{"id":"https://openalex.org/W4391361616","doi":"https://doi.org/10.1080/07391102.2024.2308770","title":"Chemical exploration of different extracts from Phytolacca americana leaves and their potential utilization for global health problems: in silico and network pharmacology validation","display_name":"Chemical exploration of different extracts from Phytolacca americana leaves and their potential utilization for global health problems: in silico and network pharmacology validation","publication_year":2024,"publication_date":"2024-01-30","ids":{"openalex":"https://openalex.org/W4391361616","doi":"https://doi.org/10.1080/07391102.2024.2308770","pmid":"https://pubmed.ncbi.nlm.nih.gov/38288952"},"language":"en","primary_location":{"id":"doi:10.1080/07391102.2024.2308770","doi":"https://doi.org/10.1080/07391102.2024.2308770","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07391102.2024.2308770","pdf_url":null,"source":{"id":"https://openalex.org/S178711970","display_name":"Journal of Biomolecular Structure and Dynamics","issn_l":"0739-1102","issn":["0739-1102","1538-0254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular Structure and Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002896069","display_name":"Nouran M. Fahmy","orcid":"https://orcid.org/0000-0003-0052-5096","observed_orcids":["https://orcid.org/0000-0003-0052-5096"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nouran M. Fahmy","raw_affiliation_strings":["Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University","Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062884164","display_name":"Shaimaa Fayez","orcid":"https://orcid.org/0000-0001-6508-0900","observed_orcids":["https://orcid.org/0000-0001-6508-0900"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Shaimaa Fayez","raw_affiliation_strings":["Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University","Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100703827","display_name":"G\u00f6khan Zengin","orcid":"https://orcid.org/0000-0001-6548-7823","observed_orcids":["https://orcid.org/0000-0001-6548-7823","https://orcid.org/0000-0002-5165-6013","https://orcid.org/0000-0003-4771-2489"]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Gokhan Zengin","raw_affiliation_strings":["Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University","Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University","institution_ids":["https://openalex.org/I137996928"]},{"raw_affiliation_string":"Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya, Turkey","institution_ids":["https://openalex.org/I137996928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101479754","display_name":"Selami Selv\u0131","orcid":"https://orcid.org/0000-0002-9959-6945","observed_orcids":["https://orcid.org/0000-0002-9959-6945"]},"institutions":[{"id":"https://openalex.org/I115600380","display_name":"Bal\u0131kesir University","ror":"https://ror.org/02tv7db43","country_code":"TR","type":"education","lineage":["https://openalex.org/I115600380"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Selami Selvi","raw_affiliation_strings":["Department of Plant and Animal Production, Alt\u0131noluk Vocational School, Bal\u0131kesir University","Department of Plant and Animal Production, Alt\u0131noluk Vocational School, Bal\u0131kesir University, Bal\u0131kesir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant and Animal Production, Alt\u0131noluk Vocational School, Bal\u0131kesir University","institution_ids":["https://openalex.org/I115600380"]},{"raw_affiliation_string":"Department of Plant and Animal Production, Alt\u0131noluk Vocational School, Bal\u0131kesir University, Bal\u0131kesir, Turkey","institution_ids":["https://openalex.org/I115600380"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008882202","display_name":"Abdullahi \u0130brahim Uba","orcid":"https://orcid.org/0000-0002-0853-108X","observed_orcids":["https://orcid.org/0000-0002-0853-108X"]},"institutions":[{"id":"https://openalex.org/I50627504","display_name":"Istanbul Arel University","ror":"https://ror.org/03natay60","country_code":"TR","type":"education","lineage":["https://openalex.org/I50627504"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Abdullahi Ibrahim Uba","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Istanbul AREL University","Department of Molecular Biology and Genetics, Istanbul AREL University, Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-0853-108X","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Istanbul