{"id":"https://openalex.org/W4391554864","doi":"https://doi.org/10.1093/noajnl/vdae003","title":"Vorasidenib in IDH mutant WHO grade 2 gliomas: time to stop sitting on the fence?","display_name":"Vorasidenib in IDH mutant WHO grade 2 gliomas: time to stop sitting on the fence?","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4391554864","doi":"https://doi.org/10.1093/noajnl/vdae003","pmid":"https://pubmed.ncbi.nlm.nih.gov/38312228","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10838118"},"language":"en","primary_location":{"id":"doi:10.1093/noajnl/vdae003","doi":"https://doi.org/10.1093/noajnl/vdae003","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdae003","pdf_url":"https://academic.oup.com/noa/article-pdf/6/1/vdae003/56576214/vdae003.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/noa/article-pdf/6/1/vdae003/56576214/vdae003.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042987327","display_name":"Angelo Dipasquale","orcid":"https://orcid.org/0000-0002-3326-8156","observed_orcids":["https://orcid.org/0000-0002-3326-8156"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelo Dipasquale","raw_affiliation_strings":["Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital , Rozzano (Milan ), Italy"],"raw_orcid":"https://orcid.org/0000-0002-3326-8156","affiliations":[{"raw_affiliation_string":"Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital , Rozzano (Milan ), Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063327760","display_name":"Enrico Franceschi","orcid":"https://orcid.org/0000-0001-9332-4677","observed_orcids":["https://orcid.org/0000-0001-9332-4677"]},"institutions":[{"id":"https://openalex.org/I4210120704","display_name":"Institute of Neurological Sciences","ror":"https://ror.org/01yg57d71","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210120704","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Franceschi","raw_affiliation_strings":["Department of Medical Oncology, IRCCS Institute of Neurological Sciences , Bologna , Italy"],"raw_orcid":"https://orcid.org/0000-0001-9332-4677","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, IRCCS Institute of Neurological Sciences , Bologna , Italy","institution_ids":["https://openalex.org/I4210120704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062223253","display_name":"Giuseppe Lombardi","orcid":"https://orcid.org/0000-0003-1316-2132","observed_orcids":["https://orcid.org/0000-0003-1316-2132","https://orcid.org/0009-0008-8485-0155"]},"institutions":[{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Lombardi","raw_affiliation_strings":["Department of Oncology, Oncology 1, Veneto Institute of Oncology IOV - IRCCS , Padua , Italy"],"raw_orcid":"https://orcid.org/0000-0003-1316-2132","affiliations":[{"raw_affiliation_string":"Department of Oncology, Oncology 1, Veneto Institute of Oncology IOV - IRCCS , Padua , Italy","institution_ids":["https://openalex.org/I4210109345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021465650","display_name":"Matteo Simonelli","orcid":"https://orcid.org/0000-0002-5264-1251","observed_orcids":["https://orcid.org/0000-0002-5264-1251"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Matteo Simonelli","raw_affiliation_strings":["Department of Biomedical Sciences, Humanitas University , Pieve Emanuele (Milan ), Italy","Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital , Rozzano (Milan ), Italy"],"raw_orcid":"https://orcid.org/0000-0002-5264-1251","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele (Milan ), Italy","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital , Rozzano (Milan ), Italy","institution_ids":["https://openalex.org/I4210163047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021465650"],"corresponding_institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"],"apc_list":{"value":2824,"currency":"USD","value_usd":2824},"apc_paid":{"value":2824,"currency":"USD","value_usd":2824},"fwci":null,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"1","first_page":"vdae003","last_page":"vdae003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vorasidenib","display_name":"vorasidenib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/idh-mutant-glioma","display_name":"IDH-mutant