{"id":"https://openalex.org/W4391542085","doi":"https://doi.org/10.1080/23744235.2024.2309348","title":"Variability in plasma rifampicin concentrations and role of SLCO1B1 , ABCB1 , AADAC2 and CES2 genotypes in Ethiopian patients with tuberculosis","display_name":"Variability in plasma rifampicin concentrations and role of SLCO1B1 , ABCB1 , AADAC2 and CES2 genotypes in Ethiopian patients with tuberculosis","publication_year":2024,"publication_date":"2024-02-05","ids":{"openalex":"https://openalex.org/W4391542085","doi":"https://doi.org/10.1080/23744235.2024.2309348","pmid":"https://pubmed.ncbi.nlm.nih.gov/38315168","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11134291"},"language":"en","primary_location":{"id":"doi:10.1080/23744235.2024.2309348","doi":"https://doi.org/10.1080/23744235.2024.2309348","is_oa":true,"landing_page_url":"https://doi.org/10.1080/23744235.2024.2309348","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/23744235.2024.2309348?needAccess=true","source":{"id":"https://openalex.org/S200495913","display_name":"Scandinavian Journal of Infectious Diseases","issn_l":"0036-5548","issn":["0036-5548","1651-1980","2374-4235","2374-4243"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/23744235.2024.2309348?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009736532","display_name":"Tesemma Sileshi","orcid":"https://orcid.org/0000-0002-3489-0051","observed_orcids":["https://orcid.org/0000-0002-3489-0051"]},"institutions":[{"id":"https://openalex.org/I4210114632","display_name":"Ambo University","ror":"https://ror.org/02e6z0y17","country_code":"ET","type":"education","lineage":["https://openalex.org/I4210114632"]},{"id":"https://openalex.org/I4537092","display_name":"Addis Ababa University","ror":"https://ror.org/038b8e254","country_code":"ET","type":"education","lineage":["https://openalex.org/I4537092"]}],"countries":["ET"],"is_corresponding":false,"raw_author_name":"Tesemma Sileshi","raw_affiliation_strings":["Department of Pharmacology and Clinical Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia","Department of Pharmacy, Ambo University, Ambo, Ethiopia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia","institution_ids":["https://openalex.org/I4537092"]},{"raw_affiliation_string":"Department of Pharmacy, Ambo University, Ambo, Ethiopia","institution_ids":["https://openalex.org/I4210114632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022301113","display_name":"Eyasu Makonnen","orcid":"https://orcid.org/0000-0002-9259-5288","observed_orcids":["https://orcid.org/0000-0002-9259-5288"]},"institutions":[{"id":"https://openalex.org/I4537092","display_name":"Addis Ababa University","ror":"https://ror.org/038b8e254","country_code":"ET","type":"education","lineage":["https://openalex.org/I4537092"]}],"countries":["ET"],"is_corresponding":false,"raw_author_name":"Eyasu Makonnen","raw_affiliation_strings":["Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), Addis Ababa University, Addis Ababa, Ethiopia","Department of Pharmacology and Clinical Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), Addis Ababa University, Addis Ababa, Ethiopia","institution_ids":["https://openalex.org/I4537092"]},{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia","institution_ids":["https://openalex.org/I4537092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003891288","display_name":"Nigus Fikrie Telele","orcid":"https://orcid.org/0000-0002-9795-8869","observed_orcids":["https://orcid.org/0000-0002-9795-8869"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Nigus Fikrie Telele","raw_affiliation_strings":["Department of Laboratory Medicines, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicines, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018425623","display_name":"Victoria Barclay","orcid":"https://orcid.org/0000-0001-5803-8691","observed_orcids":["https://orcid.org/0000-0001-5803-8691"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Victoria Barclay","raw_affiliation_strings":["Department of Laboratory Medicines, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicines, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050606821","display_name":"Alimuddin I. Zumla","orcid":"https://orcid.org/0000-0002-5111-5735","observed_orcids":["https://orcid.org/0000-0002-5111-5735"]},"institutions":[{"id":"https://openalex.org/I1340918713","display_name":"University College London Hospitals NHS Foundation Trust","ror":"https://ror.org/042fqyp44","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713"]},{"id":"https://openalex.org/I4210138523","display_name":"UCL