{"id":"https://openalex.org/W4391438504","doi":"https://doi.org/10.1161/str.55.suppl_1.tmp117","title":"Abstract TMP117: Exposure to Single or Recurrent Hypoglycemia Increases Stroke Risk in Insulin-Treated Female Diabetic Rats","display_name":"Abstract TMP117: Exposure to Single or Recurrent Hypoglycemia Increases Stroke Risk in Insulin-Treated Female Diabetic Rats","publication_year":2024,"publication_date":"2024-02-01","ids":{"openalex":"https://openalex.org/W4391438504","doi":"https://doi.org/10.1161/str.55.suppl_1.tmp117"},"language":"en","primary_location":{"id":"doi:10.1161/str.55.suppl_1.tmp117","doi":"https://doi.org/10.1161/str.55.suppl_1.tmp117","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/str.55.suppl_1.tmp117","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063510264","display_name":"Ashish Kumar Rehni","orcid":"https://orcid.org/0000-0002-9107-3277","observed_orcids":["https://orcid.org/0000-0002-9107-3277"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashish K Rehni","raw_affiliation_strings":["Univ of Miami Miller Sch o, Miami, FL","Ashish K Rehni Univ of Miami Miller Sch o, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Miami Miller Sch o, Miami, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Ashish K Rehni Univ of Miami Miller Sch o, Miami, FL","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070659084","display_name":"Sunjoo Cho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunjoo Cho","raw_affiliation_strings":["Miami, FL","Sunjoo Cho Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miami, FL","institution_ids":[]},{"raw_affiliation_string":"Sunjoo Cho Miami, FL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021393435","display_name":"Ami P. Raval","orcid":"https://orcid.org/0000-0003-1757-9947","observed_orcids":["https://orcid.org/0000-0003-1757-9947"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ami P Raval","raw_affiliation_strings":["Univ of Miami, Miami, FL","Ami P Raval Univ of Miami, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Miami, Miami, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Ami P Raval Univ of Miami, Miami, FL","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028129787","display_name":"Miguel A. P\u00e9rez\u2010Pinz\u00f3n","orcid":"https://orcid.org/0000-0001-6555-8935","observed_orcids":["https://orcid.org/0000-0001-6555-8935"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel Perez-Pinzon","raw_affiliation_strings":["Miguel Perez-Pinzon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miguel Perez-Pinzon","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006042327","display_name":"Kunjan R. Dave","orcid":"https://orcid.org/0000-0002-0173-5338","observed_orcids":["https://orcid.org/0000-0002-0173-5338"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kunjan R Dave","raw_affiliation_strings":["Neurology, Univ of Miami, Coral Gables, FL","Kunjan R Dave Neurology, Univ of Miami, Coral Gables, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, Univ of Miami, Coral Gables, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Kunjan R Dave Neurology, Univ of Miami, Coral Gables, FL","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"55","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.07450000196695328,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13966","display_name":"Neurological and metabolic disorders","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-hypoglycemia","display_name":"recurrent hypoglycemia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/stroke-risk","display_name":"stroke risk","score":0.9589999914169312},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.843999981880188},{"id":"https://openalex.org/keywords/insulin-treated-diabetes","display_name":"insulin-treated diabetes","score":0.7490000128746033},{"id":"https://openalex.org/keywords/female-rats","display_name":"female rats","score":0.8489999771118164},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5730000138282776},{"id":"https://openalex.org/keywords/prothrombotic-effects","display_name":"prothrombotic effects","score":0.7540000081062317},{"id":"https://openalex.org/keywords/hyperinsulinemic-hypoglycemia","display_name":"hyperinsulinemic hypoglycemia","score":0.8069999814033508},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.8009999990463257},{"id":"https://openalex.org/keywords/carotid-artery-thrombus","display_name":"carotid artery thrombus","score":0.46799999475479126},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.5709999799728394},{"id":"https://openalex.org/keywords/estrous-cycle","display_name":"estrous