{"id":"https://openalex.org/W4391452437","doi":"https://doi.org/10.4274/tji.galenos.2024.74745","title":"NETosis Induced by Serum of Patients with COVID-19 is Reduced with Reparixin or Antibodies Against DEK and IL-8","display_name":"NETosis Induced by Serum of Patients with COVID-19 is Reduced with Reparixin or Antibodies Against DEK and IL-8","publication_year":2024,"publication_date":"2024-01-02","ids":{"openalex":"https://openalex.org/W4391452437","doi":"https://doi.org/10.4274/tji.galenos.2024.74745"},"language":"en","primary_location":{"id":"doi:10.4274/tji.galenos.2024.74745","doi":"https://doi.org/10.4274/tji.galenos.2024.74745","is_oa":true,"landing_page_url":"https://doi.org/10.4274/tji.galenos.2024.74745","pdf_url":"https://doi.org/10.4274/tji.galenos.2024.74745","source":{"id":"https://openalex.org/S4210208591","display_name":"Turkish Journal of Immunology","issn_l":"2147-8325","issn":["2147-8325","1301-109X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4274/tji.galenos.2024.74745","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001451877","display_name":"\u0130rfan Baki K\u0131l\u0131\u00e7","orcid":"https://orcid.org/0000-0002-1225-9920","observed_orcids":["https://orcid.org/0000-0002-1225-9920","https://orcid.org/0000-0002-9512-0579"]},"institutions":[{"id":"https://openalex.org/I109297418","display_name":"Gebze Technical University","ror":"https://ror.org/01sdnnq10","country_code":"TR","type":"education","lineage":["https://openalex.org/I109297418"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u0130rfan Baki K\u0131l\u0131\u00e7","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, Kocaeli, Turkey","Gebze Technical University, Department of Molecular Biology and Genetics, Gebze, Kocaeli, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-9512-0579","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]},{"raw_affiliation_string":"Gebze Technical University, Department of Molecular Biology and Genetics, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077920997","display_name":"A\u00e7elya Ya\u015far","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109297418","display_name":"Gebze Technical University","ror":"https://ror.org/01sdnnq10","country_code":"TR","type":"education","lineage":["https://openalex.org/I109297418"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"A\u00e7elya Ya\u015far","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, Kocaeli, Turkey","Gebze Technical University, Department of Molecular Biology and Genetics, Gebze, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]},{"raw_affiliation_string":"Gebze Technical University, Department of Molecular Biology and Genetics, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027261587","display_name":"\u0130rem Yal\u0131m Camc\u0131","orcid":"https://orcid.org/0000-0002-2534-4155","observed_orcids":["https://orcid.org/0000-0002-2534-4155"]},"institutions":[{"id":"https://openalex.org/I109297418","display_name":"Gebze Technical University","ror":"https://ror.org/01sdnnq10","country_code":"TR","type":"education","lineage":["https://openalex.org/I109297418"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u0130rem Yal\u0131m Camc\u0131","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011061743","display_name":"T\u00fcrkan G\u00fczel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109297418","display_name":"Gebze Technical University","ror":"https://ror.org/01sdnnq10","country_code":"TR","type":"education","lineage":["https://openalex.org/I109297418"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"T\u00fcrkan G\u00fczel","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, Kocaeli, Turkey","Gebze Technical University, Department of Molecular Biology and Genetics, Gebze, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]},{"raw_affiliation_string":"Gebze Technical University, Department of Molecular Biology and Genetics, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ay\u015feg\u00fcl Karahasan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ay\u015feg\u00fcl Karahasan","raw_affiliation_strings":["Department of Medical Microbiology, Marmara University, Istanbul, Turkey","Marmara University Faculty of Medicine, Department of Medical Microbiology, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Marmara University, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]},{"raw_affiliation_string":"Marmara University Faculty of Medicine, Department of Medical Microbiology, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035238241","display_name":"Tamer Ya\u011fc\u0131","orcid":"https://orcid.org/0000-0003-2050-7477","observed_orcids":["https://orcid.org/0000-0003-2050-7477"]},"institutions":[{"id":"https://openalex.org/I109297418","display_name":"Gebze Technical University","ror":"https://ror.org/01sdnnq10","country_code":"TR","type":"education","lineage":["https://openalex.org/I109297418"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tamer Ya\u011fc\u0131","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056328822","display_name":"Naci \u00c7ine","orcid":"https://orcid.org/0000-0001-9063-1073","observed_orcids":["https://orcid.org/0000-0001-9063-1073"]},"institutions":[{"id":"https://openalex.org/I109297418","display_name":"Gebze