Biomedical Research Centre","ror":"https://ror.org/03r9qc142","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I124357947","https://openalex.org/I1340918713","https://openalex.org/I34931013","https://openalex.org/I4210138523","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alimuddin Zumla","raw_affiliation_strings":["Department of Infection, Division of Infection and Immunity, University College London; NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, UK","Department of Infection, Division of Infection and Immunity, University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection, Division of Infection and Immunity, University College London; NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I1340918713","https://openalex.org/I4210138523","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Department of Infection, Division of Infection and Immunity, University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041138412","display_name":"Eleni Aklillu","orcid":"https://orcid.org/0000-0002-9788-0790","observed_orcids":["https://orcid.org/0000-0002-9788-0790"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Eleni Aklillu","raw_affiliation_strings":["Department of Global Public Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Public Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5041138412"],"corresponding_institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"],"apc_list":null,"apc_paid":null,"fwci":2.3147,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.86532776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"56","issue":"4","first_page":"308","last_page":"319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/pharmacokinetic-variability","display_name":"pharmacokinetic variability","score":0.925000011920929},{"id":"https://openalex.org/keywords/slco1b1","display_name":"SLCO1B1","score":0.9020000100135803},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9900000095367432},{"id":"https://openalex.org/keywords/arylacetamide-deacetylase","display_name":"arylacetamide deacetylase","score":0.7720000147819519},{"id":"https://openalex.org/keywords/ces2","display_name":"CES2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/drug-transporter-polymorphisms","display_name":"drug transporter polymorphisms","score":0.5559999942779541},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.6819999814033508},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.38100001215934753},{"id":"https://openalex.org/keywords/ethiopian-patients","display_name":"Ethiopian patients","score":0.5540000200271606},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.42100000381469727},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C2776598434","wikidata":"https://www.wikidata.org/wiki/Q18035517","display_name":"SLCO1B1","level":5,"score":0.9227907657623291},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.8850731253623962},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7390240430831909},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6644741892814636},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5894255638122559},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5408753156661987},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45539137721061707},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.43054714798927307},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.417577862739563},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.384021133184433},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36798083782196045},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.22209537029266357},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16975489258766174},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11714592576026917},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10102212429046631},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05704522132873535}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027381","descriptor_name":"Liver-Specific Organic Anion Transporter 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043182","descriptor_name":"Carboxylesterase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1080/23744235.2024.2309348","doi":"https://doi.org/10.1080/23744235.2024.2309348","is_oa":true,"landing_page_url":"https://doi.org/10.1080/23744235.2024.2309348","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/23744235.2024.2309348?needAccess=true","source":{"id":"https://openalex.org/S200495913","display_name":"Scandinavian Journal of Infectious Diseases","issn_l":"0036-5548","issn":["0036-5548","1651-1980","2374-4235","2374-4243"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:38315168","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38315168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious diseases (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:10766829","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11134291","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11134291/pdf/nihms-1991917.