{"id":"https://openalex.org/W4391362295","doi":"https://doi.org/10.1038/s41598-024-52237-7","title":"Dysregulation of RNA splicing in early non-alcoholic fatty liver disease through hepatocellular carcinoma","display_name":"Dysregulation of RNA splicing in early non-alcoholic fatty liver disease through hepatocellular carcinoma","publication_year":2024,"publication_date":"2024-01-30","ids":{"openalex":"https://openalex.org/W4391362295","doi":"https://doi.org/10.1038/s41598-024-52237-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/38291075","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10828381"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-024-52237-7","doi":"https://doi.org/10.1038/s41598-024-52237-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-52237-7","pdf_url":"https://www.nature.com/articles/s41598-024-52237-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-024-52237-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010031854","display_name":"Nicholas J. G. Webster","orcid":"https://orcid.org/0000-0002-3827-5750","observed_orcids":["https://orcid.org/0000-0002-3827-5750"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicholas J. G. Webster","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA, 92093, USA. nwebster@health.ucsd.edu","Jennifer Moreno VA Medical Center, San Diego, CA, 92161, USA. nwebster@health.ucsd.edu","Moores Cancer Center, University of California, San Diego, CA, 92093, USA. nwebster@health.ucsd.edu","Jennifer Moreno VA Medical Center, San Diego, CA, 92161, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA, 92093, USA. nwebster@health.ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Jennifer Moreno VA Medical Center, San Diego, CA, 92161, USA. nwebster@health.ucsd.edu","institution_ids":["https://openalex.org/I4210099595"]},{"raw_affiliation_string":"Moores Cancer Center, University of California, San Diego, CA, 92093, USA. nwebster@health.ucsd.edu","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]},{"raw_affiliation_string":"Jennifer Moreno VA Medical Center, San Diego, CA, 92161, USA","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080395400","display_name":"Deepak Kumar","orcid":"https://orcid.org/0000-0001-6298-3565","observed_orcids":["https://orcid.org/0000-0001-6298-3565","https://orcid.org/0009-0002-5314-975X","https://orcid.org/0009-0009-6555-4657"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepak Kumar","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA, 92093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA, 92093, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041744904","display_name":"Panyisha Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Panyisha Wu","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA, 92093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA, 92093, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010031854"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595","https://openalex.org/I4390039236"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":2.5322,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.91093425,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"2500","last_page":"2500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.9369999766349792},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/srsf3","display_name":"SRSF3","score":0.9599999785423279},{"id":"https://openalex.org/keywords/splicing-events","display_name":"splicing events","score":0.7670000195503235},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.6679999828338623},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/liver-metabolism","display_name":"hepatic metabolism","score":0.7229999899864197},{"id":"https://openalex.org/keywords/splice-variants","display_name":"splice variants","score":0.6330000162124634},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8745853900909424},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.7870447635650635},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.7649796009063721},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5778068900108337},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.5106499791145325},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.46541452407836914},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4556882083415985},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4496843218803406},{"id":"https://openalex.org/C2775893923","wikidata":"https://www.wikidata.org/wiki/Q17113455","display_name":"Circular