Technical University","ror":"https://ror.org/01sdnnq10","country_code":"TR","type":"education","lineage":["https://openalex.org/I109297418"]},{"id":"https://openalex.org/I51826884","display_name":"Kocaeli \u00dcniversitesi","ror":"https://ror.org/0411seq30","country_code":"TR","type":"education","lineage":["https://openalex.org/I51826884"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Naci \u00c7ine","raw_affiliation_strings":["Department of Medical Genetics, Kocaeli University, Kocaeli, Turkey","Gebze Technical University, Department of Molecular Biology and Genetics, Gebze, Kocaeli, Turkey","Kocaeli University Faculty of Medicine, Department of Medical Genetics, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, Kocaeli University, Kocaeli, Turkey","institution_ids":["https://openalex.org/I51826884"]},{"raw_affiliation_string":"Gebze Technical University, Department of Molecular Biology and Genetics, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]},{"raw_affiliation_string":"Kocaeli University Faculty of Medicine, Department of Medical Genetics, Kocaeli, Turkey","institution_ids":["https://openalex.org/I51826884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083920194","display_name":"Ayten Kandilci","orcid":"https://orcid.org/0000-0003-4209-4992","observed_orcids":["https://orcid.org/0000-0003-4209-4992"]},"institutions":[{"id":"https://openalex.org/I109297418","display_name":"Gebze Technical University","ror":"https://ror.org/01sdnnq10","country_code":"TR","type":"education","lineage":["https://openalex.org/I109297418"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ayten Kandilci","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, Kocaeli, Turkey","Gebze Technical University, Department of Molecular Biology and Genetics, Gebze, Kocaeli, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-4209-4992","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]},{"raw_affiliation_string":"Gebze Technical University, Department of Molecular Biology and Genetics, Gebze, Kocaeli, Turkey","institution_ids":["https://openalex.org/I109297418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083920194"],"corresponding_institution_ids":["https://openalex.org/I109297418"],"apc_list":null,"apc_paid":null,"fwci":0.1459,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.35407499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"127","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/netosis","display_name":"NETosis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.902999997138977},{"id":"https://openalex.org/keywords/reparixin","display_name":"reparixin","score":0.953000009059906},{"id":"https://openalex.org/keywords/dek","display_name":"DEK","score":0.8759999871253967},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cxcr2","display_name":"CXCR2","score":0.8859999775886536},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9129999876022339},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.7960000038146973},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/citrullinated-histone-h3","display_name":"citrullinated histone H3","score":0.8880000114440918},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.7250000238418579},{"id":"https://openalex.org/keywords/anti-il-8-antibody","display_name":"anti-IL-8 antibody","score":0.9670000076293945},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.7102571129798889},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.693961501121521},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6353947520256042},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6255015134811401},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.5939552187919617},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5934228897094727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5463356375694275},{"id":"https://openalex.org/C84913492","wikidata":"https://www.wikidata.org/wiki/Q5014892","display_name":"CXC chemokine receptors","level":5,"score":0.5394514203071594},{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.514859139919281},{"id":"https://openalex.org/C99971728","wikidata":"https://www.wikidata.org/wiki/Q838181","display_name":"Respiratory burst","level":2,"score":0.4659973382949829},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43629294633865356},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3984014391899109},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2608959674835205},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.21670407056808472},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06354135274887085},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4274/tji.galenos.2024.74745","doi":"https://doi.org/10.4274/tji.galenos.2024.74745","is_oa":true,"landing_page_url":"https://doi.org/10.4274/tji.galenos.2024.74745","pdf_url":"https://doi.org/10.4274/tji.galenos.2024.74745","source":{"id":"https://openalex.org/S4210208591","display_name":"Turkish Journal of Immunology","issn_l":"2147-8325","issn":["2147-8325","1301-109X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Immunology","raw_type":"journal-article"},{"id":"doi:10.22541/au.168067984.41873361/v1","doi":"https://doi.org/10.22541/au.168067984.41873361/v1","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.168067984.41873361/v1","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.168067984.41873361","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"doi:10.1101/2023.03.30.534873","doi":"https://doi.org/10.1101/2023.03.30.534873","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.03.30.534873","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/03/30/2023.03.30.534873.