{"id":"https://openalex.org/W4391521292","doi":"https://doi.org/10.7554/elife.103817.3","title":"PPAR\u03b3 mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment","display_name":"PPAR\u03b3 mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment","publication_year":2025,"publication_date":"2025-12-08","ids":{"openalex":"https://openalex.org/W4391521292","doi":"https://doi.org/10.7554/elife.103817.3"},"language":"en","primary_location":{"id":"doi:10.7554/elife.103817.3","doi":"https://doi.org/10.7554/elife.103817.3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.103817.3","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4391521292"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.103817.3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007071408","display_name":"Binayak Sarkar","orcid":"https://orcid.org/0009-0009-3366-4851","observed_orcids":["https://orcid.org/0009-0009-3366-4851"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Binayak Sarkar","raw_affiliation_strings":["Immunometabolism laboratory, National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunometabolism laboratory, National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jyotsna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jyotsna","raw_affiliation_strings":["Immunometabolism laboratory, National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunometabolism laboratory, National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000576264","display_name":"Mohit Yadav","orcid":"https://orcid.org/0000-0001-5171-5573","observed_orcids":["https://orcid.org/0000-0001-5171-5573","https://orcid.org/0009-0000-3964-4047"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mohit Yadav","raw_affiliation_strings":["Immunometabolism laboratory, National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunometabolism laboratory, National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074387158","display_name":"Priya Sharma","orcid":"https://orcid.org/0000-0003-4290-3251","observed_orcids":["https://orcid.org/0000-0003-4290-3251"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":false,"raw_author_name":"Priya Sharma","raw_affiliation_strings":["Cellular Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India","institution_ids":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045817272","display_name":"Raman Deep Sharma","orcid":"https://orcid.org/0000-0003-1742-0055","observed_orcids":["https://orcid.org/0000-0003-1742-0055"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":false,"raw_author_name":"Raman Deep Sharma","raw_affiliation_strings":["Cellular Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India","institution_ids":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101762482","display_name":"Shweta Singh","orcid":"https://orcid.org/0000-0002-8790-9692","observed_orcids":["https://orcid.org/0000-0002-8790-9692"]},"institutions":[{"id":"https://openalex.org/I4210147764","display_name":"Institute of Microbial Technology","ror":"https://ror.org/055rjs771","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210147764","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shweta Singh","raw_affiliation_strings":["CSIR-Institute of Microbial Technology, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR-Institute of Microbial Technology, Chandigarh, India","institution_ids":["https://openalex.org/I4210147764","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093858617","display_name":"Aakash Chandramouli","orcid":"https://orcid.org/0009-0004-8553-1202","observed_orcids":["https://orcid.org/0009-0004-8553-1202"]},"institutions":[{"id":"https://openalex.org/I181996519","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13","country_code":"IN","type":"education","lineage":["https://openalex.org/I181996519"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aakash Chandramouli","raw_affiliation_strings":["Indian Institute of Science Education and Research, Pune, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Science Education and Research, Pune, Maharashtra, India","institution_ids":["https://openalex.org/I181996519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080885828","display_name":"Kritee Mehdiratta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kritee Mehdiratta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100636302","display_name":"Ashwani Kumar","orcid":"https://orcid.org/0000-0001-8692-5204","observed_orcids":["https://orcid.org/0000-0001-8692-5204"]},"institutions":[{"id":"https://openalex.org/I4210147764","display_name":"Institute of Microbial Technology","ror":"https://ror.org/055rjs771","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210147764","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ashwani Kumar","raw_affiliation_strings":["CSIR-Institute of Microbial Technology, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR-Institute of Microbial Technology, Chandigarh, India","institution_ids":["https://openalex.org/I4210147764","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052850826","display_name":"Siddhesh S. Kamat","orcid":"https://orcid.org/0000-0001-6132-7574","observed_orcids":["https://orcid.org/0000-0001-6132-7574"]},"institutions":[{"id":"https://openalex.org/I181996519","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13","country_code":"IN","type":"education","lineage":["https://openalex.org/I181996519"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Siddhesh