RNA","level":4,"score":0.44610702991485596},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4447762668132782},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3898216485977173},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3821873962879181},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3669992685317993},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3523186445236206},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3241100311279297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30865752696990967},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.25098609924316406},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18377766013145447}],"mesh":[{"descriptor_ui":"D000068103","descriptor_name":"Serine-Arginine Splicing Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000068103","descriptor_name":"Serine-Arginine Splicing Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000072260","descriptor_name":"RNA Splicing Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-024-52237-7","doi":"https://doi.org/10.1038/s41598-024-52237-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-52237-7","pdf_url":"https://www.nature.com/articles/s41598-024-52237-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10828381","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10828381","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:38291075","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38291075","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:43b92554437d4ba486ed097c198b928e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/43b92554437d4ba486ed097c198b928e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-024-52237-7","doi":"https://doi.org/10.1038/s41598-024-52237-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-52237-7","pdf_url":"https://www.nature.com/articles/s41598-024-52237-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1624786219","display_name":null,"funder_award_id":"I01BX004848","funder_id":"https://openalex.org/F4320332757","funder_display_name":"Veterans Affairs San Diego Healthcare System"},{"id":"https://openalex.org/G3226731898","display_name":"A novel pathway of Th17/Th2 induction: The role of cAMP signaling in DC","funder_award_id":"R01HL141999","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3304255626","display_name":null,"funder_award_id":"IK6 BX005224","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G3304335214","display_name":null,"funder_award_id":"I01 BX004848","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G5914657587","display_name":null,"funder_award_id":"HHSN276201200017C","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G6175092067","display_name":null,"funder_award_id":"I01 BX002709","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G6543560800","display_name":null,"funder_award_id":"HHSN276201200017C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7810585149","display_name":"Specialized Cancer Center Support Grant","funder_award_id":"P30CA023100","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000872323","display_name":"Time-restricted feeding and breast cancer","funder_award_id":"R01CA196853","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000875062","display_name":"San Diego Digestive Diseases Research Center","funder_award_id":"P30DK120515","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000884844","display_name":"Diabetes Research Center (DRC)","funder_award_id":"P30DK063491","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332757","display_name":"Veterans Affairs San Diego Healthcare System","ror":"https://ror.org/00znqwq11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391362295.pdf","grobid_xml":"https://content.openalex.org/works/W4391362295.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W7261346","https://openalex.org/W132273762","https://openalex.org/W267413966","https://openalex.org/W1856151485","https://openalex.org/W1992980640","https://openalex.org/W1996799455","https://openalex.org/W2006850044","https://openalex.org/W2009258895","https://openalex.org/W2014210334","https://openalex.org/W2014677321","https://openalex.org/W2021944979","https://openalex.org/W2039104072","https://openalex.org/W2061898236","https://openalex.org/W2062336519","https://openalex.org/W2072172413","https://openalex.org/W2097175728","https://openalex.org/W2117131162","https://openalex.org/W2131352239","https://openalex.org/W2136850043","https://openalex.org/W2140952049","https://openalex.org/W2141831880","https://openalex.org/W2159654904","https://openalex.org/W2169456326","https://openalex.org/W2196204028","https://openalex.org/W2223556930","https://openalex.org/W2255131131","https://openalex.org/W2259938310","https://openalex.org/W2307041907","https://openalex.org/W2327927180","https://openalex.org/W2338046461","https://openalex.org/W2516730284","https://openalex.org/W2530035865","https://openalex.org/W2549998735","https://openalex.org/W2581708200","https://openalex.org/W2625559053","https://openalex.org/W2741