{"id":"https://openalex.org/W4391553315","doi":"https://doi.org/10.26226/morressier.5c0a5c96f0ad58000b08a1d4","title":"0374 - Proteoglycan-4 Inhibits TGF-beta Induced Differentiation of Synovial Fibroblasts into Myofibroblasts in a CD44-Dependent Manner","display_name":"0374 - Proteoglycan-4 Inhibits TGF-beta Induced Differentiation of Synovial Fibroblasts into Myofibroblasts in a CD44-Dependent Manner","publication_year":2019,"publication_date":"2019-01-15","ids":{"openalex":"https://openalex.org/W4391553315","doi":"https://doi.org/10.26226/morressier.5c0a5c96f0ad58000b08a1d4"},"language":"en","primary_location":{"id":"doi:10.26226/morressier.5c0a5c96f0ad58000b08a1d4","doi":"https://doi.org/10.26226/morressier.5c0a5c96f0ad58000b08a1d4","is_oa":false,"landing_page_url":"http://dx.doi.org/10.26226/morressier.5c0a5c96f0ad58000b08a1d4","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://openresearchlibrary.org/viewer/4396982b-3fea-4607-8ade-15072a2b15f2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086816730","display_name":"Khaled A. Elsaid","orcid":"https://orcid.org/0000-0002-8925-4255","observed_orcids":["https://orcid.org/0000-0002-8925-4255"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khaled Elsaid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078086926","display_name":"Gregory D. Jay","orcid":"https://orcid.org/0000-0003-1517-8488","observed_orcids":["https://orcid.org/0000-0003-1517-8488"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory Jay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.1265999972820282,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteoglycan-4","display_name":"proteoglycan 4","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.8090000152587891},{"id":"https://openalex.org/keywords/myofibroblast-differentiation","display_name":"myofibroblast differentiation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/synovial-fibroblasts","display_name":"synovial fibroblasts","score":0.984000027179718},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/chondrosarcoma","display_name":"chondrosarcoma","score":0.9419999718666077},{"id":"https://openalex.org/keywords/palovarotene","display_name":"palovarotene","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5849999785423279},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.3190000057220459},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.7454732656478882},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.715786337852478},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.6782795190811157},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.544623076915741},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5286009311676025},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.4747374951839447},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.42425939440727234},{"id":"https://openalex.org/C111001777","wikidata":"https://www.wikidata.org/wiki/Q3562192","display_name":"TGF beta signaling pathway","level":3,"score":0.4167563021183014},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2027086317539215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18367767333984375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1763632893562317},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.1433335542678833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09845021367073059},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.056630998849868774},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.04060781002044678}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.26226/morressier.5c0a5c96f0ad58000b08a1d4","doi":"https://doi.org/10.26226/morressier.5c0a5c96f0ad58000b08a1d4","is_oa":false,"landing_page_url":"http://dx.doi.org/10.26226/morressier.5c0a5c96f0ad58000b08a1d4","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:biblioboard.com:4396982b-3fea-4607-8ade-15072a2b15f2","doi":null,"is_oa":true,"landing_page_url":"https://openresearchlibrary.org/viewer/4396982b-3fea-4607-8ade-15072a2b15f2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401131","display_name":"BiblioBoard Library Catalog (Open Research Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"MODID-759a0011d80:Morressier 