department of Chemistry, Syracuse University, Syracuse, NY, USA","institution_ids":["https://openalex.org/I70983195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071460521","display_name":"Anthony K. Shum","orcid":"https://orcid.org/0000-0001-5139-4802","observed_orcids":["https://orcid.org/0000-0001-5139-4802"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony K. Shum","raw_affiliation_strings":["Department of Medicine, University of California San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080510232","display_name":"James C. Gumbart","orcid":"https://orcid.org/0000-0002-1510-7842","observed_orcids":["https://orcid.org/0000-0002-1510-7842"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C. Gumbart","raw_affiliation_strings":["Department of Physics, Georgia Tech, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Georgia Tech, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01674995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"123","issue":"3","first_page":"65a","last_page":"65a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copa","display_name":"COPA","score":0.7620000243186951},{"id":"https://openalex.org/keywords/copa-syndrome","display_name":"COPA syndrome","score":0.9340000152587891},{"id":"https://openalex.org/keywords/peptide-binding","display_name":"peptide binding","score":0.550000011920929},{"id":"https://openalex.org/keywords/allosteric-effects","display_name":"allosteric effects","score":0.9760000109672546},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.6800000071525574},{"id":"https://openalex.org/keywords/pathogenic-variants","display_name":"pathogenic variants","score":0.7020000219345093},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.8484843969345093},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5513314604759216},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5170222520828247},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41735661029815674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3985472619533539},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3851314187049866},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31793686747550964},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29912739992141724},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14036422967910767}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2023.11.463","doi":"https://doi.org/10.1016/j.bpj.2023.11.463","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2023.11.463","pdf_url":"http://www.cell.com/article/S0006349523011633/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2023.11.463","doi":"https://doi.org/10.1016/j.bpj.2023.11.463","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2023.11.463","pdf_url":"http://www.cell.com/article/S0006349523011633/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391656494.pdf","grobid_xml":"https://content.openalex.org/works/W4391656494.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2125123967","https://openalex.org/W2118964280","https://openalex.org/W2120987137","https://openalex.org/W4410274690","https://openalex.org/W2108568833","https://openalex.org/W2971091345","https://openalex.org/W4390579063","https://openalex.org/W4409416136","https://openalex.org/W3120521654","https://openalex.org/W2021204780"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2024-02-09T00:00:00"}
