{"id":"https://openalex.org/W4391614014","doi":"https://doi.org/10.3390/cosmetics11010024","title":"Effectiveness and Safety of Boesenbergia rotunda Extract on 3T3-L1 Preadipocytes and Its Use in Capsaicin-Loaded Body-Firming Formulation: In Vitro Biological Study and In Vivo Human Study","display_name":"Effectiveness and Safety of Boesenbergia rotunda Extract on 3T3-L1 Preadipocytes and Its Use in Capsaicin-Loaded Body-Firming Formulation: In Vitro Biological Study and In Vivo Human Study","publication_year":2024,"publication_date":"2024-02-07","ids":{"openalex":"https://openalex.org/W4391614014","doi":"https://doi.org/10.3390/cosmetics11010024"},"language":"en","primary_location":{"id":"doi:10.3390/cosmetics11010024","doi":"https://doi.org/10.3390/cosmetics11010024","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cosmetics11010024","pdf_url":"https://www.mdpi.com/2079-9284/11/1/24/pdf?version=1707286627","source":{"id":"https://openalex.org/S2738608518","display_name":"Cosmetics","issn_l":"2079-9284","issn":["2079-9284"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cosmetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-9284/11/1/24/pdf?version=1707286627","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027183046","display_name":"Phaijit Sritananuwat","orcid":"https://orcid.org/0000-0002-7462-7354","observed_orcids":["https://orcid.org/0000-0002-7462-7354"]},"institutions":[{"id":"https://openalex.org/I4405277981","display_name":"Ratchathani University","ror":"https://ror.org/04hbw0v61","country_code":"TH","type":"education","lineage":["https://openalex.org/I4405277981"]},{"id":"https://openalex.org/I72091625","display_name":"Ubon Ratchathani University","ror":"https://ror.org/045nemn19","country_code":"TH","type":"education","lineage":["https://openalex.org/I72091625"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Phaijit Sritananuwat","raw_affiliation_strings":["Division of Biopharmacy, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biopharmacy, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand","institution_ids":["https://openalex.org/I4405277981","https://openalex.org/I72091625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009307234","display_name":"Tipada Samseethong","orcid":"https://orcid.org/0000-0003-1613-1075","observed_orcids":["https://orcid.org/0000-0003-1613-1075"]},"institutions":[{"id":"https://openalex.org/I4405277981","display_name":"Ratchathani University","ror":"https://ror.org/04hbw0v61","country_code":"TH","type":"education","lineage":["https://openalex.org/I4405277981"]},{"id":"https://openalex.org/I72091625","display_name":"Ubon Ratchathani University","ror":"https://ror.org/045nemn19","country_code":"TH","type":"education","lineage":["https://openalex.org/I72091625"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Tipada Samseethong","raw_affiliation_strings":["Division of Pharmacy Practices, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand"],"raw_orcid":"https://orcid.org/0000-0003-1613-1075","affiliations":[{"raw_affiliation_string":"Division of Pharmacy Practices, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand","institution_ids":["https://openalex.org/I4405277981","https://openalex.org/I72091625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057215896","display_name":"Kusuma Jitsaeng","orcid":"https://orcid.org/0009-0008-6368-547X","observed_orcids":["https://orcid.org/0009-0008-6368-547X"]},"institutions":[{"id":"https://openalex.org/I4405277981","display_name":"Ratchathani University","ror":"https://ror.org/04hbw0v61","country_code":"TH","type":"education","lineage":["https://openalex.org/I4405277981"]},{"id":"https://openalex.org/I72091625","display_name":"Ubon Ratchathani University","ror":"https://ror.org/045nemn19","country_code":"TH","type":"education","lineage":["https://openalex.org/I72091625"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Kusuma Jitsaeng","raw_affiliation_strings":["Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand","institution_ids":["https://openalex.org/I4405277981","https://openalex.org/I72091625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010105260","display_name":"Sureewan Duangjit","orcid":"https://orcid.org/0000-0002-6187-9368","observed_orcids":["https://orcid.org/0000-0002-6187-9368"]},"institutions":[{"id":"https://openalex.org/I4405277981","display_name":"Ratchathani University","ror":"https://ror.org/04hbw0v61","country_code":"TH","type":"education","lineage":["https://openalex.org/I4405277981"]},{"id":"https://openalex.org/I72091625","display_name":"Ubon Ratchathani University","ror":"https://ror.org/045nemn19","country_code":"TH","type":"education","lineage":["https://openalex.org/I72091625"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Sureewan