AREL University","institution_ids":["https://openalex.org/I50627504"]},{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Istanbul AREL University, Istanbul, Turkey","institution_ids":["https://openalex.org/I50627504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016876491","display_name":"Adriano Mollica","orcid":"https://orcid.org/0000-0002-7242-4860","observed_orcids":["https://orcid.org/0000-0002-7242-4860"]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Adriano Mollica","raw_affiliation_strings":["Department of Pharmacy, \u201cG. D\u2019Annunzio\u201d, University of Chieti-Pescara","Department of Pharmacy, \"G. D'Annunzio\", University of Chieti-Pescara, Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, \u201cG. D\u2019Annunzio\u201d, University of Chieti-Pescara","institution_ids":["https://openalex.org/I39387349"]},{"raw_affiliation_string":"Department of Pharmacy, \"G. D'Annunzio\", University of Chieti-Pescara, Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069453953","display_name":"Abdelhakim Bouyahya","orcid":"https://orcid.org/0000-0001-9317-1631","observed_orcids":["https://orcid.org/0000-0001-9317-1631"]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Abdelhakim Bouyahya","raw_affiliation_strings":["Laboratory of Human Pathologies Biology, Faculty of Sciences, Mohammed V University in Rabat","Laboratory of Human Pathologies Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Pathologies Biology, Faculty of Sciences, Mohammed V University in Rabat","institution_ids":["https://openalex.org/I126477371"]},{"raw_affiliation_string":"Laboratory of Human Pathologies Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092987346","display_name":"Sathish Kumar M. Ponniya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175691731","display_name":"Pondicherry University","ror":"https://ror.org/01a3mef16","country_code":"IN","type":"education","lineage":["https://openalex.org/I175691731"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sathish Kumar M. Ponniya","raw_affiliation_strings":["Department of Bioinformatics, Pondicherry University","Department of Bioinformatics, Pondicherry University, Pudhucherry, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Pondicherry University","institution_ids":["https://openalex.org/I175691731"]},{"raw_affiliation_string":"Department of Bioinformatics, Pondicherry University, Pudhucherry, India","institution_ids":["https://openalex.org/I175691731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024500430","display_name":"Nilofar Nilofar","orcid":"https://orcid.org/0000-0002-4254-4140","observed_orcids":["https://orcid.org/0000-0002-4254-4140"]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]},{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT","TR"],"is_corresponding":false,"raw_author_name":"Nilofar","raw_affiliation_strings":["Department of Pharmacy, Botanic Garden \u201cGiardino deiSemplici\u201d, Universit\u00e0degli Studi \u201cGabriele d\u2019Annunzio\u201d","Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University","Department of Pharmacy, Botanic Garden \u201cGiardino deiSemplici\u201d, Universit\u00e0degli Studi \u201cGabriele d\u2019Annunzio\u201d, Chieti, Italy","Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Botanic Garden \u201cGiardino deiSemplici\u201d, Universit\u00e0degli Studi \u201cGabriele d\u2019Annunzio\u201d","institution_ids":["https://openalex.org/I39387349"]},{"raw_affiliation_string":"Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University","institution_ids":["https://openalex.org/I137996928"]},{"raw_affiliation_string":"Department of Pharmacy, Botanic Garden \u201cGiardino deiSemplici\u201d, Universit\u00e0degli Studi \u201cGabriele d\u2019Annunzio\u201d, Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]},{"raw_affiliation_string":"Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya, Turkey","institution_ids":["https://openalex.org/I137996928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060574366","display_name":"Sabrina Lekmine","orcid":"https://orcid.org/0000-0002-4945-7170","observed_orcids":["https://orcid.org/0000-0002-4945-7170"]},"institutions":[{"id":"https://openalex.org/I4210130929","display_name":"Abb\u00e8s Laghrour University of Khenchela","ror":"https://ror.org/02yyskm09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I4210130929"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Sabrina Lekmine","raw_affiliation_strings":["Biotechnology, Water, Environment