{"id":"https://openalex.org/W4391533749","doi":"https://doi.org/10.1016/j.jaci.2023.11.816","title":"The IL-4R\u03b1 Q576R Polymorphism Promotes Th2 Skewing In Atopic Dermatitis Patients","display_name":"The IL-4R\u03b1 Q576R Polymorphism Promotes Th2 Skewing In Atopic Dermatitis Patients","publication_year":2024,"publication_date":"2024-02-01","ids":{"openalex":"https://openalex.org/W4391533749","doi":"https://doi.org/10.1016/j.jaci.2023.11.816"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaci.2023.11.816","doi":"https://doi.org/10.1016/j.jaci.2023.11.816","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaci.2023.11.816","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059775668","display_name":"Brian G. Woods","orcid":"https://orcid.org/0000-0003-4363-4444","observed_orcids":["https://orcid.org/0000-0003-4363-4444"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Woods","raw_affiliation_strings":["Boston Children's Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children's Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012697845","display_name":"Brenna LaBere","orcid":"https://orcid.org/0000-0002-7967-7270","observed_orcids":["https://orcid.org/0000-0002-7967-7270"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenna LaBere","raw_affiliation_strings":["Boston Children's Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children's Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anne Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Chu","raw_affiliation_strings":["Boston Children's Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children's Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077648255","display_name":"Wayne Bainter","orcid":"https://orcid.org/0000-0003-2032-8348","observed_orcids":["https://orcid.org/0000-0003-2032-8348"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne Bainter","raw_affiliation_strings":["Boston Children's Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children's Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000211630","display_name":"Barbara Carolyn Yang","orcid":"https://orcid.org/0000-0001-5018-095X","observed_orcids":["https://orcid.org/0000-0001-5018-095X"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Yang","raw_affiliation_strings":["Boston Children's Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children's Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101453371","display_name":"Mrinmoy Das","orcid":"https://orcid.org/0000-0002-9932-9548","observed_orcids":["https://orcid.org/0000-0002-9932-9548"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mrinmoy Das","raw_affiliation_strings":["Boston Childrens Hospital, Harvard Medic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Childrens Hospital, Harvard Medic","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081083158","display_name":"Patrick M. Schlievert","orcid":"https://orcid.org/0000-0001-8314-9369","observed_orcids":["https://orcid.org/0000-0001-8314-9369"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Schlievert","raw_affiliation_strings":["University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043763838","display_name":"Wanda Phipatanakul","orcid":"https://orcid.org/0000-0001-8639-0473","observed_orcids":["https://orcid.org/0000-0001-8639-0473"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wanda Phipatanakul","raw_affiliation_strings":["Boston Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children's Hospital","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103010558","display_name":"Juan Manuel Leyva-Castillo","orcid":"https://orcid.org/0000-0001-7394-4457","observed_orcids":["https://orcid.org/0000-0001-7394-4457"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JuanManuel LeyvaCastillo","raw_affiliation_strings":["BostonChildren"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BostonChildren","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033198329","display_name":"Janet S. Chou","orcid":"https://orcid.org/0000-0002-4610-2657","observed_orcids":["https://orcid.org/0000-0002-4610-2657"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janet Chou","raw_affiliation_strings":["Boston Children"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048379219","display_name":"Raif S. Geha","orcid":"https://orcid.org/0000-0002-6019-3751","observed_orcids":["https://orcid.org/0000-0002-6019-3751"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raif Geha","raw_affiliation_strings":["Boston Children"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":0.3668,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.53321957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"153","issue":"2","first_page":"AB255","last_page":"AB255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/il-4-receptor-alpha","display_name":"IL-4 receptor alpha","score":0.8659999966621399},{"id":"https://openalex.org/keywords/th2-response","display_name":"Th2 immune response","score":0.7310000061988831},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ccl17","display_name":"CCL17","score":0.5789999961853027},{"id":"https://openalex.org/keywords/staphylococcus-aureus-colonization","display_name":"Staphylococcus aureus colonization","score":0.875},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.6159999966621399},{"id":"https://openalex.org/keywords/skin-transcriptome","display_name":"skin transcriptome","score":0.5580000281333923},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.8992894291877747},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.5330143570899963},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.49138012528419495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42550987005233765},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34755849838256836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3059137463569641},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1455005407333374},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14488548040390015}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jaci.2023.11.816","doi":"https://doi.org/10.1016/j.jaci.2023.11.816","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaci.2023.11.816","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7126845193","https://openalex.org/W7128494656","https://openalex.org/W3007519866","https://openalex.org/W4317568882","https://openalex.org/W2162624882","https://openalex.org/W1572255065","https://openalex.org/W2615234940","https://openalex.org/W2054538617","https://openalex.org/W2150189277","https://openalex.org/W2054507486"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-02-06T00:00:00"}