{"id":"https://openalex.org/W4391646791","doi":"https://doi.org/10.1017/s1047951123004456","title":"Bosentan in the treatment of persistent pulmonary hypertension in newborns: a systematic review and meta-analysis","display_name":"Bosentan in the treatment of persistent pulmonary hypertension in newborns: a systematic review and meta-analysis","publication_year":2024,"publication_date":"2024-02-08","ids":{"openalex":"https://openalex.org/W4391646791","doi":"https://doi.org/10.1017/s1047951123004456","pmid":"https://pubmed.ncbi.nlm.nih.gov/38329072"},"language":"en","primary_location":{"id":"doi:10.1017/s1047951123004456","doi":"https://doi.org/10.1017/s1047951123004456","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s1047951123004456","pdf_url":null,"source":{"id":"https://openalex.org/S159891131","display_name":"Cardiology in the Young","issn_l":"1047-9511","issn":["1047-9511","1467-1107"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology in the Young","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ning Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152107","display_name":"Baoding No.1 Central Hospital","ror":"https://ror.org/022nvaw58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387152107"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Gao","raw_affiliation_strings":["Baoding No.1 Central Hospital","Neonatology Department, Baoding No.1 Central Hospital, Baoding, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baoding No.1 Central Hospital","institution_ids":["https://openalex.org/I4387152107"]},{"raw_affiliation_string":"Neonatology Department, Baoding No.1 Central Hospital, Baoding, China","institution_ids":["https://openalex.org/I4387152107"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuanyuan Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152107","display_name":"Baoding No.1 Central Hospital","ror":"https://ror.org/022nvaw58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387152107"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Lv","raw_affiliation_strings":["Baoding No.1 Central Hospital","Infection control office, Baoding No.1 Central Hospital, Baoding, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baoding No.1 Central Hospital","institution_ids":["https://openalex.org/I4387152107"]},{"raw_affiliation_string":"Infection control office, Baoding No.1 Central Hospital, Baoding, China","institution_ids":["https://openalex.org/I4387152107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000635473","display_name":"Y. Cui","orcid":"https://orcid.org/0009-0005-4458-5279","observed_orcids":["https://orcid.org/0009-0005-4458-5279"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yanbin Cui","raw_affiliation_strings":["Baoding No.3 Central Hospital","Emergency Department, Baoding No.3 Central Hospital, Baoding, China"],"raw_orcid":"https://orcid.org/0009-0005-4458-5279","affiliations":[{"raw_affiliation_string":"Baoding No.3 Central Hospital","institution_ids":[]},{"raw_affiliation_string":"Emergency Department, Baoding No.3 Central Hospital, Baoding, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113115202","display_name":"Pengchun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152107","display_name":"Baoding No.1 Central Hospital","ror":"https://ror.org/022nvaw58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387152107"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengchun Wang","raw_affiliation_strings":["Baoding No.1 Central Hospital","Neonatology Department, Baoding No.1 Central Hospital, Baoding, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baoding No.1 Central Hospital","institution_ids":["https://openalex.org/I4387152107"]},{"raw_affiliation_string":"Neonatology Department, Baoding No.1 Central Hospital, Baoding, China","institution_ids":["https://openalex.org/I4387152107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114734450","display_name":"Xin He","orcid":"https://orcid.org/0009-0006-0421-2803","observed_orcids":["https://orcid.org/0009-0006-0421-2803"]},"institutions":[{"id":"https://openalex.org/I4387152107","display_name":"Baoding No.1 Central Hospital","ror":"https://ror.org/022nvaw58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387152107"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin He","raw_affiliation_strings":["Baoding No.1 Central Hospital","Neonatology Department, Baoding No.1 Central Hospital, Baoding, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baoding No.1 Central Hospital","institution_ids":["https://openalex.org/I4387152107"]},{"raw_affiliation_string":"Neonatology Department, Baoding No.1 Central Hospital, Baoding, China","institution_ids":["https://openalex.org/I4387152107"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000635473"],"corresponding_institution_ids":[],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":null,"fwci":0.599,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.53817896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"34","issue":"6","first_page":"1334","last_page":"1341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.0502999983727932,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12272","display_name":"Cardiovascular Conditions and Treatments","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bosentan","display_name":"bosentan","score":0.9980000257492065},{"id":"https://openalex.org/keywords/persistent-pulmonary-hypertension-of-the-newborn","display_name":"persistent pulmonary hypertension of the newborn","score":0.996999979019165},{"id":"https://openalex.org/keywords/endothelin-receptor-antagonists","display_name":"endothelin receptor antagonists","score":0.906000018119812},{"id":"https://openalex.org/keywords/pulmonary-vascular-resistance","display_name":"pulmonary vascular