{"id":"https://openalex.org/W4391541149","doi":"https://doi.org/10.3390/jof10020131","title":"Galleria mellonella Model of Coccidioidomycosis for Drug Susceptibility Tests and Virulence Factor Identification","display_name":"Galleria mellonella Model of Coccidioidomycosis for Drug Susceptibility Tests and Virulence Factor Identification","publication_year":2024,"publication_date":"2024-02-05","ids":{"openalex":"https://openalex.org/W4391541149","doi":"https://doi.org/10.3390/jof10020131","pmid":"https://pubmed.ncbi.nlm.nih.gov/38392803","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10890491"},"language":"en","primary_location":{"id":"doi:10.3390/jof10020131","doi":"https://doi.org/10.3390/jof10020131","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jof10020131","pdf_url":"https://www.mdpi.com/2309-608X/10/2/131/pdf?version=1707123118","source":{"id":"https://openalex.org/S2737643958","display_name":"Journal of Fungi","issn_l":"2309-608X","issn":["2309-608X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Fungi","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2309-608X/10/2/131/pdf?version=1707123118","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109926365","display_name":"Matthew Mendoza Barker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Mendoza Barker","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78249, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78249, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101814386","display_name":"Sarah Saeger","orcid":"https://orcid.org/0000-0003-4959-3321","observed_orcids":["https://orcid.org/0000-0003-4959-3321"]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Saeger","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78249, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78249, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008581529","display_name":"Althea Campuzano","orcid":"https://orcid.org/0000-0003-3159-7113","observed_orcids":["https://orcid.org/0000-0003-3159-7113"]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Althea Campuzano","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78249, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78249, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050645487","display_name":"Jieh\u2010Juen Yu","orcid":"https://orcid.org/0000-0001-8901-3366","observed_orcids":["https://orcid.org/0000-0001-8901-3366"]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jieh-Juen Yu","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78249, USA"],"raw_orcid":"https://orcid.org/0000-0001-8901-3366","affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78249, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003041501","display_name":"Chiung-Yu Hung","orcid":"https://orcid.org/0000-0003-1091-3420","observed_orcids":["https://orcid.org/0000-0003-1091-3420"]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chiung-Yu Hung","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78249, USA"],"raw_orcid":"https://orcid.org/0000-0003-1091-3420","affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78249, USA","institution_ids":["https://openalex.org/I45438204"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003041501"],"corresponding_institution_ids":["https://openalex.org/I45438204"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2955},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2955},"fwci":2.7938,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.90896619,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"2","first_page":"131","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12317","display_name":"Actinomycetales infections and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coccidioidomycosis","display_name":"coccidioidomycosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/coccidioides-posadasii","display_name":"Coccidioides posadasii","score":0.9900000095367432},{"id":"https://openalex.org/keywords/galleria-mellonella","display_name":"Galleria mellonella","score":0.9750000238418579},{"id":"https://openalex.org/keywords/invertebrate-infection-model","display_name":"invertebrate infection model","score":0.75},{"id":"https://openalex.org/keywords/drug-susceptibility-testing","display_name":"drug susceptibility testing","score":0.7440000176429749},{"id":"https://openalex.org/keywords/antifungal-susceptibility","display_name":"antifungal susceptibility","score":0.7630000114440918},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/attenuated-mutants","display_name":"attenuated mutants","score":0.746999979019165},{"id":"https://openalex.org/keywords/lethal-dose","display_name":"lethal dose","score":0.609000027179718},{"id":"https://openalex.org/keywords/dimorphic-fungi","display_name":"dimorphic fungi","score":0.703000009059906},{"id":"https://openalex.org/keywords/fungal-pathogenesis","display_name":"fungal pathogenesis","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2779032433","wikidata":"https://www.wikidata.org/wiki/Q761648","display_name":"Galleria mellonella","level":4,"score":0.9519245624542236},{"id":"https://openalex.org/C2781030883","wikidata":"https://www.wikidata.org/wiki/Q142764","display_name":"Coccidioides","level":2,"score":0.9494727253913879},{"id":"https://openalex.org/C2778439347","wikidata":"https://www.wikidata.org/wiki/Q5139154","display_name":"Coccidioides immitis","level":2,"score":0.8901760578155518},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.8661550283432007},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7836188673973083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7339760065078735},{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.4735642671585083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11647054553031921},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10334700345993042}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/jof10020131","doi":"https://doi.org/10.3390/jof10020131","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jof10020131","pdf_url":"https://www.mdpi.com/2309-608X/10/2/131/pdf?version=1707123118","source":{"id":"https://openalex.org/S2737643958","display_name":"Journal of Fungi","issn_l":"2309-608X","issn":["2309-608X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Fungi","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10890491","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10890491","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10890491/pdf/jof-10-00131.