517930","https://openalex.org/W2782454362","https://openalex.org/W2784914640","https://openalex.org/W2789397833","https://openalex.org/W2890249306","https://openalex.org/W2891885918","https://openalex.org/W2896518632","https://openalex.org/W2899496794","https://openalex.org/W2900569176","https://openalex.org/W2911080438","https://openalex.org/W2917858269","https://openalex.org/W2928665623","https://openalex.org/W2942610007","https://openalex.org/W2947596634","https://openalex.org/W2949204189","https://openalex.org/W2949471351","https://openalex.org/W2951377271","https://openalex.org/W2951896979","https://openalex.org/W2952752416","https://openalex.org/W2959566316","https://openalex.org/W2969087302","https://openalex.org/W2969278114","https://openalex.org/W2970070032","https://openalex.org/W2976417077","https://openalex.org/W2996238154","https://openalex.org/W3002900896","https://openalex.org/W3008157409","https://openalex.org/W3008298170","https://openalex.org/W3033811193","https://openalex.org/W3048957454","https://openalex.org/W3087129640","https://openalex.org/W3100281265","https://openalex.org/W3109708108","https://openalex.org/W3121872130","https://openalex.org/W3135418033","https://openalex.org/W3145673476","https://openalex.org/W3158266183","https://openalex.org/W3161735095","https://openalex.org/W3162538759","https://openalex.org/W3188738753","https://openalex.org/W3204103158","https://openalex.org/W3210003385","https://openalex.org/W4213157033","https://openalex.org/W4213340936","https://openalex.org/W4286111501","https://openalex.org/W4308522416","https://openalex.org/W4313236650","https://openalex.org/W4313824213","https://openalex.org/W4361297397","https://openalex.org/W4391101046"],"related_works":["https://openalex.org/W3135418033","https://openalex.org/W4385142935","https://openalex.org/W2947596634","https://openalex.org/W2969087302","https://openalex.org/W4416352522","https://openalex.org/W2922562530","https://openalex.org/W2637624075","https://openalex.org/W2014210334","https://openalex.org/W2221750088","https://openalex.org/W2577586309"],"abstract_inverted_index":{"While":[0],"changes":[1,18,100,141],"in":[2,9,19,50,60,101,157,168,194,205,245],"RNA":[3,20,33,58],"splicing":[4,21,34,45,59,94,206],"have":[5,15,28,41],"been":[6],"extensively":[7],"studied":[8],"hepatocellular":[10],"carcinoma":[11],"(HCC),":[12],"no":[13],"studies":[14,27],"systematically":[16],"investigated":[17],"during":[22,104],"earlier":[23],"liver":[24,37,61,69,77,106,159,247,257],"disease.":[25],"Mouse":[26],"shown":[29,42],"that":[30,43,90,148,185,233],"disruption":[31],"of":[32,68,74,115,120,187,219,224,241,256,263],"can":[35],"trigger":[36],"disease":[38,70,78,190,202,248,258],"and":[39,117,129,139,145,171,183,260],"we":[40,56,91],"the":[44,51,113,137,149,175,181,220,228,239,254,261],"factor":[46,207],"SRSF3":[47,133],"is":[48],"decreased":[49],"diseased":[52],"human":[53],"liver,":[54],"so":[55],"profiled":[57],"samples":[62,196],"from":[63,180],"twenty-nine":[64],"individuals":[65],"with":[66,84,108,112,132,177,201,216],"no-history":[67],"or":[71],"varying":[72],"degrees":[73],"non-alcoholic":[75],"fatty":[76],"(NAFLD).":[79],"We":[80,97,173],"compared":[81,174],"our":[82],"results":[83],"three":[85],"publicly":[86],"available":[87],"transcriptome":[88],"datasets":[89],"re-analyzed":[92],"for":[93,126],"events":[95,110,128],"(SEs).":[96],"found":[98,193],"many":[99,186],"SEs":[102,123,154,165,176,191,226],"occurred":[103],"early":[105,122,138,153,189],"disease,":[107],"fewer":[109],"occurring":[111],"onset":[114],"inflammation":[116],"fibrosis.":[118],"Many":[119],"these":[121,152,188,225,242],"were":[124,130,155,166],"enriched":[125],"SRSF3-dependent":[127],"associated":[131,215],"binding":[134],"sites.":[135],"Mapping":[136],"late":[140,164],"to":[142],"gene":[143],"ontologies":[144],"pathways":[146],"showed":[147],"genes":[150],"harboring":[151,163],"involved":[156,167],"normal":[158],"metabolism,":[160],"whereas":[161],"those":[162],"inflammation,":[169],"fibrosis":[170],"proliferation.":[172],"HCC":[178,195],"data":[179],"TCGA":[182],"observed":[184],"are":[192,199,209],"and,":[197],"furthermore,":[198],"correlated":[200],"survival.":[203],"Changes":[204],"expression":[208],"also":[210],"observed,":[211],"which":[212],"may":[213,235,250],"be":[214,236],"distinct":[217],"subsets":[218],"SEs.":[221],"The":[222],"maintenance":[223],"through":[227],"multi-year":[229],"oncogenic":[230],"process":[231],"suggests":[232],"they":[234],"causative.":[237],"Understanding":[238],"role":[240],"splice":[243],"variants":[244],"metabolic":[246],"progression":[249,259],"shed":[251],"light":[252],"on":[253],"triggers":[255],"pathogenesis":[262],"HCC.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-31T00:00:00"}