{"id":"https://openalex.org/W4391647523","doi":"https://doi.org/10.2139/ssrn.4720582","title":"Characterization of the Binding Interaction of the Anti-Malarial Alkaloid Cryptolepine with the Plasma Protein Hsa Under Physiological Conditions Using Multi-Spectroscopic and Molecular Docking Techniques","display_name":"Characterization of the Binding Interaction of the Anti-Malarial Alkaloid Cryptolepine with the Plasma Protein Hsa Under Physiological Conditions Using Multi-Spectroscopic and Molecular Docking Techniques","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4391647523","doi":"https://doi.org/10.2139/ssrn.4720582"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.4720582","doi":"https://doi.org/10.2139/ssrn.4720582","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4720582","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.4720582","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Susmita Chowdhury","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susmita Chowdhury","raw_affiliation_strings":["Independent  - affiliation not provided to SSRN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Independent  - affiliation not provided to SSRN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102614983","display_name":"Tamal Mondal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tamal Mondal","raw_affiliation_strings":["Independent  - affiliation not provided to SSRN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Independent  - affiliation not provided to SSRN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111126523","display_name":"Himal Das","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Himal Das","raw_affiliation_strings":["Independent  - affiliation not provided to SSRN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Independent  - affiliation not provided to SSRN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112980067","display_name":"Rapti Goswami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rapti Goswami","raw_affiliation_strings":["Independent  - affiliation not provided to SSRN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Independent  - affiliation not provided to SSRN","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026675528","display_name":"Suman Das","orcid":"https://orcid.org/0000-0002-4148-1002","observed_orcids":["https://orcid.org/0000-0002-4148-1002"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Suman Das","raw_affiliation_strings":["Independent  - affiliation not provided to SSRN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Independent  - affiliation not provided to SSRN","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5026675528"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryptolepine","display_name":"cryptolepine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/protein-ligand-binding","display_name":"protein-ligand binding","score":0.7390000224113464},{"id":"https://openalex.org/keywords/fluorescence-quenching","display_name":"fluorescence quenching","score":0.8539999723434448},{"id":"https://openalex.org/keywords/static-quenching","display_name":"static quenching","score":0.949999988079071},{"id":"https://openalex.org/keywords/fluorescence-resonance-energy-transfer","display_name":"fluorescence resonance energy transfer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tryptophan","display_name":"tryptophan","score":0.8109999895095825},{"id":"https://openalex.org/keywords/binding-thermodynamics","display_name":"binding thermodynamics","score":0.7440000176429749},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.8301739692687988},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7953476905822754},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.7154123187065125},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.6000533103942871},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5327387452125549},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5051963925361633},{"id":"https://openalex.org/C121745418","wikidata":"https://www.wikidata.org/wiki/Q585536","display_name":"Quenching (fluorescence)","level":3,"score":0.5024540424346924},{"id":"https://openalex.org/C96305047","wikidata":"https://www.wikidata.org/wiki/Q367473","display_name":"F\u00f6rster resonance energy transfer","level":3,"score":0.4864909052848816},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4393691122531891},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.4331277906894684},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.42400503158569336},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.4101334512233734},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32843393087387085},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32303154468536377},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26037678122520447},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16630113124847412},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.12023702263832092},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06331455707550049},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.4720582","doi":"https://doi.org/10.2139/ssrn.4720582","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4720582","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.4720582","doi":"https://doi.org/10.2139/ssrn.4720582","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4720582","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4412736435","https://openalex.org/W4411069428","https://openalex.org/W2984747037","https://openalex.org/W1998598266","https://openalex.org/W2999705722","https://openalex.org/W1995214331","https://openalex.org/W2973209505","https://openalex.org/W2613456894","https://openalex.org/W2978987012","https://openalex.org/W1997539348"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2024-02-09T00:00:00"}
