{"id":"https://openalex.org/W4391443220","doi":"https://doi.org/10.1158/1538-7445.canevol23-a016","title":"Abstract A016: Positive ecological interaction between therapy-resistant and sensitive cells, mediated by stromal niche, slows the expansion of resistant subpopulations and promotes tumor heterogeneity","display_name":"Abstract A016: Positive ecological interaction between therapy-resistant and sensitive cells, mediated by stromal niche, slows the expansion of resistant subpopulations and promotes tumor heterogeneity","publication_year":2024,"publication_date":"2024-02-01","ids":{"openalex":"https://openalex.org/W4391443220","doi":"https://doi.org/10.1158/1538-7445.canevol23-a016"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.canevol23-a016","doi":"https://doi.org/10.1158/1538-7445.canevol23-a016","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.canevol23-a016","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010829737","display_name":"Bina Desai","orcid":"https://orcid.org/0000-0003-0454-7583","observed_orcids":["https://orcid.org/0000-0003-0454-7583"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bina Desai","raw_affiliation_strings":["1Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074607695","display_name":"Mark Robertson\u2010Tessi","orcid":"https://orcid.org/0000-0003-0143-9587","observed_orcids":["https://orcid.org/0000-0003-0143-9587"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Robertson-Tessi","raw_affiliation_strings":["1Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042098425","display_name":"Robert Vander Velde","orcid":"https://orcid.org/0000-0003-0776-6773","observed_orcids":["https://orcid.org/0000-0003-0776-6773"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Vander Velde","raw_affiliation_strings":["1Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029259611","display_name":"Tatiana Miti","orcid":"https://orcid.org/0000-0001-6842-8036","observed_orcids":["https://orcid.org/0000-0001-6842-8036"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatiana Miti","raw_affiliation_strings":["1Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092009649","display_name":"Sagnik Yarlagadda","orcid":"https://orcid.org/0009-0007-1396-9979","observed_orcids":["https://orcid.org/0009-0007-1396-9979"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sagnik Yarlagadda","raw_affiliation_strings":["1Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rishi Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rishi Shah","raw_affiliation_strings":["1Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023455221","display_name":"Daria Miroshnychenko","orcid":"https://orcid.org/0000-0001-6425-5000","observed_orcids":["https://orcid.org/0000-0001-6425-5000"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daria Miroshnychenko","raw_affiliation_strings":["1Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003774553","display_name":"David Basanta","orcid":"https://orcid.org/0000-0002-8527-0776","observed_orcids":["https://orcid.org/0000-0002-8527-0776"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Basanta","raw_affiliation_strings":["1Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069501174","display_name":"Alexander R.A. Anderson","orcid":"https://orcid.org/0000-0002-2536-4383","observed_orcids":["https://orcid.org/0000-0002-2536-4383"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Anderson","raw_affiliation_strings":["1Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009118439","display_name":"Andriy Marusyk","orcid":"https://orcid.org/0000-0002-0087-9575","observed_orcids":["https://orcid.org/0000-0002-0087-9575"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andriy Marusyk","raw_affiliation_strings":["1Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"3_Supplement_2","first_page":"A016","last_page":"A016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.10109999775886536,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.7699999809265137},{"id":"https://openalex.org/keywords/eml4-alk-fusion","display_name":"EML4-ALK fusion","score":0.8550000190734863},{"id":"https://openalex.org/keywords/alk-inhibitors","display_name":"ALK inhibitors","score":0.8939999938011169},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7710000276565552},{"id":"https://openalex.org/keywords/stromal-niche","display_name":"stromal niche","score":0.8830000162124634},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6150000095367432},{"id":"https://openalex.org/keywords/evolutionary-dynamics","display_name":"evolutionary dynamics","score":0.5400000214576721},{"id":"https://openalex.org/keywords/agent-based-modeling","display_name":"agent-based modeling","score":0.6830000281333923},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.7919999957084656},{"id":"https://openalex.org/keywords/competitive-fitness","display_name":"competitive fitness","score":0.5099999904632568},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.3919999897480011},{"id":"https://openalex.org/keywords/mouse-xenograft-model","display_name":"xenograft mouse