{"id":"https://openalex.org/W4391446192","doi":"https://doi.org/10.1158/1538-7445.advbc23-pr06","title":"Abstract PR06: Uncovering nuclear expulsion: chromatin-bound signals from dying cancer cells accelerate metastatic outgrowth through S100A4-RAGE pathway","display_name":"Abstract PR06: Uncovering nuclear expulsion: chromatin-bound signals from dying cancer cells accelerate metastatic outgrowth through S100A4-RAGE pathway","publication_year":2024,"publication_date":"2024-02-01","ids":{"openalex":"https://openalex.org/W4391446192","doi":"https://doi.org/10.1158/1538-7445.advbc23-pr06"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.advbc23-pr06","doi":"https://doi.org/10.1158/1538-7445.advbc23-pr06","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.advbc23-pr06","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102507955","display_name":"Woo\u2010Yong Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wooyong Park","raw_affiliation_strings":["1NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051973677","display_name":"Justin M Gray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin M Gray","raw_affiliation_strings":["1NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015218083","display_name":"Ronald J. Holewinski","orcid":"https://orcid.org/0000-0002-3337-3984","observed_orcids":["https://orcid.org/0000-0002-3337-3984"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald J Holewinski","raw_affiliation_strings":["1NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047456350","display_name":"\u00deorkell Andr\u00e9sson","orcid":"https://orcid.org/0000-0002-9545-2450","observed_orcids":["https://orcid.org/0000-0002-9545-2450"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thorkell Andresson","raw_affiliation_strings":["1NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087595760","display_name":"Jae Young So","orcid":"https://orcid.org/0000-0001-5601-4995","observed_orcids":["https://orcid.org/0000-0001-5601-4995"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jae Young So","raw_affiliation_strings":["1NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077136138","display_name":"Carmelo Carmona\u2010Rivera","orcid":"https://orcid.org/0000-0002-7706-1464","observed_orcids":["https://orcid.org/0000-0002-7706-1464"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmelo M Carmona-Rivera","raw_affiliation_strings":["1NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010407321","display_name":"Mariana J. Kaplan","orcid":"https://orcid.org/0000-0003-2968-0815","observed_orcids":["https://orcid.org/0000-0003-2968-0815"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariana J Kaplan","raw_affiliation_strings":["1NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014287334","display_name":"Steven D. Cappell","orcid":"https://orcid.org/0000-0002-2885-7327","observed_orcids":["https://orcid.org/0000-0002-2885-7327"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven D Cappell","raw_affiliation_strings":["1NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100718241","display_name":"Yang Li","orcid":"https://orcid.org/0000-0002-0930-206X","observed_orcids":["https://orcid.org/0000-0002-0930-206X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Yang","raw_affiliation_strings":["1NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"3_Supplement_1","first_page":"PR06","last_page":"PR06"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.03319999948143959,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptotic-tumor-cells","display_name":"apoptotic tumor cells","score":0.6890000104904175},{"id":"https://openalex.org/keywords/pad4","display_name":"PAD4","score":0.7699999809265137},{"id":"https://openalex.org/keywords/s100a4","display_name":"S100A4","score":0.9259999990463257},{"id":"https://openalex.org/keywords/rage","display_name":"RAGE","score":0.7950000166893005},{"id":"https://openalex.org/keywords/hmgb-proteins","display_name":"HMGB proteins","score":0.8259999752044678},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7170000076293945},{"id":"https://openalex.org/keywords/calcium-spiking","display_name":"calcium spikes","score":0.625},{"id":"https://openalex.org/keywords/erk-activation","display_name":"ERK activation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cancer-cell-communication","display_name":"cancer cell communication","score":0.46799999475479126},{"id":"https://openalex.org/keywords/chemotherapy-induced-apoptosis","display_name":"chemotherapy-induced apoptosis","score":0.6060000061988831},{"id":"https://openalex.org/keywords/prognostic-signature","display_name":"prognostic signature","score":0.796999990940094},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.609000027179718},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.841995358467102},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6261016130447388},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5429373383522034},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5417152047157288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4609428644180298},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3659626245498657},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36348846554756165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25874537229537964},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.21153512597084045},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16391724348068237},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10914