{"id":"https://openalex.org/W4391578331","doi":"https://doi.org/10.1073/pnas.2310264121","title":"DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8","display_name":"DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8","publication_year":2024,"publication_date":"2024-02-06","ids":{"openalex":"https://openalex.org/W4391578331","doi":"https://doi.org/10.1073/pnas.2310264121","pmid":"https://pubmed.ncbi.nlm.nih.gov/38319963","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10873594"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2310264121","doi":"https://doi.org/10.1073/pnas.2310264121","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2310264121","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2310264121","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066141947","display_name":"Gaurav Swarnkar","orcid":"https://orcid.org/0000-0001-6052-4971","observed_orcids":["https://orcid.org/0000-0001-6052-4971"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaurav Swarnkar","raw_affiliation_strings":["Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110"],"raw_orcid":"https://orcid.org/0000-0001-6052-4971","affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062318223","display_name":"Nicholas P. Semenkovich","orcid":"https://orcid.org/0000-0001-5266-6734","observed_orcids":["https://orcid.org/0000-0001-5266-6734"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas P. Semenkovich","raw_affiliation_strings":["Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110"],"raw_orcid":"https://orcid.org/0000-0001-5266-6734","affiliations":[{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052547823","display_name":"Manoj Arra","orcid":"https://orcid.org/0000-0002-7656-9020","observed_orcids":["https://orcid.org/0000-0002-7656-9020"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manoj Arra","raw_affiliation_strings":["Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113113564","display_name":"Dorothy K. Mims","orcid":"https://orcid.org/0009-0000-6834-3681","observed_orcids":["https://orcid.org/0009-0000-6834-3681"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorothy K. Mims","raw_affiliation_strings":["Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045938870","display_name":"Syeda Kanwal Naqvi","orcid":"https://orcid.org/0000-0002-0618-6649","observed_orcids":["https://orcid.org/0000-0002-0618-6649"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syeda Kanwal Naqvi","raw_affiliation_strings":["Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110"],"raw_orcid":"https://orcid.org/0000-0002-0618-6649","affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014785124","display_name":"Timothy R. Peterson","orcid":"https://orcid.org/0000-0002-7749-7129","observed_orcids":["https://orcid.org/0000-0002-7749-7129"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Peterson","raw_affiliation_strings":["Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110","HealthSpan Technologies, Inc, St. Louis, MO 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"HealthSpan Technologies, Inc, St. Louis, MO 63110","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086210412","display_name":"Gabriel Mbalaviele","orcid":"https://orcid.org/0000-0003-4660-0952","observed_orcids":["https://orcid.org/0000-0003-4660-0952"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Mbalaviele","raw_affiliation_strings":["Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110"],"raw_orcid":"https://orcid.org/0000-0003-4660-0952","affiliations":[{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089171919","display_name":"Chia\u2010Lung Wu","orcid":"https://orcid.org/0000-0001-9598-7036","observed_orcids":["https://orcid.org/0000-0001-9598-7036"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chia-Lung Wu","raw_affiliation_strings":["Department of Orthopedics and Physical Performance, University of Rochester, Rochester, NY 14642"],"raw_orcid":"https://orcid.org/0000-0001-9598-7036","affiliations":[{"raw_affiliation_string":"Department of Orthopedics and Physical Performance, University of Rochester, Rochester, NY 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040295712","display_name":"Yousef Abu\u2010Amer","orcid":"https://orcid.org/0000-0002-5890-5086","observed_orcids":["https://orcid.org/0000-0002-5890-5086"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210158667","display_name":"Shriners Hospitals for Children - St. Louis","ror":"https://ror.org/049mpkx27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210144267","https://openalex.org/I4210158667"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yousef Abu-Amer","raw_affiliation_strings":["Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110","Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110","Shriners Hospital for Children, St. Louis, MO 63110"],"raw_orcid":"https://orcid.org/0000-0002-5890-5086","affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Shriners Hospital for Children, St. Louis, MO 63110","institution_ids":["https://openalex.org/I4210158667"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040295712"],"corresponding_institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210158667"],"apc_list":null,"apc_paid":null,"fwci":3.5165,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.92590386,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"121","issue":"7","first_page":"e2310264121","last_page":"e2310264121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.8237000107765198,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.8237000107765198,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.14730000495910645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-hypomethylation","display_name":"DNA hypomethylation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.9810000061988831},{"id":"https://openalex.org/keywords/irf8","display_name":"IRF8","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cpg-islands","display_name":"CpG