{"id":"https://openalex.org/W4391463571","doi":"https://doi.org/10.1093/ced/llae005","title":"Comparison of S100A8 and PRAME as biomarkers for distinguishing melanoma from melanocytic naevus: a case\u2013control analysis","display_name":"Comparison of S100A8 and PRAME as biomarkers for distinguishing melanoma from melanocytic naevus: a case\u2013control analysis","publication_year":2024,"publication_date":"2024-02-02","ids":{"openalex":"https://openalex.org/W4391463571","doi":"https://doi.org/10.1093/ced/llae005","pmid":"https://pubmed.ncbi.nlm.nih.gov/38306117","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11107960"},"language":"en","primary_location":{"id":"doi:10.1093/ced/llae005","doi":"https://doi.org/10.1093/ced/llae005","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ced/llae005","pdf_url":null,"source":{"id":"https://openalex.org/S80252431","display_name":"Clinical and Experimental Dermatology","issn_l":"0307-6938","issn":["0307-6938","1365-2230"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11107960/pdf/llae005.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054794209","display_name":"Josephine Hai","orcid":"https://orcid.org/0009-0008-2524-9298","observed_orcids":["https://orcid.org/0009-0008-2524-9298"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josephine Hai","raw_affiliation_strings":["Departments of Dermatology","Departments of Dermatology, Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology","institution_ids":[]},{"raw_affiliation_string":"Departments of Dermatology, Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038192997","display_name":"Summer N. Meyer","orcid":"https://orcid.org/0000-0001-6157-5746","observed_orcids":["https://orcid.org/0000-0001-6157-5746"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Summer N Meyer","raw_affiliation_strings":["Departments of Dermatology","Departments of Dermatology, Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology","institution_ids":[]},{"raw_affiliation_string":"Departments of Dermatology, Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029906007","display_name":"Samantha L. Wong","orcid":"https://orcid.org/0000-0001-7703-4434","observed_orcids":["https://orcid.org/0000-0001-7703-4434"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha L Wong","raw_affiliation_strings":["Departments of Dermatology","Departments of Dermatology, Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology","institution_ids":[]},{"raw_affiliation_string":"Departments of Dermatology, Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059322704","display_name":"Yueju Li","orcid":"https://orcid.org/0000-0001-6537-0078","observed_orcids":["https://orcid.org/0000-0001-6537-0078"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yueju Li","raw_affiliation_strings":["Department of Public Health Sciences, University of California , Davis, Davis, CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, University of California , Davis, Davis, CA , USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064652098","display_name":"Elanee Simmons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elanee Simmons","raw_affiliation_strings":["Departments of Dermatology","Departments of Dermatology, Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology","institution_ids":[]},{"raw_affiliation_string":"Departments of Dermatology, Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050357899","display_name":"Diana L. Miglioretti","orcid":"https://orcid.org/0000-0002-5547-1833","observed_orcids":["https://orcid.org/0000-0002-5547-1833"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana Miglioretti","raw_affiliation_strings":["Department of Public Health Sciences, University of California , Davis, Davis, CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, University of California , Davis, Davis, CA , USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065310848","display_name":"Maxwell Alexander Fung","orcid":"https://orcid.org/0000-0003-1771-8257","observed_orcids":["https://orcid.org/0000-0003-1771-8257"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maxwell A Fung","raw_affiliation_strings":["Departments of Dermatology","Pathology and Laboratory Medicine, School of Medicine, University of California , Davis,\u00a0Sacramento,\u00a0CA , USA","Departments of Dermatology, Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology","institution_ids":[]},{"raw_affiliation_string":"Pathology and Laboratory Medicine, School of Medicine, University of California , Davis,\u00a0Sacramento,\u00a0CA , USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Departments of Dermatology, Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004804093","display_name":"Maija H. Kiuru","orcid":"https://orcid.org/0000-0002-7010-5516","observed_orcids":["https://orcid.org/0000-0002-7010-5516"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maija Kiuru","raw_affiliation_strings":["Departments of Dermatology","Pathology and Laboratory Medicine, School of Medicine, University of California , Davis,\u00a0Sacramento,\u00a0CA , USA","Departments of Dermatology, Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology","institution_ids":[]},{"raw_affiliation_string":"Pathology and Laboratory Medicine, School of Medicine, University of California , Davis,\u00a0Sacramento,\u00a0CA , USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Departments of Dermatology, Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004804093"],"corresponding_institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"],"apc_list":{"value":2670,"currency":"GBP","value_usd":3413},"apc_paid":null,"fwci":0.8509,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.73423753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"49","issue":"6","first_page":"584","last_page":"590"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7799999713897705},{"id":"https://openalex.org/keywords/melanocytic-naevus","display_name":"melanocytic naevus","score":0.9319999814033508},{"id":"https://openalex.org/keywords/s100a8","display_name":"S100A8","score":0.9150000214576721},{"id":"https://openalex.org/keywords/prame","display_name":"PRAME","score":1.0},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.671999990940094},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.9470000267028809},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.7720000147819519},{"id":"https://openalex.org/keywords/melanoma-diagnosis","display_name":"melanoma diagnosis","score":0.31700000166893005},{"id":"https://openalex.org/keywords/melanoma-staging","display_name":"melanoma staging","score":0.3499999940395355},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.5009999871253967},{"id":"https://openalex.org/keywords/tumour-associated-macrophages","display_name":"tumour-associated macrophages","score":0.531000018119812},{"id":"https://openalex.org/keywords/tumor-associated-neutrophils","display_name":"tumor-associated neutrophils","score":0.6610000133514404},{"id":"https://openalex.org/keywords/tumor-associated-t-cells","display_name":"tumor-associated T cells","score":0.4860000014305115},{"id":"https://openalex.org/keywords/tumor-associated-b-cells","display_name":"tumor-associated B cells","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7995693683624268},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6669549345970154},{"id":"https://openalex.org/C2778557267","wikidata":"https://www.wikidata.org/wiki/Q20969990","display_name":"S100A8","level":3,"score":0.569768488407135},{"id":"https://openalex.org/C94624232","wikidata":"https://www.wikidata.org/wiki/Q3150667","display_name":"Indeterminate","level":2,"score":0.5695379972457886},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5324479341506958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5227949023246765},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5159019231796265},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5045086145401001},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42179298400878906},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3671340346336365},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36612218618392944},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3250584006309509},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08977824449539185},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.08489823341369629},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.05200415849685669},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009508","descriptor_name":"Nevus, Pigmented","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009508","descriptor_name":"Nevus, Pigmented","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009508","descriptor_name":"Nevus, Pigmented","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040501","descriptor_name":"Calgranulin A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D040501","descriptor_name":"Calgranulin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/ced/llae005","doi":"https://doi.org/10.1093/ced/llae005","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ced/llae005","pdf_url":null,"source":{"id":"https://openalex.org/S80252431","display_name":"Clinical and Experimental Dermatology","issn_l":"0307-6938","issn":["0307-6938","1365-2230"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Dermatology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11107960","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11107960","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11107960/pdf/llae005.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Dermatol","raw_type":"Text"},{"id":"pmid:38306117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38306117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental dermatology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt9hm1643w","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/9hm1643w","pdf_url":"https://escholarship.org/content/qt9hm1643w/qt9hm1643w.pdf?t=shql4t","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Experimental Dermatology, vol 49, iss 6","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11107960","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11107960","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11107960/pdf/llae005.