and Health Laboratory, Abbes Laghrour University","Biotechnology, Water, Environment and Health Laboratory, Abbes Laghrour University, Khenchela, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology, Water, Environment and Health Laboratory, Abbes Laghrour University","institution_ids":["https://openalex.org/I4210130929"]},{"raw_affiliation_string":"Biotechnology, Water, Environment and Health Laboratory, Abbes Laghrour University, Khenchela, Algeria","institution_ids":["https://openalex.org/I4210130929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068193682","display_name":"Claudio Ferrante","orcid":"https://orcid.org/0000-0001-9431-9407","observed_orcids":["https://orcid.org/0000-0001-9431-9407"]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Ferrante","raw_affiliation_strings":["Department of Pharmacy, Botanic Garden \u201cGiardino deiSemplici\u201d, Universit\u00e0degli Studi \u201cGabriele d\u2019Annunzio\u201d","Department of Pharmacy, Botanic Garden \u201cGiardino deiSemplici\u201d, Universit\u00e0degli Studi \u201cGabriele d\u2019Annunzio\u201d, Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Botanic Garden \u201cGiardino deiSemplici\u201d, Universit\u00e0degli Studi \u201cGabriele d\u2019Annunzio\u201d","institution_ids":["https://openalex.org/I39387349"]},{"raw_affiliation_string":"Department of Pharmacy, Botanic Garden \u201cGiardino deiSemplici\u201d, Universit\u00e0degli Studi \u201cGabriele d\u2019Annunzio\u201d, Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020306270","display_name":"Omayma A. Eldahshan","orcid":"https://orcid.org/0000-0002-0972-0560","observed_orcids":["https://orcid.org/0000-0002-0972-0560"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Omayma A. Eldahshan","raw_affiliation_strings":["Center of Drug Development Research and Discovery, Ain Shams University","Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University","Center of Drug Development Research and Discovery, Ain Shams University, Cairo, Egypt","Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt"],"raw_orcid":"https://orcid.org/0000-0002-0972-0560","affiliations":[{"raw_affiliation_string":"Center of Drug Development Research and Discovery, Ain Shams University","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Center of Drug Development Research and Discovery, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5020306270","https://openalex.org/A5100703827"],"corresponding_institution_ids":["https://openalex.org/I107720978","https://openalex.org/I137996928"],"apc_list":null,"apc_paid":null,"fwci":4.9785,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.96095527,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"43","issue":"10","first_page":"5178","last_page":"5198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.3337000012397766,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.3337000012397766,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.31690001487731934,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.16459999978542328,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phytolacca-americana","display_name":"Phytolacca americana","score":1.0},{"id":"https://openalex.org/keywords/leaf-extract","display_name":"leaf extract","score":0.6880000233650208},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8069999814033508},{"id":"https://openalex.org/keywords/saponins","display_name":"saponins","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fatty-acids","display_name":"fatty acids","score":0.9940000176429749},{"id":"https://openalex.org/keywords/alpha-amylase-inhibition","display_name":"\u03b1-amylase inhibition","score":0.7590000033378601},{"id":"https://openalex.org/keywords/alpha-glucosidase-inhibition","display_name":"\u03b1-glucosidase inhibition","score":1.0},{"id":"https://openalex.org/keywords/antidiabetic-activity","display_name":"antidiabetic activity","score":0.8410000205039978},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibition","display_name":"acetylcholinesterase inhibition","score":0.9309999942779541},{"id":"https://openalex.org/keywords/butyrylcholinesterase-inhibition","display_name":"butyrylcholinesterase inhibition","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8809999823570251},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9340000152587891},{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C2779858419","wikidata":"https://www.wikidata.org/wiki/Q407153","display_name":"Ethyl