{"id":"https://openalex.org/W4391428091","doi":"https://doi.org/10.1200/jco.2024.42.4_suppl.133","title":"The efficacy and safety of tinengotinib in patients with heavily pretreated metastatic castration-resistant prostate cancer (mCRPC).","display_name":"The efficacy and safety of tinengotinib in patients with heavily pretreated metastatic castration-resistant prostate cancer (mCRPC).","publication_year":2024,"publication_date":"2024-02-01","ids":{"openalex":"https://openalex.org/W4391428091","doi":"https://doi.org/10.1200/jco.2024.42.4_suppl.133"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.4_suppl.133","doi":"https://doi.org/10.1200/jco.2024.42.4_suppl.133","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.4_suppl.133","pdf_url":"https://ascopubs.org/doi/pdf/10.1200/JCO.2024.42.4_suppl.133","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdf/10.1200/JCO.2024.42.4_suppl.133","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110688307","display_name":"Guo Hongqian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guo Hongqian","raw_affiliation_strings":["Nanjing Drum Tower Hospital, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing Drum Tower Hospital, Nanjing, China","institution_ids":["https://openalex.org/I4210111013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021224140","display_name":"Sumit Kumar Subudhi","orcid":"https://orcid.org/0000-0001-5208-7732","observed_orcids":["https://orcid.org/0000-0001-5208-7732"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumit Kumar Subudhi","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100561763","display_name":"Weiqing Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiqing Han","raw_affiliation_strings":["Hunan Cancer Hospital, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Cancer Hospital, Changsha, China","institution_ids":["https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077771845","display_name":"Chih\u2010Yi Liao","orcid":"https://orcid.org/0000-0002-5114-3162","observed_orcids":["https://orcid.org/0000-0002-5114-3162"]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chih-Yi Liao","raw_affiliation_strings":["The University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021863803","display_name":"Shun Zhang","orcid":"https://orcid.org/0000-0002-3493-1247","observed_orcids":["https://orcid.org/0000-0002-3493-1247"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shun Zhang","raw_affiliation_strings":["Nanjing Drum Tower Hospital, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing Drum Tower Hospital, Nanjing, China","institution_ids":["https://openalex.org/I4210111013"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tao Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Dai","raw_affiliation_strings":["Hunan Cancer Hospital, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Cancer Hospital, Changsha, China","institution_ids":["https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100416329","display_name":"Peng Peng","orcid":"https://orcid.org/0009-0002-7993-8001","observed_orcids":["https://orcid.org/0009-0002-7993-8001","https://orcid.org/0009-0005-7439-6196","https://orcid.org/0009-0008-6801-4720"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng Peng","raw_affiliation_strings":["TransThera Sciences (Nanjing), Inc., Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TransThera Sciences (Nanjing), Inc., Nanjing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110631223","display_name":"Caixia Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caixia Sun","raw_affiliation_strings":["TransThera Sciences (Nanjing), Inc., Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TransThera Sciences (Nanjing), Inc., Nanjing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100460899","display_name":"Hui Wang","orcid":"https://orcid.org/0000-0003-1494-6668","observed_orcids":["https://orcid.org/0000-0003-1494-6668"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui Wang","raw_affiliation_strings":["TransThera Sciences (Nanjing), Inc., Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TransThera Sciences (Nanjing), Inc., Nanjing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015241892","display_name":"Katie Hennessy","orcid":"https://orcid.org/0009-0005-1899-4642","observed_orcids":["https://orcid.org/0009-0005-1899-4642"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katie Hennessy","raw_affiliation_strings":["TransThera Sciences (US), Inc., Gaithersburg, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TransThera Sciences (US), Inc., Gaithersburg, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067063482","display_name":"Ximei Fu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ximei Fu","raw_affiliation_strings":["TransThera Sciences (Nanjing), Inc., Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TransThera Sciences (Nanjing), Inc., Nanjing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112839915","display_name":"Yingying