605855941772}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.advbc23-pr06","doi":"https://doi.org/10.1158/1538-7445.advbc23-pr06","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.advbc23-pr06","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4360991066","https://openalex.org/W4412816706","https://openalex.org/W7140829724","https://openalex.org/W2050207504","https://openalex.org/W2166616170","https://openalex.org/W2030729827","https://openalex.org/W4412785994","https://openalex.org/W2108712884","https://openalex.org/W3091684972","https://openalex.org/W1040581345"],"abstract_inverted_index":{"Abstract":[0],"Tumor":[1],"cells":[2,40,74,98,127,302,313,317,371],"are":[3,275],"highly":[4],"heterogeneous,":[5],"exhibiting":[6],"diverse":[7],"responses":[8],"when":[9],"exposed":[10],"to":[11,45,76,102,108,191,234,326],"different":[12],"environments.":[13],"We":[14,145],"have":[15],"recently":[16],"observed":[17,179],"this":[18],"heterogeneity":[19],"in":[20,43,55,111,125,138,141,160,180,210,218,228,239,256,263,278,386,390],"tumor":[21,27,39,97,126,231,282,301,312,316],"cell":[22,28,80,87],"apoptosis":[23,42,152],"by":[24,129,168,299],"which":[25,300],"some":[26],"die":[29],"for":[30,156,200],"the":[31,34,63,77,139,154,169,192,244,260,264,310,328,382],"benefits":[32],"of":[33,38,66,120,171,183,188,198,266,330,381],"population\u2019s":[35],"survival.":[36],"Majority":[37],"undergo":[41],"response":[44],"immune":[46],"surveillance,":[47],"various":[48,181],"treatments,":[49],"and":[50,57,132,213,308,335],"a":[51,93,117,142,148,296,306,323],"hostile":[52],"microenvironment,":[53],"both":[54],"circulation":[56],"at":[58],"metastatic":[59,105,136,331,373],"organ":[60],"sites.":[61],"However,":[62],"full":[64],"range":[65],"apoptotic":[67,86,123,311],"signals,":[68],"or":[69],"\"last":[70],"words,\"":[71],"that":[72,309],"dying":[73,281,369],"communicate":[75],"surviving":[78,230],"cancer":[79,185,257,370],"community":[81,307],"remains":[82],"incompletely":[83],"understood.":[84],"While":[85],"death":[88],"is":[89,321],"often":[90],"perceived":[91],"as":[92,153,208,305],"favorable":[94],"therapeutic":[95],"outcome,":[96],"can":[99],"exploit":[100],"it":[101],"enhance":[103],"their":[104],"capabilities,":[106],"leading":[107,233],"poor":[109],"prognoses":[110,255],"certain":[112],"cancers.":[113],"Here,":[114],"we":[115,270,274],"present":[116],"remarkable":[118],"discovery":[119],"an":[121,196],"altered":[122],"program":[124],"characterized":[128],"nuclear":[130,164,172,248,364],"expulsion":[131,173,249],"citrullinated":[133],"chromatin,":[134],"promoting":[135],"outgrowth":[137,374],"lungs":[140],"Padi4-dependent":[143],"manner.":[144],"further":[146],"identified":[147],"calcium":[149],"spike":[150],"during":[151],"trigger":[155],"Padi4":[157],"activation,":[158],"resulting":[159],"rapid":[161],"chromatin":[162],"de-condensation,":[163],"content":[165],"expulsion,":[166],"followed":[167],"generation":[170],"products":[174],"(NEPs).":[175],"This":[176,319],"process":[177],"was":[178,251],"types":[182],"human":[184,219],"tissues.":[186],"Profiling":[187],"proteins":[189,217],"bound":[190],"NEP":[193],"complex":[194],"unveiled":[195],"enrichment":[197],"receptor":[199],"advanced":[201],"glycation":[202],"end-products":[203],"(RAGE)":[204],"pathway":[205,236,377],"proteins,":[206],"such":[207],"S100a4":[209],"mouse":[211],"NEPs":[212,284],"high-mobility":[214],"group-binding":[215],"(HMGB)":[216],"NEPs.":[220],"These":[221],"chromatin-bound":[222,366],"RAGE":[223,226],"ligands":[224],"activated":[225],"receptors":[227],"neighboring":[229],"cells,":[232],"Erk":[235],"activation.":[237],"This,":[238],"turn,":[240],"promotes":[241],"proliferation":[242],"through":[243,375],"RAGE-MAPK":[245],"pathway.":[246],"A":[247],"signature":[250],"associated":[252],"with":[253],"worse":[254],"patients,":[258],"underscoring":[259],"clinical":[261],"efficacy":[262],"context":[265],"apoptosis-inducing":[267],"treatments.":[268],"As":[269],"continue":[271],"our":[272,293],"investigations,":[273],"particularly":[276],"interested":[277],"understanding":[279],"how":[280],"cell-derived":[283],"from":[285,368],"chemotherapy":[286],"may":[287],"affect":[288],"therapy":[289],"outcomes.":[290],"Taken":[291],"together,":[292],"studies":[294],"uncover":[295],"novel":[297],"mechanism":[298],"come":[303],"together":[304],"help":[314],"live":[315],"metastasize.":[318],"insight":[320],"likely":[322],"step":[324],"forward":[325],"understand":[327],"mechanisms":[329],"spread,":[332],"treatment":[333],"resistance":[334],"relapse.":[336],"Citation":[337],"Format:":[338],"Wooyong":[339],"Park,":[340],"Justin":[341],"M":[342,353],"Gray,":[343],"Ronald":[344],"J":[345,356],"Holewinski,":[346],"Thorkell":[347],"Andresson,":[348],"Jae":[349],"Young":[350],"So,":[351],"Carmelo":[352],"Carmona-Rivera,":[354],"Mariana":[355],"Kaplan,":[357],"Steven":[358],"D":[359],"Cappell,":[360],"Li":[361],"Yang.":[362],"Uncovering":[363],"expulsion:":[365],"signals":[367],"accelerate":[372],"S100A4-RAGE":[376],"[abstract].":[378],"In:":[379],"Proceedings":[380],"AACR":[383],"Special":[384],"Conference":[385],"Cancer":[387,392,403],"Research:":[388],"Advances":[389],"Breast":[391],"Research;":[393],"2023":[394],"Oct":[395],"19-22;":[396],"San":[397],"Diego,":[398],"California.":[399],"Philadelphia":[400],"(PA):":[401],"AACR;":[402],"Res":[404],"2024;84(3":[405],"Suppl_1):Abstract":[406],"nr":[407],"PR06.":[408]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2024-02-02T00:00:00"}