glioma","score":0.9359999895095825},{"id":"https://openalex.org/keywords/idh1-2-inhibitors","display_name":"IDH1/2 inhibitors","score":0.6650000214576721},{"id":"https://openalex.org/keywords/recurrent-glioma","display_name":"recurrent glioma","score":0.781000018119812},{"id":"https://openalex.org/keywords/idh-mutant-astrocytoma","display_name":"IDH-mutant astrocytoma","score":0.7210000157356262},{"id":"https://openalex.org/keywords/1p-19q-codeletion","display_name":"1p/19q codeletion","score":0.8690000176429749},{"id":"https://openalex.org/keywords/oligodendroglioma","display_name":"oligodendroglioma","score":0.9120000004768372},{"id":"https://openalex.org/keywords/wait-and-see-strategy","display_name":"wait-and-see strategy","score":0.753000020980835},{"id":"https://openalex.org/keywords/radio-chemotherapy","display_name":"radio-chemotherapy","score":0.6859999895095825},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.4959999918937683},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2779652578","wikidata":"https://www.wikidata.org/wiki/Q5442977","display_name":"Fence (mathematics)","level":2,"score":0.8938206434249878},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5579911470413208},{"id":"https://openalex.org/C2776370487","wikidata":"https://www.wikidata.org/wiki/Q1144593","display_name":"Sitting","level":2,"score":0.44703829288482666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3153325319290161},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22306206822395325},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21527111530303955},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11760535836219788},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.05590549111366272},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0482485294342041},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/noajnl/vdae003","doi":"https://doi.org/10.1093/noajnl/vdae003","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdae003","pdf_url":"https://academic.oup.com/noa/article-pdf/6/1/vdae003/56576214/vdae003.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10838118","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10838118","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10838118/pdf/vdae003.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurooncol Adv","raw_type":"Text"},{"id":"pmid:38312228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38312228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-oncology advances","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.1093/noajnl/vdae003","doi":"https://doi.org/10.1093/noajnl/vdae003","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdae003","pdf_url":"https://academic.oup.com/noa/article-pdf/6/1/vdae003/56576214/vdae003.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320330887","display_name":"Humanitas Research Hospital","ror":"https://ror.org/05d538656"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391554864.pdf","grobid_xml":"https://content.openalex.org/works/W4391554864.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2112567075","https://openalex.org/W2884335666","https://openalex.org/W2965607911","https://openalex.org/W3164133956","https://openalex.org/W3168617320","https://openalex.org/W4296624022","https://openalex.org/W4306247069","https://openalex.org/W4313544674","https://openalex.org/W4379284101","https://openalex.org/W4388794664"],"related_works":["https://openalex.org/W4387811718","https://openalex.org/W4379284101","https://openalex.org/W4383852586","https://openalex.org/W4379646000","https://openalex.org/W4386557984","https://openalex.org/W4411082320","https://openalex.org/W7167915529","https://openalex.org/W7125953328","https://openalex.org/W4399973103","https://openalex.org/W4390