cycle","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9586833715438843},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.8006430864334106},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6571261882781982},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6367308497428894},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6089460849761963},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5665764808654785},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4752632975578308},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.4308410882949829},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4180123209953308},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.37220433354377747},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35313647985458374},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/str.55.suppl_1.tmp117","doi":"https://doi.org/10.1161/str.55.suppl_1.tmp117","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/str.55.suppl_1.tmp117","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410168533","https://openalex.org/W4417483611","https://openalex.org/W4406962690","https://openalex.org/W7100382713","https://openalex.org/W2084787872","https://openalex.org/W2761696840","https://openalex.org/W2791285731","https://openalex.org/W7163659852","https://openalex.org/W2162474367","https://openalex.org/W2809622649"],"abstract_inverted_index":{"Stroke":[0],"is":[1],"a":[2,184,187,208],"serious":[3],"complication":[4],"of":[5,9,14,60,108,123,157,160,165,173,192,202,210],"diabetes.":[6],"Intensive":[7],"treatment":[8],"diabetes":[10],"increases":[11,43],"the":[12,53,58,106,121,124,158,166,171,175,190,193,197,217,246,268,313],"risk":[13,45,128,172,304],"recurrent":[15],"hypoglycemia":[16,30,95],"(RH).":[17],"Hypoglycemia":[18],"exposure":[19,27],"causes":[20],"prothrombotic":[21],"effects.":[22],"Earlier,":[23],"we":[24,56],"demonstrated":[25],"that":[26,294],"to":[28,87,232,283,296],"single":[29],"(SH),":[31],"5-day":[32,131,247],"RH":[33,39,63,110,115,135,301],"(once":[34],"every":[35],"day),":[36],"and":[37,62,133,142,178,189,300],"twice-a-week":[38],"for":[40,76,111,116],"6":[41,117],"weeks":[42],"stroke":[44,65,127,211,303],"in":[46,67,155,216,267,305],"male":[47,125,297],"insulin-treated":[48],"diabetic":[49,71],"(ITD)":[50],"rats.":[51,69,308],"In":[52],"present":[54],"study,":[55],"determined":[57,242],"effect":[59,107],"SH":[61,299],"on":[64,120,138,196],"risk/thrombosis":[66],"female":[68,72,306],"Streptozotocin":[70],"rats":[73],"were":[74,84,136,148,181],"treated":[75],"hyperglycemia":[77],"using":[78],"insulin":[79],"pellets":[80],"(Figure":[81,101,289],"A).":[82],"Rats":[83],"randomly":[85],"assigned":[86],"either":[88],"hyperinsulinemic":[89,94],"euglycemia":[90],"(ITD+RH+Glucose,":[91],"control)":[92],"or":[93,114],"(ITD+RH)":[96],"groups":[97,104],"(3":[98],"h":[99],"duration)":[100],"B).":[102],"Separate":[103],"tested":[105],"SH,":[109,130],"5":[112],"days,":[113],"weeks.":[118],"Based":[119],"results":[122,292],"studies,":[126],"after":[129,245],"RH,":[132],"6-week":[134,269],"assessed":[137],"days":[139,244],"1,":[140],"7,":[141],"3":[143],"post-last":[144],"hypoglycemia,":[145],"respectively.":[146],"Groups":[147],"balanced":[149],"(confirmed":[150],"by":[151,224,275],"Chi":[152],"square":[153],"test)":[154],"terms":[156],"proportion":[159],"animals":[161],"at":[162],"different":[163],"stages":[164],"estrous":[167],"cycle.":[168],"To":[169],"assess":[170],"stroke,":[174],"carotid":[176],"artery":[177],"jugular":[179],"vein":[180],"linked":[182],"with":[183],"shunt":[185],"containing":[186],"suture,":[188],"weight":[191,215,241,266],"clot":[194,214,240,265],"accumulated":[195],"suture":[198],"following":[199],"15":[200],"min":[201],"blood":[203],"flow":[204],"was":[205,221,253,272],"quantified":[206],"as":[207],"measure":[209],"risk/thrombosis.":[212],"The":[213,239,264],"SH-exposed":[218],"ITD":[219,307],"group":[220,249,260,271],"significantly":[222,254,273],"higher":[223,256,274],"47%":[225,276],"(22\u00b13":[226],"mg,":[227,237,251,262,278,287],"n=9,":[228,279],"p<0.05)":[229],"when":[230,281],"compared":[231,282],"its":[233,258,284],"respective":[234],"control":[235,259,285],"(15\u00b11":[236,261],"n=8).":[238],"7":[243],"ITD+RH":[248,270],"(18\u00b11":[250],"n=7)":[252,288],"(p<0.05)":[255],"than":[257],"n=9).":[263],"(20\u00b12":[277],"p<0.01)":[280],"(14\u00b11":[286],"C).":[290],"Our":[291],"show":[293],"similar":[295],"rats,":[298],"increase":[302],"We":[309],"are":[310],"currently":[311],"evaluating":[312],"underlying":[314],"mechanisms.":[315],"Acknowledgment:":[316],"NIH":[317],"(NS122808).":[318]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-02-02T00:00:00"}