{"id":"https://openalex.org/W4391338086","doi":"https://doi.org/10.22541/au.170665153.37212275/v1","title":"Changes in cytokines and signaling pathways in different stages of hepatic fibrosis in rats","display_name":"Changes in cytokines and signaling pathways in different stages of hepatic fibrosis in rats","publication_year":2024,"publication_date":"2024-01-30","ids":{"openalex":"https://openalex.org/W4391338086","doi":"https://doi.org/10.22541/au.170665153.37212275/v1"},"language":"en","primary_location":{"id":"doi:10.22541/au.170665153.37212275/v1","doi":"https://doi.org/10.22541/au.170665153.37212275/v1","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.170665153.37212275/v1","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.170665153.37212275","source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.authorea.com/doi/pdf/10.22541/au.170665153.37212275","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019441162","display_name":"Qiangzhong Pi","orcid":"https://orcid.org/0000-0001-8944-4182","observed_orcids":["https://orcid.org/0000-0001-8944-4182","https://orcid.org/0000-0003-1424-6880"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210131174","display_name":"Southwest Hospital","ror":"https://ror.org/02jn36537","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131174"]},{"id":"https://openalex.org/I4210157155","display_name":"Sichuan Academy of Traditional Chinese Medicine","ror":"https://ror.org/05wad7k45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157155"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiangzhong Pi","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Southwest Hospital, Army Medical University","Department of Respiratory and Critical Care Medicine, Southwest Hospital, Army Medical University ,Chongqing 400038, China","Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences","Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Southwest Hospital, Army Medical University","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210131174"]},{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Southwest Hospital, Army Medical University ,Chongqing 400038, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210131174"]},{"raw_affiliation_string":"Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences","institution_ids":["https://openalex.org/I4210157155"]},{"raw_affiliation_string":"Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences, Chengdu 610041, China","institution_ids":["https://openalex.org/I4210157155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044129843","display_name":"Xiaoping Hua","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157155","display_name":"Sichuan Academy of Traditional Chinese Medicine","ror":"https://ror.org/05wad7k45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157155"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoping Hua","raw_affiliation_strings":["Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences","Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences","institution_ids":["https://openalex.org/I4210157155"]},{"raw_affiliation_string":"Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences, Chengdu 610041, China","institution_ids":["https://openalex.org/I4210157155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Liping Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157155","display_name":"Sichuan Academy of Traditional Chinese Medicine","ror":"https://ror.org/05wad7k45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157155"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liping Wang","raw_affiliation_strings":["Department of Pharmacy, Chengdu Jinjiang Hospital for Women and Children Health","Department of Pharmacy, Chengdu Jinjiang Hospital for Women and Children Health, Chengdu 610021, China","Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences","Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Chengdu Jinjiang Hospital for Women and Children Health","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacy, Chengdu Jinjiang Hospital for Women and Children Health, Chengdu 610021, China","institution_ids":[]},{"raw_affiliation_string":"Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences","institution_ids":["https://openalex.org/I4210157155"]},{"raw_affiliation_string":"Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences, Chengdu 610041, China","institution_ids":["https://openalex.org/I4210157155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dali Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dali Fu","raw_affiliation_strings":["Clinical Pharmacy Department of Western Theater General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy Department of Western Theater General