802409"],"abstract_inverted_index":{"Approximately":[0],"2500":[1],"people":[2],"per":[3,39],"year":[4],"are":[5,149],"diagnosed":[6,46,418],"with":[7,44,90,93,242,246,261,293,328,419,427,625,636,654,665,850,862,952,990],"a":[8,22,57,94,159,180,230,235,329,334,355,441,455,501,508,595,609,623,626,652,655,715,758,816,934,949,1014],"World":[9],"Health":[10,1065],"Organization":[11,914],"grade":[12,770],"2":[13],"(WHO":[14],"G2)":[15],"isocytrate-dehydrogenase":[16],"mutant":[17,176,225],"(IDHm)":[18],"glioma,":[19],"usually":[20],"at":[21,29,406,446],"young":[23],"age":[24,72],"(approximately":[25,852],"40":[26],"years)":[27],"and":[28,35,68,73,82,101,126,190,207,316,449,483,537,550,602,687,708,775,814,917,921,936,963,984,1001,1009,1030,1044,1080,1110],"the":[30,110,153,218,224,358,373,379,393,407,412,462,474,496,512,520,559,568,579,614,690,693,709,728,731,745,844,859,880,883,909,929,970,993,1028,1033,1038,1075,1086,1104,1108],"height":[31],"of":[32,75,112,116,135,155,161,166,183,223,290,360,378,411,437,495,523,547,576,592,616,618,622,628,651,657,730,807,882,911,919,957,959,973,986,1035,1041,1064,1074,1085,1107],"their":[33,91,117,488],"social":[34],"professional":[36],"life.1":[37],"As":[38,827],"most":[40,884],"recent":[41,173],"guidelines,":[42],"patients":[43,241,345,415,471,834,867],"newly":[45],"IDHm":[47,80,244,265,423,631,660,979,1042],"gliomas":[48,268,632,661,749,813,1043],"should":[49,391,416,465,571,778,792,874,904,998],"undergo":[50],"maximal":[51],"safe":[52],"surgical":[53],"resection":[54,648,677],"followed":[55],"by":[56,1057],"wait-and-see":[58,509],"strategy":[59,510,805],"or":[60,263,272,421,738,1116],"sequential":[61],"radio-chemotherapy":[62],"(RT-CT)":[63],"depending":[64],"on":[65,613,753,1027],"WHO":[66,266,424,629,658,811,824],"grading":[67,746],"risk":[69,463,808,926],"factors":[70],"(particularly":[71],"extent":[74],"resection).1":[76],"Patients":[77,274],"having":[78],"both":[79,204,912],"astrocytomas":[81],"IDHm/1p-19q":[83],"co-deleted":[84],"oligodendrogliomas":[85],"used":[86],"to":[87,142,269,288,304,319,385,396,431,478,493,584,714,740,742,768,781,837,858,878,897,932,1024,1066,1119],"live":[88],"long":[89],"disease,":[92,549],"median":[95,309,317],"survival":[96,311,717],"ranging":[97],"between":[98],"3\u201310":[99],"years":[100,282],"15\u201320":[102],"years,":[103],"respectively.1":[104],"During":[105],"this":[106,606],"wide":[107,181],"time":[108,285,318,1021],"frame,":[109],"burden":[111],"long-term":[113,961],"side":[114],"effects":[115,185],"oncological":[118],"treatments,":[119,887],"such":[120,771,888],"as":[121,299,454,594,772,802,815,889,1004,1006],"neurocognitive":[122],"deterioration":[123],"from":[124,129,194,286,684,757,788,1061],"RT":[125],"fertility":[127],"issues":[128,366,681],"CT,":[130],"may":[131,210,485,528,786],"significantly":[132,307,981],"affect":[133],"quality":[134,615],"life.1,2":[136],"Novel":[137],"therapeutic":[138,1039],"strategies":[139],"allowing":[140],"clinicians":[141],"defer":[143],"RT-CT":[144,298,574,593,822,838,864,891],"in":[145,158,172,203,234,280,337,344,357,372,399,473,500,590,692,721,727,748,762,783,795,823,833,847,865,893,907,928,955,978,1037,1045],"these":[146,167,945,1049],"slow-growing":[147],"tumors":[148,168,894],"urgently":[150,383],"needed.":[151],"Since":[152],"discovery":[154],"IDH":[156,177,201,898],"mutation":[157],"subset":[160],"gliomas,":[162,245],"our":[163,368,400,941],"molecular":[164,776,1011],"knowledge":[165],"has":[169,341],"dramatically":[170],"expanded":[171],"years.1":[174],"The":[175,252,1101],"enzyme":[178],"induces":[179],"range":[182],"biological":[184],"including":[186,239],"impaired":[187],"cellular":[188],"differentiation":[189],"genome-wide":[191],"hyper-methylation.1,3":[192],"Evidence":[193],"several":[195,364,516,679],"preclinical":[196],"studies":[197,1047],"demonstrated":[198],"that":[199,367,382,487,567],"blocking":[200],"pathway":[202],"glioma":[205,426,434,980],"cells":[206],"mouse":[208],"models":[209],"elicit":[211],"strong":