Yu","orcid":"https://orcid.org/0009-0007-4227-333X","observed_orcids":["https://orcid.org/0009-0007-4227-333X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yingying Yu","raw_affiliation_strings":["TransThera Sciences (Nanjing), Inc., Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TransThera Sciences (Nanjing), Inc., Nanjing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109679344","display_name":"Yingtong Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yingtong Wu","raw_affiliation_strings":["TransThera Sciences (Nanjing), Inc., Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TransThera Sciences (Nanjing), Inc., Nanjing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404169","display_name":"Qing Li","orcid":"https://orcid.org/0000-0003-2652-6070","observed_orcids":["https://orcid.org/0000-0003-2652-6070","https://orcid.org/0000-0002-0467-8148"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qing Li","raw_affiliation_strings":["TransThera Sciences (Nanjing), Inc., Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TransThera Sciences (Nanjing), Inc., Nanjing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102141721","display_name":"Ruolan Xu","orcid":"https://orcid.org/0000-0002-6594-8930","observed_orcids":["https://orcid.org/0000-0002-6594-8930"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruolan Xu","raw_affiliation_strings":["TransThera Sciences (Nanjing), Inc., Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TransThera Sciences (Nanjing), Inc., Nanjing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101600758","display_name":"Peng Huang","orcid":"https://orcid.org/0000-0002-0244-0216","observed_orcids":["https://orcid.org/0000-0002-0244-0216"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng Huang","raw_affiliation_strings":["TransThera Sciences (Nanjing), Inc., Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TransThera Sciences (Nanjing), Inc., Nanjing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114123536","display_name":"L. Neo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Levin Neo","raw_affiliation_strings":["TransThera Sciences (Nanjing), Inc., Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TransThera Sciences (Nanjing), Inc., Nanjing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103296808","display_name":"Frank Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Wu","raw_affiliation_strings":["TransThera Sciences (Nanjing), Inc., Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TransThera Sciences (Nanjing), Inc., Nanjing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jean Fan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean Fan","raw_affiliation_strings":["TransThera Sciences (US), Inc., Gaithersburg, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TransThera Sciences (US), Inc., Gaithersburg, MD","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026538331","display_name":"Sarina Anne Piha-Paul","orcid":"https://orcid.org/0000-0001-9455-1660","observed_orcids":["https://orcid.org/0000-0001-9455-1660"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarina A. Piha-Paul","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"4_suppl","first_page":"133","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/multikinase-inhibitor","display_name":"multikinase inhibitor","score":0.9369999766349792},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.6940000057220459},{"id":"https://openalex.org/keywords/fgfr-signaling","display_name":"FGFR signaling","score":0.9739999771118164},{"id":"https://openalex.org/keywords/aurora-kinases","display_name":"Aurora kinases","score":0.5260000228881836},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7009999752044678},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.4560000002384186},{"id":"https://openalex.org/keywords/heavily-pretreated-patients","display_name":"heavily pretreated patients","score":0.8029999732971191},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.5139999985694885},{"id":"https://openalex.org/keywords/tumor-plasticity","display_name":"tumor plasticity","score":0.6460000276565552},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.6919999718666077},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9116721153259277},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8348283767700195},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5024449825286865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45943683385849},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4156171977519989}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.4_suppl.133","doi":"https://doi.org/10.1200/jco.2024.42.4_suppl.133","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.4_suppl.133","pdf_url":"https://ascopubs.org/doi/pdf/10.1200/JCO.2024.42.4_suppl.133","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1200/jco.2024.42.4_suppl.133","doi":"https://doi.org/10.1200/jco.2024.42.4_suppl.133","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.4_suppl.133","pdf_url":"https://ascopubs.org/doi/pdf/10.1200/JCO.2024.42.4_suppl.133","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391428091.pdf","grobid_xml":"https://content.openalex.org/works/W4391428091.