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:65346f7e-5257-4419-8ffe-54c344e1f126","doi":null,"is_oa":true,"landing_page_url":"https://avesis.kocaeli.edu.tr/publication/details/65346f7e-5257-4419-8ffe-54c344e1f126/oai","pdf_url":"https://avesis.kocaeli.edu.tr/publication/details/65346f7e-5257-4419-8ffe-54c344e1f126/oai/document.pdf","source":{"id":"https://openalex.org/S7407055291","display_name":"Kocaeli \u00dcniversitesi - AVES\u0130S","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.4274/tji.galenos.2024.74745","doi":"https://doi.org/10.4274/tji.galenos.2024.74745","is_oa":true,"landing_page_url":"https://doi.org/10.4274/tji.galenos.2024.74745","pdf_url":"https://doi.org/10.4274/tji.galenos.2024.74745","source":{"id":"https://openalex.org/S4210208591","display_name":"Turkish Journal of Immunology","issn_l":"2147-8325","issn":["2147-8325","1301-109X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391452437.pdf","grobid_xml":"https://content.openalex.org/works/W4391452437.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1605318550","https://openalex.org/W1966774641","https://openalex.org/W1973182382","https://openalex.org/W2041940308","https://openalex.org/W2097537518","https://openalex.org/W2104934425","https://openalex.org/W2108782241","https://openalex.org/W2129339954","https://openalex.org/W2587727342","https://openalex.org/W2794728842","https://openalex.org/W2944894501","https://openalex.org/W3010839841","https://openalex.org/W3018507926","https://openalex.org/W3022970339","https://openalex.org/W3028015428","https://openalex.org/W3080981445","https://openalex.org/W3085958090","https://openalex.org/W3128941599","https://openalex.org/W3138549017","https://openalex.org/W3157220044","https://openalex.org/W3172416613","https://openalex.org/W3194798108","https://openalex.org/W4281677538","https://openalex.org/W4282933794","https://openalex.org/W4287147207","https://openalex.org/W4295691302"],"related_works":["https://openalex.org/W4214914468","https://openalex.org/W3157255841","https://openalex.org/W4221032758","https://openalex.org/W3194798108","https://openalex.org/W4281677538","https://openalex.org/W4323359981","https://openalex.org/W3163453182","https://openalex.org/W3190488723","https://openalex.org/W4306321306","https://openalex.org/W4394933034"],"abstract_inverted_index":{"Objective:":[0],"NETosis,":[1],"a":[2,196,208],"suicide":[3],"mechanism":[4,12],"of":[5,43,73,82,91,116,126,132,158,205],"neutrophils,":[6],"is":[7],"an":[8],"important":[9],"immune":[10],"defense":[11],"against":[13,165],"pathogens,":[14],"and":[15,31,79,85,130,144,162,183,201],"when":[16],"uncontrolled,":[17],"it":[18],"contributes":[19],"to":[20,25,39,137],"severe":[21,32],"tissue":[22],"damage":[23],"leading":[24],"acute":[26,33],"lung":[27],"injury":[28],"in":[29,53,88,111,155,198,212],"influenza":[30],"respiratory":[34],"syndrome-coronavirus-2":[35],"infections.Here":[36],"we":[37],"aimed":[38],"determine":[40,138],"whether":[41],"blocking":[42],"C-X-C":[44],"motif":[45],"chemokine":[46],"receptors":[47],"1/2":[48],"(CXCR1/2)":[49],"by":[50,57,96,100,174,180],"reparixin":[51,206],"prevents":[52],"vitro":[54],"NETosis":[55,86,172,200],"induced":[56,99,173],"either":[58,104,166,175],"recombinant":[59,62],"DEK":[60,151,167],"(rDEK),":[61],"interleukin-8":[63],"(rIL-8)":[64],"(both":[65],"interacts":[66],"with":[67,75,103],"CXCR2":[68],"receptor)":[69],"or":[70,107,114,119,168,179],"the":[71,89,112,133,156,159,163,171,176,181,189,199,203],"serum":[72,90,110],"patients":[74,93],"coronavirus":[76],"disease-2019":[77],"(COVID-19).Materials":[78],"Methods:":[80],"Level":[81],"pro-inflammatory":[83],"cytokines":[84],"markers":[87],"COVID-19":[92,108,160],"were":[94,135,148],"determined":[95],"ELISA.NETosis":[97],"was":[98,152],"treating":[101],"neutrophils":[102],"rDEK,":[105],"rIL-8":[106],"patients'":[109,177],"presence":[113,125],"absence":[115],"reparixin,":[117],"anti-DEK":[118],"anti-IL-8":[120],"antibodies.Subsequently,":[121],"myeloperoxidase":[122],"(MPO)":[123],"activity,":[124],"extracellular":[127],"neutrophil":[128],"elastase,":[129],"morphology":[131],"cells":[134],"analyzed":[136],"NETosis.Results:":[139],"IL-8,":[140],"IL-6,":[141],"IL-1\u03b2,":[142],"MPO,":[143],"citrullinated":[145],"histone":[146],"H3":[147],"increased":[149],"whereas":[150],"moderately":[153],"decreased":[154],"circulation":[157],"patients.Reparixin":[161],"antibodies":[164],"IL-8":[169],"suppressed":[170],"serums":[178],"rDEK":[182],"rIL-8.Conclusion:":[184],"Our":[185],"results":[186],"show":[187],"for":[188],"first":[190],"time":[191],"that":[192],"DEK-CXCR2":[193],"interaction":[194],"plays":[195],"role":[197],"support":[202],"use":[204],"as":[207],"potential":[209],"therapeutic":[210],"strategy":[211],"COVID-19.":[213]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2024-02-02T00:00:00"}
