{"id":"https://openalex.org/W4391534550","doi":"https://doi.org/10.7759/cureus.53600","title":"Complete Response With Trametinib in Advanced Low-Grade Serous Ovarian Carcinoma: A Case Report","display_name":"Complete Response With Trametinib in Advanced Low-Grade Serous Ovarian Carcinoma: A Case Report","publication_year":2024,"publication_date":"2024-02-05","ids":{"openalex":"https://openalex.org/W4391534550","doi":"https://doi.org/10.7759/cureus.53600","pmid":"https://pubmed.ncbi.nlm.nih.gov/38449951","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10915706"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.53600","doi":"https://doi.org/10.7759/cureus.53600","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.53600","pdf_url":"https://assets.cureus.com/uploads/case_report/pdf/223467/20240205-19789-1dvcco8.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://assets.cureus.com/uploads/case_report/pdf/223467/20240205-19789-1dvcco8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016148937","display_name":"Pedro Antunes Meireles","orcid":"https://orcid.org/0000-0002-3356-1969","observed_orcids":["https://orcid.org/0000-0002-3356-1969"]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Pedro Antunes Meireles","raw_affiliation_strings":["Department of Medical Oncology, Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil, Lisbon, PRT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil, Lisbon, PRT","institution_ids":["https://openalex.org/I4210103180"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015216676","display_name":"Beatriz Mira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Beatriz Mira","raw_affiliation_strings":["Department of Medical Oncology, Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil, Lisbon, PRT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil, Lisbon, PRT","institution_ids":["https://openalex.org/I4210103180"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089139257","display_name":"F\u00e1tima Vaz","orcid":"https://orcid.org/0000-0002-3334-215X","observed_orcids":["https://orcid.org/0000-0002-3334-215X"]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"F\u00e1tima Vaz","raw_affiliation_strings":["Department of Medical Oncology, Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil, Lisbon, PRT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil, Lisbon, PRT","institution_ids":["https://openalex.org/I4210103180"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016148937"],"corresponding_institution_ids":["https://openalex.org/I4210103180"],"apc_list":null,"apc_paid":null,"fwci":0.3543,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.55950312,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"16","issue":"2","first_page":"e53600","last_page":"e53600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-grade-serous-ovarian-carcinoma","display_name":"low-grade serous ovarian cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/trametinib","display_name":"trametinib","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.9739999771118164},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.9190000295639038},{"id":"https://openalex.org/keywords/recurrent-ovarian-cancer","display_name":"recurrent ovarian cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9649999737739563},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/interval-cytoreduction","display_name":"interval cytoreduction","score":0.9269999861717224},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8664897084236145},{"id":"https://openalex.org/C2778472372","wikidata":"https://www.wikidata.org/wiki/Q7833138","display_name":"Trametinib","level":4,"score":0.7815516591072083},{"id":"https://openalex.org/C2777632260","wikidata":"https://www.wikidata.org/wiki/Q19000698","display_name":"Serous carcinoma","level":4,"score":0.7034096121788025},{"id":"https://openalex.org/C3019054536","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinoma","level":4,"score":0.6921672821044922},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6252490878105164},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6173774600028992},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.609323263168335},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.6008419990539551},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.5945813655853271},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5843318700790405},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4172566533088684},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36573073267936707},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2379591166973114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.53600","doi":"https://doi.org/10.7759/cureus.53600","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.53600","pdf_url":"https://assets.cureus.com/uploads/case_report/pdf/223467/20240205-19789-1dvcco8.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10915706","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10915706","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10915706/pdf/cureus-0016-00000053600.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:38449951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38449951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.7759/cureus.53600","doi":"https://doi.org/10.7759/cureus.53600","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.53600","pdf_url":"https://assets.cureus.com/uploads/case_report/pdf/223467/20240205-19789-1dvcco8.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391534550.pdf","grobid_xml":"https://content.openalex.org/works/W4391534550.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W2003929214","https://openalex.org/W2033670530","https://openalex.org/W2049839677","https://openalex.org/W2055344345","https://openalex.org/W2139290963","https://openalex.org/W2250463341","https://openalex.org/W2567323329","https://openalex.org/W2808106298","https://openalex.org/W2890946763","https://openalex.org/W3003504749","https://openalex.org/W3019688527","https://openalex.org/W3085809921","https://openalex.org/W3092489988","https://openalex.org/W4210288145","https://openalex.org/W4226022025"],"related_works":["https://openalex.org/W2978799683","https://openalex.org/W3204519709","https://openalex.org/W4417240661","https://openalex.org/W4392376658","https://openalex.org/W4411643029","https://openalex.org/W3207468505","https://openalex.org/W4210288145","https://openalex.org/W4414649587","https://openalex.org/W4409631417","https://openalex.org/W2912244462"],"abstract_inverted_index":{"Low-grade":[0],"serous":[1,39],"ovarian":[2,10,40],"carcinoma":[3,41],"(LGSOC)":[4,42],"is":[5,14,119],"an":[6,103],"uncommon":[7],"subtype":[8],"of":[9,115,124],"cancer,":[11],"and":[12,22,57,65,78,99],"it":[13],"usually":[15],"associated":[16],"with":[17,35,132,141,144,156],"reduced":[18],"sensitivity":[19],"to":[20],"chemotherapy":[21,56],"worse":[23],"outcomes.":[24],"We":[25,149],"present":[26,150],"a":[27,30,47,125,129,139],"case":[28,153],"involving":[29],"45-year-old":[31],"female":[32],"patient":[33,80,101,140],"diagnosed":[34],"stage":[36],"III-C":[37],"low-grade":[38],"in":[43,61,87,138,154],"2013.":[44],"She":[45],"achieved":[46],"complete":[48,106,130],"response":[49,107,131],"for":[50,90,108],"29":[51],"months":[52],"after":[53],"undergoing":[54],"platinum-based":[55],"interval":[58],"cytoreduction.":[59],"However,":[60],"2016,":[62],"both":[63],"local":[64],"distant":[66],"relapses":[67],"were":[68],"observed.":[69],"As":[70],"there":[71],"was":[72,84,97],"no":[73],"benefit":[74],"from":[75],"hormonal":[76],"therapy":[77,137],"the":[79,100,113,120,151,157],"refused":[81],"chemotherapy,":[82],"bevacizumab":[83],"initiated,":[85],"resulting":[86],"disease":[88,94],"stabilization":[89],"30":[91],"months.":[92,111],"At":[93],"progression,":[95],"trametinib":[96],"proposed,":[98],"experienced":[102],"ongoing":[104],"sustained":[105],"over":[109],"36":[110],"To":[112],"best":[114],"our":[116],"knowledge,":[117],"this":[118],"first":[121],"report,":[122],"outside":[123],"clinical":[126],"trial,":[127],"regarding":[128],"single":[133],"agent":[134],"MEK":[135],"inhibitor":[136],"recurrent":[142],"LGSOC,":[143],"unknown":[145],"BRAF":[146],"V600E":[147],"mutation.":[148],"following":[152],"accordance":[155],"CAse":[158],"REports":[159],"(CARE)":[160],"checklist.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-02-06T00:00:00"}