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:11134291","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11134291/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Infect Dis (Lond)","raw_type":"Text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10187513","doi":null,"is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10187513/","pdf_url":"https://discovery.ucl.ac.uk/10187513/1/Zumla_Variability%20in%20plasma%20rifampicin%20concentrations%20and%20role%20of%20SLCO1B1%2C%20ABCB1%2C%20AADAC2%20and%20CES2%20genotypes%20in%20Ethiopian%20patients%20with%20tuberculosis_VoR.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Infectious Diseases (2024) (In press).","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1080/23744235.2024.2309348","doi":"https://doi.org/10.1080/23744235.2024.2309348","is_oa":true,"landing_page_url":"https://doi.org/10.1080/23744235.2024.2309348","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/23744235.2024.2309348?needAccess=true","source":{"id":"https://openalex.org/S200495913","display_name":"Scandinavian Journal of Infectious Diseases","issn_l":"0036-5548","issn":["0036-5548","1651-1980","2374-4235","2374-4243"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3808768309","display_name":"Safety and efficacy of Dolutegravir and EFV400 for pregnant and breast feeding women: a randomized non-inferiority clinical trial","funder_award_id":"RIA2017MC-2009","funder_id":"https://openalex.org/F4320338462","funder_display_name":"European and Developing Countries Clinical Trials Partnership"},{"id":"https://openalex.org/G4550537734","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0616-10016","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G5221540170","display_name":"Pharmacovigilance infrastructure and post-marketing surveillance system capacity building for regional medicine regulatory harmonization in East Africa","funder_award_id":"CSA2016S-1618","funder_id":"https://openalex.org/F4320338462","funder_display_name":"European and Developing Countries Clinical Trials Partnership"},{"id":"https://openalex.org/G7063735130","display_name":null,"funder_award_id":"EDCTP2","funder_id":"https://openalex.org/F4320338462","funder_display_name":"European and Developing Countries Clinical Trials Partnership"},{"id":"https://openalex.org/G8408389010","display_name":"NIHR Senior Investigator Award","funder_award_id":"NIHR203795","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G9000916767","display_name":"Ethiopia-Emory TB Research Training Program","funder_award_id":"D43TW009127","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320324791","display_name":"Addis Ababa University","ror":"https://ror.org/038b8e254"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"},{"id":"https://openalex.org/F4320338462","display_name":"European and Developing Countries Clinical Trials Partnership","ror":"https://ror.org/031jv9v19"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391542085.pdf","grobid_xml":"https://content.openalex.org/works/W4391542085.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W164596951","https://openalex.org/W1454572663","https://openalex.org/W1564336530","https://openalex.org/W1607589451","https://openalex.org/W1975261946","https://openalex.org/W2005867761","https://openalex.org/W2027951201","https://openalex.org/W2048520788","https://openalex.org/W2082749288","https://openalex.org/W2089176235","https://openalex.org/W2095396294","https://openalex.org/W2095750649","https://openalex.org/W2098049342","https://openalex.org/W2098293164","https://openalex.org/W2100669275","https://openalex.org/W2117466548","https://openalex.org/W2120390077","https://openalex.org/W2128813139","https://openalex.org/W2132389528","https://openalex.org/W2141228465","https://openalex.org/W2145156925","https://openalex.org/W2152347011","https://openalex.org/W2163094860","https://openalex.org/W2322937695","https://openalex.org/W2523064628","https://openalex.org/W2537830953","https://openalex.org/W2610453835","https://openalex.org/W2610611142","https://openalex.org/W2778803543","https://openalex.org