resistance","score":0.7839999794960022},{"id":"https://openalex.org/keywords/oxygenation","display_name":"oxygenation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.7820000052452087},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.949999988079071},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8190000057220459},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.5709999799728394},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2781109936","wikidata":"https://www.wikidata.org/wiki/Q419769","display_name":"Bosentan","level":4,"score":0.9726868271827698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9632213115692139},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.7230715751647949},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6963135600090027},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.589087188243866},{"id":"https://openalex.org/C2776345702","wikidata":"https://www.wikidata.org/wiki/Q390709","display_name":"Endothelin receptor antagonist","level":4,"score":0.5772333145141602},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5693822503089905},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5090091228485107},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.481610506772995},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.47828158736228943},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.44245606660842896},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.2611393332481384},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077300","descriptor_name":"Bosentan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010547","descriptor_name":"Persistent Fetal Circulation Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D065128","descriptor_name":"Endothelin Receptor Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1017/s1047951123004456","doi":"https://doi.org/10.1017/s1047951123004456","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s1047951123004456","pdf_url":null,"source":{"id":"https://openalex.org/S159891131","display_name":"Cardiology in the Young","issn_l":"1047-9511","issn":["1047-9511","1467-1107"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology in the Young","raw_type":"journal-article"},{"id":"pmid:38329072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38329072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology in the young","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1555329455","https://openalex.org/W1967577700","https://openalex.org/W1969865218","https://openalex.org/W1994132541","https://openalex.org/W2033042544","https://openalex.org/W2039053105","https://openalex.org/W2042804390","https://openalex.org/W2045501134","https://openalex.org/W2051069436","https://openalex.org/W2053184228","https://openalex.org/W2060931019","https://openalex.org/W2063646125","https://openalex.org/W2071900542","https://openalex.org/W2090085923","https://openalex.org/W2092374648","https://openalex.org/W2100425308","https://openalex.org/W2109335746","https://openalex.org/W2121538692","https://openalex.org/W2131658357","https://openalex.org/W2145254726","https://openalex.org/W2158262028","https://openalex.org/W2163562830","https://openalex.org/W2178108213","https://openalex.org/W2331798828","https://openalex.org/W2487070109","https://openalex.org/W2735872325","https://openalex.org/W2885152735","https://openalex.org/W3090434869","https://openalex.org/W3186085978"],"related_works":["https://openalex.org/W2092374648","https://openalex.org/W7163415395","https://openalex.org/W2735872325","https://openalex.org/W4220677972","https://openalex.org/W2487070109","https://openalex.org/W2042804390","https://openalex.org/W4398223953","https://openalex.org/W3090434869","https://openalex.org/W4308375192","https://openalex.org/W4360983481"],"abstract_inverted_index":{"BACKGROUND:":[0],"Persistent":[1],"pulmonary":[2,36,43,54,77,129,180,261],"hypertension":[3,37,55,78,130,262],"of":[4,38,56,69,79,131,147,163,192,207,237,259,263],"the":[5,39,57,65,80,101,132,145,152,169,204,257,264],"newborn":[6,40,58,81,133,265],"is":[7,21,254],"a":[8,31,138,161,230,247],"life-threatening":[9],"condition":[10],"that":[11,28,119],"affects":[12],"about":[13],"1-2":[14],"per":[15],"1,000":[16],"live":[17],"births":[18],"worldwide.":[19],"Bosentan":[20,166,253],"an":[22,72],"oral":[23],"dual":[24],"endothelin":[25],"receptor":[26],"antagonist":[27],"may":[29],"have":[30],"beneficial":[32],"effect":[33],"on":[34],"persistent":[35,53,76,128,260],"by":[41],"reducing":[42],"vascular":[44],"resistance":[45],"and":[46,67,89,108,116,143,149,190,202,216,246],"improving":[47],"oxygenation.":[48],"However,":[49],"its":[50],"role":[51],"in":[52,82,134,151,256],"remains":[59],"unclear.":[60],"OBJECTIVES:":[61],"To":[62],"systematically":[63],"evaluate":[64],"efficacy":[66],"safety":[68],"bosentan":[70,121,245],"as":[71,270],"adjuvant":[73],"therapy":[74],"for":[75,105,127],"newborns.":[83,135],"METHODS:":[84],"We":[85,111,136,156],"searched":[86],"six":[87],"English":[88],"two":[90],"Chinese":[91],"databases":[92],"from":[93],"their":[94],"inception":[95],"to":[96],"1":[97],"January":[98],"2023":[99],"following":[100],"Preferred":[102],"Reporting":[103],"Items":[104],"Systematic":[106],"Reviews":[107],"Meta-Analyses":[109],"guidelines.":[110],"included":[112,153,157],"randomised":[113],"controlled":[114],"trials":[115],"retrospective":[117],"studies":[118,159],"compared":[120,228],"with":[122,160,229],"placebo":[123,231,248],"or":[124,232,249],"other":[125,233,250],"drugs":[126],"performed":[137],"meta-analysis":[139],"using":[140,278],"random-effects":[141],"models":[142],"assessed":[144],"risk":[146,174],"bias":[148],"heterogeneity":[150],"studies.":[154],"RESULTS:":[155],"10":[158],"total":[162],"550":[164],"participants.":[165],"significantly":[167,242],"reduced":[168],"treatment":[170,258],"failure":[171],"rate":[172],"(relative":[173],"=":[175,185,197,200,211,223],"0.25,":[176],"P":[177,187,199,213,225],"<":[178,188,214,226],"0.001),":[179,189],"artery":[181],"pressure":[182,206],"(mean":[183,195,209,221],"difference":[184,196,210,222],"-11.79,":[186],"length":[191],"hospital":[193],"stay":[194],"-1.04,":[198],"0.003),":[201],"increased":[203],"partial":[205],"oxygen":[208,218],"10.02,":[212],"0.001)":[215,227],"blood":[217],"saturation":[219],"(SpO2)":[220],"8.24,":[224],"drugs.":[234,251],"The":[235],"occurrence":[236],"adverse":[238,267],"reactions":[239,268],"was":[240],"not":[241],"different":[243],"between":[244],"CONCLUSIONS:":[252],"effective":[255],"but":[266],"such":[269],"abnormal":[271],"liver":[272],"function":[273],"should":[274],"be":[275],"observed":[276],"when":[277],"it.":[279]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-02-09T00:00:00"}