islands","score":0.7829999923706055},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/synovial-macrophages","display_name":"synovial macrophages","score":0.8759999871253967},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/synovial-fibroblasts","display_name":"synovial fibroblasts","score":0.9990000128746033},{"id":"https://openalex.org/keywords/joint-homeostasis","display_name":"joint homeostasis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/autoimmune-arthritis","display_name":"autoimmune arthritis","score":0.5149999856948853},{"id":"https://openalex.org/keywords/mertk","display_name":"MERTK","score":0.5009999871253967},{"id":"https://openalex.org/keywords/trem2","display_name":"TREM2","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cx3cr1","display_name":"CX3CR1","score":0.9570000171661377},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.859000027179718},{"id":"https://openalex.org/keywords/podoplanin","display_name":"podoplanin","score":0.953000009059906},{"id":"https://openalex.org/keywords/fibroblast-activation-protein","display_name":"fibroblast activation protein","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C117705580","wikidata":"https://www.wikidata.org/wiki/Q18027494","display_name":"IRF8","level":4,"score":0.6839903593063354},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.666580319404602},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6104564070701599},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5595725774765015},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5077725052833557},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.49746063351631165},{"id":"https://openalex.org/C2776821229","wikidata":"https://www.wikidata.org/wiki/Q16965166","display_name":"Inflammatory arthritis","level":3,"score":0.4940963089466095},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4872950315475464},{"id":"https://openalex.org/C2776966659","wikidata":"https://www.wikidata.org/wiki/Q18028003","display_name":"IRF7","level":4,"score":0.4858965277671814},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.480131596326828},{"id":"https://openalex.org/C2780235182","wikidata":"https://www.wikidata.org/wiki/Q1181878","display_name":"Decitabine","level":5,"score":0.4712579548358917},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.45716819167137146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4292599856853485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35367342829704285},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.34985870122909546},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2826473116874695},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1776672899723053},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11791673302650452},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08931320905685425}],"mesh":[{"descriptor_ui":"D000077209","descriptor_name":"Decitabine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000099185","descriptor_name":"Interferon Regulatory Factor-8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001168","descriptor_name":"Arthritis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.2310264121","doi":"https://doi.org/10.1073/pnas.2310264121","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2310264121","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10873594","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10873594","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:38319963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38319963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:oa_4-4236","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/oa_4/3252","pdf_url":null,"source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2020-Current year OA Pubs","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1073/pnas.2310264121","doi":"https://doi.org/10.1073/pnas.2310264121","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2310264121","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2376528013","display_name":"Cabinet microCT System for Musculoskeletal Specimen Imaging","funder_award_id":"1s10od028573-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2603298569","display_name":"Novel insulin-sensitizing NASH/diabetes drugs.","funder_award_id":"R42DK121652","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4112807153","display_name":"Mechanisms of Physiologic and Pathologic Osteoclastogenesis","funder_award_id":"R01AR072623","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4496193474","display_name":"Epigenetic Regulation of Chondrogenesis and Cartilage Development","funder_award_id":"R00AR075899","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5056753225","display_name":"Epigenetic Regulation of Chondrogenesis and Cartilage Development","funder_award_id":"K99AR075899","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6799867860","display_name":"Role of gasdermin D in bone resorption","funder_award_id":"R01AR076758","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7098106372","display_name":"Drug target identification using CRISPRi/a screening","funder_award_id":"1r41gm137625-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000230194","display_name":null,"funder_award_id":"K99/R00-AR075899","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000880103","display_name":"RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINE","funder_award_id":"P30AR074992","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000887677","display_name":"Regulation of Osteoclastogenesis and Inflammatory Osteolysis","funder_award_id":"R01AR082192","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000888074","display_name":"Differential Inflammasome Regulation in the pathogenesis of S. aureus osteomyelitis","funder_award_id":"R01AI161022","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000904334","display_name":"Molecular pathways of calcium