{"id":"https://openalex.org/W4391380205","doi":"https://doi.org/10.1021/acssynbio.3c00426","title":"Optimization of RNA Pepper Sensors for the Detection of Arbitrary RNA Targets","display_name":"Optimization of RNA Pepper Sensors for the Detection of Arbitrary RNA Targets","publication_year":2024,"publication_date":"2024-01-31","ids":{"openalex":"https://openalex.org/W4391380205","doi":"https://doi.org/10.1021/acssynbio.3c00426","pmid":"https://pubmed.ncbi.nlm.nih.gov/38295291"},"language":"en","primary_location":{"id":"doi:10.1021/acssynbio.3c00426","doi":"https://doi.org/10.1021/acssynbio.3c00426","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acssynbio.3c00426","pdf_url":null,"source":{"id":"https://openalex.org/S54167817","display_name":"ACS Synthetic Biology","issn_l":"2161-5063","issn":["2161-5063"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Synthetic Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2023/06/19/2023.06.01.543282.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108118373","display_name":"Anli A. Tang","orcid":"https://orcid.org/0009-0007-2831-9469","observed_orcids":["https://orcid.org/0009-0007-2831-9469"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anli A. Tang","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, University of California at Los Angeles, Los Angeles, California 90095, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, University of California at Los Angeles, Los Angeles, California 90095, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021169516","display_name":"Anna Afasizheva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Afasizheva","raw_affiliation_strings":["Department of Biological Chemistry, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114054696","display_name":"Clara T. Cano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clara T. Cano","raw_affiliation_strings":["Department of Biological Chemistry, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017513011","display_name":"Kathrin Plath","orcid":"https://orcid.org/0000-0001-7796-3372","observed_orcids":["https://orcid.org/0000-0001-7796-3372"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathrin Plath","raw_affiliation_strings":["Department of Biological Chemistry, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095, United States","Jonsson Comprehensive Cancer Center, Brain Research Institute, Graduate Program in the Biosciences, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, California 90095, United States","Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095, United States","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, Brain Research Institute, Graduate Program in the Biosciences, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, California 90095, United States","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066636273","display_name":"Douglas L. Black","orcid":"https://orcid.org/0000-0002-2705-8187","observed_orcids":["https://orcid.org/0000-0002-2705-8187"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Black","raw_affiliation_strings":["Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California 90095, United States","Jonsson Comprehensive Cancer Center, Brain Research Institute, Graduate Program in the Biosciences, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, California 90095, United States","Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California 90095, United States","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, Brain Research Institute, Graduate Program in the Biosciences, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, California 90095, United States","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029645424","display_name":"Elisa Franco","orcid":"https://orcid.org/0000-0003-1103-2668","observed_orcids":["https://orcid.org/0000-0003-1103-2668","https://orcid.org/0000-0001-5919-1401"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elisa Franco","raw_affiliation_strings":["Department of Bioengineering, University of California at Los Angeles, Los Angeles, California 90095, United States","Department of Mechanical and Aerospace Engineering, University of California at Los Angeles, Los Angeles, California 90095, United States","Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, United States"],"raw_orcid":"https://orcid.org/0000-0003-1103-2668","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California at Los Angeles, Los Angeles, California 90095, United States","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, University of California at Los Angeles, Los Angeles, California 90095, United States","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, United States","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029645424"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.5876,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.91062627,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"13","issue":"2","first_page":"498","last_page":"508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-sensors","display_name":"RNA sensors","score":0.8899999856948853},{"id":"https://openalex.org/keywords/rna-detection","display_name":"RNA detection","score":0.7820000052452087},{"id":"https://openalex.org/keywords/rna-biomarkers","display_name":"RNA biomarkers","score":0.45899999141693115},{"id":"https://openalex.org/keywords/live-cell-rna-imaging","display_name":"live-cell RNA imaging","score":0.656000018119812},{"id":"https://openalex.org/keywords/signal-to-background-ratio","display_name":"signal-to-background ratio","score":0.8029999732971191},{"id":"https://openalex.org/keywords/sensor-optimization","display_name":"sensor optimization","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.8281894326210022},{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.7488716840744019},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5098599791526794},{"id":"https://openalex.org/C122682173","wikidata":"https://www.wikidata.org/wiki/Q907101","display_name":"Systematic evolution of ligands by exponential enrichment","level":4,"score":0.4466905891895294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3927764296531677},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.24601203203201294},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17117002606391907},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14383086562156677}],"mesh":[{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acssynbio.3c00426","doi":"https://doi.org/10.1021/acssynbio.3c00426","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acssynbio.3c00426","pdf_url":null,"source":{"id":"https://openalex.org/S54167817","display_name":"ACS Synthetic Biology","issn_l":"2161-5063","issn":["2161-5063"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Synthetic Biology","raw_type":"journal-article"},{"id":"doi:10.1101/2023.06.01.543282","doi":"https://doi.org/10.1101/2023.06.01.543282","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.06.01.543282","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/06/19/2023.06.01.543282.