acetate","level":2,"score":0.6982377767562866},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6302189826965332},{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.5256073474884033},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4831656813621521},{"id":"https://openalex.org/C40684141","wikidata":"https://www.wikidata.org/wiki/Q902061","display_name":"Electrospray ionization","level":3,"score":0.4716208279132843},{"id":"https://openalex.org/C2779311684","wikidata":"https://www.wikidata.org/wiki/Q17774539","display_name":"Bioactive compound","level":2,"score":0.42643308639526367},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39997413754463196},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.39549392461776733},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3756009042263031},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.34706735610961914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16715064644813538},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.14558911323547363},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1146814227104187}],"mesh":[{"descriptor_ui":"D000091484","descriptor_name":"Network Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000516","descriptor_name":"alpha-Amylases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000520","descriptor_name":"alpha-Glucosidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000520","descriptor_name":"alpha-Glucosidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029604","descriptor_name":"Phytolacca americana","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/07391102.2024.2308770","doi":"https://doi.org/10.1080/07391102.2024.2308770","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07391102.2024.2308770","pdf_url":null,"source":{"id":"https://openalex.org/S178711970","display_name":"Journal of Biomolecular Structure and Dynamics","issn_l":"0739-1102","issn":["0739-1102","1538-0254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular Structure and Dynamics","raw_type":"journal-article"},{"id":"pmid:38288952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38288952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomolecular structure & dynamics","raw_type":"Journal Article"},{"id":"pmh:oai:arelarsiv.arel.edu.tr:20.500.12294/4069","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.12294/4069","pdf_url":null,"source":{"id":"https://openalex.org/S7407055341","display_name":"Istanbul Arel University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W298864664","https://openalex.org/W1667661552","https://openalex.org/W1772174995","https://openalex.org/W1968400569","https://openalex.org/W1975261837","https://openalex.org/W1975770902","https://openalex.org/W1977108112","https://openalex.org/W1992123323","https://openalex.org/W1993000626","https://openalex.org/W2030850720","https://openalex.org/W2048432848","https://openalex.org/W2058049213","https://openalex.org/W2105668062","https://openalex.org/W2112121431","https://openalex.org/W2115117224","https://openalex.org/W2132629607","https://openalex.org/W2145978854","https://openalex.org/W2159548807","https://openalex.org/W2182760280","https://openalex.org/W2183362213","https://openalex.org/W2316710035","https://openalex.org/W2345926390","https://openalex.org/W2408469245","https://openalex.org/W2481759650","https://openalex.org/W2523045014","https://openalex.org/W2538637462","https://openalex.org/W2550257263","https://openalex.org/W2593436234","https://openalex.org/W2613335053","https://openalex.org/W2702570342","https://openalex.org/W2729688826","https://openalex.org/W2774623109","https://openalex.org/W2794828326","https://openalex.org/W2799613805","https://openalex.org/W2884086862","https://openalex.org/W2911724323","https://openalex.org/W2936630915","https://openalex.org/W2942400557","https://openalex.org/W2947840327","https://openalex.org/W2951446638","https://openalex.org/W2952159156","https://openalex.org/W2969865576","https://openalex.org/W2972148293","https://openalex.org/W3010181808","https://openalex.org/W3045268997","https://openalex.org/W3049199541","https://openalex.org/W3081993376","https://openalex.org/W3107062700","https://openalex.org/W3143660303","https://openalex.org/W3159726287","https://openalex.org/W3165679413","https://openalex.org/W3171596094","https://openalex.org/W3172330398","https://openalex.org/W3191380660","https://openalex.org/W3195492701","https://openalex.org/W3197874870","https://openalex.org/W3202292984","