model","score":0.6669999957084656},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.7778278589248657},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7333170175552368},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.4573492407798767},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.4298098385334015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4096081852912903},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33846503496170044},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3156237006187439}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.canevol23-a016","doi":"https://doi.org/10.1158/1538-7445.canevol23-a016","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.canevol23-a016","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404451267","https://openalex.org/W2905636811","https://openalex.org/W4280506270","https://openalex.org/W3110054047","https://openalex.org/W7037618625","https://openalex.org/W4395452825","https://openalex.org/W4404451244","https://openalex.org/W2736683174","https://openalex.org/W2527582579","https://openalex.org/W4404451202"],"abstract_inverted_index":{"Abstract":[0],"Despite":[1],"strong":[2],"initial":[3],"responses,":[4],"advanced":[5,287],"cancers":[6,171],"inevitably":[7],"develop":[8],"resistance":[9,44,89,103,272,303],"to":[10,39,63,70,133,151,190,305],"pharmacological":[11],"inhibitors":[12],"of":[13,27,34,43,67,75,83,92,107,122,137,141,148,161,168,186,202,210,234,243,261,283,298,301,311,320,361,371],"mutant":[14],"tyrosine":[15],"kinases,":[16],"including":[17],"EML4-ALK":[18],"fusion,":[19],"which":[20],"drives":[21],"neoplastic":[22,68],"transformation":[23],"in":[24,60,164,174,279,315,376],"a":[25,57,138,183,191,215,280,295],"subset":[26,282],"lung":[28,170],"cancers.":[29],"Whereas":[30,254],"the":[31,41,65,81,84,93,97,101,135,145,200,206,230,240,258,299,309,317,359,372],"main":[32],"thrust":[33],"research":[35],"and":[36,49,208,232,246,264,307,351,364,382],"development":[37],"efforts":[38],"tackle":[40],"issue":[42],"is":[45,55,78,96,273],"directed":[46],"toward":[47,194],"identification":[48],"targeting":[50],"specific":[51],"molecular":[52],"mechanisms,":[53],"there":[54],"also":[56],"growing":[58],"interest":[59],"developing":[61],"strategies":[62,77],"suppress":[64],"ability":[66],"populations":[69,111],"evolve":[71],"resistance.":[72],"The":[73,385],"success":[74],"these":[76],"contingent":[79],"on":[80,87,144],"accuracy":[82],"basic":[85],"assumptions":[86],"how":[88],"arises.":[90],"One":[91],"key":[94],"issues":[95],"uncertainty":[98],"over":[99],"whether":[100],"acquired":[102],"reflects":[104],"an":[105,159],"expansion":[106,185,209,233,260,360],"pre-existing":[108,187,271],"fully":[109],"resistant":[110,118,142,197,262,362],"or":[112],"develops":[113],"de":[114],"novo":[115],"from":[116],"weakly":[117],"cells":[119,143,198,245,263],"initially":[120],"capable":[121],"only":[123],"narrowly":[124],"avoiding":[125],"elimination.":[126],"To":[127,154],"elucidate":[128],"this":[129,155,224,255],"question,":[130],"we":[131,157],"decided":[132],"examine":[134],"impact":[136],"minor":[139],"subpopulation":[140],"evolutionary":[146,318],"dynamics":[147,201,319],"therapy":[149,181,306,321],"responses":[150],"ALK":[152,288],"inhibitors.":[153,289],"end,":[156],"used":[158],"integration":[160],"experimental":[162],"studies":[163],"mouse":[165],"xenograft":[166],"models":[167],"ALK+":[169],"with":[172,275,286],"agent-based":[173],"silico":[175],"modeling":[176],"approaches.":[177],"We":[178],"found":[179],"that":[180,223,237,270],"induces":[182],"rapid":[184],"subpopulations,":[188],"leading":[189],"quick":[192],"transition":[193],"relapse.":[195],"Surprisingly,":[196],"modulated":[199],"sensitive":[203,212,352],"cells,":[204,353],"preserving":[205],"survival":[207],"their":[211,248],"competitors,":[213],"indicating":[214],"positive":[216,225],"ecological":[217,313,347],"interaction.":[218],"Spatial":[219],"histological":[220],"analyses":[221,268],"revealed":[222],"interaction":[226,348],"was":[227],"mediated":[228,354],"by":[229,355],"preservation":[231],"stromal":[235,356],"niches":[236],"both":[238],"boosted":[239],"competitive":[241,259],"fitness":[242],"therapy-sensitive":[244],"promoted":[247],"adaptation,":[249],"thus":[250],"facilitating":[251],"tumor":[252,265,366],"heterogeneity.":[253],"effect":[256],"inhibited":[257],"relapse,":[266],"our":[267,292],"suggest":[269],"incompatible":[274],"long":[276],"remissions":[277],"observed":[278],"large":[281],"patients":[284],"treated":[285],"In":[290],"summary,":[291],"results":[293],"challenge":[294],"common":[296],"assumption":[297],"pre-existence":[300],"full":[302],"prior":[304],"highlight":[308],"essentiality":[310],"considering":[312],"factors":[314],"understanding":[316],"responses.":[322],"Citation":[323],"Format:":[324],"Bina":[325],"Desai,":[326],"Mark":[327],"Robertson-Tessi,":[328],"Robert":[329],"Vander":[330],"Velde,":[331],"Tatiana":[332],"Miti,":[333],"Sagnik":[334],"Yarlagadda,":[335],"Rishi":[336],"Shah,":[337],"Daria":[338],"Miroshnychenko,":[339],"David":[340],"Basanta,":[341],"Alexander":[342],"Anderson,":[343],"Andriy":[344],"Marusyk.":[345],"Positive":[346],"between":[349],"therapy-resistant":[350],"niche,":[357],"slows":[358],"subpopulations":[363],"promotes":[365],"heterogeneity":[367],"[abstract].":[368],"In:":[369],"Proceedings":[370],"AACR":[373],"Special":[374],"Conference":[375],"Cancer":[377,380,396],"Research:":[378],"Translating":[379],"Evolution":[381],"Data":[383],"Science:":[384],"Next":[386],"Frontier;":[387],"2023":[388],"Dec":[389],"3-6;":[390],"Boston,":[391],"Massachusetts.":[392],"Philadelphia":[393],"(PA):":[394],"AACR;":[395],"Res":[397],"2024;84(3":[398],"Suppl_2):Abstract":[399],"nr":[400],"A016.":[401]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-02-02T00:00:00"}