/W2790694322","https://openalex.org/W2795509126","https://openalex.org/W2799300912","https://openalex.org/W2811190177","https://openalex.org/W2887184336","https://openalex.org/W2914237926","https://openalex.org/W2924733306","https://openalex.org/W2925722354","https://openalex.org/W2944770919","https://openalex.org/W2972749921","https://openalex.org/W2993753673","https://openalex.org/W3004687593","https://openalex.org/W3009705041","https://openalex.org/W3033461373","https://openalex.org/W3048214389","https://openalex.org/W3096070943","https://openalex.org/W3114083633","https://openalex.org/W3118862238","https://openalex.org/W3127546456","https://openalex.org/W3135682442","https://openalex.org/W3149613193","https://openalex.org/W3200448135","https://openalex.org/W3201047840","https://openalex.org/W4200016487","https://openalex.org/W4200239741","https://openalex.org/W4280546967","https://openalex.org/W4281671471","https://openalex.org/W4283722343","https://openalex.org/W4384405887"],"related_works":["https://openalex.org/W2993753673","https://openalex.org/W2145156925","https://openalex.org/W2610453835","https://openalex.org/W2098049342","https://openalex.org/W2511728985","https://openalex.org/W4388736154","https://openalex.org/W2581802811","https://openalex.org/W4412479486","https://openalex.org/W3127162100","https://openalex.org/W2132389528"],"abstract_inverted_index":{"Background":[0],"Rifampicin,":[1],"a":[2],"key":[3],"drug":[4],"against":[5],"tuberculosis":[6],"(TB),":[7],"displays":[8],"wide":[9],"between-patient":[10],"pharmacokinetics":[11],"variability":[12,19],"and":[13,24,33,92,110,119,126,166,177,183,194,222,249,252,255,273],"concentration-dependent":[14],"antimicrobial":[15],"effect.":[16],"We":[17,43],"investigated":[18],"in":[20,38,237],"plasma":[21,100,229,234,265],"rifampicin":[22,108,117,181,192,204,228,233,264,276],"concentrations":[23,235],"the":[25,137],"role":[26],"of":[27,59,107,134,191,203,211,239,262],"SLCO1B1,":[28],"ABCB1,":[29],"arylacetamide":[30],"deacetylase":[31],"(AADAC)":[32],"carboxylesterase":[34],"2":[35,57],"(CES-2)":[36],"genotypes":[37,187,199,254],"Ethiopian":[39,240],"patients":[40,46,135,257],"with":[41,47,246],"TB.Methods":[42],"enrolled":[44],"adult":[45],"newly":[48],"diagnosed":[49],"TB":[50,241,270],"(n":[51],"=":[52],"119)":[53],"who":[54],"had":[55],"received":[56],"weeks":[58],"rifampicin-based":[60],"anti-TB":[61],"therapy.":[62],"Venous":[63],"blood":[64],"samples":[65],"were":[66,97,113,121,171,188,200],"obtained":[67],"at":[68,259],"three":[69],"time":[70],"points":[71],"post-dose.":[72],"Genotypes":[73],"for":[74,146],"SLCO1B1":[75,212],"(c.388A":[76,148,213],">":[77,80,84,87,90,95,149,153,157,160,164,169,185,197,214,217,220,225],"G,":[78,161,186,215],"c.521T":[79,216],"C),":[81,154,218],"ABCB1":[82,155],"(c.3435C":[83],"T,":[85,158],"c.4036A":[86],"G),":[88,150],"AADACc.841G":[89,196],"A":[91,165,198],"CES-2":[93,167,223],"(c.269-965A":[94],"G)":[96],"determined.":[98],"Rifampicin":[99,243],"concentration":[101],"was":[102,207],"quantified":[103],"using":[104],"LC-MS/MS.":[105],"Predictors":[106],"Cmax":[109,118,193],"AUC0\u20137":[111,120],"h":[112],"analysed.Results":[114],"The":[115,143,267],"median":[116],"6.76":[122],"\u00b5g/mL":[123],"(IQR":[124,129],"5.37\u20138.48)":[125],"17.05":[127],"\u00b5g\u00b7h/mL":[128],"13.87\u201322.26),":[130],"respectively.":[131,179],"Only":[132],"30.3%":[133],"achieved":[136],"therapeutic":[138,281],"efficacy":[139,282],"threshold":[140],"(Cmax>8":[141],"\u00b5g/mL).":[142],"allele":[144],"frequency":[145],"SLCO1B1*1B":[147],"SLCO1B1*5":[151],"(c.521T":[152],"c.3435C":[156],"ABCB1c.4036A":[159,184],"AADAC":[162],"c.841G":[163],"c.269-965A":[168,224],"G":[170,226],"2.2%,":[172],"20.2%,":[173],"24.4%,":[174],"14.6%,":[175],"86.1%":[176],"30.6%,":[178],"Sex,":[180],"dose":[182,248],"significant":[189,201,209],"predictors":[190,202],"AUC0\u20137.":[195],"Cmax.":[205],"There":[206],"no":[208],"influence":[210],"ABCB1c.3435C":[219],"T":[221],"on":[227,269],"exposure":[230,244],"variability.Conclusions":[231],"Subtherapeutic":[232],"occurred":[236],"two-thirds":[238],"patients.":[242],"varied":[245],"sex,":[247],"genotypes.":[250],"AADACc.841G/G":[251],"ABCB1c.4036A/A":[253],"male":[256],"are":[258],"higher":[260],"risk":[261],"lower":[263],"exposure.":[266],"impact":[268],"treatment":[271],"outcomes":[272],"whether":[274],"high-dose":[275],"is":[277],"required":[278],"to":[279],"improve":[280],"requires":[283],"further":[284],"investigation.":[285]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-02-06T00:00:00"}