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Fungi (Basel)","raw_type":"Text"},{"id":"pmid:38392803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38392803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of fungi (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f2969185131b407a905f6751ef2c817a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f2969185131b407a905f6751ef2c817a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Fungi, Vol 10, Iss 2, p 131 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/jof10020131","doi":"https://doi.org/10.3390/jof10020131","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jof10020131","pdf_url":"https://www.mdpi.com/2309-608X/10/2/131/pdf?version=1707123118","source":{"id":"https://openalex.org/S2737643958","display_name":"Journal of Fungi","issn_l":"2309-608X","issn":["2309-608X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Fungi","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1251466681","display_name":null,"funder_award_id":"U19AI166761 357","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6186340955","display_name":"IMSD at the University of Texas at San Antonio","funder_award_id":"T32GM148393","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7304735917","display_name":"Development of a multivalent vaccine against Coccidioides infection","funder_award_id":"R01AI135005","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7309172719","display_name":"Apply an imaging flow cytometry method to screen chemical libraries for identifying and repurposing novel drugs against coccidioidomycosis","funder_award_id":"R21AI149015","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000887647","display_name":"SA-CCRC-Development of Therapeutics and Vaccines Against Coccidioidomycosis.","funder_award_id":"U19AI166761","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391541149.pdf","grobid_xml":"https://content.openalex.org/works/W4391541149.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W141500025","https://openalex.org/W1592427016","https://openalex.org/W1977855522","https://openalex.org/W1992998807","https://openalex.org/W2004835017","https://openalex.org/W2005800004","https://openalex.org/W2006787162","https://openalex.org/W2035068769","https://openalex.org/W2060064095","https://openalex.org/W2081736048","https://openalex.org/W2098785804","https://openalex.org/W2103445583","https://openalex.org/W2109335866","https://openalex.org/W2114749809","https://openalex.org/W2117184765","https://openalex.org/W2147347499","https://openalex.org/W2162577709","https://openalex.org/W2195029035","https://openalex.org/W2262970286","https://openalex.org/W2304870262","https://openalex.org/W2344955866","https://openalex.org/W2522912104","https://openalex.org/W2575268702","https://openalex.org/W2594895580","https://openalex.org/W2808732329","https://openalex.org/W2887612837","https://openalex.org/W2892049897","https://openalex.org/W2903809447","https://openalex.org/W2911397280","https://openalex.org/W2970817563","https://openalex.org/W2999106736","https://openalex.org/W3000665355","https://openalex.org/W3011465664","https://openalex.org/W3087518924","https://openalex.org/W3093766421","https://openalex.org/W3128296919","https://openalex.org/W3134633551","https://openalex.org/W4206301643","https://openalex.org/W4225503377","https://openalex.org/W4225660617","https://openalex.org/W4236165009","https://openalex.org/W4283719221","https://openalex.org/W4382940804","https://openalex.org/W4390777257"],"related_works":["https://openalex.org/W2474322613","https://openalex.org/W2035068769","https://openalex.org/W2198539446","https://openalex.org/W4285217036","https://openalex.org/W4224435237","https://openalex.org/W4407223813","https://openalex.org/W4407701709","https://openalex.org/W3093766421","https://openalex.org/W2903925328","https://openalex.org/W4407887372"],"abstract_inverted_index":{"Coccidioidomycosis":[0],"(CM)":[1],"can":[2,92,193],"manifest":[3],"as":[4,17,196],"respiratory":[5],"and":[6,45,77,94,113],"disseminated":[7],"diseases":[8],"that":[9,89,190],"are":[10],"caused":[11],"by":[12],"dimorphic":[13],"fungal":[14],"pathogens,":[15],"such":[16],"Coccidioides":[18,90,123,159,201],"species.":[19],"The":[20],"inhaled":[21],"arthroconidia":[22],"generated":[23],"during":[24],"the":[25,34,38,62,81,96,100,103,108,120,129,142,167],"saprobic":[26],"growth":[27],"phase":[28],"convert":[29,93],"into":[30],"multinucleated":[31],"spherules":[32],"in":[33,135,177],"lungs":[35],"to":[36,70,80,140,156],"complete":[37,95],"parasitic":[39,97],"lifecycle.":[40],"Research":[41],"on":[42],"coccidioidal":[43,170],"virulence":[44,176],"pathogenesis":[46],"primarily":[47],"employs":[48],"murine":[49,181],"models":[50],"typically":[51],"associated":[52],"with":[53],"low":[54],"lethal":[55],"doses":[56],"(LD100":[57],"<":[58],"100":[59],"spores).":[60],"However,":[61],"Galleria":[63,104,191],"model":[64,133,155,182,198],"has":[65],"recently":[66],"garnered":[67],"attention":[68],"due":[69],"its":[71],"immune":[72],"system":[73,83],"bearing":[74],"both":[75],"structural":[76],"functional":[78],"similarities":[79],"innate":[82],"of":[84,102,131,144,175,183],"mammals.":[85],"Our":[86],"findings":[87],"indicate":[88],"posadasii":[91,124,160],"cycle":[98],"within":[99],"hemocoel":[101],"larva.":[105],"In":[106,185],"Galleria,":[107],"LD100":[109],"is":[110],"between":[111],"0.5":[112],"1.0":[114],"\u00d7":[115],"106":[116],"viable":[117],"spores":[118],"for":[119,134,199],"clinical":[121],"isolate":[122],"C735.":[125],"Furthermore,":[126],"we":[127,151,188],"demonstrated":[128,189],"suitability":[130],"this":[132,153,186],"vivo":[136],"antifungal":[137],"susceptibility":[138],"tests":[139],"validate":[141],"bioreactivity":[143],"newly":[145],"discovered":[146],"antifungals":[147],"against":[148],"Coccidioides.":[149],"Additionally,":[150],"utilized":[152],"larva":[154],"screen":[157],"a":[158,173,178,197],"mutant":[161],"library":[162],"showing":[163],"attenuated":[164,169],"virulence.":[165],"Similarly,":[166],"identified":[168],"mutants":[171],"displayed":[172],"loss":[174],"commonly":[179],"used":[180],"coccidioidomycosis.":[184],"study,":[187],"larvae":[192],"be":[194],"applied":[195],"studying":[200],"infection.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-02-06T00:00:00"}
