{"id":"https://openalex.org/W4391539946","doi":"https://doi.org/10.1016/j.jphs.2024.02.004","title":"Presynaptic inhibition of excitatory synaptic transmission from the calcitonin gene-related peptide-containing parabrachial neurons to the central amygdala in mice \u2013 unexpected influence of systemic inflammation thereon","display_name":"Presynaptic inhibition of excitatory synaptic transmission from the calcitonin gene-related peptide-containing parabrachial neurons to the central amygdala in mice \u2013 unexpected influence of systemic inflammation thereon","publication_year":2024,"publication_date":"2024-02-05","ids":{"openalex":"https://openalex.org/W4391539946","doi":"https://doi.org/10.1016/j.jphs.2024.02.004","pmid":"https://pubmed.ncbi.nlm.nih.gov/38485344"},"language":"en","primary_location":{"id":"doi:10.1016/j.jphs.2024.02.004","doi":"https://doi.org/10.1016/j.jphs.2024.02.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jphs.2024.02.004","pdf_url":null,"source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jphs.2024.02.004","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108471339","display_name":"Naoko Sato","orcid":"https://orcid.org/0000-0001-7732-1433","observed_orcids":["https://orcid.org/0000-0001-7732-1433"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoko Sato","raw_affiliation_strings":["Department of Neuroscience, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan; Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan","Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan","Department of Neuroscience, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan; Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Department of Neuroscience, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102783819","display_name":"Yukari Takahashi","orcid":"https://orcid.org/0000-0002-7098-5971","observed_orcids":["https://orcid.org/0000-0002-7098-5971"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukari Takahashi","raw_affiliation_strings":["Department of Neuroscience, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan; Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan","Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan","Department of Neuroscience, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan; Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Department of Neuroscience, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089698124","display_name":"Yae K. Sugimura","orcid":"https://orcid.org/0000-0001-8840-797X","observed_orcids":["https://orcid.org/0000-0001-8840-797X"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yae K. Sugimura","raw_affiliation_strings":["Department of Neuroscience, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan; Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan","Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan","Department of Neuroscience, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan; Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Department of Neuroscience, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020485700","display_name":"Fusao Kato","orcid":"https://orcid.org/0000-0003-0031-9946","observed_orcids":["https://orcid.org/0000-0003-0031-9946"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Fusao Kato","raw_affiliation_strings":["Department of Neuroscience, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan; Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan. Electronic address: fusao@jikei.ac.jp","Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan","Department of Neuroscience, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0031-9946","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan; Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan. Electronic address: fusao@jikei.ac.jp","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Center for Neuroscience of Pain, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8461, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Department of Neuroscience, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020485700"],"corresponding_institution_ids":["https://openalex.org/I115498069"],"apc_list":{"value":2070,"currency":"USD","value_usd":2070},"apc_paid":{"value":2070,"currency":"USD","value_usd":2070},"fwci":1.5099,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.78333051,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"154","issue":"4","first_page":"264","last_page":"273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.12380000203847885,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/presynaptic-inhibition","display_name":"presynaptic inhibition","score":0.9760000109672546},{"id":"https://openalex.org/keywords/lateral-parabrachial-nucleus","display_name":"lateral parabrachial nucleus","score":0.8970000147819519},{"id":"https://openalex.org/keywords/central-nucleus-of-the-amygdala","display_name":"central amygdala","score":0.9990000128746033},{"id":"https://openalex.org/keywords/calcitonin-gene-related-peptide","display_name":"calcitonin gene-related peptide","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.8809999823570251},{"id":"https://openalex.org/keywords/damgo","display_name":"DAMGO","score":0.6899999976158142},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.843999981880188},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6740000247955322},{"id":"https://openalex.org/keywords/paired-pulse-ratio","display_name":"paired-pulse ratio","score":0.8519999980926514},{"id":"https://openalex.org/keywords/postsynaptic-currents","display_name":"postsynaptic currents","score":0.625}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6334642767906189},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5483483076095581},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.5469127893447876},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.5467416644096375},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.5368794202804565},{"id":"https://openalex.org/C2777426569","wikidata":"https://www.wikidata.org/wiki/Q5062126","display_name":"Central nucleus of the amygdala","level":3,"score":0.5269837379455566},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4888993799686432},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.4552958011627197},{"id":"https://openalex.org/C163170386","wikidata":"https://www.wikidata.org/wiki/Q419432","display_name":"Calcitonin gene-related peptide","level":4,"score":0.4508979320526123},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.39654824137687683},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.2508871853351593},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.22866106033325195},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22235316038131714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1673392653465271},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015740","descriptor_name":"Calcitonin Gene-Related Peptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066274","descriptor_name":"Central Amygdaloid Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jphs.2024.02.004","doi":"https://doi.org/10.1016/j.jphs.2024.02.