Hospital","institution_ids":["https://openalex.org/I2800150677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100425554","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0002-3617-2627","observed_orcids":["https://orcid.org/0000-0002-3617-2627","https://orcid.org/0000-0003-2756-2620","https://orcid.org/0009-0001-8129-4308"]},"institutions":[{"id":"https://openalex.org/I4210157155","display_name":"Sichuan Academy of Traditional Chinese Medicine","ror":"https://ror.org/05wad7k45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157155"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":["Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences","Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences","institution_ids":["https://openalex.org/I4210157155"]},{"raw_affiliation_string":"Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences, Chengdu 610041, China","institution_ids":["https://openalex.org/I4210157155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071415088","display_name":"Wanying Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157155","display_name":"Sichuan Academy of Traditional Chinese Medicine","ror":"https://ror.org/05wad7k45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157155"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanying Tan","raw_affiliation_strings":["Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences","institution_ids":["https://openalex.org/I4210157155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072128170","display_name":"Zheng-Huai Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157155","display_name":"Sichuan Academy of Traditional Chinese Medicine","ror":"https://ror.org/05wad7k45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157155"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenghuai Tan","raw_affiliation_strings":["Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences","Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences","institution_ids":["https://openalex.org/I4210157155"]},{"raw_affiliation_string":"Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan academy of Chinese Medicine Sciences, Chengdu 610041, China","institution_ids":["https://openalex.org/I4210157155"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5072128170"],"corresponding_institution_ids":["https://openalex.org/I4210157155"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.878000020980835},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.9010000228881836},{"id":"https://openalex.org/keywords/common-bile-duct-ligation","display_name":"common bile duct ligation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/thioacetamide","display_name":"thioacetamide","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8529999852180481},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.9890000224113464},{"id":"https://openalex.org/keywords/fibrogenic-factors","display_name":"fibrogenic factors","score":0.6980000138282776},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6209999918937683},{"id":"https://openalex.org/keywords/p70s6k","display_name":"p70S6K","score":0.8370000123977661},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8450000286102295},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.7300000190734863},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9539999961853027},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hydroxyproline","display_name":"hydroxyproline","score":0.8669999837875366},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2781057625","wikidata":"https://www.wikidata.org/wiki/Q416253","display_name":"Thioacetamide","level":2,"score":0.730532705783844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6115922331809998},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6057614684104919},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5691334009170532},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5414263606071472},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.5390052795410156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5092107057571411},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.42842045426368713},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4128193259239197},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.38404572010040283},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25234663486480713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22541/au.170665153.37212275/v1","doi":"https://doi.org/10.22541/au.170665153.37212275/v1","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.170665153.37212275/v1","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.170665153.37212275","source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.22541/au.170665153.37212275/v1","doi":"https://doi.org/10.22541/au.170665153.37212275/v1","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.170665153.37212275/v1","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.170665153.37212275","source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5375207702","display_name":null,"funder_award_id":"21861142007","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391338086.pdf","grobid_xml":"https://content.openalex.org/works/W4391338086.