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4407700360","https://openalex.org/W4409626290","https://openalex.org/W4379283154","https://openalex.org/W7170196843","https://openalex.org/W4391443527","https://openalex.org/W4409631145","https://openalex.org/W4387811521","https://openalex.org/W2794223852","https://openalex.org/W2591518323","https://openalex.org/W2598798363"],"abstract_inverted_index":{"133":[0],"Background:":[1],"Tinengotinib":[2,95,319],"is":[3,212,350],"a":[4],"spectrum-selective":[5],"multi-kinase":[6],"inhibitor":[7],"that":[8,34],"targets":[9],"cell":[10,314],"proliferation,":[11],"angiogenesis,":[12],"and":[13,24,39,56,75,107,122,167,204,254,311,324],"immune-oncology":[14],"pathways":[15],"by":[16],"inhibiting":[17],"Aurora":[18],"kinases":[19,22,27],"A/B,":[20],"Janus":[21],"(JAK),":[23],"receptor":[25,43],"tyrosine":[26],"(FGFRs,":[28],"VEGFRs).":[29],"It":[30],"has":[31],"been":[32],"reported":[33],"the":[35,53,73,92,255],"activation":[36],"of":[37,59,147,158,183,187,221,265,334,345],"JAK/STAT":[38],"fibroblast":[40],"growth":[41],"factor":[42],"(FGFR)":[44],"signaling":[45],"drives":[46],"prostate":[47],"tumor":[48,112],"plasticity.":[49],"Here":[50],"we":[51],"present":[52],"preliminary":[54,327],"safety":[55,143,320],"efficacy":[57,219,328],"data":[58,329],"tinengotinib":[60,335,346],"in":[61,72,185,283,337,347],"patients":[62,80,150,190,217,231,285,338],"with":[63,151,179,339],"mCRPC":[64,79,152],"from":[65],"three":[66,93],"early":[67],"phase":[68],"clinical":[69,332],"trials":[70],"conducted":[71],"US":[74],"China.":[76],"Methods:":[77],"Eligible":[78],"who":[81],"have":[82],"no":[83],"available":[84],"standard":[85],"therapeutic":[86],"treatment":[87],"options":[88],"were":[89,114,153,218,224,232],"enrolled":[90],"to":[91],"studies.":[94],"was":[96,135,140,174,241,251,260,268,275,322],"given":[97],"as":[98],"monotherapy":[99,336],"at":[100,155,192],"8":[101,159],"mg":[102,105,109,160,164,169],"QD,":[103],"10":[104,163],"QD":[106,161,165,170],"12":[108,168],"QD.":[110],"Efficacy":[111],"assessments":[113],"based":[115],"on":[116],"RECIST":[117,227],"v1.1":[118],"for":[119,129,142],"measurable":[120],"disease":[121,256,349],"Prostate":[123],"Cancer":[124],"Working":[125],"Group":[126],"3":[127],"criteria":[128],"non-measurable":[130],"(bone)":[131],"disease.":[132],"PSA50":[133,272],"response":[134,248,266,273],"also":[136],"evaluated.":[137],"CTCAE":[138],"v5.0":[139],"used":[141],"assessments.":[144],"Results:":[145],"As":[146],"28AUG2023,":[148],"30":[149],"treated":[154],"dose":[156],"levels":[157],"(n=1),":[162],"(n=19)":[166],"(n=10).":[171],"Median":[172,263],"age":[173],"67":[175],"years":[176],"(range":[177],"52-82)":[178],"ECOG":[180],"performance":[181],"status":[182],"1":[184],"93%":[186],"patients.":[188],"All":[189],"had":[191],"least":[193],"2":[194],"prior":[195,199,202,206],"therapies":[196],"including":[197],"77%":[198],"docetaxel,":[200],"87%":[201],"abiraterone,":[203],"30%":[205],"enzalutamide.":[207],"The":[208,235,271,287,326],"median":[209,236],"follow-up":[210],"time":[211],"5.4":[213],"months.":[214,270],"Twenty-two":[215],"(22)":[216],"evaluable,":[220],"which":[222],"13":[223],"evaluable":[225],"per":[226],"v1.1.":[228],"Fourteen":[229],"(14)":[230],"PSA":[233],"evaluable.":[234],"radiographic":[237],"progression-free":[238],"survival":[239],"(rPFS)":[240],"5.6":[242],"months":[243],"(95%":[244],"CI,":[245],"3.3-7.3).":[246],"Overall":[247],"rate":[249,258,274],"(ORR)":[250],"46%":[252],"(6/13)":[253],"control":[257],"(DCR)":[259],"85%":[261],"(11/13).":[262],"duration":[264],"(DoR)":[267],"3.0":[269],"50%":[276],"(7/14).":[277],"Treatment-related":[278],"adverse":[279],"events":[280],"(TRAEs)":[281],"occurred":[282],"28":[284],"(93%).":[286],"most":[288],"common":[289],"TRAEs":[290],"(\u226520%)":[291],"included":[292],"blood":[293,313],"thyroid":[294],"stimulating":[295],"hormone":[296],"increase":[297,305],"(43%),":[298],"anemia":[299],"(37%),":[300],"hypertension":[301],"(27%),":[302],"aspartate":[303],"aminotransferase":[304],"(23%),":[306],"electrocardiogram":[307],"QT":[308],"prolongation":[309],"(20%)":[310],"white":[312],"count":[315],"decrease":[316],"(20%).":[317],"Conclusions:":[318],"profile":[321],"tolerable":[323],"manageable.":[325],"showed":[330],"promising":[331],"benefit":[333],"heavily":[340],"pretreated":[341],"mCRPC.":[342],"Further":[343],"study":[344],"this":[348],"warranted.":[351],"Clinical":[352],"trial":[353],"information:":[354],"NCT03654547":[355],",":[356,358],"NCT04742959":[357],"NCT05253053":[359],".":[360]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2024-02-02T00:00:00"}