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Dermatol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1378265149","display_name":"Molecular basis of melanocytic nevi","funder_award_id":"K23AR074530","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G1585092768","display_name":null,"funder_award_id":"NCI P30CA093373","funder_id":"https://openalex.org/F4320337900","funder_display_name":"Comprehensive Cancer Center, University of California, Davis"},{"id":"https://openalex.org/G2075359013","display_name":null,"funder_award_id":"P30CA093373","funder_id":"https://openalex.org/F4320332564","funder_display_name":"University of California, Davis"},{"id":"https://openalex.org/G3035950223","display_name":null,"funder_award_id":"NCI P30 CA093373","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5705938078","display_name":null,"funder_award_id":"NCI P30CA093373","funder_id":"https://openalex.org/F4320332564","funder_display_name":"University of California, Davis"},{"id":"https://openalex.org/G7938659809","display_name":null,"funder_award_id":"P30CA093373","funder_id":"https://openalex.org/F4320337900","funder_display_name":"Comprehensive Cancer Center, University of California, Davis"},{"id":"https://openalex.org/G9000885888","display_name":"Cancer Center Support Grant P30","funder_award_id":"P30CA093373","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310408","display_name":"Comprehensive Cancer Center, City of Hope","ror":"https://ror.org/00w6g5w60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332564","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337900","display_name":"Comprehensive Cancer Center, University of California, Davis","ror":"https://ror.org/02kcc1z29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391463571.pdf","grobid_xml":"https://content.openalex.org/works/W4391463571.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1950981769","https://openalex.org/W1990120792","https://openalex.org/W2042475475","https://openalex.org/W2120061605","https://openalex.org/W2141268830","https://openalex.org/W2544404210","https://openalex.org/W2884769110","https://openalex.org/W2992897657","https://openalex.org/W3120902077","https://openalex.org/W3210179912","https://openalex.org/W4288969910"],"related_works":["https://openalex.org/W4285992327","https://openalex.org/W4302763047","https://openalex.org/W4415206765","https://openalex.org/W4328048231","https://openalex.org/W4288969910","https://openalex.org/W4411224466","https://openalex.org/W4310707605","https://openalex.org/W4205695243","https://openalex.org/W4390778216","https://openalex.org/W7036289077"],"abstract_inverted_index":{"BACKGROUND:":[0],"S100A8":[1,31,64,156,208,229,241],"is":[2],"a":[3,45,112,214],"melanoma":[4,41],"biomarker":[5],"expressed":[6],"in":[7,36,44,234],"the":[8,28,37,75,119,150,235,269],"melanoma-associated":[9],"epidermal":[10],"keratinocytes,":[11],"but":[12],"its":[13],"diagnostic":[14,172,236],"utility":[15,29,233],"has":[16],"not":[17,162],"been":[18],"compared":[19],"with":[20,116,240],"other":[21,167],"biomarkers,":[22],"including":[23],"PRAME.":[24],"OBJECTIVES:":[25],"To":[26],"compare":[27],"of":[30,40,53,77,121,216,223,238,271],"and":[32,42,58,65,111,158,174,183,190,195,209,221,230,245],"PRAME":[33,66,102,159,210,231,246],"immunohistochemistry":[34],"(IHC)":[35],"differential":[38],"diagnosis":[39],"naevi":[43,59],"case-control":[46],"study.":[47],"METHODS:":[48],"A":[49,137,203],"previously":[50,71],"described":[51],"cohort":[52],"209":[54],"melanomas":[55],"(case":[56],"samples)":[57,61],"(control":[60],"dual-immunostained":[62],"for":[63,155,188,200],"were":[67,100,161,176],"included.":[68],"For":[69],"S100A8,":[70,189],"reported":[72],"scores":[73],"indicating":[74,118],"proportion":[76,120],"tumour-associated":[78],"epidermis":[79],"stained":[80,123],"(0":[81,124],"=":[82,85,88,91,94,97,125,128,131,134,169],"indeterminate;":[83,126],"1":[84,127],"0-4%;":[86],"2":[87,130],"5-25%;":[89],"3":[90,133],"26-50%;":[92],"4":[93],"51-75%;":[95],"5":[96],">":[98,135,143],"75%)":[99],"utilized.":[101],"IHC":[103,211],"was":[104,140],"reviewed":[105],"by":[106],"at":[107],"least":[108],"two":[109,259],"reviewers":[110],"consensus":[113],"score":[114,117],"assigned,":[115],"tumour":[122],"0%;":[129],"1-50%;":[132],"50%).":[136],"positive":[138],"test":[139,205],"defined":[141],"as":[142],"50%":[144],"staining.":[145],"RESULTS:":[146],"The":[147,171],"area":[148],"under":[149],"receiver":[151],"operating":[152],"characteristic":[153],"curves":[154],"(0.833)":[157],"(0.874)":[160],"significantly":[163],"different":[164],"from":[165],"each":[166],"(P":[168],"0.22).":[170],"sensitivity":[173,215],"specificity":[175,222],"42.4%":[177],"[95%":[178],"confidence":[179],"interval":[180],"(CI)":[181],"32.6-52.8%]":[182],"98.2%":[184],"(95%":[185,192,197,218,225],"CI":[186,193,198,219,226],"93.6-99.8%)":[187],"79.8%":[191],"70.5-87.2%)":[194],"87.3%":[196],"79.6-92.9%)":[199],"PRAME,":[201],"respectively.":[202],"combined":[204],"requiring":[206],"both":[207],"positivity":[212],"had":[213],"39.4%":[217],"29.7-49.7%)":[220],"99.1%":[224],"95.0-100.0%).":[227],"CONCLUSIONS:":[228],"have":[232],"workup":[237],"melanoma,":[239],"being":[242,247],"more":[243,248],"specific":[244],"sensitive":[249],"when":[250],"using":[251],"this":[252],"threshold.":[253],"Our":[254],"findings":[255],"suggest":[256],"that":[257],"these":[258],"immunohistochemical":[260],"markers":[261],"may":[262],"favourably":[263],"complement":[264],"one":[265],"another":[266],"to":[267],"improve":[268],"detection":[270],"melanoma.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-02-02T00:00:00"}