{"id":"https://openalex.org/W4391635656","doi":"https://doi.org/10.1002/btm2.10650","title":"Engineering a \u201cmuco\u2010trapping\u201d ACE2 \u2010immunoglobulin hybrid with picomolar affinity as an inhaled, pan\u2010variant immunotherapy for COVID \u201019","display_name":"Engineering a \u201cmuco\u2010trapping\u201d ACE2 \u2010immunoglobulin hybrid with picomolar affinity as an inhaled, pan\u2010variant immunotherapy for COVID \u201019","publication_year":2024,"publication_date":"2024-02-07","ids":{"openalex":"https://openalex.org/W4391635656","doi":"https://doi.org/10.1002/btm2.10650","pmid":"https://pubmed.ncbi.nlm.nih.gov/39036085","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11256170"},"language":"en","primary_location":{"id":"doi:10.1002/btm2.10650","doi":"https://doi.org/10.1002/btm2.10650","is_oa":true,"landing_page_url":"https://doi.org/10.1002/btm2.10650","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/btm2.10650","source":{"id":"https://openalex.org/S4210212656","display_name":"Bioengineering & Translational Medicine","issn_l":"2380-6761","issn":["2380-6761"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering & Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/btm2.10650","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032880051","display_name":"Karthik Tiruthani","orcid":"https://orcid.org/0000-0002-8939-7774","observed_orcids":["https://orcid.org/0000-0002-8939-7774"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karthik Tiruthani","raw_affiliation_strings":["Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078287508","display_name":"Carlos A. Cruz-Teran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Cruz\u2010Teran","raw_affiliation_strings":["Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043764643","display_name":"Jasper Fuk\u2010Woo Chan","orcid":"https://orcid.org/0000-0001-6336-6657","observed_orcids":["https://orcid.org/0000-0001-6336-6657"]},"institutions":[{"id":"https://openalex.org/I2800906782","display_name":"Hong Kong Science and Technology Parks Corporation","ror":"https://ror.org/05q8mqd91","country_code":"HK","type":"nonprofit","lineage":["https://openalex.org/I2800906782"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Jasper F. W. Chan","raw_affiliation_strings":["Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China","State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I2800906782"]},{"raw_affiliation_string":"State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101529088","display_name":"Alice L. Ma","orcid":"https://orcid.org/0000-0002-4647-3239","observed_orcids":["https://orcid.org/0000-0002-4647-3239"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I4210131205","display_name":"Lampe Joint Department of Biomedical Engineering","ror":"https://ror.org/03hakdk41","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177","https://openalex.org/I137902535","https://openalex.org/I4210131205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice Ma","raw_affiliation_strings":["UNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I137902535","https://openalex.org/I4210131205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089827081","display_name":"Morgan D. McSweeney","orcid":"https://orcid.org/0000-0003-3246-4283","observed_orcids":["https://orcid.org/0000-0003-3246-4283"]},"institutions":[{"id":"https://openalex.org/I4405267255","display_name":"Inhalon Biopharma, Inc. (United States)","ror":"https://ror.org/01wwy4233","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgan McSweeney","raw_affiliation_strings":["Inhalon Biopharma, Inc., Morrisville, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inhalon Biopharma, Inc., Morrisville, North Carolina, USA","institution_ids":["https://openalex.org/I4405267255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023945864","display_name":"Whitney Wolf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Whitney Wolf","raw_affiliation_strings":["Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101302358","display_name":"Shoufeng Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800906782","display_name":"Hong Kong Science and Technology Parks Corporation","ror":"https://ror.org/05q8mqd91","country_code":"HK","type":"nonprofit","lineage":["https://openalex.org/I2800906782"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Shoufeng Yuan","raw_affiliation_strings":["Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China","State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I2800906782"]},{"raw_affiliation_string":"State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004940633","display_name":"Vincent Kwok\u2010Man Poon","orcid":"https://orcid.org/0000-0002-7737-8912","observed_orcids":["https://orcid.org/0000-0002-7737-8912"]},"institutions":[{"id":"https://openalex.org/I2800906782","display_name":"Hong Kong Science and Technology Parks Corporation","ror":"https://ror.org/05q8mqd91","country_code":"HK","type":"nonprofit","lineage":["https://openalex.org/I2800906782"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Vincent K. M. Poon","raw_affiliation_strings":["Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China","State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I2800906782"]},{"raw_affiliation_string":"State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111126332","display_name":"Chris C. S. Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800906782","display_name":"Hong Kong Science and Technology Parks Corporation","ror":"https://ror.org/05q8mqd91","country_code":"HK","type":"nonprofit","lineage":["https://openalex.org/I2800906782"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Chris C. S. Chan","raw_affiliation_strings":["Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China","State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I2800906782"]},{"raw_affiliation_string":"State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052959830","display_name":"Lakshmi Botta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267255","display_name":"Inhalon Biopharma, Inc. (United States)","ror":"https://ror.org/01wwy4233","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lakshmi Botta","raw_affiliation_strings":["Inhalon Biopharma, Inc., Morrisville, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inhalon Biopharma, Inc., Morrisville, North Carolina, USA","institution_ids":["https://openalex.org/I4405267255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075155514","display_name":"Brian T. Farrer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267255","display_name":"Inhalon Biopharma, Inc. (United States)","ror":"https://ror.org/01wwy4233","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Farrer","raw_affiliation_strings":["Inhalon Biopharma, Inc., Morrisville, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inhalon Biopharma, Inc., Morrisville, North Carolina, USA","institution_ids":["https://openalex.org/I4405267255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046013845","display_name":"Ian E. Stewart","orcid":"https://orcid.org/0000-0002-1752-632X","observed_orcids":["https://orcid.org/0000-0002-1752-632X"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Stewart","raw_affiliation_strings":["RTI International, Research Triangle Park, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RTI International, Research Triangle Park, North Carolina, USA","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102956379","display_name":"Alison Schaefer","orcid":"https://orcid.org/0000-0001-7869-2826","observed_orcids":["https://orcid.org/0000-0001-7869-2826"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I4210131205","display_name":"Lampe Joint Department of Biomedical Engineering","ror":"https://ror.org/03hakdk41","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177","https://openalex.org/I137902535","https://openalex.org/I4210131205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison Schaefer","raw_affiliation_strings":["UNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I137902535","https://openalex.org/I4210131205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029540582","display_name":"Jasmine Edelstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I4210131205","display_name":"Lampe Joint Department of Biomedical Engineering","ror":"https://ror.org/03hakdk41","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177","https://openalex.org/I137902535","https://openalex.org/I4210131205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasmine Edelstein","raw_affiliation_strings":["UNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I137902535","https://openalex.org/I4210131205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101462022","display_name":"Priya Kumar","orcid":"https://orcid.org/0009-0008-0060-1224","observed_orcids":["https://orcid.org/0009-0008-0060-1224"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priya Kumar","raw_affiliation_strings":["Department of Anesthesiology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112634698","display_name":"Harendra Arora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harendra Arora","raw_affiliation_strings":["Department of Anesthesiology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111821064","display_name":"Jeff T. Hutchins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267255","display_name":"Inhalon Biopharma, Inc. (United States)","ror":"https://ror.org/01wwy4233","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff T. Hutchins","raw_affiliation_strings":["Inhalon Biopharma, Inc., Morrisville, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inhalon Biopharma, Inc., Morrisville, North