2020-2021","raw_type":"OTHER_DOCUMENT"}],"best_oa_location":{"id":"pmh:oai:biblioboard.com:4396982b-3fea-4607-8ade-15072a2b15f2","doi":null,"is_oa":true,"landing_page_url":"https://openresearchlibrary.org/viewer/4396982b-3fea-4607-8ade-15072a2b15f2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401131","display_name":"BiblioBoard Library Catalog (Open Research Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"MODID-759a0011d80:Morressier 2020-2021","raw_type":"OTHER_DOCUMENT"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2993400195","https://openalex.org/W4400584654","https://openalex.org/W4282943499","https://openalex.org/W4282944672","https://openalex.org/W3216197561","https://openalex.org/W2970711074","https://openalex.org/W3015859224","https://openalex.org/W1950994603","https://openalex.org/W7155880154","https://openalex.org/W2397976146"],"abstract_inverted_index":{"Introduction:":[0],"Chondrosarcoma":[1],"(CS)":[2],"is":[3,15,48,229,701],"the":[4,38,42,161,166,174,239,271,287,308,342,360,400,432,494,517,603,618,621,638,702,724,744,758],"most":[5],"common":[6],"primary":[7,731],"skeletal":[8],"sarcoma":[9],"in":[10,63,85,93,118,129,206,209,211,214,231,240,243,251,382,387,457,469,474,573,588,684,757],"adults.":[11],"Treatment":[12],"of":[13,65,91,108,126,137,163,168,203,220,247,289,345,359,366,403,431,440,486,497,516,524,546,602,612,620,641,663,705,707,726,746],"CS":[14,24,66,92,191,254,282,320,631],"currently":[16],"limited":[17],"to":[18,34,100,173,185,225,237,307,556,562,568,668,673],"surgery.":[19],"An":[20],"ideal":[21],"therapy":[22,752],"for":[23,67,124,151,348,755],"would":[25],"be":[26,183,557],"a":[27,49,58,119,143,252,419,505,550,710,749],"minimally-invasive":[28],"local":[29,201,456,607],"or":[30,61,341,399,493,753],"systemic":[31,199,375,596],"treatment":[32,125,460,597,608,636,754,762],"modality":[33],"halt":[35],"growth":[36,84,208,601,733],"within":[37],"lesion":[39],"and":[40,87,178,196,200,213,235,242,257,267,275,296,355,435,442,452,520,526,536,549,579,582,606,623,654,658,676,723],"kill":[41],"tumor":[43,416,433,502,518,604,615,678,732],"cells.":[44,590],"At":[45],"present":[46],"this":[47,80,700],"far":[50],"reaching":[51],"goal":[52],"as":[53,158,160,748,760],"there":[54],"has":[55,77,98,115,148],"not":[56,728],"been":[57,116,149],"major":[59],"breakthrough":[60],"improvement":[62],"survival":[64],"over":[68],"30":[69],"years.":[70],"Previous":[71],"research":[72],"on":[73,146,165,312,709,719,730,736,743],"retinoic":[74,110],"acid":[75,111],"(RA)":[76],"demonstrated":[78,418,504,594],"that":[79,176,189,197,595],"molecule":[81],"alters":[82],"chondrocyte":[83],"vitro":[86,212,241,574],"can":[88],"cause":[89,101],"regression":[90],"animal":[94,216,260],"studies,":[95],"but":[96,734],"RA":[97],"potential":[99],"severe":[102],"adverse":[103],"effects.":[104],"Palovarotene,":[105],"an":[106,210],"agonist":[107],"nuclear":[109],"receptor":[112],"gamma":[113],"(RARu03b3),":[114],"studied":[117],"Phase-III":[120],"human":[121,169,190,232,253,319,630,645,711],"clinical":[122,144],"trial":[123,145],"heterotopic":[127],"ossification":[128],"patients":[130],"with":[131,298,314,338,395,461,489,598],"fibrodysplasia":[132],"ossificans":[133],"progressiva":[134],"without":[135],"reports":[136],"critical":[138],"side":[139],"effects":[140,162,706],"(NCT03312634).":[141],"Furthermore,":[142],"Palovarotene":[147,164,177,340,396,459,490,576,599,613,635,708,727,747],"started":[150],"Multiple":[152],"Osteochondroma":[153],"(NCT03442985).":[154],"These":[155],"prior":[156],"findings":[157],"well":[159],"biology":[167],"cartilage":[170,367,584,664],"lead":[171],"us":[172],"idea":[175],"other":[179],"RARu03b3":[180,194,228,249,570,674],"agonists":[181,250,675],"may":[182],"applicable":[184],"chondrosarcoma.":[186],"We":[187],"hypothesized":[188],"specimens":[192,234,283,632],"retain":[193,569],"signaling":[195],"both":[198],"administration":[202],"palovarotene":[204,376],"results":[205,593],"decreased":[207,577,651],"vivo":[215,244,458,592],"model.":[217],"The":[218,438],"aims":[219],"our":[221,698],"study":[222],"were":[223,262,268,284,304,336,362,370,384,393,445,471,529,566],"(1)":[224