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1879419008","https://openalex.org/W1995201433","https://openalex.org/W2006041438","https://openalex.org/W2045142779","https://openalex.org/W2093116780","https://openalex.org/W2114376411","https://openalex.org/W2159397163","https://openalex.org/W2171925512","https://openalex.org/W2182434170","https://openalex.org/W2199654259","https://openalex.org/W2263554124","https://openalex.org/W2417923433","https://openalex.org/W2496328675","https://openalex.org/W2554615634","https://openalex.org/W2779040327","https://openalex.org/W2805688147","https://openalex.org/W2807105819","https://openalex.org/W2909722404","https://openalex.org/W2923582448","https://openalex.org/W2941772899","https://openalex.org/W2943032176","https://openalex.org/W2945970528","https://openalex.org/W2965264299","https://openalex.org/W2973130852","https://openalex.org/W3019623382","https://openalex.org/W3028000920","https://openalex.org/W3030435724","https://openalex.org/W3039747720","https://openalex.org/W3047506804","https://openalex.org/W3081079791","https://openalex.org/W3093357569","https://openalex.org/W3095695868","https://openalex.org/W3098031338","https://openalex.org/W3111668102","https://openalex.org/W3115411386","https://openalex.org/W3117034696","https://openalex.org/W3128402462","https://openalex.org/W4200519416","https://openalex.org/W4234818780","https://openalex.org/W4246844166","https://openalex.org/W6639903657"],"related_works":["https://openalex.org/W1918588012","https://openalex.org/W2318458560","https://openalex.org/W2351016415","https://openalex.org/W2073317151","https://openalex.org/W2416352929","https://openalex.org/W2979153489","https://openalex.org/W2374194019","https://openalex.org/W4313334052","https://openalex.org/W2020137195","https://openalex.org/W2162661249"],"abstract_inverted_index":{"Background":[0],"&":[1],"Purpose:":[2],"Liver":[3],"fibrosis":[4,90,188,206],"is":[5],"a":[6],"disease":[7],"that":[8,173,190],"seriously":[9],"threatens":[10],"people\u2019s":[11],"health,":[12],"and":[13,36,55,70,72,112,115,121,139,150,153,158,168,175,189,196],"its":[14],"etiopathogenesis":[15],"has":[16],"not":[17],"been":[18],"described":[19],"clearly.":[20],"Experimental":[21],"Approach:":[22],"Female":[23],"rats":[24,38,96],"were":[25,39,60,79],"subjected":[26],"to":[27,213],"common":[28],"bile":[29],"duct":[30],"ligation":[31],"(BDL)":[32],"for":[33,43],"one":[34],"month,":[35],"male":[37],"treated":[40],"with":[41],"thioacetamide":[42,95,165],"23":[44],"weeks.":[45],"The":[46,64],"expression":[47],"of":[48,66,88,104,118,127,133,156,186,193,204,239],"cytokines,":[49],"signal":[50],"pathways,":[51],"histopathology":[52],"in":[53,58,68,76,82,94,98,124,161,164,217],"liver":[54,78,89,187,233],"biochemical":[56],"indexes":[57],"serum":[59,69],"detected.":[61],"Key":[62],"Results:":[63],"levels":[65,103,117,132,155,192],"transaminases":[67],"hydroxyproline":[71],"\u03b1-smooth":[73],"muscle":[74],"actin":[75],"the":[77,86,102,116,125,131,154,162,179,191,202,218,236],"remarkably":[80],"increased":[81,123,160],"both":[83],"models,":[84],"although":[85],"degree":[87],"was":[91],"more":[92,227],"severe":[93],"than":[97],"BDL":[99,128],"rats.":[100,166],"However,":[101],"IL-1\u03b1,":[105,134],"IL-4,":[106,135],"IL-10,":[107,136],"TNF\u03b1,":[108,141],"MCP-1,":[109,142],"PDGF-BB,":[110,143],"p-Akt":[111],"p-STAT5":[113,151],"decreased,":[114,152],"IL-18,":[119],"TGF\u03b21":[120,174],"p-p70s6k":[122],"livers":[126,163],"rats,":[129],"while":[130],"IL-1\u03b2,":[137],"IL-6":[138],"IL-12p70,":[140],"p-CREB,":[144],"p-JNK,":[145],"p-NF\u03baB,":[146],"p-Akt,":[147],"p-p70s6k,":[148],"p-STAT3":[149],"IL-18":[157,176],"TGF-\u03b21":[159],"Conclusion":[167],"Implications:":[169],"These":[170],"data":[171],"suggest":[172],"may":[177,210],"be":[178,211],"main":[180],"fibrogenic":[181],"factors":[182],"at":[183,235],"different":[184],"stages":[185],"inflammation-associated":[194],"cytokines":[195,231],"signaling":[197],"pathway":[198],"components":[199],"decrease":[200],"as":[201],"severity":[203],"hepatic":[205,240],"progresses.":[207],"Therefore,":[208],"it":[209],"better":[212],"apply":[214],"anti-inflammatory":[215],"drugs":[216,224],"early":[219],"stage":[220,238],"or":[221,230],"use":[222],"these":[223],"which":[225],"facilitating":[226],"inflammatory":[228],"cells":[229],"into":[232],"tissue":[234],"end":[237],"fibrosis.":[241]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-01-31T00:00:00"}