Carolina, USA","institution_ids":["https://openalex.org/I4405267255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071846305","display_name":"Anthony James Hickey","orcid":"https://orcid.org/0000-0002-3324-9326","observed_orcids":["https://orcid.org/0000-0002-3324-9326"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony J. Hickey","raw_affiliation_strings":["RTI International, Research Triangle Park, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RTI International, Research Triangle Park, North Carolina, USA","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074675036","display_name":"Kwok\u2010Yung Yuen","orcid":"https://orcid.org/0000-0002-2083-1552","observed_orcids":["https://orcid.org/0000-0002-2083-1552"]},"institutions":[{"id":"https://openalex.org/I2800906782","display_name":"Hong Kong Science and Technology Parks Corporation","ror":"https://ror.org/05q8mqd91","country_code":"HK","type":"nonprofit","lineage":["https://openalex.org/I2800906782"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Kwok\u2010Yung Yuen","raw_affiliation_strings":["Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China","State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I2800906782"]},{"raw_affiliation_string":"State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079956311","display_name":"Samuel K. Lai","orcid":"https://orcid.org/0000-0003-4721-528X","observed_orcids":["https://orcid.org/0000-0003-4721-528X","https://orcid.org/0000-0001-5293-9296"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405267255","display_name":"Inhalon Biopharma, Inc. (United States)","ror":"https://ror.org/01wwy4233","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267255"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Samuel K. Lai","raw_affiliation_strings":["Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","Inhalon Biopharma, Inc., Morrisville, North Carolina, USA"],"raw_orcid":"https://orcid.org/0000-0003-4721-528X","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Inhalon Biopharma, Inc., Morrisville, North Carolina, USA","institution_ids":["https://openalex.org/I4405267255"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5079956311"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4405267255"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":2.1028,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.85689514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9","issue":"4","first_page":"e10650","last_page":"e10650"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ace2","display_name":"ACE2","score":0.7540000081062317},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9549999833106995},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9700000286102295},{"id":"https://openalex.org/keywords/decoy-receptor","display_name":"decoy receptor","score":0.7580000162124634},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.5730000138282776},{"id":"https://openalex.org/keywords/flexible-linkers","display_name":"flexible linkers","score":0.7020000219345093},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.7369999885559082},{"id":"https://openalex.org/keywords/nebulization","display_name":"nebulization","score":0.7519999742507935},{"id":"https://openalex.org/keywords/viral-load-reduction","display_name":"viral load reduction","score":0.6050000190734863},{"id":"https://openalex.org/keywords/hamster-model","display_name":"hamster model","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6430504322052002},{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.6116368174552917},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.5235328674316406},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.511959433555603},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.48426029086112976},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.45044130086898804},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.4490925073623657},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.43399202823638916},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3786372244358063},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35339683294296265},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34908753633499146},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3089025616645813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24385306239128113},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18607917428016663},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.1413867473602295},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10780462622642517}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1002/btm2.10650","doi":"https://doi.org/10.1002/btm2.10650","is_oa":true,"landing_page_url":"https://doi.org/10.1002/btm2.10650","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/btm2.10650","source":{"id":"https://openalex.org/S4210212656","display_name":"Bioengineering & Translational Medicine","issn_l":"2380-6761","issn":["2380-6761"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering & Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11256170","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11256170","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11256170/pdf/BTM2-9-e10650.