https://openalex.org/W3204949673","https://openalex.org/W3207004388","https://openalex.org/W3214934314","https://openalex.org/W3216141837","https://openalex.org/W4205228223","https://openalex.org/W4210327135","https://openalex.org/W4210871180","https://openalex.org/W4220669494","https://openalex.org/W4224295717","https://openalex.org/W4280495297","https://openalex.org/W4283392298","https://openalex.org/W4283393115","https://openalex.org/W4283691727","https://openalex.org/W4297006533","https://openalex.org/W4309002814","https://openalex.org/W4319006084","https://openalex.org/W4319862097","https://openalex.org/W4319877189","https://openalex.org/W4321785360","https://openalex.org/W4362453719","https://openalex.org/W4362589525","https://openalex.org/W4366974853","https://openalex.org/W4385423656","https://openalex.org/W4386940567","https://openalex.org/W4390966555"],"related_works":["https://openalex.org/W7130830537","https://openalex.org/W3209919523","https://openalex.org/W2891240192","https://openalex.org/W2885459534","https://openalex.org/W2067351888","https://openalex.org/W4399886169","https://openalex.org/W7139075045","https://openalex.org/W3013982919","https://openalex.org/W7164587456","https://openalex.org/W4413962323"],"abstract_inverted_index":{"Phytolacca":[0],"americana":[1,62,195,214],"L.":[2],"is":[3],"of":[4,37,79,83,101,164,166,183,198,212,225,236],"great":[5],"interest":[6],"as":[7,222],"a":[8,99,223],"traditional":[9],"additive":[10],"in":[11,15,69,170,200,215,238],"various":[12],"folk":[13],"remedies":[14],"several":[16],"countries,":[17],"including":[18],"Turkey.":[19],"We":[20],"aimed":[21],"to":[22,107],"determine":[23],"the":[24,80,84,122,141,146,161,193,209,239],"chemical":[25],"profile":[26],"(assisted":[27],"by":[28,41,71,247],"high-Performance":[29],"liquid":[30],"chromatography-electrospray":[31],"ionization-tandem":[32],"mass":[33],"apectrometry":[34],"(HPLC-ESI-MS/MS)":[35],"experiments":[36,97],"three":[38,85],"extracts":[39,86],"obtained":[40],"different":[42],"polarity":[43],"solvents":[44],"viz.":[45],"ethyl":[46,123,142],"acetate":[47,124,143],"(to":[48,55],"extract":[49,56,148],"semipolar":[50],"compounds),":[51],"methanol":[52,126,147],"and":[53,76,92,112,125,181,187,221],"water":[54],"highly":[57],"polar":[58],"metabolites)":[59],"from":[60],"P.":[61,194,213],"leaves.":[63],"Their":[64],"anti-diabetic":[65],"effects":[66],"were":[67,174],"investigated":[68],"vitro":[70],"assessing":[72],"their":[73,171],"inhibition":[74,130],"to\u03b1-amylase":[75],"\u03b1-glucosidase.":[77],"Assessment":[78],"neuroprotective":[81],"potential":[82],"was":[87,131],"carried":[88],"out":[89],"against":[90],"acetyl-(AChE)":[91],"butyryl-(BChE)":[93],"cholinesterase":[94,229],"enzymes.":[95],"HPLC-ESI-MS/MS":[96],"showed":[98],"total":[100],"17":[102],"chromatographic":[103],"peaks":[104],"primarily":[105],"classified":[106],"six":[108,113],"flavonoids,":[109],"two":[110],"saponins,":[111],"fatty":[114],"acids.":[115],"Antioxidant":[116],"assays":[117],"revealed":[118],"remarkable":[119],"activity":[120],"for":[121,140,153,208,244],"extracts.":[127],"The":[128,176,204],"BChE":[129],"considerably":[132],"more":[133],"significant":[134],"(4.08":[135],"mg":[136,156],"galantamine":[137],"equivalent":[138],"(GALAE)/g)":[139],"extract,":[144],"whereas":[145],"had":[149],"good":[150],"inhibitory":[151,231],"efficacy":[152],"AChE":[154],"(2.05":[155],"GALAE/g).":[157],"Through":[158],"network":[159],"pharmacology,":[160],"compounds\u2019":[162],"mechanism":[163],"action":[165,199],"targeted":[167],"key":[168],"gene":[169,178],"associated":[172],"diseases":[173],"identified.":[175],"hubb":[177],"signal":[179],"transducer":[180],"activator":[182],"transcription":[184],"3":[185],"(STAT3)":[186],"tumour":[188],"necrosis":[189],"factor":[190],"(TNF\u03b1)":[191],"where":[192],"compound\u2019s":[196],"site":[197],"inflammation":[201],"bowel":[202],"disease.":[203],"results":[205],"offer":[206],"possibilities":[207],"prospective":[210],"application":[211],"metabolic":[216],"regulation,":[217],"blood":[218],"glucose":[219],"control,":[220],"source":[224],"bioactive":[226],"compounds":[227],"with":[228],"enzyme":[230],"characteristics":[232],"which":[233],"could":[234],"be":[235],"relevance":[237],"cosmetic":[240],"or":[241],"pharmaceutical":[242],"industry":[243],"combating":[245],"melanogenesis.Communicated":[246],"Ramaswamy":[248],"H.":[249],"Sarma":[250]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-01-31T00:00:00"}