Duangjit","raw_affiliation_strings":["Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand"],"raw_orcid":"https://orcid.org/0000-0002-6187-9368","affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand","institution_ids":["https://openalex.org/I4405277981","https://openalex.org/I72091625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011581277","display_name":"Praneet Opanasopit","orcid":"https://orcid.org/0000-0002-4878-2529","observed_orcids":["https://orcid.org/0000-0002-4878-2529"]},"institutions":[{"id":"https://openalex.org/I86677382","display_name":"Silpakorn University","ror":"https://ror.org/02d0tyt78","country_code":"TH","type":"education","lineage":["https://openalex.org/I86677382"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Praneet Opanasopit","raw_affiliation_strings":["Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand"],"raw_orcid":"https://orcid.org/0000-0002-4878-2529","affiliations":[{"raw_affiliation_string":"Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand","institution_ids":["https://openalex.org/I86677382"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046046915","display_name":"Worranan Rangsimawong","orcid":"https://orcid.org/0000-0002-0753-0720","observed_orcids":["https://orcid.org/0000-0002-0753-0720"]},"institutions":[{"id":"https://openalex.org/I4405277981","display_name":"Ratchathani University","ror":"https://ror.org/04hbw0v61","country_code":"TH","type":"education","lineage":["https://openalex.org/I4405277981"]},{"id":"https://openalex.org/I72091625","display_name":"Ubon Ratchathani University","ror":"https://ror.org/045nemn19","country_code":"TH","type":"education","lineage":["https://openalex.org/I72091625"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Worranan Rangsimawong","raw_affiliation_strings":["Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand"],"raw_orcid":"https://orcid.org/0000-0002-0753-0720","affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand","institution_ids":["https://openalex.org/I4405277981","https://openalex.org/I72091625"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011581277","https://openalex.org/A5046046915"],"corresponding_institution_ids":["https://openalex.org/I4405277981","https://openalex.org/I72091625","https://openalex.org/I86677382"],"apc_list":{"value":1800,"currency":"CHF","value_usd":2046},"apc_paid":{"value":1800,"currency":"CHF","value_usd":2046},"fwci":2.0832,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.84707921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"24","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.05510000139474869,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/boesenbergia-rotunda","display_name":"Boesenbergia rotunda","score":0.9990000128746033},{"id":"https://openalex.org/keywords/turmeric-extract","display_name":"turmeric extract","score":0.718999981880188},{"id":"https://openalex.org/keywords/3t3-l1-preadipocytes","display_name":"3T3-L1 preadipocytes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.902999997138977},{"id":"https://openalex.org/keywords/panduratin-a","display_name":"panduratin A","score":0.8740000128746033},{"id":"https://openalex.org/keywords/skin-permeation","display_name":"skin permeation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/thigh-circumference","display_name":"thigh circumference","score":0.7839999794960022},{"id":"https://openalex.org/keywords/melanin-index","display_name":"melanin index","score":0.9470000267028809},{"id":"https://openalex.org/keywords/erythema","display_name":"erythema","score":0.9890000224113464},{"id":"https://openalex.org/keywords/anti-obesity-effect","display_name":"anti-obesity","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.6976175308227539},{"id":"https://openalex.org/C2779121184","wikidata":"https://www.wikidata.org/wiki/Q1166142","display_name":"Erythema","level":2,"score":0.5471949577331543},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4906841516494751},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47615620493888855},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4606947600841522},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.42752838134765625},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.22069278359413147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19783660769462585},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15604901313781738},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.058847635984420776},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/cosmetics11010024","doi":"https://doi.org/10.3390/cosmetics11010024","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cosmetics11010024","pdf_url":"https://www.mdpi.com/2079-9284/11/1/24/pdf?version=1707286627","source":{"id":"https://openalex.org/S2738608518","display_name":"Cosmetics","issn_l":"2079-9284","issn":["2079-9284"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cosmetics","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:a624b73447984a678d08057c9a215274","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a624b73447984a678d08057c9a215274","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cosmetics, Vol 