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioeng Transl Med","raw_type":"Text"},{"id":"pmid:39036085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39036085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering & translational medicine","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:ft8493671","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/6j94-g634","pdf_url":"https://cdr.lib.unc.edu/downloads/h989rf29n","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioengineering and Translational Medicine, 9(4)","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:0194f8a6b25b4295b585d8f6aa9503ad","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0194f8a6b25b4295b585d8f6aa9503ad","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioengineering & Translational Medicine, Vol 9, Iss 4, Pp n/a-n/a (2024)","raw_type":"article"},{"id":"doi:10.17615/6j94-g634","doi":"https://doi.org/10.17615/6j94-g634","is_oa":true,"landing_page_url":"https://doi.org/10.17615/6j94-g634","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1002/btm2.10650","doi":"https://doi.org/10.1002/btm2.10650","is_oa":true,"landing_page_url":"https://doi.org/10.1002/btm2.10650","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/btm2.10650","source":{"id":"https://openalex.org/S4210212656","display_name":"Bioengineering & Translational Medicine","issn_l":"2380-6761","issn":["2380-6761"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering & Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1178480161","display_name":null,"funder_award_id":"COVID1903010","funder_id":"https://openalex.org/F4320323291","funder_display_name":"Food and Health Bureau"},{"id":"https://openalex.org/G125048801","display_name":null,"funder_award_id":"SLFRP0129","funder_id":"https://openalex.org/F748310585","funder_display_name":"North Carolina Policy Collaboratory"},{"id":"https://openalex.org/G1310399414","display_name":null,"funder_award_id":"2013-39274","funder_id":"https://openalex.org/F4320306079","funder_display_name":"David and Lucile Packard Foundation"},{"id":"https://openalex.org/G2804681616","display_name":"RAPID: A Lung Mucus Strategy for COVID-19 Viral Protection","funder_award_id":"2028758","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5075788835","display_name":"Preparing for COVID-19 upcoming challenges by clinical and virological investigations","funder_award_id":"COVID1903010","funder_id":"https://openalex.org/F4320335055","funder_display_name":"Health and Medical Research Fund"},{"id":"https://openalex.org/G5795104851","display_name":null,"funder_award_id":"2013-39274","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6195424223","display_name":null,"funder_award_id":"2013-39274","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6628848920","display_name":"North Carolina Translational and Clinical Science Institute (NC TraCS)","funder_award_id":"UL1TR002489","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6745797215","display_name":"Aerosol immunotherapy for treatment of human metapneumovirus infection","funder_award_id":"R43AI149894","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000916162","display_name":"North Carolina Translational and Clinical Sciences Institute (NC TraCS)","funder_award_id":"UM1TR004406","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306079","display_name":"David and Lucile Packard Foundation","ror":"https://ror.org/032atxq54"},{"id":"https://openalex.org/F4320321920","display_name":"Innovation and Technology Commission","ror":"https://ror.org/04vf9tr09"},{"id":"https://openalex.org/F4320323291","display_name":"Food and Health Bureau","ror":"https://ror.org/03qh32912"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332600","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33"},{"id":"https://openalex.org/F4320335055","display_name":"Health and Medical Research Fund","ror":"https://ror.org/03qh32912"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F748310585","display_name":"North Carolina Policy Collaboratory","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391635656.pdf","grobid_xml":"https://content.openalex.org/works/W4391635656.