pyrophosphate deposition disease","funder_award_id":"R01AG077732","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000921390","display_name":"Diabetes and Related Metabolic Diseases","funder_award_id":"T32DK007120","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306463","display_name":"Orthopaedic Research and Education Foundation","ror":"https://ror.org/029xgej46"},{"id":"https://openalex.org/F4320313002","display_name":"Shriners Hospitals for Children","ror":"https://ror.org/03e8tm275"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1563402960","https://openalex.org/W1742769645","https://openalex.org/W1879966002","https://openalex.org/W1968142189","https://openalex.org/W1971108601","https://openalex.org/W1974277276","https://openalex.org/W1978897662","https://openalex.org/W1981396910","https://openalex.org/W1983019708","https://openalex.org/W1989126519","https://openalex.org/W2000651976","https://openalex.org/W2008228521","https://openalex.org/W2012376370","https://openalex.org/W2028442512","https://openalex.org/W2028934624","https://openalex.org/W2035462330","https://openalex.org/W2040393829","https://openalex.org/W2045510187","https://openalex.org/W2050988558","https://openalex.org/W2063209252","https://openalex.org/W2067398334","https://openalex.org/W2076382804","https://openalex.org/W2077477281","https://openalex.org/W2083826829","https://openalex.org/W2085132270","https://openalex.org/W2089605078","https://openalex.org/W2089801128","https://openalex.org/W2106341988","https://openalex.org/W2123699841","https://openalex.org/W2130913446","https://openalex.org/W2132005991","https://openalex.org/W2140261170","https://openalex.org/W2149014007","https://openalex.org/W2170621724","https://openalex.org/W2344490183","https://openalex.org/W2344918730","https://openalex.org/W2404605060","https://openalex.org/W2471391425","https://openalex.org/W2530386703","https://openalex.org/W2536331209","https://openalex.org/W2545267365","https://openalex.org/W2556744489","https://openalex.org/W2744443859","https://openalex.org/W2755358477","https://openalex.org/W2766665119","https://openalex.org/W2783037826","https://openalex.org/W2789239266","https://openalex.org/W2789246699","https://openalex.org/W2794426141","https://openalex.org/W2796931796","https://openalex.org/W2806675488","https://openalex.org/W2902102863","https://openalex.org/W2902555145","https://openalex.org/W2902593728","https://openalex.org/W2912764306","https://openalex.org/W2921429259","https://openalex.org/W2944564829","https://openalex.org/W2964834213","https://openalex.org/W2967647113","https://openalex.org/W2971188351","https://openalex.org/W2989614033","https://openalex.org/W3012873186","https://openalex.org/W3037615636","https://openalex.org/W3049659582","https://openalex.org/W3080288422","https://openalex.org/W3081735976","https://openalex.org/W3094146068","https://openalex.org/W3118507382","https://openalex.org/W3126243513","https://openalex.org/W3157291649","https://openalex.org/W3190511425","https://openalex.org/W4211054359","https://openalex.org/W4220934739","https://openalex.org/W4293746091","https://openalex.org/W4296195278","https://openalex.org/W4304136343","https://openalex.org/W4315785445","https://openalex.org/W4323074795","https://openalex.org/W4362657175","https://openalex.org/W4385520050"],"related_works":["https://openalex.org/W2755330171","https://openalex.org/W7165180966","https://openalex.org/W2921429259","https://openalex.org/W3162442445","https://openalex.org/W2989614033","https://openalex.org/W4384295958","https://openalex.org/W3157291649","https://openalex.org/W1971108601","https://openalex.org/W1955453756","https://openalex.org/W2140261170"],"abstract_inverted_index":{"Epigenetic":[0],"regulation":[1],"plays":[2],"a":[3,64,116],"crucial":[4],"role":[5],"in":[6,49,70,132,161],"the":[7,34,73,99,124,156],"pathogenesis":[8],"of":[9,53,67,76,91,98,127,130,159,168],"autoimmune":[10],"diseases":[11],"such":[12,19],"as":[13,20],"inflammatory":[14],"arthritis.":[15,54,175],"DNA":[16],"hypomethylating":[17],"agents,":[18],"decitabine":[21],"(DAC),":[22],"have":[23],"been":[24],"shown":[25],"to":[26,172],"dampen":[27],"inflammation":[28,131],"and":[29,45,56,83,110,137,142,145,164],"restore":[30],"immune":[31],"homeostasis.":[32],"In":[33,147],"present":[35],"study,":[36],"we":[37,149],"demonstrate":[38],"that":[39,60,151,165],"DAC":[40,118,160],"elicits":[41],"potent":[42],"anti-inflammatory":[43,77],"effects":[44],"attenuates":[46],"disease":[47],"symptoms":[48],"several":[50],"animal":[51],"models":[52],"Transcriptomic":[55],"epigenomic":[57],"profiling":[58],"show":[59],"DAC-mediated":[61,89],"hypomethylation":[62],"regulates":[63],"wide":[65],"range":[66],"cell":[68],"types":[69],"arthritis,":[71],"altering":[72],"differentiation":[74],"trajectories":[75],"macrophage":[78],"populations,":[79],"regulatory":[80,104],"T":[81,139],"cells,":[82],"tissue-protective":[84],"synovial":[85,133],"fibroblasts":[86],"(SFs).":[87],"Mechanistically,":[88],"demethylation":[90],"intragenic":[92],"5'-Cytosine":[93],"phosphate":[94],"Guanine-3'":[95],"(CpG)":[96],"islands":[97],"transcription":[100],"factor":[101,105],"Irf8":[102,152,169],"(interferon":[103],"8)":[106],"induced":[107],"its":[108,112],"re-expression":[109],"promoted":[111],"repressor":[113],"activity.":[114],"As":[115],"result,":[117],"restored":[119],"joint":[120],"homeostasis":[121],"by":[122],"resetting":[123],"transcriptomic":[125],"signature":[126],"negative":[128],"regulators":[129],"macrophages":[134],"(MerTK,":[135],"Trem2,":[136],"Cx3cr1),":[138],"REGs":[140],"(Foxp3),":[141],"SFs":[143],"(Pdpn":[144],"Fap\u03b1).":[146],"conclusion,":[148],"found":[150],"is":[153,170],"necessary":[154],"for":[155],"inhibitory":[157],"effect":[158],"murine":[162],"arthritis":[163],"direct":[166],"expression":[167],"sufficient":[171],"significantly":[173],"mitigate":[174]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2024-02-07T00:00:00"}