[212,610],"anticancer":[213,321,600,987],"effects.1,3":[214],"Among":[215],"small":[216],"molecules,":[217],"first-in-class,":[219],"brain-penetrant,":[220],"dual":[221],"inhibitor":[222],"IDH1-2":[226],"enzymes":[227],"vorasidenib":[228,271,306,347,398,532,637,666,704,791,851,968,997,1036],"showed":[229],"favorable":[231],"safety":[232,331],"profile":[233,774],"Phase":[236,254],"I":[237],"study":[238,561],"52":[240],"recurrent":[243,264,422],"promising":[247],"activity":[248],"against":[249],"nonenhancing":[250],"tumors.1,4":[251],"subsequent":[253],"III":[255],"INDIGO":[256,413,560,1076,1087],"trial":[257,447,475,580],"randomized":[258],"331":[259],"subjects":[260],"residual":[262,420],"G2":[267,425,630,659,812],"receive":[270,397,514],"placebo.5":[273],"must":[275],"have":[276,479,572,582,608],"received":[277,573],"surgery":[278,287],"alone":[279],"1\u20135":[281],"before":[283],"(median":[284],"randomization":[289],"2.2\u20132.5":[291],"years),":[292],"no":[294,540,1111],"need":[295,541],"for":[296,300,531,542,634,663,810,828,915,996,1022],"immediate":[297],"physicians\u2019":[301],"judgment.5":[302],"Compared":[303],"placebo,":[305],"improved":[308],"progression-free":[310],"(11.1":[312],"vs":[313,325,349],"27.7":[314],"months)":[315,854],"next":[320],"interventions":[322,988],"(17.8":[323],"months":[324],"not":[326,700,712],"reached),":[327],"tolerable":[330],"profile.5":[332],"Moreover,":[333],"significant":[335,365],"decrease":[336],"tumor":[338,442,489,554,732,1016],"growth":[339],"rate":[340],"been":[342],"observed":[343],"receiving":[346],"(13.9%":[348],"\u20132.5%).6":[350],"These":[351],"results":[352],"represent":[353],"undoubtedly":[354],"breakthrough":[356],"field":[359],"neuro-oncology":[361],"but":[362],"raise":[363],"community":[369],"will":[370,607,688,705,711,947],"face":[371],"very":[374],"close":[375],"future.":[376],"One":[377],"key":[380,587],"questions":[381,954],"needs":[384],"be":[386,392,417,451,466,529,779,793,840,856,905],"addressed":[387],"is":[388,698,750,1020,1103],"which":[389],"patient":[390,624,653,995],"ideal":[394],"candidate":[395],"daily":[401],"clinical":[402,517,535,763,797,942,1000],"practice.":[403],"Looking":[404],"exclusively":[405],"main":[408],"inclusion":[409,448],"criteria":[410],"trial,":[414],"measurable":[428],"disease":[429,482,736],"according":[430],"RANO":[432],"low-grade":[433],"criteria.5":[435],"Most":[436],"them":[438],"(82%\u201384%)":[439],"presented":[440],"dimension":[443],"\u22652":[444],"cm":[445],"would":[450,581],"formally":[452,701],"classified":[453],"high-risk":[456,866],"group,":[457],"therefore":[458],"needing":[459],"RT-CT.1":[460],"Although":[461],"estimation":[464],"performed":[467],"soon":[468],"after":[469,733,821],"surgery,":[470],"recruited":[472],"were":[476,1082],"considered":[477,530],"an":[480,524,803,901],"indolent":[481],"we":[484,723],"assume":[486],"size":[490,555],"was":[491,1054,1072],"comparable":[492],"one":[494,860],"postoperative":[497,863,886],"time.":[498],"However,":[499],"current":[502],"scenario":[503],"where":[504],"\u201clow-risk\u201d":[505],"cases":[506],"follow":[507],"while":[511],"\u201chigh-risk\u201d":[513],"RT-CT,":[515],"features":[518],"outline":[519],"potential":[521],"existence":[522],"\u201cintermediate-risk\"":[525],"group":[526,570],"who":[527,785,835],"treatment:":[533],"preserved":[534],"condition":[536],"neurological":[538],"status,":[539],"corticosteroids,":[543],"well-controlled":[544],"seizures,":[545],"absence":[546],"enhancing":[548],"possibly":[551,1010],"low":[552],"preoperative":[553],"(Table":[556],"1).5\u20137":[557],"Discussing":[558],"design,":[562],"someone":[563],"could":[564],"even":[565,830],"argue":[566],"control":[569,596],"instead":[575],"placebo.":[577],"Nevertheless,":[578],"failed":[583],"investigate":[585],"its":[586,800,831,1120],"secondary":[588],"endpoint":[589],"case":[591],"arm:":[597],"deferring":[598],"other":[599,680,796],"therapies":[601],"related":[603],"toxicities.5":[604],"Undoubtedly,":[605