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:38295291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38295291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS synthetic biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/2023.06.01.543282","doi":"https://doi.org/10.1101/2023.06.01.543282","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.06.01.543282","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/06/19/2023.06.01.543282.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2585832507","display_name":null,"funder_award_id":"2020039","funder_id":"https://openalex.org/F4320337397","funder_display_name":"Division of Molecular and Cellular Biosciences"},{"id":"https://openalex.org/G3058216672","display_name":"BBSRC-NSF/BIO: Characterizing efficiency and limitations of RNA regulators to achieve robust dynamic behaviors","funder_award_id":"2020039","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320315928","display_name":"Rose Hills Foundation","ror":"https://ror.org/01nebar93"},{"id":"https://openalex.org/F4320337397","display_name":"Division of Molecular and Cellular Biosciences","ror":"https://ror.org/002jdaq33"},{"id":"https://openalex.org/F4320337596","display_name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles","ror":"https://ror.org/046rm7j60"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391380205.pdf","grobid_xml":"https://content.openalex.org/works/W4391380205.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W27699049","https://openalex.org/W1600206056","https://openalex.org/W1975536372","https://openalex.org/W1976135176","https://openalex.org/W1976647752","https://openalex.org/W1989020100","https://openalex.org/W1989799657","https://openalex.org/W2004791359","https://openalex.org/W2005436483","https://openalex.org/W2005774975","https://openalex.org/W2036656644","https://openalex.org/W2052936390","https://openalex.org/W2053614105","https://openalex.org/W2112495562","https://openalex.org/W2120831623","https://openalex.org/W2137232836","https://openalex.org/W2148857891","https://openalex.org/W2161628037","https://openalex.org/W2216033157","https://openalex.org/W2296279197","https://openalex.org/W2332645767","https://openalex.org/W2559648576","https://openalex.org/W2589560199","https://openalex.org/W2607480055","https://openalex.org/W2621507294","https://openalex.org/W2737886736","https://openalex.org/W2759158289","https://openalex.org/W2763354999","https://openalex.org/W2777967852","https://openalex.org/W2803572544","https://openalex.org/W2806353550","https://openalex.org/W2810300431","https://openalex.org/W2900157224","https://openalex.org/W2936259264","https://openalex.org/W2951438030","https://openalex.org/W2973356168","https://openalex.org/W2973830670","https://openalex.org/W3035068224","https://openalex.org/W3048619568","https://openalex.org/W3121958458","https://openalex.org/W3141493888","https://openalex.org/W4220839685","https://openalex.org/W4226077922","https://openalex.org/W4280505962","https://openalex.org/W4376131704","https://openalex.org/W4394748752"],"related_works":["https://openalex.org/W4385226276","https://openalex.org/W3152989556","https://openalex.org/W2128168702","https://openalex.org/W4405303687","https://openalex.org/W2909190419","https://openalex.org/W4377141094","https://openalex.org/W4391115200","https://openalex.org/W2055272075","https://openalex.org/W1988169781","https://openalex.org/W7213341803"],"abstract_inverted_index":{"ABSTRACT":[0],"The":[1,67],"development":[2,169],"of":[3,17,135,146,170],"fluorescent":[4],"light":[5],"up":[6],"RNA":[7,21,93,98,129,150,171,180],"aptamers":[8],"(FLAPs)":[9],"has":[10],"paved":[11],"the":[12,15,53,123,133],"way":[13],"for":[14,121,126,143,167,178],"creation":[16],"sensors":[18,30,51,68,96,142,172],"to":[19,64,71,79,81,159],"track":[20],"in":[22,40,43,105,114],"live":[23],"cells.":[24],"A":[25],"major":[26],"challenge":[27],"with":[28,91,107,173,182],"FLAP":[29],"is":[31],"their":[32,35,92],"brightness":[33,59],"and":[34,42,60,78,117,154,162,176],"limited":[36],"signal-to-background":[37],"ratio":[38],"both":[39],"vivo":[41],"vitro":[44,115],".":[45],"To":[46,131],"address":[47],"this,":[48],"we":[49,118,139],"develop":[50],"using":[52],"Pepper":[54,141],"aptamer,":[55],"which":[56],"exhibits":[57],"superior":[58],"photostability":[61],"when":[62],"compared":[63],"other":[65,160],"FLAPs.":[66],"are":[69,157],"designed":[70],"fold":[72],"into":[73],"a":[74,82,108,144,164],"low":[75],"fluorescence":[76,84],"conformation,":[77],"switch":[80],"high":[83,174],"conformation":[85],"through":[86],"toehold":[87],"or":[88],"loop-mediated":[89],"interactions":[90],"target.":[94],"Our":[95,152],"detect":[97],"targets":[99],"as":[100,102],"short":[101],"20":[103],"nucleotides":[104],"length":[106],"wide":[109],"dynamic":[110],"range":[111,145],"over":[112],"300-fold":[113],",":[116],"describe":[119],"strategies":[120,156],"optimizing":[122],"sensor\u2019s":[124],"performance":[125],"any":[127],"given":[128],"targets.":[130],"demonstrate":[132],"versatility":[134],"our":[136],"design":[137,153],"approach,":[138],"generate":[140],"specific,":[147],"biologically":[148],"relevant":[149],"sequences.":[151],"optimization":[155],"portable":[158],"FLAPs,":[161],"offer":[163],"promising":[165],"foundation":[166],"future":[168],"specificity":[175],"sensitivity":[177],"detecting":[179],"biomarkers":[181],"multiple":[183],"applications.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-02-01T00:00:00"}