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jphs.2024.02.004","pdf_url":null,"source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},{"id":"pmid:38485344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38485344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacological sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jphs.2024.02.004","doi":"https://doi.org/10.1016/j.jphs.2024.02.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jphs.2024.02.004","pdf_url":null,"source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1519700797","display_name":"Pain-associated synaptic plasticity in the spino-parabrachio-amygdaloid descending loop regulatory system","funder_award_id":"18H02722","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G1848005407","display_name":"\u75db\u307f\u306e\u8a8d\u77e5\u3092\u62c5\u3046\u65b0\u898f\u795e\u7d4c\u56de\u8def\u300c\u6241\u6843\u4f53-\u524d\u969c\u30b7\u30b9\u30c6\u30e0\u300d\u306e\u5f79\u5272\u89e3\u660e","funder_award_id":"23K16589","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2134061291","display_name":"Analysis of the functional role of pain-associated neurons identified by Fos-TRAP method","funder_award_id":"20K09207","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4625535539","display_name":"Role of parabrachial-central amygdala system in inflammation-pain association","funder_award_id":"21H02816","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G942061416","display_name":"Elucidation of the brain network for pain chronification by functional identification of pain-activated neurons","funder_award_id":"23K08391","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320310759","display_name":"Nakatomi Foundation","ror":"https://ror.org/0196vdc40"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W249163298","https://openalex.org/W1846298518","https://openalex.org/W1899857231","https://openalex.org/W1970809582","https://openalex.org/W2005198003","https://openalex.org/W2008021363","https://openalex.org/W2017860510","https://openalex.org/W2033715816","https://openalex.org/W2059635921","https://openalex.org/W2114024266","https://openalex.org/W2121960517","https://openalex.org/W2142638485","https://openalex.org/W2278798383","https://openalex.org/W2338409004","https://openalex.org/W2464530791","https://openalex.org/W2569704946","https://openalex.org/W2623656223","https://openalex.org/W2745373007","https://openalex.org/W2754465188","https://openalex.org/W2767493153","https://openalex.org/W2775139643","https://openalex.org/W2786697307","https://openalex.org/W2800979197","https://openalex.org/W2895332843","https://openalex.org/W2895537563","https://openalex.org/W2896887971","https://openalex.org/W2903966941","https://openalex.org/W2979822571","https://openalex.org/W3010840911","https://openalex.org/W3013066705","https://openalex.org/W3087719424","https://openalex.org/W3106772924","https://openalex.org/W3137380809","https://openalex.org/W3139431112","https://openalex.org/W3210230790","https://openalex.org/W3214642075","https://openalex.org/W3216733537","https://openalex.org/W4281734933","https://openalex.org/W4282936225","https://openalex.org/W4283162213","https://openalex.org/W4303699451","https://openalex.org/W4307848524","https://openalex.org/W4321452648","https://openalex.org/W4362672090","https://openalex.org/W4372211732"],"related_works":["https://openalex.org/W2979848972","https://openalex.org/W2278798383","https://openalex.org/W4362556847","https://openalex.org/W3216733537","https://openalex.org/W3013798941","https://openalex.org/W3110964573","https://openalex.org/W2623656223","https://openalex.org/W4385580781","https://openalex.org/W4220709670","https://openalex.org/W4313200239"],"abstract_inverted_index":{"The":[0,26],"monosynaptic":[1],"connection":[2],"from":[3,31],"the":[4,10,24,32,43,55,68,109,125,167,177,182,199],"lateral":[5],"parabrachial":[6],"nucleus":[7,38],"(LPB)":[8],"to":[9,23,42,155],"central":[11],"amygdala":[12],"(CeA)":[13],"serves":[14],"as":[15],"a":[16,117],"fundamental":[17],"pathway":[18],"for":[19],"transmitting":[20],"nociceptive":[21,29,51,179],"signals":[22],"brain.":[25],"LPB":[27,85],"receives":[28],"information":[30],"dorsal":[33],"horn":[34],"and":[35,39,50,100,198],"spinal":[36],"trigeminal":[37],"sends":[40],"it":[41],"\u201cnociceptive\u201d":[44],"CeA,":[45],"which":[46],"modulates":[47],"pain-associated":[48],"emotions":[49],"sensitivity.":[52],"To":[53],"elucidate":[54],"role":[56],"of":[57,70,111,131],"densely":[58],"expressed":[59],"mu-opioid":[60],"receptors":[61],"(MORs)":[62],"within":[63],"this":[64,138,189,204],"pathway,":[65],"we":[66],"investigated":[67],"effects":[69],"exogenously":[71],"applied":[72,146],"opioids":[73,173],"on":[74],"LPB-CeA":[75,183],"synaptic":[76],"transmission,":[77],"employing":[78],"optogenetics":[79],"in":[80,84,116,124,152],"mice":[81,153],"expressing":[82],"channelrhodopsin-2":[83],"neurons":[86],"with":[87,121],"calcitonin":[88],"gene-related":[89],"peptide":[90],"(CGRP).":[91],"A":[92],"MOR":[93],"agonist":[94,130,140],"([D-Ala(Kato":[95],"et":[96,103],"al.,":[97,104],"2018)":[98],",22N\u2013Me-Phe(Thompson":[99],"Neugebauer,":[101],"2017),Glycinol(Aicher":[102],"2013)]-enkephalin,":[105],"DAMGO)":[106],"significantly":[107,133,141],"reduced":[108],"amplitude":[110,144],"light-evoked":[112],"postsynaptic":[113],"currents":[114],"(leEPSCs),":[115],"manner":[118],"negatively":[119],"correlated":[120],"an":[122,148],"increase":[123],"paired-pulse":[126],"ratio.":[127],"An":[128],"inverse":[129,139],"MORs":[132],"attenuated":[134],"these":[135],"effects.":[136],"Notably,":[137],"increased":[142],"leEPSC":[143],"when":[145],"alone,":[147],"effect":[149],"further":[150],"amplified":[151],"subjected":[154],"lipopolysaccharide":[156],"injection":[157],"2":[158],"h":[159],"before":[160],"brain":[161],"isolation,":[162],"yet":[163],"not":[164],"observed":[165],"at":[166,181],"24-h":[168],"mark.":[169],"We":[170],"conclude":[171],"that":[172],"could":[174],"shut":[175],"off":[176],"ascending":[178],"signal":[180],"synapse":[184],"through":[185],"presynaptic":[186],"mechanisms.":[187],"Moreover,":[188],"gating":[190],"process":[191],"might":[192],"be":[193],"modulated":[194],"by":[195],"endogenous":[196],"opioids,":[197],"innate":[200],"immune":[201],"system":[202],"influences":[203],"modulation.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-02-06T00:00:00"}