S. Kamat","raw_affiliation_strings":["Indian Institute of Science Education and Research, Pune, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Science Education and Research, Pune, Maharashtra, India","institution_ids":["https://openalex.org/I181996519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087753587","display_name":"Devram Sampat Ghorpade","orcid":"https://orcid.org/0009-0000-6600-6390","observed_orcids":["https://orcid.org/0009-0000-6600-6390"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Devram S. Ghorpade","raw_affiliation_strings":["Immunometabolism laboratory, National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunometabolism laboratory, National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066836332","display_name":"Debasisa Mohanty","orcid":"https://orcid.org/0000-0002-3374-0588","observed_orcids":["https://orcid.org/0000-0002-3374-0588"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Debasisa Mohanty","raw_affiliation_strings":["Immunometabolism laboratory, National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunometabolism laboratory, National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076624139","display_name":"Dhiraj Kumar","orcid":"https://orcid.org/0000-0001-7578-2930","observed_orcids":["https://orcid.org/0000-0001-7578-2930"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":false,"raw_author_name":"Dhiraj Kumar","raw_affiliation_strings":["Cellular Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India"],"raw_orcid":"https://orcid.org/0000-0001-7578-2930","affiliations":[{"raw_affiliation_string":"Cellular Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India","institution_ids":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067311849","display_name":"Rajesh S. Gokhale","orcid":"https://orcid.org/0000-0001-6597-2685","observed_orcids":["https://orcid.org/0000-0001-6597-2685"]},"institutions":[{"id":"https://openalex.org/I181996519","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13","country_code":"IN","type":"education","lineage":["https://openalex.org/I181996519"]},{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Rajesh S. Gokhale","raw_affiliation_strings":["Immunometabolism laboratory, National Institute of Immunology, New Delhi, India","Indian Institute of Science Education and Research, Pune, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunometabolism laboratory, National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]},{"raw_affiliation_string":"Indian Institute of Science Education and Research, Pune, Maharashtra, India","institution_ids":["https://openalex.org/I181996519"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5067311849"],"corresponding_institution_ids":["https://openalex.org/I181996519","https://openalex.org/I4210156726"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":1.7842,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.80852085,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":1.0},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.906000018119812},{"id":"https://openalex.org/keywords/drug-tolerance","display_name":"drug tolerance","score":0.902999997138977},{"id":"https://openalex.org/keywords/drug-metabolizing-enzymes","display_name":"drug-metabolizing enzymes","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hepatotropism","display_name":"hepatotropism","score":0.8420000076293945},{"id":"https://openalex.org/keywords/chronic-tuberculosis","display_name":"chronic tuberculosis","score":0.4659999907016754},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.5809999704360962},{"id":"https://openalex.org/keywords/cachexia","display_name":"cachexia","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6994372606277466},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6880888342857361},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5377953052520752},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4880791902542114},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46639367938041687},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4538414180278778},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4409445822238922},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33135783672332764},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24208873510360718},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19522705674171448},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.7554/elife.103817.3","doi":"https://doi.org/10.7554/elife.103817.3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.103817.3","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.1101/2024.02.02.578554","doi":"https://doi.org/10.1101/2024.02.02.578554","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.02.02.578554","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/02/03/2024.02.02.578554.