11, Iss 1, p 24 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cosmetics11010024","doi":"https://doi.org/10.3390/cosmetics11010024","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cosmetics11010024","pdf_url":"https://www.mdpi.com/2079-9284/11/1/24/pdf?version=1707286627","source":{"id":"https://openalex.org/S2738608518","display_name":"Cosmetics","issn_l":"2079-9284","issn":["2079-9284"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cosmetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323106","display_name":"Agricultural Research Development Agency","ror":"https://ror.org/01shbv660"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391614014.pdf","grobid_xml":"https://content.openalex.org/works/W4391614014.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1590773377","https://openalex.org/W1972477005","https://openalex.org/W1972647563","https://openalex.org/W1977132855","https://openalex.org/W1978415294","https://openalex.org/W1996634599","https://openalex.org/W2001201827","https://openalex.org/W2046805974","https://openalex.org/W2055103508","https://openalex.org/W2063599936","https://openalex.org/W2064414398","https://openalex.org/W2091159528","https://openalex.org/W2122778205","https://openalex.org/W2127850038","https://openalex.org/W2134253798","https://openalex.org/W2134902551","https://openalex.org/W2137294760","https://openalex.org/W2154835651","https://openalex.org/W2161972691","https://openalex.org/W2398600282","https://openalex.org/W2464631818","https://openalex.org/W2576886517","https://openalex.org/W2610817848","https://openalex.org/W2900986843","https://openalex.org/W2969815719","https://openalex.org/W2984815616","https://openalex.org/W4211062831","https://openalex.org/W4297973231","https://openalex.org/W4315795729","https://openalex.org/W4353018896","https://openalex.org/W4389164734","https://openalex.org/W4399052358","https://openalex.org/W6682804172","https://openalex.org/W6886106379"],"related_works":["https://openalex.org/W4389164734","https://openalex.org/W2034640612","https://openalex.org/W4296925828","https://openalex.org/W2739231873","https://openalex.org/W2068854137","https://openalex.org/W2552091031","https://openalex.org/W2084518799","https://openalex.org/W4390779406","https://openalex.org/W2942215848","https://openalex.org/W2922850261"],"abstract_inverted_index":{"Boesenbergia":[0],"rotunda":[1,22,36,47,62,92,110,121,189,201],"has":[2],"been":[3],"used":[4],"as":[5,207],"an":[6],"antiobesity":[7],"agent":[8],"by":[9],"suppressing":[10],"adipogenesis.":[11],"This":[12],"study":[13],"aimed":[14],"to":[15,27,143,157],"investigate":[16],"the":[17,29,57,60,67,87,108,138,144,147,187],"biological":[18],"activity":[19],"of":[20,33,45,59,69,90,107,116,146],"B.":[21,35,46,61,91,109,120,188,200],"on":[23,66],"preadipocyte":[24,54],"cells":[25,98],"and":[26,31,78,132,136,164,203],"evaluate":[28],"effectiveness":[30],"safety":[32],"using":[34],"extract":[37,49,89,111,122,190,202],"in":[38,52,161,170,181],"a":[39,114,151,158],"capsaicin-loaded":[40],"body-firming":[41,64,130,209],"formulation.":[42],"The":[43,83,119,197],"antiadipogenesis":[44,106],"ethanolic":[48,88],"was":[50,93,126,173,177],"evaluated":[51],"3T3-L1":[53,97],"cells.":[55],"After":[56],"application":[58],"extract-loaded":[63],"formulation":[65,142],"skin":[68,79,171],"volunteers":[70,148],"for":[71,153],"28":[72],"d,":[73],"thigh":[74,162],"circumference,":[75],"melanin":[76,165],"index,":[77],"erythema":[80,172],"were":[81],"investigated.":[82],"results":[84],"showed":[85,205],"that":[86,194],"not":[94],"toxic":[95],"toward":[96],"at":[99,113],"concentrations":[100],"lower":[101],"than":[102],"20":[103],"\u00b5g/mL,":[104],"with":[105,128],"occurring":[112],"concentration":[115],"1":[117],"\u00b5g/mL.":[118],"containing":[123,199],"panduratin":[124],"A":[125,167],"mixed":[127],"capsaicin":[129,204],"products":[131],"successfully":[133],"permeated":[134],"into":[135],"through":[137],"skin.":[139],"Applying":[140],"this":[141],"thighs":[145],"two":[149],"times":[150],"day":[152],"21":[154],"days":[155],"led":[156],"significant":[159,179],"reduction":[160],"circumference":[163],"index.":[166],"slight":[168],"elevation":[169],"observed,":[174],"but":[175],"there":[176],"no":[178],"increase":[180],"redness":[182],"or":[183],"pain.":[184],"In":[185],"conclusion,":[186],"contained":[191],"bioactive":[192],"compounds":[193],"inhibited":[195],"antiadipogenesis.":[196],"formulations":[198],"potential":[206],"effective":[208],"products.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-02-08T00:00:00"}