],"positive":[611],"impact":[612],"life":[617],"patients.":[619],"Potential":[620,649],"characteristics":[621,650],"diagnosis":[627,656],"suitable":[633,662],"treatment":[635,664],"KPS,":[638,667],"Karnofsky":[639,668],"Performance":[640,669],"Status;":[641,670],"MRI,":[642,671],"magnetic":[643,672],"resonance":[644,673],"imaging;":[645,674],"STR,":[646,675],"subtotal":[647,676],"Still,":[678],"remain":[682],"far":[683],"being":[685],"solved":[686],"nourish":[689],"debate":[691],"coming":[694],"years.":[695],"First,":[696],"it":[697],"still":[699,751],"known":[702],"whether":[703],"improve":[706],"OS":[707],"crossover":[710],"lead":[713],"meaningful":[716],"analysis.5":[718],"At":[719],"least":[720],"theory,":[722],"cannot":[724,839,855],"exclude":[725],"changes":[726],"biology":[729],"vorasidenib,":[734],"accelerating":[735],"progression":[737,983],"leading":[739],"resistance":[741],"RT-CT.":[743],"Second,":[744],"system":[747,939],"based":[752],"pathological":[754],"features,":[755,1003],"suffering":[756],"relevant":[759],"interobserver":[760],"variability":[761],"practice.8":[764],"More":[765],"reliable":[766],"methods":[767],"refine":[769],"methylation":[773],"markers":[777],"implemented":[780,906],"help":[782],"selecting":[784],"benefit":[787],"vorasidenib.9":[789],"Third,":[790],"tested":[794],"contexts,":[798],"exploring":[799],"role":[801],"\u201call-comers\u201d":[804],"regardless":[806],"stratification":[809],"concurrent":[817],"and/or":[818],"maintenance":[819],"agent":[820],"G2\u20134":[825],"gliomas.":[826],"now,":[829],"use":[832,881,985],"progressed":[836],"put":[841],"aside.":[842],"Fourth,":[843],"overall":[845],"magnitude":[846],"PFS":[848],"achieved":[849],"16":[853],"compared":[857],"obtained":[861],"(more":[868],"than":[869],"5":[870],"years).1,5":[871],"Future":[872],"research":[873],"identify":[875],"predictive":[876],"biomarkers":[877],"tailor":[879],"appropriate":[885,994],"delivering":[890],"immediately":[892],"primary":[895],"resistant":[896],"blockade.":[899],"Finally,":[900],"international":[902],"effort":[903],"revising":[908],"performance":[910],"European":[913],"Research":[916,1069],"Treatment":[918],"Cancer":[920],"Radiation":[922],"Therapy":[923],"Oncology":[924],"Group":[925],"classifications":[927],"modern":[930],"era,":[931],"design":[933],"high-quality":[935],"unified":[937],"prognostication":[938],"supporting":[940],"decision-making.10":[943],"All":[944],"considerations":[946],"trigger":[948],"cascade":[950],"effect,":[951],"further":[953],"terms":[956],"duration":[958],"therapy,":[960],"costs":[962],"chronic":[964],"toxicities.":[965,991],"In":[966],"conclusion,":[967],"represents":[969],"first":[971],"example":[972],"truly":[974],"successful":[975],"targeted":[976],"therapy":[977],"delaying":[982],"burdened":[989],"Selecting":[992],"consider":[999],"radiological":[1002],"well":[1005],"patients\u2019":[1007],"preferences":[1008],"make-up,":[1012],"within":[1013],"multidisciplinary":[1015],"board":[1017],"discussion.":[1018],"It":[1019],"neuro-oncologists":[1023],"stop":[1025],"sitting":[1026],"fence":[1029],"push":[1031],"forward":[1032],"introduction":[1034],"algorithm":[1040],"future":[1046],"addressing":[1048],"still-devasting":[1050],"diseases.":[1051],"This":[1052],"work":[1053],"partially":[1055],"supported":[1056],"\u201cRicerca":[1058],"Corrente\u201d":[1059],"funding":[1060],"Italian":[1062],"Ministry":[1063],"IRCCS":[1067],"Humanitas":[1068],"Hospital.":[1070],"A.D.":[1071],"sub-investigator":[1073],"study.":[1077,1088],"E.F.,":[1078,1095],"G.L.,":[1079,1096],"M.S.":[1081],"principal":[1083],"investigators":[1084],"A.D.:":[1089],"conceptualization,":[1090,1098],"original":[1091],"draft,":[1092],"final":[1093,1099],"draft;":[1094],"M.S.:":[1097],"draft.":[1100],"text":[1102],"sole":[1105],"product":[1106],"author(s)":[1109],"third":[1112],"party":[1113],"had":[1114],"input":[1115],"gave":[1117],"support":[1118],"writing.":[1121]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-02-06T00:00:00"}