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.7554/elife.103817.3","doi":"https://doi.org/10.7554/elife.103817.3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.103817.3","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G113696694","display_name":null,"funder_award_id":"SB/SJF/2021\u201322/01","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G5190591205","display_name":null,"funder_award_id":"SB/ SJF /2021-22/01","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"}],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320324168","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13"},{"id":"https://openalex.org/F4320327182","display_name":"Indian Institute of Science Education and Research Mohali","ror":"https://ror.org/01vztzd79"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391521292.pdf","grobid_xml":"https://content.openalex.org/works/W4391521292.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W112108882","https://openalex.org/W1944860507","https://openalex.org/W2009388240","https://openalex.org/W2013050862","https://openalex.org/W2025123467","https://openalex.org/W2067278779","https://openalex.org/W2078663039","https://openalex.org/W2091442643","https://openalex.org/W2095591310","https://openalex.org/W2107340859","https://openalex.org/W2110418084","https://openalex.org/W2117041691","https://openalex.org/W2122742700","https://openalex.org/W2134745197","https://openalex.org/W2139492141","https://openalex.org/W2152311269","https://openalex.org/W2152791986","https://openalex.org/W2160517489","https://openalex.org/W2168293740","https://openalex.org/W2187426740","https://openalex.org/W2205019274","https://openalex.org/W2237544788","https://openalex.org/W2302817961","https://openalex.org/W2343836182","https://openalex.org/W2528806650","https://openalex.org/W2538201653","https://openalex.org/W2550538007","https://openalex.org/W2593405738","https://openalex.org/W2767088716","https://openalex.org/W2781107938","https://openalex.org/W2794044688","https://openalex.org/W2804524829","https://openalex.org/W2809320065","https://openalex.org/W2883254287","https://openalex.org/W2902449467","https://openalex.org/W2923123093","https://openalex.org/W3006476224","https://openalex.org/W3023347597","https://openalex.org/W3024548582","https://openalex.org/W3035751002","https://openalex.org/W3038615313","https://openalex.org/W3112435365","https://openalex.org/W3117028850","https://openalex.org/W3128568502","https://openalex.org/W3138924483","https://openalex.org/W3173364861","https://openalex.org/W3212419595","https://openalex.org/W4205776105","https://openalex.org/W4292262037","https://openalex.org/W4292975102","https://openalex.org/W4306850104","https://openalex.org/W4307549732","https://openalex.org/W4309333412","https://openalex.org/W4315436185","https://openalex.org/W4316014106","https://openalex.org/W4367311429","https://openalex.org/W4376603034","https://openalex.org/W4382135148","https://openalex.org/W4386630419","https://openalex.org/W4391563669","https://openalex.org/W4394758766","https://openalex.org/W4395696084","https://openalex.org/W4399430101"],"related_works":["https://openalex.org/W2113578500","https://openalex.org/W4386697245","https://openalex.org/W4321615219","https://openalex.org/W2187426740","https://openalex.org/W3178395850","https://openalex.org/W4283807870","https://openalex.org/W7021172012","https://openalex.org/W2894411540","https://openalex.org/W7172509842"],"abstract_inverted_index":{"Mycobacterium":[0],"tuberculosis":[1],"(Mtb)":[2],"infection":[3],"of":[4,22,75,107,127,139,153],"the":[5,35,39,89,98,108,111,137,156],"lungs,":[6],"besides":[7],"producing":[8],"prolonged":[9],"cough":[10],"with":[11,19,124,144],"mucus,":[12],"also":[13],"causes":[14],"progressive":[15],"fatigue":[16],"and":[17,48,61,85,129,168],"cachexia":[18],"debilitating":[20],"loss":[21],"muscle":[23],"mass.":[24],"While":[25],"anti-tuberculosis":[26],"(TB)":[27],"drug":[28],"therapy":[29],"is":[30,52],"directed":[31],"toward":[32],"eliminating":[33],"bacilli,":[34],"treatment":[36],"regimen":[37],"ignores":[38],"systemic":[40,169],"pathogenic":[41],"derailments":[42],"that":[43,69,164],"probably":[44],"dictate":[45],"TB-associated":[46],"mortality":[47],"morbidity.":[49],"Presently,":[50],"it":[51],"not":[53],"understood":[54],"whether":[55],"Mtb":[56,70,94,140,154],"spreads":[57],"to":[58],"metabolic":[59],"organs":[60],"brings":[62],"about":[63],"these":[64],"impairments.":[65],"Here,":[66],"we":[67],"show":[68],"creates":[71],"a":[72],"replication-conducive":[73],"milieu":[74],"lipid":[76],"droplets":[77],"in":[78,110,112,141,147,161],"hepatocytes":[79,109,142],"by":[80,102],"upregulating":[81],"transcription":[82],"factor":[83],"PPAR\u03b3":[84,128],"scavenging":[86],"lipids":[87],"from":[88],"host":[90],"cells.":[91],"In":[92],"hepatocytes,":[93],"shields":[95],"itself":[96],"against":[97],"common":[99],"anti-TB":[100],"drugs":[101],"inducing":[103],"drug-metabolizing":[104,130],"enzymes.":[105,131],"Infection":[106],"vivo":[113],"aerosol":[114],"mice":[115],"model":[116],"can":[117],"be":[118],"consistently":[119],"observed":[120],"post-week,":[121],"4":[122],"along":[123,143],"enhanced":[125],"expression":[126],"Moreover,":[132],"histopathological":[133],"analysis":[134],"indeed":[135],"shows":[136],"presence":[138],"granuloma-like":[145],"structures":[146],"human":[148],"biopsied":[149],"liver":[150],"sections.":[151],"Hepatotropism":[152],"during":[155],"chronic":[157],"infectious":[158],"cycle":[159],"results":[160],"immuno-metabolic":[162],"dysregulation":[163],"could":[165],"magnify":[166],"local":[167],"pathogenicity,":[170],"altering":[171],"clinical":[172],"presentations.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2024-02-05T00:00:00"}