],"determine":[226,238],"if":[227],"expressed":[230,633],"chondrosarcoma":[233,328,646,712,756],"(2)":[236],"therapeutic":[245],"action":[246],"selective":[248],"cell":[255,321,421,507,647,713,721],"line.Materials":[256],"Methods:":[258],"All":[259,629],"experiments":[261],"performed":[263,542],"following":[264],"institutional":[265],"guidelines":[266],"approved":[269],"by":[270,372,429,447,514,531],"Institutional":[272],"Animal":[273],"Care":[274],"Use":[276],"Committee":[277,311],"(IACUC)":[278],"at":[279],"UMB.":[280],"Human":[281,564],"obtained":[285],"from":[286,316,325],"University":[288],"Maryland":[290],"Pathology":[291],"Biorepository":[292],"Shared":[293],"Service":[294],"(PBBS)":[295],"immunostained":[297],"anti-RARu03b3":[299],"antibody":[300],"(Sigma).":[301],"Tumor":[302,424,509],"sections":[303],"graded":[305],"according":[306],"American":[309],"Joint":[310],"Cancer":[313],"support":[315],"PBBS.":[317],"A":[318],"line":[322,648],"(HCS2.8)":[323],"established":[324],"grade":[326],"II":[327],"(72yr,":[329],"male)":[330],"was":[331,427,512,541,554,688,695],"used.":[332],"Pellet":[333],"cultures":[334,643],"(300,000/tube)":[335],"treated":[337,394,441,525],"100nM":[339],"same":[343,401,495],"volume":[344,402,425,496,510],"ethanol":[346],"(vehicle)":[347],"7":[349],"days":[350],"(n=3,":[351],"3":[352,410],"times).":[353],"Protein":[354],"glycosaminoglycan":[356],"(GAG)":[357],"content":[358,581],"pellets":[361],"measured.":[363],"Gene":[364],"expression":[365,587,662],"matrix-related":[368],"genes":[369],"evaluated":[371],"qPCR.":[373],"For":[374,455,572],"treatment,":[377],"cells":[378,381,465,468,671],"(1":[379,466],"million":[380,467],"100ml)":[383,470],"inoculated":[385,472],"subcutaneously":[386,473,682],"NOD/Shi-scid":[388,475],"IL2rgamma(null)":[389,476],"(NOG)":[390,477],"mice.":[391,478,685],"Mice":[392,479],"(5":[397,491],"mg/kg)":[398,492],"vehicle":[404],"(1:9,":[405],"DMSO:corn":[406],"oil)":[407],"via":[408],"gavage":[409],"times/week":[411],"starting":[412],"1":[413],"week":[414],"after":[415,450,501,534],"inoculation":[417,503],"viable":[420,506],"mass":[422,605,639,679],"(n=10).":[423],"(WxWxLx1/2)":[426,511],"calculated":[428,513],"measurement":[430,515],"width":[434,519],"length":[436,521],"weekly.":[437,522],"histology":[439],"control":[443,527],"tumors":[444,528],"analyzed":[446,530],"light":[448,532],"microscopy":[449,533],"hematoxylin":[451,535],"eosin":[453,537],"staining.":[454,538],"nanoparticle":[462,610,692],"drug":[463,693],"delivery,":[464],"received":[480],"subcutaneous":[481],"injections":[482],"(every":[483],"3-4":[484],"days)":[485],"nanoparticles":[487,499],"tagged":[488],"untagged":[498],"(n=5)":[500],"mass.":[508],"Histology":[523],"Statistical":[539],"analysis":[540,545],"using":[543,609],"one-way":[544],"variance":[547],"(ANOVA)":[548],"p-value":[551],"<":[552],"0.05":[553],"considered":[555],"statistically":[558],"significant":[559],"when":[560,681,691],"compared":[561,667],"control.Results:":[563],"chondrosarcomas":[565],"found":[567],"expression.":[571],"analysis,":[575],"GAG":[578,653],"protein":[580,656],"reduced":[583,617,637,660,677],"matrix":[585,665],"gene":[586,661],"HCS2/8":[589,670],"In":[591],"inhibited":[600,614],"delivery":[611,694],"growth,":[616],"size":[619,640,680],"mass,":[622],"stimulated":[624],"surrounding":[625],"fibrous":[626],"connective":[627],"tissue.Conclusions:":[628],"RARu03b3.":[634],"pellet":[642],"(HCS2/8":[644],"cells),":[649],"significantly":[650],"total":[652,655],"levels,":[657],"strongly":[659],"molecules":[666],"control.":[669],"responded":[672],"implanted":[683],"This":[686,738],"finding":[687],"more":[689],"pronounced":[690],"utilized.":[696],"To":[697],"knowledge,":[699],"first":[703],"evaluation":[704],"line.":[714],"Future":[715],"studies":[716],"will":[717],"focus":[718],"multiple":[720],"lines":[722],"effect":[725],"only":[729],"also":[735],"metastasis.":[737],"data":[739],"supports":[740],"further":[741],"investigations":[742],"role":[745],"possible":[750],"adjuvant":[751],"future":[759],"current":[761],"modalities":[763],"are":[764],"limited.":[765]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2024-02-06T00:00:00"}