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1965435260","https://openalex.org/W1966238900","https://openalex.org/W1975627577","https://openalex.org/W1975787081","https://openalex.org/W2020172485","https://openalex.org/W2043191762","https://openalex.org/W2096387523","https://openalex.org/W2109501799","https://openalex.org/W2123199112","https://openalex.org/W2132629607","https://openalex.org/W2136461776","https://openalex.org/W2141959911","https://openalex.org/W2149789513","https://openalex.org/W2417997453","https://openalex.org/W2565787028","https://openalex.org/W2750464792","https://openalex.org/W2762381981","https://openalex.org/W2799948466","https://openalex.org/W2851621281","https://openalex.org/W2929904777","https://openalex.org/W3007643904","https://openalex.org/W3009219040","https://openalex.org/W3010441732","https://openalex.org/W3012831148","https://openalex.org/W3015851157","https://openalex.org/W3016829967","https://openalex.org/W3017850114","https://openalex.org/W3022435472","https://openalex.org/W3024560213","https://openalex.org/W3024602798","https://openalex.org/W3034724500","https://openalex.org/W3044660350","https://openalex.org/W3044914269","https://openalex.org/W3047003416","https://openalex.org/W3047552884","https://openalex.org/W3083406432","https://openalex.org/W3086112984","https://openalex.org/W3087347658","https://openalex.org/W3087410177","https://openalex.org/W3093802804","https://openalex.org/W3095090886","https://openalex.org/W3096064145","https://openalex.org/W3096641283","https://openalex.org/W3103844685","https://openalex.org/W3105466102","https://openalex.org/W3109052585","https://openalex.org/W3110580506","https://openalex.org/W3111431752","https://openalex.org/W3112792752","https://openalex.org/W3120790477","https://openalex.org/W3123551159","https://openalex.org/W3126773380","https://openalex.org/W3131016929","https://openalex.org/W3135215866","https://openalex.org/W3136390341","https://openalex.org/W3138734145","https://openalex.org/W3168747594","https://openalex.org/W3180445914","https://openalex.org/W4200615558","https://openalex.org/W4205942662","https://openalex.org/W4280510519","https://openalex.org/W4283319609","https://openalex.org/W4293553596","https://openalex.org/W4296553964","https://openalex.org/W4309077152","https://openalex.org/W4386167656","https://openalex.org/W4407270062"],"related_works":["https://openalex.org/W3160783384","https://openalex.org/W4386274943","https://openalex.org/W4289337038","https://openalex.org/W4313428845","https://openalex.org/W4399518676","https://openalex.org/W3093802804","https://openalex.org/W4296553964","https://openalex.org/W4389777937","https://openalex.org/W4389564397","https://openalex.org/W4398168502"],"abstract_inverted_index":{"Abstract":[0],"Soluble":[1],"angiotensin\u2010converting":[2],"enzyme":[3],"2":[4,19,159],"(ACE2)":[5],"can":[6],"act":[7],"as":[8,156,158,189,195,197],"a":[9,45,141,163],"decoy":[10],"molecule":[11],"that":[12,67,201],"neutralizes":[13],"severe":[14],"acute":[15],"respiratory":[16],"syndrome":[17],"coronavirus":[18],"(SARS\u2010CoV\u20102)":[20],"by":[21,174],"blocking":[22],"spike":[23],"(S)":[24],"proteins":[25],"on":[26,31,35],"virions":[27],"from":[28],"binding":[29,87,108],"ACE2":[30,39,61,203],"host":[32],"cells.":[33],"Based":[34],"structural":[36],"insights":[37],"of":[38,56,60,148,183],"and":[40,89,110,116,136],"S":[41],"proteins,":[42],"we":[43],"designed":[44],"\u201cmuco\u2010trapping\u201d":[46],"ACE2\u2010Fc":[47,96,101],"conjugate,":[48],"termed":[49],"ACE2\u2010(G":[50,79,119,149,184],"4":[51,80,120,150,185],"S)":[52,81,121,151,186],"6":[53,82,122,152,187],"\u2010Fc,":[54],"comprised":[55],"the":[57,63,170],"extracellular":[58],"segment":[59],"(lacking":[62],"C\u2010terminal":[64],"collectrin":[65],"domain)":[66],"is":[68],"linked":[69],"to":[70],"mucin\u2010binding":[71],"IgG1\u2010Fc":[72],"via":[73],"an":[74,190],"extended":[75],"glycine\u2010serine":[76],"flexible":[77,104],"linker.":[78],"\u2010Fc":[83,123,153,188],"exhibits":[84],"substantially":[85],"greater":[86],"affinity":[88,109],"neutralization":[90,112],"potency":[91,113],"than":[92],"conventional":[93],"full":[94],"length":[95],"decoys":[97,102],"or":[98],"similar":[99],"truncated":[100],"without":[103],"linkers,":[105],"possessing":[106],"picomolar":[107],"strong":[111],"against":[114],"pseudovirus":[115],"live":[117],"virus.":[118],"effectively":[124],"trapped":[125],"fluorescent":[126],"SARS\u2010CoV\u20102":[127],"virus":[128],"like":[129],"particles":[130],"in":[131,154,166,169],"fresh":[132],"human":[133],"airway":[134],"mucus":[135],"was":[137],"stably":[138],"nebulized":[139],"using":[140],"commercial":[142],"vibrating":[143],"mesh":[144],"nebulizer.":[145],"Intranasal":[146],"dosing":[147],"hamsters":[155],"late":[157],"days":[160],"postinfection":[161],"provided":[162],"10\u2010fold":[164],"reduction":[165],"viral":[167],"load":[168],"nasal":[171],"turbinate":[172],"tissues":[173],"Day":[175],"4.":[176],"These":[177],"results":[178],"strongly":[179],"support":[180],"further":[181],"development":[182],"inhaled":[191],"immunotherapy":[192],"for":[193,204],"COVID\u201019,":[194],"well":[196],"other":[198],"emerging":[199],"viruses":[200],"bind":[202],"cellular":[205],"entry.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-02-09T00:00:00"}